GB0907551D0 - Treatment or prophylaxis of proliferative conditions - Google Patents

Treatment or prophylaxis of proliferative conditions

Info

Publication number
GB0907551D0
GB0907551D0 GBGB0907551.6A GB0907551A GB0907551D0 GB 0907551 D0 GB0907551 D0 GB 0907551D0 GB 0907551 A GB0907551 A GB 0907551A GB 0907551 D0 GB0907551 D0 GB 0907551D0
Authority
GB
United Kingdom
Prior art keywords
prophylaxis
treatment
proliferative conditions
proliferative
conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0907551.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Priority to GBGB0907551.6A priority Critical patent/GB0907551D0/en
Publication of GB0907551D0 publication Critical patent/GB0907551D0/en
Priority to JP2012507812A priority patent/JP2012525364A/ja
Priority to EP10719367A priority patent/EP2424524A1/en
Priority to KR1020217012850A priority patent/KR20210100598A/ko
Priority to RU2019133319A priority patent/RU2019133319A/ru
Priority to CN2010800288714A priority patent/CN102458394A/zh
Priority to RU2011148945A priority patent/RU2705548C2/ru
Priority to KR1020177012122A priority patent/KR102248044B1/ko
Priority to US12/771,923 priority patent/US8283340B2/en
Priority to CA2759883A priority patent/CA2759883C/en
Priority to KR1020227005644A priority patent/KR20220025949A/ko
Priority to EP25199504.9A priority patent/EP4691558A3/en
Priority to AU2010243388A priority patent/AU2010243388A1/en
Priority to KR1020117026418A priority patent/KR20120042733A/ko
Priority to EP14194445.4A priority patent/EP2857018B1/en
Priority to PCT/GB2010/000860 priority patent/WO2010125350A1/en
Priority to US13/318,321 priority patent/US20120190639A1/en
Priority to ES14194445T priority patent/ES3053101T3/es
Priority to US13/407,436 priority patent/US20120302748A1/en
Priority to US14/485,122 priority patent/US20150011512A1/en
Priority to JP2015032957A priority patent/JP2015117248A/ja
Priority to HK15109841.5A priority patent/HK1209056A1/en
Priority to JP2016104884A priority patent/JP2016153428A/ja
Priority to US15/425,758 priority patent/US9919060B2/en
Priority to US15/924,520 priority patent/US20190060472A1/en
Priority to JP2018098050A priority patent/JP2018141007A/ja
Priority to US16/710,711 priority patent/US20200360521A1/en
Priority to JP2020173553A priority patent/JP2021006583A/ja
Priority to US17/200,065 priority patent/US20220031852A1/en
Priority to JP2023010993A priority patent/JP2023038370A/ja
Priority to US18/934,886 priority patent/US20250295789A1/en
Priority to JP2024192787A priority patent/JP2025013454A/ja
Priority to JP2025196835A priority patent/JP2026020235A/ja
Ceased legal-status Critical Current

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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GBGB0907551.6A 2009-05-01 2009-05-01 Treatment or prophylaxis of proliferative conditions Ceased GB0907551D0 (en)

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Application Number Priority Date Filing Date Title
GBGB0907551.6A GB0907551D0 (en) 2009-05-01 2009-05-01 Treatment or prophylaxis of proliferative conditions
KR1020227005644A KR20220025949A (ko) 2009-05-01 2010-04-30 증식성 상태의 치료 또는 예방
US13/318,321 US20120190639A1 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
ES14194445T ES3053101T3 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
KR1020217012850A KR20210100598A (ko) 2009-05-01 2010-04-30 증식성 상태의 치료 또는 예방
RU2019133319A RU2019133319A (ru) 2009-05-01 2010-04-30 Лечение или профилактика пролиферативных состояний
CN2010800288714A CN102458394A (zh) 2009-05-01 2010-04-30 增殖性疾病状态的治疗或预防
RU2011148945A RU2705548C2 (ru) 2009-05-01 2010-04-30 Лечение или профилактика пролиферативных состояний
KR1020177012122A KR102248044B1 (ko) 2009-05-01 2010-04-30 증식성 상태의 치료 또는 예방
US12/771,923 US8283340B2 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
CA2759883A CA2759883C (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
EP10719367A EP2424524A1 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
EP25199504.9A EP4691558A3 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
AU2010243388A AU2010243388A1 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
KR1020117026418A KR20120042733A (ko) 2009-05-01 2010-04-30 증식성 상태의 치료 또는 예방
EP14194445.4A EP2857018B1 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
PCT/GB2010/000860 WO2010125350A1 (en) 2009-05-01 2010-04-30 Treatment or prophylaxis of proliferative conditions
JP2012507812A JP2012525364A (ja) 2009-05-01 2010-04-30 増殖性状態の処置または予防
US13/407,436 US20120302748A1 (en) 2009-05-01 2012-02-28 Treatment or prophylaxis of proliferative conditions
US14/485,122 US20150011512A1 (en) 2009-05-01 2014-09-12 Treatment or prophylaxis of proliferative conditions
JP2015032957A JP2015117248A (ja) 2009-05-01 2015-02-23 増殖性状態の処置または予防
HK15109841.5A HK1209056A1 (en) 2009-05-01 2015-10-08 Treatment or prophylaxis of proliferative conditions
JP2016104884A JP2016153428A (ja) 2009-05-01 2016-05-26 増殖性状態の処置または予防
US15/425,758 US9919060B2 (en) 2009-05-01 2017-02-06 Treatment or prophylaxis of proliferative conditions
US15/924,520 US20190060472A1 (en) 2009-05-01 2018-03-19 Treatment or prophylaxis of proliferative conditions
JP2018098050A JP2018141007A (ja) 2009-05-01 2018-05-22 増殖性状態の処置または予防
US16/710,711 US20200360521A1 (en) 2009-05-01 2019-12-11 Treatment or prophylaxis of proliferative conditions
JP2020173553A JP2021006583A (ja) 2009-05-01 2020-10-14 増殖性状態の処置または予防
US17/200,065 US20220031852A1 (en) 2009-05-01 2021-03-12 Treatment or prophylaxis of proliferative conditions
JP2023010993A JP2023038370A (ja) 2009-05-01 2023-01-27 増殖性状態の処置または予防
US18/934,886 US20250295789A1 (en) 2009-05-01 2024-11-01 Treatment or prophylaxis of proliferative conditions
JP2024192787A JP2025013454A (ja) 2009-05-01 2024-11-01 増殖性状態の処置または予防
JP2025196835A JP2026020235A (ja) 2009-05-01 2025-11-17 増殖性状態の処置または予防

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
PL223225B1 (pl) * 2012-02-21 2016-10-31 Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk Halogenopochodne benzo[b]furanów, ewentualnie w postaci farmaceutycznie dopuszczalnej soli oraz zastosowanie halogenopochodnych benzo[b]furanów
CN102993157B (zh) * 2012-11-21 2015-04-01 上海交通大学 α-萘黄酮衍生物及其制备方法、用途
CA2926771C (en) * 2013-10-11 2022-07-05 Beyondspring Pharmaceuticals, Inc. Cancer treatment with combination of plinabulin and taxane
WO2015160664A1 (en) 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
WO2015160665A1 (en) 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
SG11201707128TA (en) 2015-03-06 2017-09-28 Beyondspring Pharmaceuticals Inc Method of treating a brain tumor
JP6969848B2 (ja) 2015-07-13 2021-11-24 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド プリナブリン組成物
KR20180105685A (ko) 2016-02-08 2018-09-28 비욘드스프링 파마수티컬스, 인코포레이티드. 투카레솔 또는 이의 유사체를 함유하는 조성물
JP7025416B2 (ja) 2016-06-06 2022-02-24 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 好中球減少症を低減させるための組成物および方法
EP3525786A4 (en) * 2016-10-12 2020-03-18 Merck Sharp & Dohme Corp. KDM5 INHIBITORS
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CA3090272A1 (en) * 2018-02-02 2019-08-08 Maverix Oncology, Inc. Novel small molecule drug conjugates of gemcitabine derivatives
AU2019216531A1 (en) * 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
GR1009958B (el) * 2019-04-24 2021-03-18 ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης
JP7739051B2 (ja) * 2020-06-10 2025-09-16 アムジエン・インコーポレーテツド シクロブチルジヒドロキノリンスルホンアミド化合物
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
CR20230057A (es) 2020-07-02 2023-08-15 Incyte Corp Compuestos tríciclicos de urea como inhibidores de jak2 v617f
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
CN112409368B (zh) * 2020-11-23 2021-10-01 昆明医科大学 一类c-4位取代香豆素类化合物及其制备方法和应用
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
AU2023235313A1 (en) 2022-03-17 2024-10-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
TW202508560A (zh) * 2023-08-15 2025-03-01 美商史考皮恩治療有限公司 製備ｐ１３ｋ抑制劑之方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU389090A1 (ru) * 1971-05-17 1973-07-05 Ташкентский государственный медицинский институт Библиотека
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US5229272A (en) 1989-04-25 1993-07-20 Igen, Inc. Catalytic antibody components
EP0184365B1 (en) 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
ZA859008B (en) 1984-12-04 1987-07-29 Lilly Co Eli The treatment of tumors in mammals
DE3786834T2 (de) * 1986-04-30 1994-03-03 Otsuka Pharma Co Ltd 5-Fluoro-Uracil-Derivate.
US6702705B1 (en) 1988-05-04 2004-03-09 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
JPH04501253A (ja) * 1988-05-25 1992-03-05 リサーチ　コーポレーシヨン　テクノロジーズ　インコーポレーテツド 抗腫瘍剤として有用なホスホラミド
DE3834861A1 (de) * 1988-10-13 1990-04-19 Basf Ag Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3834860A1 (de) * 1988-10-13 1990-04-19 Basf Ag Heterocyclisch substituierte alkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
US6258360B1 (en) 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
US6060592A (en) 1990-01-11 2000-05-09 Isis Pharmaceuticals, Inc. Pyrimidine nucleoside compounds and oligonucleoside compounds containing same
US5401838A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
HU217779B (hu) * 1993-06-08 2000-04-28 Cancer Research Campaign Technology Limited O6-Helyettesített guaninszármazékok, ezeket tartalmazó gyógyászati készítmények, valamint eljárás e vegyületek előállítására
EP0795334B1 (de) * 1996-03-12 2006-02-01 Sanofi-Aventis Deutschland GmbH Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen
WO1998011484A1 (fr) 1996-09-13 1998-03-19 Hitachi, Ltd. Processeur de commande a memoire d'historique
CA2278056C (en) 1997-01-24 2006-12-12 Norsk Hydro Asa Gemcitabine derivatives
NZ330360A (en) 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
JP4642226B2 (ja) 1998-02-06 2011-03-02 デ モントフォート ユニヴァーシティ ヒドロキシル化により活性化されたプロドラッグ
GB2334256A (en) * 1998-02-12 1999-08-18 Univ Montfort Hydroxylation activated prodrugs
WO1999040944A2 (en) 1998-02-12 1999-08-19 De Montfort University Hydroxylation activated drug release
DE19834751A1 (de) 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
KR100523119B1 (ko) * 2000-03-16 2005-10-20 에프. 호프만-라 로슈 아게 Ｉｐ 길항제로서의 카복실산 유도체
GB0007401D0 (en) 2000-03-27 2000-05-17 Cancer Res Campaign Tech Substituted chalcones as therapeeutic compounds
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
JP3692927B2 (ja) 2000-11-07 2005-09-07 日本電気株式会社 ファクシミリ装置
UA74852C2 (en) * 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
CA2438737A1 (en) * 2001-03-02 2002-09-12 F. Hoffmann-La Roche Ag Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as ip antagonists
US6780859B2 (en) * 2001-09-14 2004-08-24 Bayer Pharmaceuticals Corporation Benzofuran and dihydrobenzofuran derivatives useful as beta-3 adrenoreceptor agonists
EP1300403A1 (en) * 2001-10-02 2003-04-09 Aventis Pharma S.A. Process for the manufacture of hypoxyxylerone derivatives
GB0123780D0 (en) 2001-10-03 2001-11-21 Cancer Res Ventures Ltd Substituted chalcones as therapeutic agents
GB0123777D0 (en) 2001-10-03 2001-11-21 Cancer Res Ventures Ltd Substituted chalcones as therapeutic agents
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN102174038A (zh) 2003-02-19 2011-09-07 耶鲁大学 用于治疗病毒感染的抗病毒核苷
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
CA2548513A1 (en) * 2003-12-04 2005-07-07 Wyeth Biaryl sulfonamides and methods for using same
CA2550299C (en) 2003-12-22 2010-03-30 Christopher R. Roberts Process for fluorocytidine derivatives
WO2005072061A2 (en) 2004-02-02 2005-08-11 Biosight Ltd. Conjugates for cancer therapy and diagnosis
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
GB0421294D0 (en) 2004-09-24 2004-10-27 Angiogene Pharm Ltd Bioreductively-activated prodrugs
CA2589850C (en) 2004-12-17 2012-05-01 Eli Lilly And Company Amide prodrug of gemcitabine, compositions and use thereof
EP1676834A1 (en) * 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
NO322682B1 (no) 2005-03-18 2006-11-27 Clavis Pharma Asa Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
EP1937658A1 (en) * 2005-10-06 2008-07-02 Sanofi-Aventis 4-oxy-n-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
US20090069557A1 (en) 2006-02-06 2009-03-12 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
US20080004237A1 (en) 2006-02-23 2008-01-03 Tam Joemy C Polysacchocride prodrug of 5-fluorouracil (5-FU) with enhanced target specificity for galectin-3 expressing cancers
US20070225248A1 (en) 2006-03-21 2007-09-27 Clavis Pharma As Oral dosage forms of gemcitabine derivatives
GB0722769D0 (en) * 2007-11-21 2008-01-02 Biolipox Ab New compounds
EP2136626A4 (en) 2007-03-19 2011-02-23 Oregon State Mannich base n-oxide drugs
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
KR20100102107A (ko) 2007-11-06 2010-09-20 파마이센시아 코퍼레이션 β-뉴클레오시드의 새로운 합성 방법
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions

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AU2010243388A2 (en) 2012-03-08
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US20220031852A1 (en) 2022-02-03
US20170368188A1 (en) 2017-12-28
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HK1209056A1 (en) 2016-03-24
US8283340B2 (en) 2012-10-09
KR20210100598A (ko) 2021-08-17
US9919060B2 (en) 2018-03-20
US20100305070A1 (en) 2010-12-02
KR20120042733A (ko) 2012-05-03
JP2012525364A (ja) 2012-10-22
ES3053101T3 (en) 2026-01-19
JP2015117248A (ja) 2015-06-25
JP2018141007A (ja) 2018-09-13
US20200360521A1 (en) 2020-11-19
KR20170053735A (ko) 2017-05-16
CA2759883C (en) 2021-12-07
CA2759883A1 (en) 2010-11-04
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