JP2007502864A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007502864A5 JP2007502864A5 JP2006533279A JP2006533279A JP2007502864A5 JP 2007502864 A5 JP2007502864 A5 JP 2007502864A5 JP 2006533279 A JP2006533279 A JP 2006533279A JP 2006533279 A JP2006533279 A JP 2006533279A JP 2007502864 A5 JP2007502864 A5 JP 2007502864A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- alkyl
- alkenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44617003A | 2003-05-23 | 2003-05-23 | |
| US10/457,034 US7354932B2 (en) | 2001-12-21 | 2003-06-06 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| PCT/US2004/015977 WO2004106493A2 (en) | 2003-05-23 | 2004-05-21 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502864A JP2007502864A (ja) | 2007-02-15 |
| JP2007502864A5 true JP2007502864A5 (enExample) | 2007-07-19 |
Family
ID=33493026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533279A Pending JP2007502864A (ja) | 2003-05-23 | 2004-05-21 | 有効性を高めたケモカインレセプタ結合複素環化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (6) | US7354932B2 (enExample) |
| EP (1) | EP1628533A4 (enExample) |
| JP (1) | JP2007502864A (enExample) |
| CA (1) | CA2522535C (enExample) |
| WO (1) | WO2004106493A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354932B2 (en) * | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US20220409589A1 (en) * | 2001-12-21 | 2022-12-29 | Genzyme Corporation | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| EP1619193A4 (en) * | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| US7332605B2 (en) * | 2004-03-15 | 2008-02-19 | Anormed, Inc. | Process for the synthesis of CXCR4 antagonist |
| DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| US7951816B2 (en) * | 2004-08-27 | 2011-05-31 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| TW200619206A (en) * | 2004-09-29 | 2006-06-16 | Anormed Inc | Chemokine-binding heterocyclic compound salts, and methods of use thereof |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| AU2006203826A1 (en) | 2005-01-07 | 2006-07-13 | Emory University | CXCR4 antagonists for the treatment of HIV infection |
| WO2006096444A2 (en) * | 2005-03-04 | 2006-09-14 | Smithkline Beecham Corporation | Chemical compounds |
| US20080214562A1 (en) * | 2005-07-11 | 2008-09-04 | Kristjan Gudmundsson | Chemical Compounds |
| PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
| ES2385924T3 (es) | 2006-02-02 | 2012-08-03 | Allergan, Inc. | Inhibidores de la actividad de CXCR4 para su uso en el tratamiento de trastornos oculares |
| US7601716B2 (en) * | 2006-05-01 | 2009-10-13 | Cephalon, Inc. | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors |
| US8618122B2 (en) * | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| US8080659B2 (en) | 2006-07-11 | 2011-12-20 | Emory University | CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders |
| US7999107B2 (en) | 2007-01-31 | 2011-08-16 | Merck Sharp & Dohme Corp. | Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators |
| KR20110005819A (ko) * | 2008-03-28 | 2011-01-19 | 알티리스 쎄라퓨틱스 | 케모카인 수용체 조절제 |
| WO2010099600A1 (en) * | 2009-03-02 | 2010-09-10 | Tucker William G | Compounds and methods for treating cancer and viral infections |
| EA026134B1 (ru) | 2010-12-16 | 2017-03-31 | Ф. Хоффманн-Ля Рош Аг | Трициклические ингибиторы pi3k и способы их применения |
| US8653089B2 (en) | 2011-02-09 | 2014-02-18 | F. Hoffmann-La Roche Ag | Heterocyclic compounds and methods of use |
| CN109069486A (zh) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| US10610527B2 (en) | 2015-12-22 | 2020-04-07 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス4 ファーマシューティカルズ, インコーポレイテッド | Cxcr4阻害剤およびその使用 |
| EP3808748B1 (en) | 2016-06-21 | 2026-05-20 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| CA3085763A1 (en) * | 2017-12-19 | 2019-06-27 | X4 Pharmaceuticals, Inc. | Acyclic cxcr4 inhibitors and uses thereof |
| WO2020010290A1 (en) * | 2018-07-05 | 2020-01-09 | Abb Schweiz Ag | Technologies for solar power system performance model tuning |
| US10548889B1 (en) * | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| WO2020117782A1 (en) * | 2018-12-03 | 2020-06-11 | The University Of North Carolina At Chapel Hill | Methods for attenuating graft-versus-host disease and opportunistic infections |
| CN115515585A (zh) | 2020-03-10 | 2022-12-23 | X4 制药有限公司 | 用于治疗中性粒细胞减少症的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4933447A (en) * | 1987-09-24 | 1990-06-12 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
| US6001826A (en) * | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) * | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9511357D0 (en) * | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| US6506770B1 (en) * | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| IL133212A (en) | 1997-06-02 | 2005-12-18 | Janssen Pharmaceutica Nv | History of use (imidazolil-5-yl) methyl-2-quinolinone that act as culture inhibitors of smooth muscle cells |
| EP1003514A4 (en) | 1997-07-25 | 2000-10-11 | Merck & Co Inc | CYCLIC AMINE MODULATORS OF CHEMOKIN RECEPTORS |
| WO1999016747A1 (en) | 1997-09-30 | 1999-04-08 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| IL145401A0 (en) | 1999-03-24 | 2002-06-30 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| US6683192B2 (en) * | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| NZ524421A (en) | 2000-09-15 | 2005-02-25 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| RU2289581C2 (ru) | 2000-09-15 | 2006-12-20 | Анормед, Инк. | Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение |
| KR20030034184A (ko) * | 2000-09-15 | 2003-05-01 | 아노르메드 인코포레이티드 | 케모킨 수용체 결합 헤테로사이클릭 화합물 |
| NZ526622A (en) * | 2000-12-11 | 2006-07-28 | Amgen Sf Llc | CXCR3 antagonists |
| US6794379B2 (en) * | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
| US7169750B2 (en) | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| CN102302493B (zh) | 2001-07-31 | 2015-08-12 | 健赞股份有限公司 | 活化祖细胞/干细胞的方法 |
| US8178123B2 (en) * | 2001-08-29 | 2012-05-15 | Femina Pharma Incorporated | Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration |
| EP1487795B1 (en) | 2001-09-12 | 2010-11-03 | Anormed Inc. | Synthesis of enantiomerically pure amino-substituted fused bicyclic rings |
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| CA2467718C (en) * | 2001-12-21 | 2011-04-26 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| CA2520259A1 (en) | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
| US7332605B2 (en) | 2004-03-15 | 2008-02-19 | Anormed, Inc. | Process for the synthesis of CXCR4 antagonist |
| TW200619206A (en) * | 2004-09-29 | 2006-06-16 | Anormed Inc | Chemokine-binding heterocyclic compound salts, and methods of use thereof |
-
2003
- 2003-06-06 US US10/457,034 patent/US7354932B2/en not_active Expired - Lifetime
-
2004
- 2004-05-21 EP EP04752905A patent/EP1628533A4/en not_active Withdrawn
- 2004-05-21 JP JP2006533279A patent/JP2007502864A/ja active Pending
- 2004-05-21 CA CA2522535A patent/CA2522535C/en not_active Expired - Lifetime
- 2004-05-21 WO PCT/US2004/015977 patent/WO2004106493A2/en not_active Ceased
-
2008
- 2008-02-22 US US12/036,187 patent/US20080167341A1/en not_active Abandoned
-
2012
- 2012-01-25 US US13/358,041 patent/US8778967B2/en not_active Expired - Fee Related
-
2014
- 2014-06-12 US US14/302,828 patent/US20150038509A1/en not_active Abandoned
-
2016
- 2016-02-08 US US15/018,698 patent/US10322111B2/en not_active Expired - Lifetime
-
2019
- 2019-04-10 US US16/380,365 patent/US20200000774A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230233579A1 (en) | Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids | |
| CA2522535A1 (en) | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | |
| RU2004105961A (ru) | Способы активации клеток-предшественников/стволовых клеток | |
| Cai et al. | The specific roles of JAK/STAT signaling pathway in sepsis | |
| Guinan et al. | Intravascular hemolysis and renal insufficiency after bone marrow transplantation | |
| JP2006526646A5 (enExample) | ||
| Loftus et al. | The postinjury inflammatory state and the bone marrow response to anemia | |
| Hesse et al. | Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: an animal study in rabbits | |
| JP2013231086A (ja) | 化学療法の強化方法 | |
| KR20100017763A (ko) | 상승 효과가 있는 암 치료용 약제 조합물 | |
| JP2024519845A5 (enExample) | ||
| Couban et al. | Bone marrow mobilized with granulocyte colony-stimulating factor in related allogeneic transplant recipients: a study of 29 patients | |
| JP2012522841A5 (enExample) | ||
| KR20130142164A (ko) | 암 치료 및 면역억제를 위한 시로신고핀과 미토콘드리아 억제제의 조합물 | |
| JP2005532373A5 (enExample) | ||
| JP5457196B2 (ja) | Cndac(2’−シアノ−2’−デオキシ−n4−パルミトイル−1−ベータ−d−アラビノフラノシル−シトシン)及び細胞毒性薬を含む組合せ | |
| JP5818905B2 (ja) | エリスロポエチン産生促進剤 | |
| Maron-Gutierrez et al. | Insult-dependent effect of bone marrow cell therapy on inflammatory response in a murine model of extrapulmonary acute respiratory distress syndrome | |
| Russo et al. | Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells | |
| TWI245643B (en) | Composition for selective cancer chemotherapy | |
| RU2008151054A (ru) | Применение ингибиторов рецептора эндотелиального фактора роста сосудов для лечения рака | |
| Fowler et al. | Targeting the canonical nuclear factor-κB pathway with a high-potency IKK2 inhibitor improves outcomes in a mouse model of idiopathic pneumonia syndrome | |
| EP4313028A1 (en) | Use of the sesquiterpene lactone tomentosin in the treatment of tumors caused by lymphoid cell lines | |
| Kumar et al. | BET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD | |
| JP6549107B2 (ja) | がんの処置のための、ro5503781、カペシタビン及びオキサリプラチンの組み合わせ |