JP2012519850A5 - - Google Patents
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- JP2012519850A5 JP2012519850A5 JP2011553046A JP2011553046A JP2012519850A5 JP 2012519850 A5 JP2012519850 A5 JP 2012519850A5 JP 2011553046 A JP2011553046 A JP 2011553046A JP 2011553046 A JP2011553046 A JP 2011553046A JP 2012519850 A5 JP2012519850 A5 JP 2012519850A5
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- JP
- Japan
- Prior art keywords
- probe
- antibody
- analyte
- tip
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000523 sample Substances 0.000 claims description 58
- 239000003153 chemical reaction reagent Substances 0.000 claims description 21
- 239000012491 analyte Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 230000003321 amplification Effects 0.000 claims description 14
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 14
- 238000004140 cleaning Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 239000007850 fluorescent dye Substances 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 125000005228 aryl sulfonate group Chemical group 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 238000012921 fluorescence analysis Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20911609P | 2009-03-03 | 2009-03-03 | |
| US61/209,116 | 2009-03-03 | ||
| US29952510P | 2010-01-29 | 2010-01-29 | |
| US61/299,525 | 2010-01-29 | ||
| US30356710P | 2010-02-11 | 2010-02-11 | |
| US61/303,567 | 2010-02-11 | ||
| PCT/US2010/025938 WO2010101931A2 (en) | 2009-03-03 | 2010-03-02 | Detection system and method for high sensitivity fluorescent assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015133458A Division JP6461732B2 (ja) | 2009-03-03 | 2015-07-02 | 高感度蛍光分析のための検出システム及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519850A JP2012519850A (ja) | 2012-08-30 |
| JP2012519850A5 true JP2012519850A5 (enExample) | 2014-05-22 |
| JP5775004B2 JP5775004B2 (ja) | 2015-09-09 |
Family
ID=42710193
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553046A Active JP5775004B2 (ja) | 2009-03-03 | 2010-03-02 | 高感度蛍光分析のための検出システム及び方法 |
| JP2015133458A Active JP6461732B2 (ja) | 2009-03-03 | 2015-07-02 | 高感度蛍光分析のための検出システム及び方法 |
| JP2018195316A Active JP6737856B2 (ja) | 2009-03-03 | 2018-10-16 | 高感度蛍光分析のための検出システム及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015133458A Active JP6461732B2 (ja) | 2009-03-03 | 2015-07-02 | 高感度蛍光分析のための検出システム及び方法 |
| JP2018195316A Active JP6737856B2 (ja) | 2009-03-03 | 2018-10-16 | 高感度蛍光分析のための検出システム及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US8309369B2 (enExample) |
| EP (1) | EP2404162B1 (enExample) |
| JP (3) | JP5775004B2 (enExample) |
| CN (2) | CN102341696B (enExample) |
| WO (1) | WO2010101931A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050118727A1 (en) * | 2003-12-01 | 2005-06-02 | Carsten Schelp | Conjugates and their use in detection methods |
| EP2404162B1 (en) * | 2009-03-03 | 2017-12-27 | Access Medical System Co., Ltd. | Detection system and method for high sensitivity fluorescent assays |
| US9804179B2 (en) | 2011-01-08 | 2017-10-31 | Access Medical Systems, Ltd. | Systems for immunoassay tests |
| JP5922678B2 (ja) * | 2011-01-08 | 2016-05-24 | アクセス メディカル システムズ，リミティド | 免疫学的検定試験のためのシステム |
| EP2699906B1 (en) | 2011-04-20 | 2017-11-29 | Access Medical Systems, Ltd. | Luminescent polymer cyclic amplification |
| US9568431B2 (en) * | 2012-04-16 | 2017-02-14 | Access Medical Systems, Ltd. | Luminescent immunoassays for quantitating analytes having a wide concentration range |
| US20130330711A1 (en) * | 2012-06-06 | 2013-12-12 | National Taiwan University | Sensor for detection of a target of interest |
| US20170248587A1 (en) * | 2014-11-12 | 2017-08-31 | Becton, Dickinson And Company | Polymeric Dye Specific Binding Members and Methods of Making and Using the Same |
| GB201506992D0 (en) * | 2014-11-14 | 2015-06-10 | Nplex Pty Ltd | A portable in-vitro diagnostic detector |
| JP6810055B2 (ja) * | 2015-05-11 | 2021-01-06 | アクセス メディカル システムズ，リミティド | イムノアッセイにおける試験プローブおよび試薬の再利用方法 |
| CN205091263U (zh) * | 2015-07-01 | 2016-03-16 | 上海睿钰生物科技有限公司 | 一种荧光显微成像装置 |
| CN107923908B (zh) * | 2015-08-26 | 2021-01-05 | 万迈医疗仪器有限公司 | 具有提高的灵敏度的免疫检定 |
| US10379049B2 (en) | 2015-10-15 | 2019-08-13 | Lumos Diagnostics IP Pty Ltd | Device for reading an IVD assay |
| CN110036276A (zh) | 2016-10-11 | 2019-07-19 | 万迈医疗仪器有限公司 | 使用干涉仪的生物分子光学传感器 |
| CN110023756B (zh) * | 2016-10-31 | 2023-06-30 | 万迈医疗仪器有限公司 | 基于干涉测量在免疫测定中重复使用测试探针和试剂的方法 |
| CN106841133A (zh) * | 2016-12-31 | 2017-06-13 | 必欧瀚生物技术（合肥）有限公司 | 一种基于荧光免疫层析技术的定量检测计算方法 |
| WO2019050837A1 (en) * | 2017-09-06 | 2019-03-14 | Clemson University Research Foundation | COUPON DESIGN WITH ENHANCED COLOR SENSITIVITY FOR LIQUID-BASED CHEMICAL ANALYSIS OF LIQUIDS |
| WO2019050976A1 (en) | 2017-09-06 | 2019-03-14 | Access Medical Systems, Ltd. | FERROMAGNETIC ROTORS FOR STIRRING A LIQUID IN A MICROCAVITY |
| WO2019165014A1 (en) * | 2018-02-21 | 2019-08-29 | Dots Technology Corp. | Systems and methods for allergen detection |
| JP7035972B2 (ja) * | 2018-11-09 | 2022-03-15 | 横河電機株式会社 | 核酸配列計測用デバイス |
| CN109765407B (zh) * | 2019-01-10 | 2020-03-17 | 西安交通大学 | 一种基于一维纳米材料的大长径比探针制备方法 |
| EP3946737B1 (en) | 2019-04-03 | 2025-06-04 | Access Medical Systems, Ltd. | Method for re-using hapten-coated probe in an immunoassay |
| KR102204918B1 (ko) * | 2019-07-30 | 2021-01-19 | 피씨엘 주식회사 | 다중 바이오마커 동시 분석 기기 및 다중 바이오마커 동시 분석 방법 |
| TWI902784B (zh) | 2020-04-17 | 2025-11-01 | 美商英代斯實驗公司 | 螢光淬滅免疫分析 |
| CN116648458A (zh) * | 2020-12-23 | 2023-08-25 | 万迈医疗仪器有限公司 | 使用荧光和化学发光标记两者的检测方法 |
| CN113125421B (zh) * | 2021-04-09 | 2022-07-12 | 华中农业大学 | 一种光纤生物传感器及其在均相化学发光生物检测中的应用 |
| JP2024529353A (ja) * | 2021-07-14 | 2024-08-06 | ザルトリウス バイオアナリティカル インストゥルメンツ， インコーポレイテッド | アッセイを実施するための物品および方法 |
| WO2023060139A1 (en) * | 2021-10-08 | 2023-04-13 | Access Medical Systems, Ltd. | Method for re-using a test solid surface in a biochemical assay |
| CN119452254A (zh) * | 2022-04-18 | 2025-02-14 | 万迈医疗仪器有限公司 | 用于确定dna病毒中的dna浓度的方法 |
| WO2023205612A1 (en) * | 2022-04-18 | 2023-10-26 | Access Medical Systems, Ltd. | High sensitivity biolayer interferometry with enzyme amplification |
| KR20240092833A (ko) * | 2022-12-15 | 2024-06-24 | 광운대학교 산학협력단 | 정밀 면역 검사 자동화 시스템 |
| EP4754282A1 (en) * | 2023-08-04 | 2026-06-10 | Access Medical Systems, Ltd. | Method for determining dna concentration by biolayer interferometry |
| CN117269473B (zh) * | 2023-08-16 | 2024-09-20 | 星童医疗技术(苏州)有限公司 | 用于放大信号的生物探针包被方法 |
| WO2026084948A1 (en) * | 2024-10-14 | 2026-04-23 | Access Medical Systems, Ltd. | High sensitivity fluorescent detection system |
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| EP2404162B1 (en) * | 2009-03-03 | 2017-12-27 | Access Medical System Co., Ltd. | Detection system and method for high sensitivity fluorescent assays |
| US9568431B2 (en) * | 2012-04-16 | 2017-02-14 | Access Medical Systems, Ltd. | Luminescent immunoassays for quantitating analytes having a wide concentration range |
-
2010
- 2010-03-02 EP EP10749212.6A patent/EP2404162B1/en active Active
- 2010-03-02 CN CN201080010177XA patent/CN102341696B/zh active Active
- 2010-03-02 CN CN201310549211.6A patent/CN103604786B/zh active Active
- 2010-03-02 WO PCT/US2010/025938 patent/WO2010101931A2/en not_active Ceased
- 2010-03-02 JP JP2011553046A patent/JP5775004B2/ja active Active
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2011
- 2011-09-01 US US13/224,174 patent/US8309369B2/en active Active
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2012
- 2012-10-16 US US13/653,362 patent/US8415172B2/en active Active
- 2012-10-24 US US13/659,576 patent/US8492139B2/en active Active
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2013
- 2013-03-18 US US13/846,517 patent/US9434789B2/en active Active
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2015
- 2015-07-02 JP JP2015133458A patent/JP6461732B2/ja active Active
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2016
- 2016-09-02 US US15/256,319 patent/US10379116B2/en active Active
-
2018
- 2018-10-16 JP JP2018195316A patent/JP6737856B2/ja active Active
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