HK1202293A1 - Benzofuran derivatives - Google Patents

Benzofuran derivatives Download PDF

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Publication number
HK1202293A1
HK1202293A1 HK15102842.9A HK15102842A HK1202293A1 HK 1202293 A1 HK1202293 A1 HK 1202293A1 HK 15102842 A HK15102842 A HK 15102842A HK 1202293 A1 HK1202293 A1 HK 1202293A1
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HK
Hong Kong
Prior art keywords
compound
substituted
reaction
alkyl
moles
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HK15102842.9A
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English (en)
Chinese (zh)
Inventor
Tetsuya Tsukamoto
Takeshi Wakabayashi
Taiichi Ohra
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Takeda Pharmaceutical Company Limited
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Publication of HK1202293A1 publication Critical patent/HK1202293A1/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
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    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pain & Pain Management (AREA)
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  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK15102842.9A 2009-03-10 2015-03-20 Benzofuran derivatives HK1202293A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009056719 2009-03-10
JP2009056719 2009-03-10

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HK1202293A1 true HK1202293A1 (en) 2015-09-25

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US (4) US8957069B2 (enExample)
EP (2) EP2781513A1 (enExample)
JP (2) JP5746631B2 (enExample)
KR (1) KR20110128913A (enExample)
CN (2) CN103965147B (enExample)
AR (1) AR076098A1 (enExample)
AU (1) AU2010221979A1 (enExample)
BR (1) BRPI1009252A2 (enExample)
CA (1) CA2754904A1 (enExample)
CL (1) CL2011002206A1 (enExample)
CO (1) CO6420340A2 (enExample)
CR (1) CR20110474A (enExample)
CY (1) CY1115469T1 (enExample)
DK (1) DK2406243T3 (enExample)
DO (1) DOP2011000281A (enExample)
EA (1) EA201171020A1 (enExample)
EC (1) ECSP11011318A (enExample)
ES (1) ES2487616T3 (enExample)
HK (1) HK1202293A1 (enExample)
HR (1) HRP20140687T1 (enExample)
IL (1) IL214667A0 (enExample)
MA (1) MA33159B1 (enExample)
MX (1) MX2011009394A (enExample)
NZ (1) NZ594847A (enExample)
PE (1) PE20120357A1 (enExample)
PL (1) PL2406243T3 (enExample)
PT (1) PT2406243E (enExample)
RS (1) RS53416B (enExample)
SG (1) SG173757A1 (enExample)
SI (1) SI2406243T1 (enExample)
SM (1) SMT201500027B (enExample)
TN (1) TN2011000422A1 (enExample)
TW (1) TWI477497B (enExample)
UA (1) UA107657C2 (enExample)
UY (1) UY32481A (enExample)
WO (1) WO2010104194A1 (enExample)
ZA (1) ZA201106045B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA33159B1 (fr) * 2009-03-10 2012-03-01 Takeda Pharmaceutical Derives de la coumarone
WO2011062194A1 (ja) 2009-11-18 2011-05-26 武田薬品工業株式会社 アミノピリジン誘導体
ES2861300T3 (es) 2012-02-20 2021-10-06 Basf Se Potenciación de la actividad antimicrobiana de biocidas con polímeros
US9908680B2 (en) 2012-09-28 2018-03-06 Kimberly-Clark Worldwide, Inc. Tree-free fiber compositions and uses in containerboard packaging
US9816233B2 (en) * 2012-09-28 2017-11-14 Kimberly-Clark Worldwide, Inc. Hybrid fiber compositions and uses in containerboard packaging
RU2647585C2 (ru) * 2012-10-01 2018-03-16 Ф. Хоффманн-Ля Рош Аг Бензимидазолы в качестве активных агентов для центральной нервной системы
KR101716099B1 (ko) * 2013-09-12 2017-03-13 에프. 호프만-라 로슈 아게 인돌-카복스아마이드 유도체
US11447471B2 (en) 2017-06-23 2022-09-20 Kyowa Kirin Co., Ltd. α,β-unsaturated amide compound
CN109580790A (zh) * 2017-09-28 2019-04-05 安徽省庆云医药股份有限公司 一种液相色谱法分离测定西洛多辛及其光学异构体的方法
CN108530405A (zh) * 2018-05-08 2018-09-14 南京晓庄学院 非金属路易斯酸催化烯烃分子内加成c-o键合成苯并呋喃衍生物的方法
CN109879839B (zh) * 2019-03-12 2023-04-25 沈阳大学 6-哌嗪甲基-7-羟基苯并呋喃类化合物及其医药用途
CN113045523B (zh) * 2019-12-27 2022-09-23 上海泓博智源医药股份有限公司 一种咪唑啉吡啶化合物中间体的制备方法
UY39129A (es) * 2020-03-16 2021-10-29 Novartis Ag Derivados de biarilo como inhibidores de la interacción proteína-proteína de yap/taz-tead
CN111362965B (zh) * 2020-04-27 2022-05-03 梯尔希（南京）药物研发有限公司 一种莫西菌素杂质的制备方法
CN113219085B (zh) * 2021-03-31 2022-05-13 河北国龙制药有限公司 一种2,3-二甲基溴苯有关物质的检测方法
CN113214205B (zh) * 2021-04-09 2022-06-10 南方海洋科学与工程广东省实验室(湛江) 一种色原酮衍生物的制备方法
CN115260136B (zh) * 2022-08-09 2023-08-15 嘉兴学院 一种苯酞类化合物及其制备方法
CN115724721A (zh) * 2022-12-19 2023-03-03 山东京博石油化工有限公司 一种2-取代基-4-溴苯酚的制备方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106800A1 (de) 1982-10-08 1984-04-25 Ciba-Geigy Ag Furane
JPH04149546A (ja) 1990-10-15 1992-05-22 Konica Corp 有機着色物質の光褪色防止方法
IE68675B1 (en) 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
US5681954A (en) 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
DE4333254A1 (de) 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
CA2214247C (en) 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
DE19514567A1 (de) 1995-04-20 1996-10-24 Merck Patent Gmbh Benzofurane
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
ATE298765T1 (de) 1996-08-27 2005-07-15 Praecis Pharm Inc Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren
JP4149546B2 (ja) 1996-12-24 2008-09-10 株式会社東芝 半導体装置の製造方法
JPH1149765A (ja) * 1997-06-05 1999-02-23 Takeda Chem Ind Ltd 複素環化合物、その製造法および剤
WO1998055454A2 (en) * 1997-06-05 1998-12-10 Takeda Chemical Industries, Ltd. Benzofurans and benzothophenes as suppressors of neurodegeneration
KR100545329B1 (ko) 1997-07-25 2006-01-24 하. 룬트벡 아크티에 셀스카브 인돌 및 2,3-디히드로인돌 유도체, 그들의 제조방법 및 사용
CN1297550C (zh) * 1998-12-04 2007-01-31 武田药品工业株式会社 苯并呋喃衍生物及其制备和用途
DE19932314A1 (de) * 1999-07-10 2001-01-11 Merck Patent Gmbh Benzofuranderivate
JP2003506365A (ja) 1999-07-29 2003-02-18 イーライ・リリー・アンド・カンパニー ベンゾフリルピペラジンおよびベンゾフリルホモピペラジン：セロトニンアゴニスト
DE19958496A1 (de) 1999-12-04 2001-06-07 Merck Patent Gmbh Verfahren zur Herstellung von 5-(1-Piperazinyl)-benzofuran-2-carboxamid durch Übergangsmetallkatalysierte Aminierung
US20040094431A1 (en) * 2000-06-12 2004-05-20 Howard A. Fromson Brush graining
EP1323716B1 (en) 2000-10-05 2009-01-14 Takeda Pharmaceutical Company Limited Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells
WO2003004485A1 (fr) 2001-07-05 2003-01-16 Takeda Chemical Industries, Ltd. Composes heterocycles a 5 chainons condenses avec un benzo, leur procede de preparation et leur utilisation
US20050148650A1 (en) * 2002-03-01 2005-07-07 Shigenori Ohkawa Antidepressant
BR0308309A (pt) 2002-04-02 2004-12-28 Janssen Pharmaceutica Nv Derivados de isoxazolina amino substituìdo e seu uso como antidepressivos
EP1350769A1 (de) * 2002-04-04 2003-10-08 Bystronic Maschinen AG Vorrichtung und Verfahren zum Teilen von vertikalen Glasplatten
CA2495383A1 (en) 2002-08-12 2004-02-26 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
PT1622912E (pt) 2003-04-23 2009-08-17 Schering Corp Antagonistas 2-alcinil- e 2-alcenilpirazolo-[4,3-b]-1,2,4- triazolo-[1,5-c]-pirimidina do receptor a2a da adenosina
JP2007500221A (ja) 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
DE10326939A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
DK1637527T3 (da) 2003-06-26 2013-07-01 Takeda Pharmaceutical Cannabinoid receptor modulator.
JP3678733B2 (ja) * 2003-10-03 2005-08-03 株式会社エヌ・ティ・ティ・ドコモ 携帯通信端末及び位置情報提供方法
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050095401A1 (en) * 2003-11-04 2005-05-05 Fuji Photo Film Co., Ltd. Image recording material and depression-and-protrusion forming method
EP1730145A1 (en) 2004-03-22 2006-12-13 Boehringer Ingelheim Pharmaceuticals Inc. Alpha-trifluoromethyl alcohols or amines as glucocorticoid mimetics
ATE461932T1 (de) * 2004-04-21 2010-04-15 Schering Corp Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
CN101163706A (zh) * 2005-04-21 2008-04-16 贝林格尔·英格海姆国际有限公司 用于治疗炎性疾病的二氢噻吩并嘧啶
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
KR20090004976A (ko) 2006-04-19 2009-01-12 아스테라스 세이야쿠 가부시키가이샤 아졸카르복사미드 유도체
GB0707000D0 (en) 2007-04-12 2007-05-30 Istituto Di Ricerche D Biolog Antiviral agents
HU230729B1 (hu) 2007-05-30 2017-12-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Új, szelektív 5HT7-receptorgátló benzofurán-származékok és eljárás előállításukra
US8382180B2 (en) * 2007-10-31 2013-02-26 Applied Material, Inc. Advanced FI blade for high temperature extraction
NZ588011A (en) 2008-03-05 2012-06-29 Takeda Pharmaceutical Heterocyclic compounds having glucagon antagonistic action useful for treating diabetes
EP2110374A1 (en) * 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
MA33159B1 (fr) * 2009-03-10 2012-03-01 Takeda Pharmaceutical Derives de la coumarone

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