|
DE10252667A1
(de)
*
|
2002-11-11 |
2004-05-27 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
ES2401335T3
(es)
|
2004-03-15 |
2013-04-18 |
Ptc Therapeutics, Inc. |
Derivados de carbolina útiles en la inhibición de la angiogénesis
|
|
US7767689B2
(en)
|
2004-03-15 |
2010-08-03 |
Ptc Therapeutics, Inc. |
Carboline derivatives useful in the treatment of cancer
|
|
US8076352B2
(en)
|
2004-03-15 |
2011-12-13 |
Ptc Therapeutics, Inc. |
Administration of carboline derivatives useful in the treatment of cancer and other diseases
|
|
US8076353B2
(en)
|
2004-03-15 |
2011-12-13 |
Ptc Therapeutics, Inc. |
Inhibition of VEGF translation
|
|
WO2006068760A2
(en)
|
2004-11-19 |
2006-06-29 |
The Regents Of The University Of California |
Anti-inflammatory pyrazolopyrimidines
|
|
DE102005016460A1
(de)
*
|
2005-04-11 |
2006-10-19 |
Grünenthal GmbH |
Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
|
|
JP5204650B2
(ja)
|
2005-06-24 |
2013-06-05 |
イーライ リリー アンド カンパニー |
アンドロゲン受容体調節物質として有用なテトラヒドロカルバゾール誘導体
|
|
WO2007062175A2
(en)
*
|
2005-11-21 |
2007-05-31 |
Amgen Inc. |
Spiro-substituted tricyclic heterocycles cxcr3 antagonists
|
|
CA2635581C
(en)
|
2005-12-28 |
2017-02-28 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
CA2909277A1
(en)
|
2006-04-04 |
2007-10-11 |
Kevan M. Shokat |
Kinase antagonists
|
|
KR101433395B1
(ko)
|
2006-07-19 |
2014-08-26 |
이 아이 듀폰 디 네모아 앤드 캄파니 |
3-치환된 2-아미노-5-할로벤즈아미드의 제조 방법
|
|
ITMI20061581A1
(it)
*
|
2006-08-04 |
2008-02-05 |
Univ Bari |
Ligandi del recettore beta-3 adrenergico e loro uso in terapia
|
|
UA98777C2
(en)
|
2006-11-20 |
2012-06-25 |
Эли Лилли Энд Компани |
Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
|
|
DE102007009235A1
(de)
*
|
2007-02-22 |
2008-09-18 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
US20100267712A1
(en)
*
|
2007-09-27 |
2010-10-21 |
The United States of America, as represented by the Secretary, Department of Health and |
Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
|
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
|
JP5366211B2
(ja)
*
|
2007-12-18 |
2013-12-11 |
国立大学法人富山大学 |
アルドース還元酵素阻害活性を有する縮合三環化合物
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
DK2240451T3
(da)
|
2008-01-04 |
2017-11-20 |
Intellikine Llc |
Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer
|
|
EP2252293B1
(en)
|
2008-03-14 |
2018-06-27 |
Intellikine, LLC |
Kinase inhibitors and methods of use
|
|
WO2009114874A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
|
AR071067A1
(es)
*
|
2008-03-27 |
2010-05-26 |
Gruenenthal Chemie |
Ciclohexildiaminas sustituidas
|
|
PT2260042E
(pt)
*
|
2008-03-27 |
2011-12-06 |
Gruenenthal Gmbh |
Derivados de ciclo-hexano espirocíclicos substituídos
|
|
EP2502907B1
(de)
|
2008-03-27 |
2018-08-29 |
Grünenthal GmbH |
Substituierte 4-Aminocyclohexan-Derivate
|
|
PL2271613T3
(pl)
*
|
2008-03-27 |
2014-09-30 |
Gruenenthal Gmbh |
Hydroksymetylocykloheksyloaminy
|
|
CA2719736C
(en)
|
2008-03-27 |
2016-02-09 |
Gruenenthal Gmbh |
Spiro(5.5)undecane derivatives
|
|
HRP20120917T1
(hr)
|
2008-05-16 |
2012-12-31 |
Eli Lilly & Company |
TETRAHIDROCIKLOPENTA[b]INDOLSKI MODULATORI ANDROGENOG RECEPTORA
|
|
US9096611B2
(en)
|
2008-07-08 |
2015-08-04 |
Intellikine Llc |
Kinase inhibitors and methods of use
|
|
US20110224223A1
(en)
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
|
WO2010036380A1
(en)
|
2008-09-26 |
2010-04-01 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
|
US8697709B2
(en)
|
2008-10-16 |
2014-04-15 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
|
US8476431B2
(en)
|
2008-11-03 |
2013-07-02 |
Itellikine LLC |
Benzoxazole kinase inhibitors and methods of use
|
|
CA2743861A1
(en)
*
|
2008-11-14 |
2010-05-20 |
The Scripps Research Institute |
Methods and compositions related to targeting monoacylglycerol lipase
|
|
EP2427195B1
(en)
|
2009-05-07 |
2019-05-01 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
WO2010138685A1
(en)
|
2009-05-27 |
2010-12-02 |
Ptc Therapeutics, Inc. |
Methods for treating prostate conditions
|
|
CN102480957A
(zh)
|
2009-05-27 |
2012-05-30 |
Ptc医疗公司 |
治疗癌症及非肿瘤病症的方法
|
|
CA2763479A1
(en)
|
2009-05-27 |
2010-12-02 |
Ptc Therapeutics, Inc. |
Processes for the preparation of substituted tetrahydro beta-carbolines
|
|
WO2010138652A1
(en)
|
2009-05-27 |
2010-12-02 |
Ptc Therapeutics, Inc. |
Methods for treating kaposi sarcoma
|
|
IN2012DN00352A
(enExample)
|
2009-06-16 |
2015-08-21 |
Bikam Pharmaceuticals Inc |
|
|
WO2011014128A1
(en)
*
|
2009-07-30 |
2011-02-03 |
National University Of Singapore |
Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
|
|
WO2011047384A2
(en)
|
2009-10-16 |
2011-04-21 |
The Regents Of The University Of California |
Methods of inhibiting ire1
|
|
WO2011059839A1
(en)
*
|
2009-10-29 |
2011-05-19 |
Sirtris Pharmaceuticals, Inc. |
Bicyclic pyridines and analogs as sirtuin modulators
|
|
MX338831B
(es)
*
|
2010-02-04 |
2016-05-03 |
Radius Health Inc |
Moduladores selectivos de receptores de androgenos.
|
|
ME02474B
(me)
|
2010-05-12 |
2017-02-20 |
Radius Health Inc |
Terapijski režimi
|
|
EP2571357B1
(en)
|
2010-05-21 |
2016-07-06 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
WO2011155983A1
(en)
*
|
2010-06-07 |
2011-12-15 |
Bikam Pharmaceuticals Inc. |
Opsin-binding ligands, compositions and methods of use
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2621901B1
(en)
|
2010-09-28 |
2015-07-29 |
Radius Health, Inc |
Selective androgen receptor modulators
|
|
RS63430B1
(sr)
|
2010-10-01 |
2022-08-31 |
Modernatx Inc |
Ribonukleinske kiseline koje sadrže n1-metil-pseudouracile i njihove primene
|
|
WO2012064973A2
(en)
|
2010-11-10 |
2012-05-18 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
US8980924B2
(en)
|
2010-11-24 |
2015-03-17 |
The Trustees Of Columbia University In The City Of New York |
Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease
|
|
GB201021103D0
(en)
*
|
2010-12-13 |
2011-01-26 |
Univ Leuven Kath |
New compounds for the treatment of neurodegenerative diseases
|
|
DK2663309T3
(en)
|
2011-01-10 |
2017-06-19 |
Infinity Pharmaceuticals Inc |
METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES
|
|
WO2012105610A1
(ja)
*
|
2011-02-02 |
2012-08-09 |
公立大学法人名古屋市立大学 |
眼内血管新生及び/又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬
|
|
EP2678018A4
(en)
|
2011-02-23 |
2015-09-30 |
Intellikine Llc |
COMBINATION OF CHINESE HEMMER AND USES THEREOF
|
|
ES2587856T3
(es)
|
2011-03-18 |
2016-10-27 |
Ono Pharmaceutical Co., Ltd. |
Derivado de tetrahidrocarbolina
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
KR20140063605A
(ko)
|
2011-07-19 |
2014-05-27 |
인피니티 파마슈티칼스, 인코포레이티드 |
헤테로사이클릭 화합물 및 그의 용도
|
|
US8969363B2
(en)
|
2011-07-19 |
2015-03-03 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
AR091790A1
(es)
|
2011-08-29 |
2015-03-04 |
Infinity Pharmaceuticals Inc |
Derivados de isoquinolin-1-ona y sus usos
|
|
MX370814B
(es)
|
2011-09-02 |
2020-01-08 |
Univ California |
Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
CN103030643B
(zh)
*
|
2011-09-29 |
2015-04-29 |
中国科学院化学研究所 |
六环吲哚类生物碱及其制备方法
|
|
DK3682905T3
(da)
|
2011-10-03 |
2022-02-28 |
Modernatx Inc |
Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf
|
|
AR088377A1
(es)
*
|
2011-10-20 |
2014-05-28 |
Siena Biotech Spa |
Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
|
|
DE12858350T1
(de)
|
2011-12-16 |
2021-10-07 |
Modernatx, Inc. |
Modifizierte mrna zusammensetzungen
|
|
EP2606726A1
(de)
|
2011-12-21 |
2013-06-26 |
Bayer CropScience AG |
N-Arylamidine-substituierte trifluoroethylsulfid-Derivate als Akarizide und Insektizide
|
|
US9878056B2
(en)
|
2012-04-02 |
2018-01-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cosmetic proteins and peptides
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
CN104411338A
(zh)
|
2012-04-02 |
2015-03-11 |
现代治疗公司 |
用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
|
|
HK1206601A1
(en)
|
2012-04-02 |
2016-01-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
WO2013166037A1
(en)
|
2012-05-01 |
2013-11-07 |
The Trustees Of Columbia University In The City Of New York |
Non-retinoid antagonists for treatment of eye disorders
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
EP2690091A1
(en)
|
2012-07-25 |
2014-01-29 |
Studiengesellschaft Kohle mbH |
Process for preparing substituted indole derivatives
|
|
WO2014041125A1
(en)
*
|
2012-09-13 |
2014-03-20 |
Baden-Württemberg Stiftung Gmbh |
Specific inhibitors of protein p21 as therapeutic agents
|
|
AU2013323426A1
(en)
|
2012-09-26 |
2015-04-23 |
The Regents Of The University Of California |
Modulation of ire1
|
|
KR102229478B1
(ko)
|
2012-11-01 |
2021-03-18 |
인피니티 파마슈티칼스, 인코포레이티드 |
Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
|
|
HRP20220607T1
(hr)
|
2012-11-26 |
2022-06-24 |
Modernatx, Inc. |
Terminalno modificirana rna
|
|
US9938291B2
(en)
|
2013-03-14 |
2018-04-10 |
The Trustess Of Columbia University In The City Of New York |
N-alkyl-2-phenoxyethanamines, their preparation and use
|
|
ES2700541T3
(es)
|
2013-03-14 |
2019-02-18 |
Univ Columbia |
Octahidrociclopentapirroles, su preparación y uso
|
|
WO2014151936A1
(en)
|
2013-03-14 |
2014-09-25 |
The Trustees Of Columbia University In The City Of New York |
Octahydropyrrolopyrroles, their preparation and use
|
|
EP2968304B1
(en)
|
2013-03-14 |
2018-10-10 |
The Trustees of Columbia University in the City of New York |
4-phenylpiperidines, their preparation and use
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
CA2909442A1
(en)
|
2013-04-17 |
2014-10-23 |
Pfizer Inc. |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
|
US10561707B2
(en)
*
|
2013-09-08 |
2020-02-18 |
Technion Research And Development Foundation Ltd. |
Semaphorin 3C variants, compositions comprising said variants and methods of use thereof in treating eye diseases
|
|
WO2015048744A2
(en)
|
2013-09-30 |
2015-04-02 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
WO2015051214A1
(en)
|
2013-10-03 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
PL3052485T3
(pl)
|
2013-10-04 |
2022-02-28 |
Infinity Pharmaceuticals, Inc. |
Związki heterocykliczne i ich zastosowania
|
|
US9751888B2
(en)
|
2013-10-04 |
2017-09-05 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
CA2943075C
(en)
|
2014-03-19 |
2023-02-28 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
|
|
EP3125920B1
(en)
|
2014-04-04 |
2020-12-23 |
Del Mar Pharmaceuticals |
Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer
|
|
US20150320755A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
WO2015168286A1
(en)
|
2014-04-30 |
2015-11-05 |
The Trustees Of Columbia University In The City Of New York |
Substituted 4-phenylpiperidines, their preparaiton and use
|
|
KR20250004174A
(ko)
*
|
2014-06-27 |
2025-01-07 |
노그라 파마 리미티드 |
아릴 수용체 조정제, 및 그의 제조 및 사용 방법
|
|
EP3171895A1
(en)
|
2014-07-23 |
2017-05-31 |
Modernatx, Inc. |
Modified polynucleotides for the production of intrabodies
|
|
US10570146B2
(en)
*
|
2014-07-25 |
2020-02-25 |
Northeastern University |
Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
|
|
US10266526B2
(en)
*
|
2014-09-10 |
2019-04-23 |
Epizyme, Inc. |
Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer
|
|
WO2016054491A1
(en)
|
2014-10-03 |
2016-04-07 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2749213C2
(ru)
|
2014-10-07 |
2021-06-07 |
Вертекс Фармасьютикалз Инкорпорейтед |
Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе
|
|
US10421756B2
(en)
|
2015-07-06 |
2019-09-24 |
Rodin Therapeutics, Inc. |
Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
|
|
RS62639B1
(sr)
|
2015-07-06 |
2021-12-31 |
Alkermes Inc |
Hetero-halo inhibitori histonskih deacetilaza
|
|
NZ740616A
(en)
|
2015-09-14 |
2023-05-26 |
Infinity Pharmaceuticals Inc |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2022108295A
(ru)
|
2016-06-22 |
2022-04-06 |
Эллипсес Фарма Лтд |
Способы лечения ar+ рака молочной железы
|
|
IL263680B2
(en)
|
2016-06-24 |
2025-10-01 |
Infinity Pharmaceuticals Inc |
PI3K inhibitors for use in combination with a second therapeutic agent for the treatment, management or prevention of cancer
|
|
EP3484528B1
(en)
|
2016-07-18 |
2020-11-25 |
Janssen Pharmaceutica NV |
Tau pet imaging ligands
|
|
AR109405A1
(es)
|
2016-08-26 |
2018-11-28 |
Sumitomo Chemical Co |
Compuestos de fenilurea y su uso
|
|
US10893676B2
(en)
|
2016-08-26 |
2021-01-19 |
Sumitomo Chemical Company, Limited |
1-acetyl-3-phenyl urea compound, and use thereof
|
|
RU2771166C2
(ru)
|
2016-12-21 |
2022-04-27 |
Биотерикс, Инк. |
Производные тиенопиррола для применения для нацеливания на белки, композиции с указанными производными, способы и применения
|
|
MD3570834T2
(ro)
|
2017-01-11 |
2022-04-30 |
Alkermes Inc |
Inhibitori biciclici ai histon deacetilazei
|
|
KR102697360B1
(ko)
|
2017-03-10 |
2024-08-20 |
루트거스, 더 스테이트 유니버시티 오브 뉴 저지 |
유출 펌프 억제제로서의 인돌 유도체
|
|
US11180459B2
(en)
|
2017-03-10 |
2021-11-23 |
Rutgers, The State University Of New Jersey |
Bacterial efflux pump inhibitors
|
|
US11938114B2
(en)
|
2017-03-10 |
2024-03-26 |
Rutgers, The State University Of New Jersey |
Bacterial efflux pump inhibitors
|
|
EP3630109A4
(en)
|
2017-05-26 |
2021-03-17 |
Rutgers, the State University of New Jersey |
BACTERIAL EFFLUX PUMP INHIBITORS
|
|
EP3638215A4
(en)
|
2017-06-15 |
2021-03-24 |
Modernatx, Inc. |
RNA FORMULATIONS
|
|
WO2019005841A1
(en)
*
|
2017-06-26 |
2019-01-03 |
Rutgers, The State University Of New Jersey |
THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION
|
|
EP3664803A4
(en)
|
2017-08-01 |
2021-05-05 |
PTC Therapeutics, Inc. |
DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS
|
|
JP7152471B2
(ja)
|
2017-08-07 |
2022-10-12 |
ロダン・セラピューティクス,インコーポレーテッド |
ヒストン脱アセチル化酵素の二環阻害剤
|
|
JP7275111B2
(ja)
|
2017-08-31 |
2023-05-17 |
モデルナティエックス インコーポレイテッド |
脂質ナノ粒子の生成方法
|
|
US10882821B1
(en)
|
2017-09-26 |
2021-01-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes
|
|
CN111787916B
(zh)
|
2018-01-11 |
2023-09-05 |
森陶鲁斯治疗公司 |
用于治疗疾病的二氢神经酰胺去饱和酶抑制剂
|
|
US12090235B2
(en)
|
2018-09-20 |
2024-09-17 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|
|
EP4267578A4
(en)
|
2020-12-23 |
2024-11-20 |
Recurium IP Holdings, LLC |
ESTROGEN RECEPTOR MODULATORS
|
|
EP4434968A4
(en)
*
|
2021-11-19 |
2025-10-22 |
Nain Biotech Hangzhou Co Ltd |
TETRAHYDROCARBAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
|