CN102458394A - 增殖性疾病状态的治疗或预防 - Google Patents
增殖性疾病状态的治疗或预防 Download PDFInfo
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- CN102458394A CN102458394A CN2010800288714A CN201080028871A CN102458394A CN 102458394 A CN102458394 A CN 102458394A CN 2010800288714 A CN2010800288714 A CN 2010800288714A CN 201080028871 A CN201080028871 A CN 201080028871A CN 102458394 A CN102458394 A CN 102458394A
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- 0 CCOC(*)COc(c(F)c1)c(C=O)cc1F Chemical compound CCOC(*)COc(c(F)c1)c(C=O)cc1F 0.000 description 5
- OXAWETKTYCJICN-UHFFFAOYSA-N C=[Br]Cc1cc2ccccc2[o]1 Chemical compound C=[Br]Cc1cc2ccccc2[o]1 OXAWETKTYCJICN-UHFFFAOYSA-N 0.000 description 1
- DPJUROWPJDXHIS-UHFFFAOYSA-N CC(c(c(O1)c2)ccc2OCc(cc2)ccc2OCc2cc3ccccc3[o]2)=CC1=O Chemical compound CC(c(c(O1)c2)ccc2OCc(cc2)ccc2OCc2cc3ccccc3[o]2)=CC1=O DPJUROWPJDXHIS-UHFFFAOYSA-N 0.000 description 1
- QPVADCWSCSNHJG-UHFFFAOYSA-N CC(c(c(O1)c2)ccc2OCc2cc(cc(cc3F)F)c3[o]2)=CC1=O Chemical compound CC(c(c(O1)c2)ccc2OCc2cc(cc(cc3F)F)c3[o]2)=CC1=O QPVADCWSCSNHJG-UHFFFAOYSA-N 0.000 description 1
- YBJAKKZYWSEDEH-UHFFFAOYSA-N CCOC(c(cc1)ccc1OCc1cc(cc(CC(c2cc3ccccc3[o]2)Br)cc2)c2[o]1)=O Chemical compound CCOC(c(cc1)ccc1OCc1cc(cc(CC(c2cc3ccccc3[o]2)Br)cc2)c2[o]1)=O YBJAKKZYWSEDEH-UHFFFAOYSA-N 0.000 description 1
- MLQSLNORIQDEDS-UHFFFAOYSA-N CCc1cc(cc(cc2F)F)c2[o]1 Chemical compound CCc1cc(cc(cc2F)F)c2[o]1 MLQSLNORIQDEDS-UHFFFAOYSA-N 0.000 description 1
- ZOIWVMLIALAPLL-UHFFFAOYSA-N COc(cc1OC)cc2c1[o]c(CO)c2 Chemical compound COc(cc1OC)cc2c1[o]c(CO)c2 ZOIWVMLIALAPLL-UHFFFAOYSA-N 0.000 description 1
- KJTWWDLKXWRJPO-UHFFFAOYSA-N Cc(nn1)c2nn[n](Cc3ccccc3F)c2c1OCc1cc2ccccc2[o]1 Chemical compound Cc(nn1)c2nn[n](Cc3ccccc3F)c2c1OCc1cc2ccccc2[o]1 KJTWWDLKXWRJPO-UHFFFAOYSA-N 0.000 description 1
- RISKINCQRSLFRK-UHFFFAOYSA-N O=CC1=Cc(cccc2)c2OC1 Chemical compound O=CC1=Cc(cccc2)c2OC1 RISKINCQRSLFRK-UHFFFAOYSA-N 0.000 description 1
- QGSAZWCEHUYVMW-UHFFFAOYSA-N Oc(c(F)c1)c(C=O)cc1F Chemical compound Oc(c(F)c1)c(C=O)cc1F QGSAZWCEHUYVMW-UHFFFAOYSA-N 0.000 description 1
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| PCT/GB2010/000860 WO2010125350A1 (en) | 2009-05-01 | 2010-04-30 | Treatment or prophylaxis of proliferative conditions |
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| CA (1) | CA2759883C (https=) |
| ES (1) | ES3053101T3 (https=) |
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| CN102993157A (zh) * | 2012-11-21 | 2013-03-27 | 上海交通大学 | α-萘黄酮衍生物及其制备方法、用途 |
| CN112135634A (zh) * | 2018-02-02 | 2020-12-25 | 马福瑞克斯肿瘤学股份有限公司 | 单磷酸吉西他滨的小分子药物偶联物 |
| CN112135635A (zh) * | 2018-02-02 | 2020-12-25 | 马福瑞克斯肿瘤学股份有限公司 | 吉西他滨衍生物的新型小分子药物偶联物 |
| CN112409368A (zh) * | 2020-11-23 | 2021-02-26 | 昆明医科大学 | 一类c-4位取代香豆素类化合物及其制备方法和应用 |
| CN113748118A (zh) * | 2019-04-24 | 2021-12-03 | 阿诺拉西斯制药医疗产品机械商业股份有限公司 | 胞苷衍生物和形成胞苷衍生物的方法 |
| CN115697971A (zh) * | 2020-06-10 | 2023-02-03 | 美国安进公司 | 环丁基二氢喹啉磺酰胺化合物 |
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| GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| PL223225B1 (pl) * | 2012-02-21 | 2016-10-31 | Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk | Halogenopochodne benzo[b]furanów, ewentualnie w postaci farmaceutycznie dopuszczalnej soli oraz zastosowanie halogenopochodnych benzo[b]furanów |
| JP6411523B2 (ja) * | 2013-10-11 | 2018-10-24 | ビヨンドスプリング インコーポレイテッド | プリナブリン及びタキサンの組合せがん治療 |
| US9944664B2 (en) * | 2014-04-15 | 2018-04-17 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds as fungicides |
| JP6532480B2 (ja) * | 2014-04-15 | 2019-06-19 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としての金属酵素阻害剤化合物 |
| MX383691B (es) | 2015-03-06 | 2025-03-14 | Beyondspring Pharmaceuticals Inc | Método de tratamiento de cáncer asociado con una mutación de ras. |
| HK1249051A1 (zh) | 2015-03-06 | 2018-10-26 | BeyondSpring Pharmaceuticals Inc. | 治疗脑肿瘤的方法 |
| US10155748B2 (en) | 2015-07-13 | 2018-12-18 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| WO2017139231A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| RU2760348C2 (ru) | 2016-06-06 | 2021-11-24 | Бейондспринг Фармасьютикалс, Инк. | Способ уменьшения нейтропении |
| US20200048259A1 (en) * | 2016-10-12 | 2020-02-13 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| SMT202500271T1 (it) | 2020-07-02 | 2025-09-12 | Incyte Corp | Composti di urea triciclici come inibitori di v617f di jak2 |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
| CN119173514A (zh) | 2022-03-17 | 2024-12-20 | 因赛特公司 | 作为jak2 v617f抑制剂的三环脲化合物 |
| IL326324A (en) * | 2023-08-15 | 2026-04-01 | Scorpion Therapeutics Inc | PI3K inhibitor preparation processes |
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2009
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2010
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- 2010-04-30 US US12/771,923 patent/US8283340B2/en active Active - Reinstated
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- 2010-04-30 AU AU2010243388A patent/AU2010243388A1/en not_active Abandoned
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- 2010-04-30 US US13/318,321 patent/US20120190639A1/en not_active Abandoned
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- 2015-10-08 HK HK15109841.5A patent/HK1209056A1/en unknown
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- 2016-05-26 JP JP2016104884A patent/JP2016153428A/ja not_active Withdrawn
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2017
- 2017-02-06 US US15/425,758 patent/US9919060B2/en active Active
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2018
- 2018-03-19 US US15/924,520 patent/US20190060472A1/en not_active Abandoned
- 2018-05-22 JP JP2018098050A patent/JP2018141007A/ja active Pending
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2019
- 2019-12-11 US US16/710,711 patent/US20200360521A1/en not_active Abandoned
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2020
- 2020-10-14 JP JP2020173553A patent/JP2021006583A/ja not_active Withdrawn
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- 2021-03-12 US US17/200,065 patent/US20220031852A1/en not_active Abandoned
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993157A (zh) * | 2012-11-21 | 2013-03-27 | 上海交通大学 | α-萘黄酮衍生物及其制备方法、用途 |
| CN112135634A (zh) * | 2018-02-02 | 2020-12-25 | 马福瑞克斯肿瘤学股份有限公司 | 单磷酸吉西他滨的小分子药物偶联物 |
| CN112135635A (zh) * | 2018-02-02 | 2020-12-25 | 马福瑞克斯肿瘤学股份有限公司 | 吉西他滨衍生物的新型小分子药物偶联物 |
| CN113748118A (zh) * | 2019-04-24 | 2021-12-03 | 阿诺拉西斯制药医疗产品机械商业股份有限公司 | 胞苷衍生物和形成胞苷衍生物的方法 |
| CN115697971A (zh) * | 2020-06-10 | 2023-02-03 | 美国安进公司 | 环丁基二氢喹啉磺酰胺化合物 |
| US12240839B2 (en) | 2020-06-10 | 2025-03-04 | Amgen Inc. | Cyclobutyl dihydroquinoline sulfonamide compounds |
| CN112409368A (zh) * | 2020-11-23 | 2021-02-26 | 昆明医科大学 | 一类c-4位取代香豆素类化合物及其制备方法和应用 |
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