JP2012525364A - 増殖性状態の処置または予防 - Google Patents
増殖性状態の処置または予防 Download PDFInfo
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- JP2012525364A JP2012525364A JP2012507812A JP2012507812A JP2012525364A JP 2012525364 A JP2012525364 A JP 2012525364A JP 2012507812 A JP2012507812 A JP 2012507812A JP 2012507812 A JP2012507812 A JP 2012507812A JP 2012525364 A JP2012525364 A JP 2012525364A
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- compound
- amide
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- 0 CC(c(ccc(OCc1cc(cc(*)cc2)c2[o]1)c1)c1O1)=CC1=O Chemical compound CC(c(ccc(OCc1cc(cc(*)cc2)c2[o]1)c1)c1O1)=CC1=O 0.000 description 2
- ZHUUJVAVOVMLCK-UHFFFAOYSA-N BrCc(cc1)ccc1-c1ccc[s]1 Chemical compound BrCc(cc1)ccc1-c1ccc[s]1 ZHUUJVAVOVMLCK-UHFFFAOYSA-N 0.000 description 1
- ARJOJUQBOMFBDN-UHFFFAOYSA-N BrCc1cc2ccccc2[o]1 Chemical compound BrCc1cc2ccccc2[o]1 ARJOJUQBOMFBDN-UHFFFAOYSA-N 0.000 description 1
- OKVSAMOSASCWJX-UHFFFAOYSA-N CC(CC(Oc1c2)=O)c1ccc2OCc(cc1)ccc1-c1ccc[s]1 Chemical compound CC(CC(Oc1c2)=O)c1ccc2OCc(cc1)ccc1-c1ccc[s]1 OKVSAMOSASCWJX-UHFFFAOYSA-N 0.000 description 1
- KJTWWDLKXWRJPO-UHFFFAOYSA-N Cc(c1c2[n](Cc3ccccc3F)nn1)nnc2OCc1cc2ccccc2[o]1 Chemical compound Cc(c1c2[n](Cc3ccccc3F)nn1)nnc2OCc1cc2ccccc2[o]1 KJTWWDLKXWRJPO-UHFFFAOYSA-N 0.000 description 1
- GZFFZKUCWATTTQ-UHFFFAOYSA-N NCc1cc(cc(C(F)(F)F)cc2)c2[o]1 Chemical compound NCc1cc(cc(C(F)(F)F)cc2)c2[o]1 GZFFZKUCWATTTQ-UHFFFAOYSA-N 0.000 description 1
- VYAQYZARCPGAMD-UHFFFAOYSA-N c([nH]c1ncn2)nc1c2SC(c1ccccc1)c1ccccc1 Chemical compound c([nH]c1ncn2)nc1c2SC(c1ccccc1)c1ccccc1 VYAQYZARCPGAMD-UHFFFAOYSA-N 0.000 description 1
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| JP2021512953A (ja) * | 2018-02-02 | 2021-05-20 | メイベリックス オンコロジー インコーポレイテッド | ゲムシタビンモノホスフェートの小分子薬物コンジュゲート |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247381A2 (en) * | 1986-04-30 | 1987-12-02 | Otsuka Pharmaceutical Co., Ltd. | 5-flurorouracil derivatives |
| JPH02149579A (ja) * | 1988-10-13 | 1990-06-08 | Basf Ag | ヘテロ環置換アルコキシクマリン、その製造方法およびこれを含有する治療剤 |
| JPH02157273A (ja) * | 1988-10-13 | 1990-06-18 | Basf Ag | アリールアルコキシクマリン、その製造方法及びこれを含有する治療剤 |
| JPH04501253A (ja) * | 1988-05-25 | 1992-03-05 | リサーチ コーポレーシヨン テクノロジーズ インコーポレーテツド | 抗腫瘍剤として有用なホスホラミド |
| JPH08511773A (ja) * | 1993-06-08 | 1996-12-10 | キャンサー・リサーチ・キャンペーン・テクノロジー・リミテッド | O▲上6▼−置換グアニン誘導体、それらの製造方法および腫瘍細胞の処置におけるそれらの使用 |
| US20050130973A1 (en) * | 2003-12-04 | 2005-06-16 | Wyeth | Biaryl sulfonamides and methods for using same |
| JP2005526046A (ja) * | 2002-02-27 | 2005-09-02 | インスパイアー ファーマシューティカルズ,インコーポレイティド | 上皮及び網膜組織疾患の治療のための組成物及び治療方法 |
| JP2005526696A (ja) * | 2001-09-14 | 2005-09-08 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | ベータ−3アドレナリン受容体アゴニストとして有用なベンゾフランおよびジヒドロベンゾフラン誘導体 |
| WO2006009826A1 (en) * | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| JP2008526695A (ja) * | 2004-12-30 | 2008-07-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 炎症の治療においてcxcr2阻害剤として使用される縮合二環式カルボキサミド誘導体 |
| WO2008110793A1 (en) * | 2007-03-12 | 2008-09-18 | Biolipox Ab | Piperidinones useful in the treatment of inflammation |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU389090A1 (ru) * | 1971-05-17 | 1973-07-05 | Ташкентский государственный медицинский институт | Библиотека |
| US4526988A (en) | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US5229272A (en) | 1989-04-25 | 1993-07-20 | Igen, Inc. | Catalytic antibody components |
| ATE92499T1 (de) | 1984-12-04 | 1993-08-15 | Lilly Co Eli | Tumorbehandlung bei saeugetieren. |
| ZA859008B (en) | 1984-12-04 | 1987-07-29 | Lilly Co Eli | The treatment of tumors in mammals |
| US6702705B1 (en) | 1988-05-04 | 2004-03-09 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
| US6258360B1 (en) | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
| US6060592A (en) | 1990-01-11 | 2000-05-09 | Isis Pharmaceuticals, Inc. | Pyrimidine nucleoside compounds and oligonucleoside compounds containing same |
| US5401838A (en) | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| DK0795334T3 (da) * | 1996-03-12 | 2006-06-06 | Sanofi Aventis Deutschland | Nye prodrugs til behandling af tumorer og betændelsessygdomme |
| WO1998011484A1 (fr) | 1996-09-13 | 1998-03-19 | Hitachi, Ltd. | Processeur de commande a memoire d'historique |
| ATE236188T1 (de) | 1997-01-24 | 2003-04-15 | Conpharma As | Gemcitabin-derivate |
| NZ330360A (en) | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| TW434252B (en) | 1997-07-23 | 2001-05-16 | Univ Georgia Res Found | Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine |
| EP1051383B1 (en) | 1998-02-06 | 2004-07-28 | De Montfort University | Hydroxylation activated prodrugs |
| AU2531599A (en) * | 1998-02-12 | 1999-08-30 | De Montfort University | Hydroxylation activated drug release |
| GB2334256A (en) * | 1998-02-12 | 1999-08-18 | Univ Montfort | Hydroxylation activated prodrugs |
| DE19834751A1 (de) | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6175001B1 (en) | 1998-10-16 | 2001-01-16 | The Scripps Research Institute | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same |
| YU68102A (sh) | 2000-03-16 | 2006-01-16 | F. Hoffmann-La Roche Ag. | Derivati karboksilne kiseline kao ip antagonisti |
| GB0007401D0 (en) | 2000-03-27 | 2000-05-17 | Cancer Res Campaign Tech | Substituted chalcones as therapeeutic compounds |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| JP3692927B2 (ja) | 2000-11-07 | 2005-09-07 | 日本電気株式会社 | ファクシミリ装置 |
| UA75622C2 (en) * | 2000-12-08 | 2006-05-15 | 3M Innovative Properties Co | Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon |
| BR0207795A (pt) * | 2001-03-02 | 2004-03-23 | Hoffmann La Roche | Derivados de ácido alcoxicarbonilamino benzóico ou alcoxicarbonilamino tetrazolil fenila como antagonistas de ip |
| EP1300403A1 (en) * | 2001-10-02 | 2003-04-09 | Aventis Pharma S.A. | Process for the manufacture of hypoxyxylerone derivatives |
| GB0123780D0 (en) | 2001-10-03 | 2001-11-21 | Cancer Res Ventures Ltd | Substituted chalcones as therapeutic agents |
| GB0123777D0 (en) | 2001-10-03 | 2001-11-21 | Cancer Res Ventures Ltd | Substituted chalcones as therapeutic agents |
| US7265096B2 (en) | 2002-11-04 | 2007-09-04 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| EA012844B1 (ru) | 2003-02-19 | 2009-12-30 | Йельский Университет | Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций |
| ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| CA2550299C (en) | 2003-12-22 | 2010-03-30 | Christopher R. Roberts | Process for fluorocytidine derivatives |
| EP3075247B1 (en) | 2004-02-02 | 2022-10-12 | BioSight Ltd. | Conjugates for cancer therapy and diagnosis |
| GB0421294D0 (en) | 2004-09-24 | 2004-10-27 | Angiogene Pharm Ltd | Bioreductively-activated prodrugs |
| KR100874052B1 (ko) | 2004-12-17 | 2008-12-12 | 일라이 릴리 앤드 캄파니 | 젬시타빈의 아미드 전구약, 그의 조성물 및 그의 용도 |
| NO322682B1 (no) | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| CA2624726A1 (en) * | 2005-10-06 | 2007-04-12 | Sanofi-Aventis | 4-oxy-n-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals |
| WO2007117760A2 (en) | 2006-02-06 | 2007-10-18 | Dr. Reddy's Laboratories Ltd. | Preparation of gemcitabine |
| US20080182816A1 (en) | 2006-02-23 | 2008-07-31 | Tam Joemy C | Methods for preparing a novel family of polysaccharride prodrugs for colonic delivery |
| US20070225248A1 (en) | 2006-03-21 | 2007-09-27 | Clavis Pharma As | Oral dosage forms of gemcitabine derivatives |
| EP2136626A4 (en) | 2007-03-19 | 2011-02-23 | Oregon State | Mannich base n-oxide drugs |
| CN100475832C (zh) | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | 一种新颖的高立体选择性合成吉西他滨工艺及中间体 |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| TWI415858B (zh) | 2007-11-06 | 2013-11-21 | Pharmaessentia Corp | β-核苷之新穎合成技術 |
| GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
-
2009
- 2009-05-01 GB GBGB0907551.6A patent/GB0907551D0/en not_active Ceased
-
2010
- 2010-04-30 EP EP10719367A patent/EP2424524A1/en not_active Withdrawn
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- 2010-04-30 JP JP2012507812A patent/JP2012525364A/ja not_active Withdrawn
- 2010-04-30 KR KR1020217012850A patent/KR20210100598A/ko not_active Ceased
- 2010-04-30 CA CA2759883A patent/CA2759883C/en active Active
-
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- 2012-02-28 US US13/407,436 patent/US20120302748A1/en not_active Abandoned
-
2014
- 2014-09-12 US US14/485,122 patent/US20150011512A1/en not_active Abandoned
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2015
- 2015-02-23 JP JP2015032957A patent/JP2015117248A/ja active Pending
- 2015-10-08 HK HK15109841.5A patent/HK1209056A1/en unknown
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2016
- 2016-05-26 JP JP2016104884A patent/JP2016153428A/ja not_active Withdrawn
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2017
- 2017-02-06 US US15/425,758 patent/US9919060B2/en active Active
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2018
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2019
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2020
- 2020-10-14 JP JP2020173553A patent/JP2021006583A/ja not_active Withdrawn
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2021
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-
2023
- 2023-01-27 JP JP2023010993A patent/JP2023038370A/ja not_active Withdrawn
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- 2024-11-01 JP JP2024192787A patent/JP2025013454A/ja active Pending
- 2024-11-01 US US18/934,886 patent/US20250295789A1/en active Pending
-
2025
- 2025-11-17 JP JP2025196835A patent/JP2026020235A/ja active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247381A2 (en) * | 1986-04-30 | 1987-12-02 | Otsuka Pharmaceutical Co., Ltd. | 5-flurorouracil derivatives |
| JPH04501253A (ja) * | 1988-05-25 | 1992-03-05 | リサーチ コーポレーシヨン テクノロジーズ インコーポレーテツド | 抗腫瘍剤として有用なホスホラミド |
| JPH02149579A (ja) * | 1988-10-13 | 1990-06-08 | Basf Ag | ヘテロ環置換アルコキシクマリン、その製造方法およびこれを含有する治療剤 |
| JPH02157273A (ja) * | 1988-10-13 | 1990-06-18 | Basf Ag | アリールアルコキシクマリン、その製造方法及びこれを含有する治療剤 |
| JPH08511773A (ja) * | 1993-06-08 | 1996-12-10 | キャンサー・リサーチ・キャンペーン・テクノロジー・リミテッド | O▲上6▼−置換グアニン誘導体、それらの製造方法および腫瘍細胞の処置におけるそれらの使用 |
| JP2005526696A (ja) * | 2001-09-14 | 2005-09-08 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | ベータ−3アドレナリン受容体アゴニストとして有用なベンゾフランおよびジヒドロベンゾフラン誘導体 |
| JP2005526046A (ja) * | 2002-02-27 | 2005-09-02 | インスパイアー ファーマシューティカルズ,インコーポレイティド | 上皮及び網膜組織疾患の治療のための組成物及び治療方法 |
| US20050130973A1 (en) * | 2003-12-04 | 2005-06-16 | Wyeth | Biaryl sulfonamides and methods for using same |
| WO2006009826A1 (en) * | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| JP2008526695A (ja) * | 2004-12-30 | 2008-07-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 炎症の治療においてcxcr2阻害剤として使用される縮合二環式カルボキサミド誘導体 |
| WO2008110793A1 (en) * | 2007-03-12 | 2008-09-18 | Biolipox Ab | Piperidinones useful in the treatment of inflammation |
Non-Patent Citations (2)
| Title |
|---|
| FLADER C: "DEVELOPMENT OF NOVEL QUINONE PHOSPHORODIAMIDATE PRODRUGS TARGETED TO DT-DIAPHORASE", JOURNAL OF MEDICINAL CHEMISTRY, vol. V43 N16, JPN5012012140, 10 August 2000 (2000-08-10), pages 3157 - 3167, ISSN: 0002820191 * |
| JOHN W.; ALESSI, THOMAS R.; DOLAK, TERENCE M.; NGUYEN, THOMAS T.; TOMER, JOHN D.; GUZZO, FRIEDA; BA: "Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxidesEllingbo", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35(7), JPN6014021858, 1992, pages 1176 - 1183, ISSN: 0002820190 * |
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