CO5170535A1 - Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica - Google Patents

Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica

Info

Publication number
CO5170535A1
CO5170535A1 CO00022433A CO00022433A CO5170535A1 CO 5170535 A1 CO5170535 A1 CO 5170535A1 CO 00022433 A CO00022433 A CO 00022433A CO 00022433 A CO00022433 A CO 00022433A CO 5170535 A1 CO5170535 A1 CO 5170535A1
Authority
CO
Colombia
Prior art keywords
group
alkylcarbamoyl
oxo
phenyl
alkoxy
Prior art date
Application number
CO00022433A
Other languages
English (en)
Inventor
Evanno Yannick
Peretti Daniele De
Francois Gilbert Jean
Michel Peynot
Jocelyne Roy
Garcia Antonio Almario
Maria-Carmen Renones
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5170535A1 publication Critical patent/CO5170535A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Abstract

Compuesto, en forma de enantiómero puro o de mezcla de enantiómeros, que responde a la fórmula general (I)<EMI FILE="00022433_1" ID="1" IMF=JPEG >en la cual X representa un átomo de hidrógeno o de halógeno o un grupo ciano, un grupo nitro, un grupo hidroxi, un grupo (C1-C4) alquilo, un grupo fenilo, un grupo tienilo, un grupo tienilmetoxi, un grupo (C1-C4) alcoxi, un grupo ciclo (C3-C6) alquilmetoxi, un grupo fenilmetoxi, un grupo (C1-C4) alcoxicarbonilo, un grupo (C1-C4) alcoxicarbonilmetilo, un grupo pirrolidin-1-ilcarbonilo, un grupo carbamoilo, un grupo N-(C1-C4) alquilcarbamoilo, un grupo N,N-di(C1-C4) alquilcarbamoilo, un grupo trifluorometilsulfoniloxi, un grupo dimetilaminocarboniloxi, un grupo dimetilaminocarbonilmetoxi, un grupo acetilamino, un grupo acetilaminometilo, o bien dos grupos elegidos entre los átomos de halógenos y los grupos nitro, ciano, (C1-C4) alquilos y (C1-C4) alcoxi, R1 representa un átomo de hidrógeno o un grupo metilo, y R2, tomado aisladamente, representa ya sea un grupo (C1-C4) alcanoilo, ya sea un grupo fenil (C1-C4) alcanoilo, ya sea un grupo metoxiacetilo, ya sea un grupo (C3-C6) cicloalquilcarbonilo, ya sea un grupo benzoilo eventualmente sustituido por un átomo de halógeno, por un grupo (C1-C4) alquilo, por un grupo (C1-C4) alcoxi, por un grupo metoximetilo o por un grupo metoxi y un grupo etilsulfonilo, ya sea un grupo N-fenilcarbamoilo, ya sea un grupo N-((C1-C4) alquilcarbamoilo, ya sea un grupo N-(2-metoxietil) carbamoilo, ya sea un grupo (C1-C4) alcoxicarbonilo, ya sea un grupo (C1-C4)alquilsulfonilo, ya sea un grupo fenilsulfonilo, ya sea un grupo piridin-4-ilcarbonilo, ya sea también un grupo divalente de fórmula COCH2 ó COCH2CH2 enlazado al ciclo fenilo en posición orto del átomo de nitrógeno, de manera tal de formar con este ciclo un grupo 2-oxo-3H-indol-5-ilo ó 2-oxo-3,4-dihidroquinolein-6-ilo, o también NR1R2 representa un grupo 2-oxo-4,5-dihidrooxazolidin-3-ilo, en estado de base o de sal de adición a un ácido.
CO00022433A 1999-03-30 2000-03-29 Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica CO5170535A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903936A FR2791675B1 (fr) 1999-03-30 1999-03-30 Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO5170535A1 true CO5170535A1 (es) 2002-06-27

Family

ID=9543788

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00022433A CO5170535A1 (es) 1999-03-30 2000-03-29 Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica

Country Status (6)

Country Link
AU (1) AU3660700A (es)
CO (1) CO5170535A1 (es)
FR (1) FR2791675B1 (es)
PE (1) PE20001598A1 (es)
UY (1) UY26085A1 (es)
WO (1) WO2000058301A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
BRPI0608353A2 (pt) 2005-02-17 2009-12-01 Wyeth Corp derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos
MX2007013163A (es) 2005-04-22 2008-01-21 Wyeth Corp Derivados de cromano y cromeno y usos de los mismos.
MX2007013151A (es) * 2005-04-22 2008-01-16 Wyeth Corp Derivados de benzodioxano y benzodioxolano y usos de los mismos.
AR060493A1 (es) * 2006-04-18 2008-06-18 Wyeth Corp Derivados de benzodioxano y benzodioxolano. procesos de obtencion.
TW200823187A (en) * 2006-10-24 2008-06-01 Wyeth Corp Benzodioxane derivatives and uses thereof
JP2011519839A (ja) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
AU2009242092A1 (en) 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
CN102015674B (zh) 2008-04-29 2014-10-29 Nsab神经研究瑞典公司分公司 多巴胺神经传递调节剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE635203A (es) * 1962-07-20
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives

Also Published As

Publication number Publication date
UY26085A1 (es) 2000-10-31
PE20001598A1 (es) 2001-04-01
FR2791675A1 (fr) 2000-10-06
WO2000058301A1 (fr) 2000-10-05
FR2791675B1 (fr) 2001-05-04
AU3660700A (en) 2000-10-16

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