|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
GB8610551D0
(en)
|
1986-04-30 |
1986-06-04 |
Hoffmann La Roche |
Polypeptide & protein derivatives
|
|
JPH0665280B2
(ja)
|
1987-03-04 |
1994-08-24 |
味の素株式会社 |
タンパクゲル化剤及びそれを用いるタンパクのゲル化方法
|
|
DE68929273T2
(de)
*
|
1988-08-24 |
2001-07-05 |
American Cyanamid Co., Wayne |
Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
DE68929151T2
(de)
|
1988-10-28 |
2000-07-20 |
Genentech, Inc. |
Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
|
|
DE68929217T2
(de)
|
1989-03-20 |
2000-11-30 |
The General Hospital Corp., Boston |
Insulinotropes hormon
|
|
US5101018A
(en)
*
|
1989-06-12 |
1992-03-31 |
International Minerals & Chemical Corp. |
Method for recovering recombinant proteins
|
|
DE3930696A1
(de)
|
1989-09-14 |
1991-03-28 |
Hoechst Ag |
Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
|
|
WO1991011457A1
(en)
|
1990-01-24 |
1991-08-08 |
Buckley Douglas I |
Glp-1 analogs useful for diabetes treatment
|
|
US5545618A
(en)
|
1990-01-24 |
1996-08-13 |
Buckley; Douglas I. |
GLP-1 analogs useful for diabetes treatment
|
|
US5951972A
(en)
|
1990-05-04 |
1999-09-14 |
American Cyanamid Company |
Stabilization of somatotropins and other proteins by modification of cysteine residues
|
|
JP2849773B2
(ja)
|
1990-08-27 |
1999-01-27 |
天野製薬株式会社 |
ストレプトミセス属由来のトランスグルタミナーゼの製造法
|
|
DK220890D0
(da)
|
1990-09-14 |
1990-09-14 |
Ole Buchardt |
Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
IT1251895B
(it)
|
1991-09-27 |
1995-05-26 |
Eniricerche Spa |
Mutanti dell'ormone della crescita umano e loro impiego
|
|
EP0555649B1
(en)
|
1992-01-14 |
2004-12-08 |
Ajinomoto Co., Inc. |
Gene encoding transglutaminase derived from fish
|
|
ZA936811B
(en)
|
1992-10-28 |
1995-03-15 |
Upjohn Co |
Somatotropin modifications
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US5849535A
(en)
|
1995-09-21 |
1998-12-15 |
Genentech, Inc. |
Human growth hormone variants
|
|
DE69533606T2
(de)
|
1994-01-28 |
2006-03-02 |
Ajinomoto Co., Inc. |
Transglutaminase aus japanischer auster
|
|
ATE329014T1
(de)
|
1994-08-26 |
2006-06-15 |
Novozymes As |
Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung
|
|
WO1996010089A1
(en)
|
1994-09-29 |
1996-04-04 |
Ajinomoto Co., Inc. |
Modification of peptide and protein
|
|
DE4437604A1
(de)
|
1994-10-21 |
1996-04-25 |
Basf Ag |
Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
|
|
EP0871712B1
(en)
|
1995-01-19 |
2003-08-27 |
Novozymes A/S |
Transglutaminases from oomycetes
|
|
JP3669390B2
(ja)
|
1995-02-09 |
2005-07-06 |
味の素株式会社 |
バチルス属細菌由来のトランスグルタミナーゼ
|
|
US5869602A
(en)
|
1995-03-17 |
1999-02-09 |
Novo Nordisk A/S |
Peptide derivatives
|
|
EP0929576A1
(en)
|
1996-08-30 |
1999-07-21 |
Novo Nordisk A/S |
Glp-2 derivatives
|
|
DK0944648T3
(da)
|
1996-08-30 |
2007-07-02 |
Novo Nordisk As |
GLP-1 derivater
|
|
US6268343B1
(en)
|
1996-08-30 |
2001-07-31 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
CN1231675A
(zh)
|
1996-09-26 |
1999-10-13 |
味之素株式会社 |
修饰的生理活性蛋白及含有该蛋白的药物组合物
|
|
US5985627A
(en)
|
1997-02-28 |
1999-11-16 |
Carlsberg Laboratory |
Modified carboxypeptidase
|
|
JPH1156378A
(ja)
*
|
1997-06-11 |
1999-03-02 |
Nippon Chem Res Kk |
変異型ヒト成長ホルモンとその用途
|
|
EP1775346B1
(en)
*
|
1997-06-25 |
2009-08-12 |
Merck Serono SA |
Disulfide crosslinked glycoprotein hormone analogs, their preparation and use
|
|
DE69838552T2
(de)
*
|
1997-07-14 |
2008-05-21 |
Bolder Biotechnology, Inc., Louisville |
Derivate des wachstumshormons und verwandte proteine
|
|
US6136536A
(en)
|
1997-10-29 |
2000-10-24 |
Genetics Institute, Inc. |
Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
|
|
AU3247799A
(en)
|
1998-02-27 |
1999-09-15 |
Novo Nordisk A/S |
Glp-1 derivatives of glp-1 and exendin with protracted profile of action
|
|
JP2002504527A
(ja)
|
1998-02-27 |
2002-02-12 |
ノボ ノルディスク アクティーゼルスカブ |
部分的に組織化したミセル様凝集物を形成する25%を越えるヘリックス成分を有するglp−2誘導体
|
|
ATE265224T1
(de)
|
1998-02-27 |
2004-05-15 |
Novo Nordisk As |
Glp-1 derivate mit einem helix-gehalt über 25 , die partiell strukturierte mizellenartige aggregate bilden
|
|
EP1056774A1
(en)
|
1998-02-27 |
2000-12-06 |
Novo Nordisk A/S |
N-terminally truncated glp-1 derivatives
|
|
WO1999043707A1
(en)
|
1998-02-27 |
1999-09-02 |
Novo Nordisk A/S |
N-terminally modified glp-1 derivatives
|
|
US6656922B2
(en)
|
1998-05-28 |
2003-12-02 |
Mediplex Corporation, Korea |
Oral delivery of macromolecules
|
|
US6358705B1
(en)
|
1998-07-16 |
2002-03-19 |
Novo Nordisk A/S |
Method of making proteins in transformed yeast cells
|
|
AU762012B2
(en)
|
1998-12-07 |
2003-06-19 |
Ipsen Pharma S.A.S. |
Analogues of GLP-1
|
|
ATE252601T1
(de)
|
1999-05-17 |
2003-11-15 |
Conjuchem Inc |
Lang wirkende insulinotrope peptide
|
|
US6309663B1
(en)
|
1999-08-17 |
2001-10-30 |
Lipocine Inc. |
Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
|
|
WO2001004287A1
(en)
|
1999-07-07 |
2001-01-18 |
Maxygen Aps |
A method for preparing modified polypeptides
|
|
US6528486B1
(en)
|
1999-07-12 |
2003-03-04 |
Zealand Pharma A/S |
Peptide agonists of GLP-1 activity
|
|
EP1076066A1
(en)
|
1999-07-12 |
2001-02-14 |
Zealand Pharmaceuticals A/S |
Peptides for lowering blood glucose levels
|
|
GB2355009A
(en)
|
1999-07-30 |
2001-04-11 |
Univ Glasgow |
Peptides conjugated to bile acids/salts
|
|
US20040001827A1
(en)
|
2002-06-28 |
2004-01-01 |
Dennis Mark S. |
Serum albumin binding peptides for tumor targeting
|
|
AU2353701A
(en)
|
2000-01-11 |
2001-07-24 |
Novo Nordisk A/S |
Transepithelial delivery of glp-1 derivatives
|
|
WO2001058935A2
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
FACTOR VII OR VIIa-LIKE MOLECULES
|
|
US20020142964A1
(en)
|
2000-11-02 |
2002-10-03 |
Nissen Torben Lauesgaard |
Single-chain polypeptides
|
|
SK288342B6
(en)
|
2000-12-07 |
2016-03-01 |
Lilly Co Eli |
GLP-1 fusion proteins
|
|
US20060183197A1
(en)
|
2001-01-11 |
2006-08-17 |
Andersen Kim V |
Variant growth hormone molecules conjugated with macromolecules compounds
|
|
AU2002219021A1
(en)
|
2001-01-11 |
2002-07-24 |
Maxygen Aps |
Variant growth hormone molecules conjugated with macromolecular compounds
|
|
FR2819810B1
(fr)
|
2001-01-23 |
2004-05-28 |
Pf Medicament |
Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
AU2002310438B2
(en)
*
|
2001-06-14 |
2008-05-01 |
The Scripps Research Institute |
Stabilized proteins with engineered disulfide bonds
|
|
ATE382057T1
(de)
|
2001-06-28 |
2008-01-15 |
Novo Nordisk As |
Stabile formulierung von modifiziertem glp-1
|
|
WO2003013573A1
(en)
|
2001-08-10 |
2003-02-20 |
Epix Medical, Inc. |
Polypeptide conjugates with extended circulating half-lives
|
|
AR036711A1
(es)
|
2001-10-05 |
2004-09-29 |
Bayer Corp |
Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
|
|
EA200700431A1
(ru)
|
2001-11-20 |
2008-02-28 |
Фармация Корпорейшн |
Конъюгаты химически модифицированного гормона роста человека
|
|
JP2003199569A
(ja)
|
2001-12-17 |
2003-07-15 |
Food Industry Research & Development Inst |
ストレプトベルティシリウム・ラダカヌムのトランスグルタミナーゼ遺伝子及び該遺伝子によってコードされるトランスグルタミナーゼ
|
|
WO2004065621A1
(en)
|
2002-03-01 |
2004-08-05 |
Dyax Corp. |
Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
|
|
MXPA04009929A
(es)
|
2002-04-10 |
2006-03-10 |
Lilly Co Eli |
Tratamiento de la gastroparesis.
|
|
ATE488581T1
(de)
|
2002-04-30 |
2010-12-15 |
Bayer Healthcare Llc |
Faktor vii oder faktor viia polypeptidvarianten
|
|
DE60332358D1
(de)
|
2002-09-09 |
2010-06-10 |
Hanall Pharmaceutical Co Ltd |
Protease-resistente modifizierte interferon alpha polypeptide
|
|
EP2067483A1
(en)
|
2003-02-19 |
2009-06-10 |
Ipsen Pharma |
Analogues of GLP-1
|
|
AU2004235872A1
(en)
|
2003-05-09 |
2004-11-18 |
Novo Nordisk A/S |
Peptides for use in treating obesity
|
|
JP2007501811A
(ja)
|
2003-08-08 |
2007-02-01 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
治療的な関心対象のタンパク質に対する遅延分子の選択的な化学物質接合のためのガラクトースオキシダーゼの使用。
|
|
JP2007537981A
(ja)
|
2003-09-19 |
2007-12-27 |
ノボ ノルディスク アクティーゼルスカブ |
新規の血漿タンパク質親和性タグ
|
|
EP1670515A2
(en)
|
2003-09-19 |
2006-06-21 |
Novo Nordisk A/S |
Albumin-binding derivatives of therapeutic peptides
|
|
RU2401276C2
(ru)
|
2003-09-19 |
2010-10-10 |
Ново Нордиск А/С |
Производные глюкагон-подобного пептида-1 (glp-1)
|
|
WO2005034988A1
(en)
|
2003-10-10 |
2005-04-21 |
Novo Nordisk A/S |
Long-acting molecules in sustained release formulations
|
|
KR20060109940A
(ko)
|
2003-12-18 |
2006-10-23 |
노보 노르디스크 에이/에스 |
알부민-유사제에 연결된 신규 glp-1 유사체
|
|
RU2006120079A
(ru)
|
2003-12-18 |
2008-01-27 |
Ново Нордиск А/С (DK) |
Производные глюкагоноподобного пептида-1 (glp-1)
|
|
RU2385879C2
(ru)
|
2004-01-21 |
2010-04-10 |
Ново Нордиск Хелс Кеа Аг |
Способ конъюгации пептидов, опосредованной трансглутаминазой
|
|
GB2429207A
(en)
*
|
2004-02-02 |
2007-02-21 |
Ambrx Inc |
Modified human interferon polypeptides and their uses
|
|
US7906137B2
(en)
|
2004-05-21 |
2011-03-15 |
Mediplex Corporation, Korea |
Delivery agents for enhancing mucosal absorption of therapeutic agents
|
|
EP1765408B1
(en)
|
2004-07-08 |
2015-12-09 |
Novo Nordisk A/S |
Polypeptide protracting tags comprising a tetrazole moiety
|
|
US20090176967A1
(en)
|
2004-08-02 |
2009-07-09 |
Novo Nordisk Healthcare A/G |
Conjugation of FVII
|
|
US7893017B2
(en)
|
2004-10-07 |
2011-02-22 |
Novo Nordisk A/S |
Protracted GLP-1 compounds
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
EP1863537A2
(en)
|
2005-03-18 |
2007-12-12 |
Novo Nordisk A/S |
Dimeric peptide agonists of the glp-1 receptor
|
|
TWI372629B
(en)
|
2005-03-18 |
2012-09-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
|
JP5755398B2
(ja)
|
2005-03-18 |
2015-07-29 |
ノヴォ ノルディスク アー/エス |
伸長されたglp−1化合物
|
|
ES2553160T3
(es)
|
2005-06-17 |
2015-12-04 |
Novo Nordisk Health Care Ag |
Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
|
|
CN101263225A
(zh)
|
2005-08-18 |
2008-09-10 |
诺沃-诺迪斯克保健股份有限公司 |
改进转谷氨酰胺酶的底物特异性
|
|
WO2007093594A1
(en)
|
2006-02-14 |
2007-08-23 |
Novo Nordisk Health Care Ag |
Coupling of polypeptides at the c-terminus
|
|
BRPI0713963A2
(pt)
|
2006-07-07 |
2012-11-27 |
Novo Nordisk Healthcare Ag |
conjugados de proteìna e métodos para sua preparação
|
|
CA2672267C
(en)
|
2006-07-27 |
2016-05-31 |
Emisphere Technologies, Inc. |
Arylsulfanyl compounds and compositions for delivering active agents
|
|
WO2008020075A1
(en)
|
2006-08-18 |
2008-02-21 |
Novo Nordisk Health Care Ag |
Transglutaminase variants with improved specificity
|
|
US20080095837A1
(en)
|
2006-08-31 |
2008-04-24 |
Emisphere Technologies, Inc. |
Human growth hormone formulations
|
|
WO2008027854A2
(en)
|
2006-08-31 |
2008-03-06 |
Novartis Ag |
Pharmaceutical compositions comprising hgh for oral delivery
|
|
JP5390404B2
(ja)
|
2007-02-16 |
2014-01-15 |
エミスフェアー・テクノロジーズ・インク |
活性薬剤を送達するための環状部分を有する化合物及び組成物
|
|
WO2008112836A2
(en)
|
2007-03-15 |
2008-09-18 |
Novartis Ag |
Pharmaceutical composition comprising human growth hormon
|
|
EP2190460B1
(en)
|
2007-09-05 |
2014-12-17 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
AU2009279090A1
(en)
|
2008-08-06 |
2010-02-11 |
Novo Nordisk Health Care Ag |
Conjugated proteins with prolonged in vivo efficacy
|
|
CN102149411A
(zh)
|
2008-09-12 |
2011-08-10 |
诺沃—诺迪斯克有限公司 |
酰化肽或蛋白的方法
|
|
KR20110122100A
(ko)
|
2009-01-22 |
2011-11-09 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
안정한 성장 호르몬 화합물
|