JP2007502864A5 - - Google Patents

Download PDF

Info

Publication number
JP2007502864A5
JP2007502864A5 JP2006533279A JP2006533279A JP2007502864A5 JP 2007502864 A5 JP2007502864 A5 JP 2007502864A5 JP 2006533279 A JP2006533279 A JP 2006533279A JP 2006533279 A JP2006533279 A JP 2006533279A JP 2007502864 A5 JP2007502864 A5 JP 2007502864A5
Authority
JP
Japan
Prior art keywords
composition
subject
alkyl
alkenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006533279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007502864A (ja
Filing date
Publication date
Priority claimed from US10/457,034 external-priority patent/US7354932B2/en
Application filed filed Critical
Publication of JP2007502864A publication Critical patent/JP2007502864A/ja
Publication of JP2007502864A5 publication Critical patent/JP2007502864A5/ja
Pending legal-status Critical Current

Links

JP2006533279A 2003-05-23 2004-05-21 有効性を高めたケモカインレセプタ結合複素環化合物 Pending JP2007502864A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44617003A 2003-05-23 2003-05-23
US10/457,034 US7354932B2 (en) 2001-12-21 2003-06-06 Chemokine receptor binding heterocyclic compounds with enhanced efficacy
PCT/US2004/015977 WO2004106493A2 (en) 2003-05-23 2004-05-21 Chemokine receptor binding heterocyclic compounds with enhanced efficacy

Publications (2)

Publication Number Publication Date
JP2007502864A JP2007502864A (ja) 2007-02-15
JP2007502864A5 true JP2007502864A5 (enExample) 2007-07-19

Family

ID=33493026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006533279A Pending JP2007502864A (ja) 2003-05-23 2004-05-21 有効性を高めたケモカインレセプタ結合複素環化合物

Country Status (5)

Country Link
US (6) US7354932B2 (enExample)
EP (1) EP1628533A4 (enExample)
JP (1) JP2007502864A (enExample)
CA (1) CA2522535C (enExample)
WO (1) WO2004106493A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US20220409589A1 (en) * 2001-12-21 2022-12-29 Genzyme Corporation Chemokine receptor binding heterocyclic compounds with enhanced efficacy
EP1619193A4 (en) * 2003-04-18 2010-08-11 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
US7332605B2 (en) * 2004-03-15 2008-02-19 Anormed, Inc. Process for the synthesis of CXCR4 antagonist
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
US7951816B2 (en) * 2004-08-27 2011-05-31 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
TW200619206A (en) * 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
AU2006203826A1 (en) 2005-01-07 2006-07-13 Emory University CXCR4 antagonists for the treatment of HIV infection
WO2006096444A2 (en) * 2005-03-04 2006-09-14 Smithkline Beecham Corporation Chemical compounds
US20080214562A1 (en) * 2005-07-11 2008-09-04 Kristjan Gudmundsson Chemical Compounds
PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
ES2385924T3 (es) 2006-02-02 2012-08-03 Allergan, Inc. Inhibidores de la actividad de CXCR4 para su uso en el tratamiento de trastornos oculares
US7601716B2 (en) * 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
US8618122B2 (en) * 2006-05-16 2013-12-31 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
US8080659B2 (en) 2006-07-11 2011-12-20 Emory University CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
KR20110005819A (ko) * 2008-03-28 2011-01-19 알티리스 쎄라퓨틱스 케모카인 수용체 조절제
WO2010099600A1 (en) * 2009-03-02 2010-09-10 Tucker William G Compounds and methods for treating cancer and viral infections
EA026134B1 (ru) 2010-12-16 2017-03-31 Ф. Хоффманн-Ля Рош Аг Трициклические ингибиторы pi3k и способы их применения
US8653089B2 (en) 2011-02-09 2014-02-18 F. Hoffmann-La Roche Ag Heterocyclic compounds and methods of use
CN109069486A (zh) 2015-12-14 2018-12-21 X4 制药有限公司 治疗癌症的方法
CN109069426B (zh) 2015-12-14 2021-10-29 X4 制药有限公司 治疗癌症的方法
US10610527B2 (en) 2015-12-22 2020-04-07 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
US11337969B2 (en) 2016-04-08 2022-05-24 X4 Pharmaceuticals, Inc. Methods for treating cancer
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス4 ファーマシューティカルズ, インコーポレイテッド Cxcr4阻害剤およびその使用
EP3808748B1 (en) 2016-06-21 2026-05-20 X4 Pharmaceuticals, Inc. Substituted piperidines as cxcr4-inhibitors
US10988465B2 (en) 2016-06-21 2021-04-27 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
CA3085763A1 (en) * 2017-12-19 2019-06-27 X4 Pharmaceuticals, Inc. Acyclic cxcr4 inhibitors and uses thereof
WO2020010290A1 (en) * 2018-07-05 2020-01-09 Abb Schweiz Ag Technologies for solar power system performance model tuning
US10548889B1 (en) * 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
WO2020117782A1 (en) * 2018-12-03 2020-06-11 The University Of North Carolina At Chapel Hill Methods for attenuating graft-versus-host disease and opportunistic infections
CN115515585A (zh) 2020-03-10 2022-12-23 X4 制药有限公司 用于治疗中性粒细胞减少症的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933447A (en) * 1987-09-24 1990-06-12 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
US6001826A (en) * 1989-12-21 1999-12-14 Anormed, Inc. Chemical compounds
US5021409A (en) 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
GB9126677D0 (en) * 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9400411D0 (en) * 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
US6506770B1 (en) * 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
IL133212A (en) 1997-06-02 2005-12-18 Janssen Pharmaceutica Nv History of use (imidazolil-5-yl) methyl-2-quinolinone that act as culture inhibitors of smooth muscle cells
EP1003514A4 (en) 1997-07-25 2000-10-11 Merck & Co Inc CYCLIC AMINE MODULATORS OF CHEMOKIN RECEPTORS
WO1999016747A1 (en) 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
US6365583B1 (en) * 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
IL145401A0 (en) 1999-03-24 2002-06-30 Anormed Inc Chemokine receptor binding heterocyclic compounds
US6683192B2 (en) * 2000-03-30 2004-01-27 Curis, Inc. Small organic molecule regulators of cell proliferation
NZ524421A (en) 2000-09-15 2005-02-25 Anormed Inc Chemokine receptor binding heterocyclic compounds
RU2289581C2 (ru) 2000-09-15 2006-12-20 Анормед, Инк. Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение
KR20030034184A (ko) * 2000-09-15 2003-05-01 아노르메드 인코포레이티드 케모킨 수용체 결합 헤테로사이클릭 화합물
NZ526622A (en) * 2000-12-11 2006-07-28 Amgen Sf Llc CXCR3 antagonists
US6794379B2 (en) * 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
US7169750B2 (en) 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
CN102302493B (zh) 2001-07-31 2015-08-12 健赞股份有限公司 活化祖细胞/干细胞的方法
US8178123B2 (en) * 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
EP1487795B1 (en) 2001-09-12 2010-11-03 Anormed Inc. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
US7354932B2 (en) 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
CA2467718C (en) * 2001-12-21 2011-04-26 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
CA2520259A1 (en) 2003-04-11 2004-10-28 Anormed Inc. Cxcr4 chemokine receptor binding compounds
US7332605B2 (en) 2004-03-15 2008-02-19 Anormed, Inc. Process for the synthesis of CXCR4 antagonist
TW200619206A (en) * 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof

Similar Documents

Publication Publication Date Title
US20230233579A1 (en) Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids
CA2522535A1 (en) Chemokine receptor binding heterocyclic compounds with enhanced efficacy
RU2004105961A (ru) Способы активации клеток-предшественников/стволовых клеток
Cai et al. The specific roles of JAK/STAT signaling pathway in sepsis
Guinan et al. Intravascular hemolysis and renal insufficiency after bone marrow transplantation
JP2006526646A5 (enExample)
Loftus et al. The postinjury inflammatory state and the bone marrow response to anemia
Hesse et al. Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: an animal study in rabbits
JP2013231086A (ja) 化学療法の強化方法
KR20100017763A (ko) 상승 효과가 있는 암 치료용 약제 조합물
JP2024519845A5 (enExample)
Couban et al. Bone marrow mobilized with granulocyte colony-stimulating factor in related allogeneic transplant recipients: a study of 29 patients
JP2012522841A5 (enExample)
KR20130142164A (ko) 암 치료 및 면역억제를 위한 시로신고핀과 미토콘드리아 억제제의 조합물
JP2005532373A5 (enExample)
JP5457196B2 (ja) Cndac(2’−シアノ−2’−デオキシ−n4−パルミトイル−1−ベータ−d−アラビノフラノシル−シトシン)及び細胞毒性薬を含む組合せ
JP5818905B2 (ja) エリスロポエチン産生促進剤
Maron-Gutierrez et al. Insult-dependent effect of bone marrow cell therapy on inflammatory response in a murine model of extrapulmonary acute respiratory distress syndrome
Russo et al. Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells
TWI245643B (en) Composition for selective cancer chemotherapy
RU2008151054A (ru) Применение ингибиторов рецептора эндотелиального фактора роста сосудов для лечения рака
Fowler et al. Targeting the canonical nuclear factor-κB pathway with a high-potency IKK2 inhibitor improves outcomes in a mouse model of idiopathic pneumonia syndrome
EP4313028A1 (en) Use of the sesquiterpene lactone tomentosin in the treatment of tumors caused by lymphoid cell lines
Kumar et al. BET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD
JP6549107B2 (ja) がんの処置のための、ro5503781、カペシタビン及びオキサリプラチンの組み合わせ