JP2012520238A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012520238A5 JP2012520238A5 JP2011538739A JP2011538739A JP2012520238A5 JP 2012520238 A5 JP2012520238 A5 JP 2012520238A5 JP 2011538739 A JP2011538739 A JP 2011538739A JP 2011538739 A JP2011538739 A JP 2011538739A JP 2012520238 A5 JP2012520238 A5 JP 2012520238A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- atom
- ring
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 48
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000001424 substituent group Chemical group 0.000 claims 21
- 125000005843 halogen group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- -1 hydroxy, amino Chemical group 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 6
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 150000004885 piperazines Chemical group 0.000 claims 5
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 3
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical group C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical group C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
- USMYLEIMHJBZIK-UHFFFAOYSA-N [5-[4-(4-methoxyphenyl)piperazin-1-yl]-2,4,6,7-tetramethyl-3h-1-benzofuran-2-yl]methanol Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C(=C(C)C=3OC(C)(CO)CC=3C=2C)C)CC1 USMYLEIMHJBZIK-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- APUZBYOMJYSTGT-UHFFFAOYSA-N (3-methyl-5-morpholin-4-yl-1-benzofuran-2-yl)methanol Chemical compound C1=C2C(C)=C(CO)OC2=CC=C1N1CCOCC1 APUZBYOMJYSTGT-UHFFFAOYSA-N 0.000 claims 1
- HOLPXUYAXOUELB-UHFFFAOYSA-N (5-piperazin-1-yl-2,3-dihydro-1-benzofuran-2-yl)methanol Chemical compound C=1C=C2OC(CO)CC2=CC=1N1CCNCC1 HOLPXUYAXOUELB-UHFFFAOYSA-N 0.000 claims 1
- CCCWDSKOVIQNOE-UHFFFAOYSA-N (6-fluoro-5-piperazin-1-yl-2,3-dihydro-1-benzofuran-2-yl)methanol Chemical compound FC=1C=C2OC(CO)CC2=CC=1N1CCNCC1 CCCWDSKOVIQNOE-UHFFFAOYSA-N 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- RWBZIVWGBQJMCL-UHFFFAOYSA-N 1-(4-ethoxyphenyl)-4-(7-methoxy-2,2,4,6-tetramethyl-3h-1-benzofuran-5-yl)piperazine Chemical compound C1=CC(OCC)=CC=C1N1CCN(C=2C(=C(OC)C=3OC(C)(C)CC=3C=2C)C)CC1 RWBZIVWGBQJMCL-UHFFFAOYSA-N 0.000 claims 1
- BBLZNCBOMKSSDU-UHFFFAOYSA-N 1-(4-methoxyphenyl)-4-(2,2,4,6,7-pentamethyl-3h-1-benzofuran-5-yl)piperazine Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C(=C(C)C=3OC(C)(C)CC=3C=2C)C)CC1 BBLZNCBOMKSSDU-UHFFFAOYSA-N 0.000 claims 1
- WRPMWTPZEKOJIH-UHFFFAOYSA-N 1-(4-methoxyphenyl)-4-(7-methoxy-2,2,4,6-tetramethyl-3h-1-benzofuran-5-yl)piperazine Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C(=C(OC)C=3OC(C)(C)CC=3C=2C)C)CC1 WRPMWTPZEKOJIH-UHFFFAOYSA-N 0.000 claims 1
- YVBZPAWLIVCPHA-OAHLLOKOSA-N 1-(4-methoxyphenyl)-4-[(2r)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C(=C(C)C=3O[C@H](C)CC=3C=2C)C)CC1 YVBZPAWLIVCPHA-OAHLLOKOSA-N 0.000 claims 1
- YVBZPAWLIVCPHA-HNNXBMFYSA-N 1-(4-methoxyphenyl)-4-[(2s)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C(=C(C)C=3O[C@@H](C)CC=3C=2C)C)CC1 YVBZPAWLIVCPHA-HNNXBMFYSA-N 0.000 claims 1
- HXXWQGPFTCUMRG-UHFFFAOYSA-N 1-[2-(methoxymethyl)-2,3-dihydro-1-benzofuran-5-yl]piperazine Chemical compound C=1C=C2OC(COC)CC2=CC=1N1CCNCC1 HXXWQGPFTCUMRG-UHFFFAOYSA-N 0.000 claims 1
- LYIXHSHLRKNUDJ-UHFFFAOYSA-N 1-[6-fluoro-2-(methoxymethyl)-2,3-dihydro-1-benzofuran-5-yl]piperazine Chemical compound FC=1C=C2OC(COC)CC2=CC=1N1CCNCC1 LYIXHSHLRKNUDJ-UHFFFAOYSA-N 0.000 claims 1
- BNHNDMCOCCMSLO-UHFFFAOYSA-N 2-[4-(6-amino-2,3-dihydro-1-benzofuran-5-yl)piperazin-1-yl]acetamide Chemical compound C1CN(CC(=O)N)CCN1C(C(=C1)N)=CC2=C1OCC2 BNHNDMCOCCMSLO-UHFFFAOYSA-N 0.000 claims 1
- DUSDRDVPZZFQHC-UHFFFAOYSA-N 3-[[4-[[cyclohexyl-(3-methyl-5-morpholin-4-yl-1-benzofuran-2-yl)methyl]amino]benzoyl]-methylamino]propanoic acid Chemical compound C1=CC(C(=O)N(CCC(O)=O)C)=CC=C1NC(C1=C(C2=CC(=CC=C2O1)N1CCOCC1)C)C1CCCCC1 DUSDRDVPZZFQHC-UHFFFAOYSA-N 0.000 claims 1
- VGOCTMNMAFRJJN-UHFFFAOYSA-N 4-(2,3,4,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)morpholine Chemical compound CC1C(C)OC(C(=C2)C)=C1C(C)=C2N1CCOCC1 VGOCTMNMAFRJJN-UHFFFAOYSA-N 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 108091008611 Protein Kinase B Proteins 0.000 claims 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- JNZOEWQIUBLZQU-UHFFFAOYSA-N cyclohexyl-(3-methyl-5-morpholin-4-yl-1-benzofuran-2-yl)methanol Chemical compound C1=C2C(C)=C(C(O)C3CCCCC3)OC2=CC=C1N1CCOCC1 JNZOEWQIUBLZQU-UHFFFAOYSA-N 0.000 claims 1
- RKTGGAKUVNUVGY-UHFFFAOYSA-N ethyl 3-[[4-[[cyclohexyl-(3-methyl-5-morpholin-4-yl-1-benzofuran-2-yl)methyl]amino]benzoyl]-methylamino]propanoate Chemical compound C1=CC(C(=O)N(C)CCC(=O)OCC)=CC=C1NC(C1=C(C2=CC(=CC=C2O1)N1CCOCC1)C)C1CCCCC1 RKTGGAKUVNUVGY-UHFFFAOYSA-N 0.000 claims 1
- 150000004050 homopiperazines Chemical group 0.000 claims 1
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011538739A JP5746631B2 (ja) | 2009-03-10 | 2010-03-09 | ベンゾフラン誘導体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009056719 | 2009-03-10 | ||
| JP2009056719 | 2009-03-10 | ||
| JP2011538739A JP5746631B2 (ja) | 2009-03-10 | 2010-03-09 | ベンゾフラン誘導体 |
| PCT/JP2010/054286 WO2010104194A1 (en) | 2009-03-10 | 2010-03-09 | Benzofuran derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226377A Division JP5841651B2 (ja) | 2009-03-10 | 2014-11-06 | ベンゾフラン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520238A JP2012520238A (ja) | 2012-09-06 |
| JP2012520238A5 true JP2012520238A5 (enExample) | 2013-04-18 |
| JP5746631B2 JP5746631B2 (ja) | 2015-07-08 |
Family
ID=42224778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538739A Expired - Fee Related JP5746631B2 (ja) | 2009-03-10 | 2010-03-09 | ベンゾフラン誘導体 |
| JP2014226377A Expired - Fee Related JP5841651B2 (ja) | 2009-03-10 | 2014-11-06 | ベンゾフラン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226377A Expired - Fee Related JP5841651B2 (ja) | 2009-03-10 | 2014-11-06 | ベンゾフラン誘導体 |
Country Status (37)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ594847A (en) * | 2009-03-10 | 2013-10-25 | Takeda Pharmaceutical | Benzofuran derivatives |
| EP2502909A4 (en) | 2009-11-18 | 2013-04-03 | Takeda Pharmaceutical | aminopyridine derivative |
| MX375124B (es) * | 2012-02-20 | 2025-03-06 | Basf Se | Intensificación de la acción antimicrobiana de biocidas con polímeros. |
| US9908680B2 (en) | 2012-09-28 | 2018-03-06 | Kimberly-Clark Worldwide, Inc. | Tree-free fiber compositions and uses in containerboard packaging |
| US9816233B2 (en) * | 2012-09-28 | 2017-11-14 | Kimberly-Clark Worldwide, Inc. | Hybrid fiber compositions and uses in containerboard packaging |
| MX2015002398A (es) * | 2012-10-01 | 2015-06-05 | Hoffmann La Roche | Benzimidazoles como agentes activos del sistema nervioso central. |
| MX2016001528A (es) * | 2013-09-12 | 2016-06-23 | Hoffmann La Roche | Derivados de indol-carboxamida. |
| SG11201912770SA (en) | 2017-06-23 | 2020-01-30 | Kyowa Kirin Co Ltd | a, ß-UNSATURATED AMIDE COMPOUND |
| CN109580790A (zh) * | 2017-09-28 | 2019-04-05 | 安徽省庆云医药股份有限公司 | 一种液相色谱法分离测定西洛多辛及其光学异构体的方法 |
| CN108530405A (zh) * | 2018-05-08 | 2018-09-14 | 南京晓庄学院 | 非金属路易斯酸催化烯烃分子内加成c-o键合成苯并呋喃衍生物的方法 |
| CN109879839B (zh) * | 2019-03-12 | 2023-04-25 | 沈阳大学 | 6-哌嗪甲基-7-羟基苯并呋喃类化合物及其医药用途 |
| CN113045523B (zh) * | 2019-12-27 | 2022-09-23 | 上海泓博智源医药股份有限公司 | 一种咪唑啉吡啶化合物中间体的制备方法 |
| TWI894229B (zh) * | 2020-03-16 | 2025-08-21 | 瑞士商諾華公司 | 作為yap/taz-tead蛋白-蛋白相互作用抑制劑之聯芳基衍生物 |
| CN111362965B (zh) * | 2020-04-27 | 2022-05-03 | 梯尔希（南京）药物研发有限公司 | 一种莫西菌素杂质的制备方法 |
| CN113219085B (zh) * | 2021-03-31 | 2022-05-13 | 河北国龙制药有限公司 | 一种2,3-二甲基溴苯有关物质的检测方法 |
| CN113214205B (zh) * | 2021-04-09 | 2022-06-10 | 南方海洋科学与工程广东省实验室(湛江) | 一种色原酮衍生物的制备方法 |
| CN115260136B (zh) * | 2022-08-09 | 2023-08-15 | 嘉兴学院 | 一种苯酞类化合物及其制备方法 |
| CN115724721A (zh) * | 2022-12-19 | 2023-03-03 | 山东京博石油化工有限公司 | 一种2-取代基-4-溴苯酚的制备方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0106800A1 (de) | 1982-10-08 | 1984-04-25 | Ciba-Geigy Ag | Furane |
| JPH04149546A (ja) | 1990-10-15 | 1992-05-22 | Konica Corp | 有機着色物質の光褪色防止方法 |
| IE68675B1 (en) | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| DE4333254A1 (de) | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| JPH11514333A (ja) | 1995-03-14 | 1999-12-07 | プレーシス ファーマスーティカルズ インコーポレイテッド | アミロイドの凝集の調節剤 |
| DE19514567A1 (de) | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Benzofurane |
| JP2992677B2 (ja) | 1995-06-05 | 1999-12-20 | 武田薬品工業株式会社 | 骨形成促進医薬組成物 |
| WO1998008868A1 (en) | 1996-08-27 | 1998-03-05 | Praecis Pharmaceuticals Incorporated | MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS |
| JP4149546B2 (ja) | 1996-12-24 | 2008-09-10 | 株式会社東芝 | 半導体装置の製造方法 |
| AU7550398A (en) * | 1997-06-05 | 1998-12-21 | Takeda Chemical Industries Ltd. | Heterocyclic compounds, their production and use |
| JPH1149765A (ja) * | 1997-06-05 | 1999-02-23 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および剤 |
| CZ295937B6 (cs) | 1997-07-25 | 2005-12-14 | H. Lundbeck A/S | Indolové nebo 2,3-dihydroindolové deriváty |
| DE69915508T2 (de) | 1998-12-04 | 2005-01-27 | Takeda Chemical Industries, Ltd. | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
| DE19932314A1 (de) | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzofuranderivate |
| WO2001009111A1 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists |
| DE19958496A1 (de) | 1999-12-04 | 2001-06-07 | Merck Patent Gmbh | Verfahren zur Herstellung von 5-(1-Piperazinyl)-benzofuran-2-carboxamid durch Übergangsmetallkatalysierte Aminierung |
| US20040094431A1 (en) * | 2000-06-12 | 2004-05-20 | Howard A. Fromson | Brush graining |
| CA2424870A1 (en) | 2000-10-05 | 2003-04-04 | Takeda Chemical Industries, Ltd. | Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells |
| ATE527247T1 (de) * | 2001-07-05 | 2011-10-15 | Takeda Pharmaceutical | Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung |
| EP1481679B1 (en) * | 2002-03-01 | 2010-08-25 | Takeda Pharmaceutical Company Limited | Antidepressant |
| EP1492796B1 (en) | 2002-04-02 | 2007-09-05 | Janssen Pharmaceutica N.V. | Substituted amino isoxazoline derivatives and their use as anti-depressants. |
| EP1350769A1 (de) * | 2002-04-04 | 2003-10-08 | Bystronic Maschinen AG | Vorrichtung und Verfahren zum Teilen von vertikalen Glasplatten |
| WO2004016576A1 (ja) | 2002-08-12 | 2004-02-26 | Takeda Pharmaceutical Company Limited | 縮合ベンゼン誘導体および用途 |
| MXPA05011366A (es) | 2003-04-23 | 2005-11-28 | Schering Corp | Antagonistas del receptor a2a de 2-alquinil- y 2-alquenil-pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidina adenosina. |
| US7273886B2 (en) | 2003-05-20 | 2007-09-25 | Genentech, Inc. | Benzofuran inhibitors of factor VIIa |
| DE10326939A1 (de) | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| US7465815B2 (en) | 2003-06-26 | 2008-12-16 | Takeda Pharmaceutical Company Limited | Cannabinoid receptor modulator |
| JP3678733B2 (ja) * | 2003-10-03 | 2005-08-03 | 株式会社エヌ・ティ・ティ・ドコモ | 携帯通信端末及び位置情報提供方法 |
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050095401A1 (en) * | 2003-11-04 | 2005-05-05 | Fuji Photo Film Co., Ltd. | Image recording material and depression-and-protrusion forming method |
| US20050234091A1 (en) | 2004-03-22 | 2005-10-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| DE602005020127D1 (de) | 2004-04-21 | 2010-05-06 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| DE102004063797A1 (de) | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| WO2006111549A1 (de) * | 2005-04-21 | 2006-10-26 | Boehringer Ingelheim International Gmbh | Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen |
| US7994220B2 (en) | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| CN101426774B (zh) | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| GB0707000D0 (en) | 2007-04-12 | 2007-05-30 | Istituto Di Ricerche D Biolog | Antiviral agents |
| HU230729B1 (hu) | 2007-05-30 | 2017-12-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Új, szelektív 5HT7-receptorgátló benzofurán-származékok és eljárás előállításukra |
| US8382180B2 (en) * | 2007-10-31 | 2013-02-26 | Applied Material, Inc. | Advanced FI blade for high temperature extraction |
| US8436043B2 (en) | 2008-03-05 | 2013-05-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP2110374A1 (en) | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
| NZ594847A (en) * | 2009-03-10 | 2013-10-25 | Takeda Pharmaceutical | Benzofuran derivatives |
-
2010
- 2010-03-09 NZ NZ594847A patent/NZ594847A/xx not_active IP Right Cessation
- 2010-03-09 KR KR1020117023545A patent/KR20110128913A/ko not_active Withdrawn
- 2010-03-09 PE PE2011001615A patent/PE20120357A1/es not_active Application Discontinuation
- 2010-03-09 EA EA201171020A patent/EA201171020A1/ru unknown
- 2010-03-09 RS RS20140341A patent/RS53416B/sr unknown
- 2010-03-09 AU AU2010221979A patent/AU2010221979A1/en not_active Abandoned
- 2010-03-09 CN CN201410213851.4A patent/CN103965147B/zh not_active Expired - Fee Related
- 2010-03-09 CA CA2754904A patent/CA2754904A1/en not_active Abandoned
- 2010-03-09 EP EP10710111.5A patent/EP2406243B1/en active Active
- 2010-03-09 DK DK10710111.5T patent/DK2406243T3/da active
- 2010-03-09 US US13/255,366 patent/US8957069B2/en not_active Expired - Fee Related
- 2010-03-09 SI SI201030676T patent/SI2406243T1/sl unknown
- 2010-03-09 US US12/659,447 patent/US8288390B2/en not_active Expired - Fee Related
- 2010-03-09 EP EP14167019.0A patent/EP2781513A1/en not_active Withdrawn
- 2010-03-09 BR BRPI1009252A patent/BRPI1009252A2/pt not_active IP Right Cessation
- 2010-03-09 WO PCT/JP2010/054286 patent/WO2010104194A1/en not_active Ceased
- 2010-03-09 SG SG2011059607A patent/SG173757A1/en unknown
- 2010-03-09 TW TW099106723A patent/TWI477497B/zh not_active IP Right Cessation
- 2010-03-09 PL PL10710111T patent/PL2406243T3/pl unknown
- 2010-03-09 AR ARP100100697A patent/AR076098A1/es unknown
- 2010-03-09 HR HRP20140687AT patent/HRP20140687T1/hr unknown
- 2010-03-09 JP JP2011538739A patent/JP5746631B2/ja not_active Expired - Fee Related
- 2010-03-09 ES ES10710111.5T patent/ES2487616T3/es active Active
- 2010-03-09 CN CN201080020315.2A patent/CN102421767B/zh not_active Expired - Fee Related
- 2010-03-09 UA UAA201110792A patent/UA107657C2/uk unknown
- 2010-03-09 MA MA34219A patent/MA33159B1/fr unknown
- 2010-03-09 MX MX2011009394A patent/MX2011009394A/es active IP Right Grant
- 2010-03-09 UY UY0001032481A patent/UY32481A/es not_active Application Discontinuation
- 2010-03-09 PT PT107101115T patent/PT2406243E/pt unknown
-
2011
- 2011-08-15 IL IL214667A patent/IL214667A0/en unknown
- 2011-08-17 TN TN2011000422A patent/TN2011000422A1/fr unknown
- 2011-08-17 ZA ZA2011/06045A patent/ZA201106045B/en unknown
- 2011-08-23 CO CO11106899A patent/CO6420340A2/es active IP Right Grant
- 2011-09-05 CR CR20110474A patent/CR20110474A/es not_active Application Discontinuation
- 2011-09-08 CL CL2011002206A patent/CL2011002206A1/es unknown
- 2011-09-09 DO DO2011000281A patent/DOP2011000281A/es unknown
- 2011-09-09 EC EC2011011318A patent/ECSP11011318A/es unknown
-
2012
- 2012-05-24 US US13/479,955 patent/US20120232095A1/en not_active Abandoned
- 2012-05-24 US US13/479,981 patent/US20120232096A1/en not_active Abandoned
-
2014
- 2014-08-07 CY CY20141100625T patent/CY1115469T1/el unknown
- 2014-11-06 JP JP2014226377A patent/JP5841651B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-04 SM SM201500027T patent/SMT201500027B/xx unknown
- 2015-03-20 HK HK15102842.9A patent/HK1202293A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012520238A5 (enExample) | ||
| RU2386620C2 (ru) | Производные пиридазин-3(2н)-она и их применение в качестве ингибиторов фдэ4 | |
| RU2406725C2 (ru) | Соединения и композиции как ингибиторы протеинкиназы | |
| HRP20140687T1 (hr) | Derivati benzofurana | |
| RU2497813C2 (ru) | 4-(4-циано-2-тиоарил)-дигидропиримидиноны и их применение | |
| RU2012134306A (ru) | Азотосодержащие производные гетероарилов | |
| JP2018511587A5 (enExample) | ||
| RU2342383C2 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗОЛ-4-ИЛЭТИНИЛПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ (ВАРИАНТЫ) И ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНКСИОЛИТИКА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ НАРУШЕНИЙ, ОПОСРЕДУЕМЫХ РЕЦЕПТОРОМ mGLuR5 | |
| RU2009103313A (ru) | Индолы в качестве модуляторов 5-нт6 | |
| JP2016517878A5 (enExample) | ||
| JP2017524026A5 (enExample) | ||
| JP2012519179A5 (enExample) | ||
| JP2014511869A5 (enExample) | ||
| JP2008513514A5 (enExample) | ||
| ZA200205551B (en) | Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors. | |
| JP2010510242A5 (enExample) | ||
| JP2010526800A5 (enExample) | ||
| JP2006206609A5 (enExample) | ||
| JP2005500986A5 (enExample) | ||
| JP2013503901A5 (enExample) | ||
| MXPA05000081A (es) | Quinolinas sustituidas antagonistas del receptor ccr5. | |
| RU2008126391A (ru) | Производные 1,5-замещенного индол-2-иламида | |
| JP2007519695A5 (enExample) | ||
| EA201000486A1 (ru) | Ингибитор белка, активирующего 5-липоксигеназу (flap) | |
| RU2008120850A (ru) | Соединения и композиции в качестве ингибиторов протеинкиназ |