JP2012509846A5 - - Google Patents
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- JP2012509846A5 JP2012509846A5 JP2011532298A JP2011532298A JP2012509846A5 JP 2012509846 A5 JP2012509846 A5 JP 2012509846A5 JP 2011532298 A JP2011532298 A JP 2011532298A JP 2011532298 A JP2011532298 A JP 2011532298A JP 2012509846 A5 JP2012509846 A5 JP 2012509846A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pharmaceutical composition
- group
- amino acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10640008P | 2008-10-17 | 2008-10-17 | |
| US61/106,400 | 2008-10-17 | ||
| PCT/US2009/061068 WO2010045599A1 (en) | 2008-10-17 | 2009-10-16 | Pharmaceutical compositions with attenuated release of phenolic opioids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037724A Division JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509846A JP2012509846A (ja) | 2012-04-26 |
| JP2012509846A5 true JP2012509846A5 (enExample) | 2012-12-06 |
| JP5706825B2 JP5706825B2 (ja) | 2015-04-22 |
Family
ID=41466912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532298A Active JP5706825B2 (ja) | 2008-10-17 | 2009-10-16 | フェノール性オピオイドの放出が減弱された医薬組成物 |
| JP2015037724A Pending JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037724A Pending JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8802681B2 (enExample) |
| EP (1) | EP2349241B1 (enExample) |
| JP (2) | JP5706825B2 (enExample) |
| KR (1) | KR20110081852A (enExample) |
| CN (1) | CN102186467B (enExample) |
| AU (1) | AU2009305563C1 (enExample) |
| CA (1) | CA2739936C (enExample) |
| IL (1) | IL212081A (enExample) |
| MX (1) | MX2011004095A (enExample) |
| RU (1) | RU2562583C2 (enExample) |
| WO (1) | WO2010045599A1 (enExample) |
| ZA (1) | ZA201102361B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2349241B1 (en) | 2008-10-17 | 2019-06-19 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| WO2011008636A1 (en) * | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
| BR112012005124B1 (pt) * | 2009-09-08 | 2021-11-09 | Signature Therapeutics, Inc. | Pro-fármaco de opioide modificado por cetona, seu método de preparação, sua composição farmacêutica, sua unidade de dose, métodos e usos |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| WO2011133178A1 (en) * | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| EP2560489A4 (en) * | 2010-04-21 | 2014-01-22 | Signature Therapeutics Inc | COMPOSITIONS WITH ENZYMSPALTBAR OPIOID PRODRUGS AND HEMMER FOR THIS |
| US20110262359A1 (en) * | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable prodrugs of active agents and inhibitors thereof |
| WO2011133348A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| WO2011133151A1 (en) * | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable phenol-modified opioid prodrugs and inhibitors thereof |
| CN103384472B (zh) * | 2011-01-11 | 2016-01-20 | 特色疗法股份有限公司 | 包含酶可裂解的羟考酮药物前体的组合物 |
| US8497237B2 (en) | 2011-01-11 | 2013-07-30 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| BR112013022946A2 (pt) * | 2011-03-09 | 2017-07-18 | Signature Therapeutics Inc | pró-fármacos de agentes ativos com ligantes heterocíclocos |
| WO2012122420A2 (en) * | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| WO2016064914A1 (en) | 2014-10-20 | 2016-04-28 | Elysium Therapeutics, Inc. | Diversion-resistant opioid formulations |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| CA2998708C (en) * | 2015-10-01 | 2019-09-03 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| EP3463576A4 (en) | 2016-05-25 | 2020-01-15 | Concentric Analgesics, Inc. | PRODRUGS BY PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETIC AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA |
| JP7234130B2 (ja) * | 2017-03-17 | 2023-03-07 | エリージウム セラピューティクス， インコーポレイテッド | 過剰摂取および乱用に対して抵抗性のポリサブユニットオピオイドプロドラッグ |
| CA3107433A1 (en) | 2018-07-27 | 2020-01-30 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic trpv1 agonists |
| EP3934635A4 (en) | 2019-03-06 | 2022-12-07 | Ensysce Biosciences, Inc. | COMPOSITIONS OF ENZYME-CLEAVABLE AMPHETAMINE PRODRUGS AND INHIBITORS THEREOF |
| KR20230175187A (ko) * | 2021-03-09 | 2023-12-29 | 엔사이스 바이오사이언시즈 인크. | 효소-절단가능한 전구약물 및 제어된 방출 나파모스타트를 포함하는 조성물 및 그의 사용 방법 |
| US12384744B2 (en) | 2021-09-29 | 2025-08-12 | Ensysce Biosciences Inc. | Enzyme-cleavable methadone prodrugs and methods of use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527371B2 (en) | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| US5109118A (en) * | 1989-07-06 | 1992-04-28 | Yutaka Mizushima | Modified biologically active proteins |
| CA2032420A1 (en) | 1989-12-22 | 1991-06-23 | Akira Okuyama | Guanidinobenzene derivatives |
| US6692766B1 (en) | 1994-06-15 | 2004-02-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Controlled release oral drug delivery system |
| RU2166512C2 (ru) * | 1995-01-16 | 2001-05-10 | Коммонвелт Сайентифик Энд Индастриал Рисерч Организейшн | Конъюгаты терапевтического соединения с жирной кислотой |
| US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
| WO2000036098A1 (en) | 1998-12-15 | 2000-06-22 | Tropix, Inc. | Multiple enzyme assays |
| US6849263B2 (en) * | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
| AU3000800A (en) | 1999-02-18 | 2000-09-04 | Supergen, Inc. | Phosphocholine linked prodrug derivatives |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20030180352A1 (en) | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| EP1404356B1 (en) | 2001-06-11 | 2011-04-06 | Medarex, Inc. | Method for designing cd10-activated prodrug compounds |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US20100092562A1 (en) | 2002-11-26 | 2010-04-15 | Hollenbeck R Gary | Sustained-release drug delivery compositions and methods |
| NZ544162A (en) | 2003-05-29 | 2008-09-26 | Shire Llc | Abuse resistant amphetamine compounds |
| EP1928881A2 (en) * | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
| CA2620364A1 (en) * | 2005-08-26 | 2007-03-01 | David C. Yeomans | Methods for treatment of headaches by administration of oxytocin |
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| AU2006322051B2 (en) | 2005-12-05 | 2011-09-29 | Xenoport, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| JP2009533459A (ja) | 2006-04-14 | 2009-09-17 | シャイア エルエルシー | 共有結合する化合物の鎮痛作用の増強と、有害な副作用の減衰と、前記化合物の乱用の予防とのための組成物及び方法 |
| WO2007140272A2 (en) * | 2006-05-26 | 2007-12-06 | Pharmacofore, Inc. | Controlled release of phenolic opioids |
| TWI401237B (zh) | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| US20120142718A1 (en) * | 2007-02-16 | 2012-06-07 | Jenkins Thomas E | N-17-Alkylated Prodrugs of Opioids |
| WO2008101187A2 (en) | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | Pro-drugs of peripheral phenolic opioid antagonists |
| CN102065852B (zh) | 2007-11-23 | 2015-06-17 | 格吕伦塔尔有限公司 | 他喷他多组合物 |
| US9023860B2 (en) | 2007-11-26 | 2015-05-05 | Signature Therapeutics, Inc. | Pro-drugs for controlled release of biologically active compounds |
| WO2009092071A2 (en) | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide pro-drugs of phenolic analgesics and uses thereof |
| US8354534B2 (en) | 2008-02-14 | 2013-01-15 | Alkermes, Inc. | Selective opioid compounds |
| EP2349241B1 (en) | 2008-10-17 | 2019-06-19 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| WO2010100477A2 (en) | 2009-03-03 | 2010-09-10 | Shire Llc | Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof |
| AU2010231126A1 (en) | 2009-04-02 | 2011-10-13 | Shire Llc | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof |
| MX2012000752A (es) | 2009-07-17 | 2012-05-08 | Shire Llc | Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. |
| EP2560491A1 (en) | 2010-04-21 | 2013-02-27 | Signature Therapeutics, Inc. | Peripheral opioid agonists and peripheral opioid antagonists |
-
2009
- 2009-10-16 EP EP09740597.1A patent/EP2349241B1/en active Active
- 2009-10-16 CN CN200980141547.0A patent/CN102186467B/zh active Active
- 2009-10-16 US US13/121,335 patent/US8802681B2/en active Active
- 2009-10-16 RU RU2011119643/15A patent/RU2562583C2/ru active
- 2009-10-16 AU AU2009305563A patent/AU2009305563C1/en active Active
- 2009-10-16 KR KR1020117011102A patent/KR20110081852A/ko not_active Withdrawn
- 2009-10-16 MX MX2011004095A patent/MX2011004095A/es not_active Application Discontinuation
- 2009-10-16 WO PCT/US2009/061068 patent/WO2010045599A1/en not_active Ceased
- 2009-10-16 JP JP2011532298A patent/JP5706825B2/ja active Active
- 2009-10-16 CA CA2739936A patent/CA2739936C/en active Active
-
2011
- 2011-03-30 ZA ZA2011/02361A patent/ZA201102361B/en unknown
- 2011-04-03 IL IL212081A patent/IL212081A/en active IP Right Grant
-
2014
- 2014-06-30 US US14/320,351 patent/US9534014B2/en active Active
-
2015
- 2015-02-27 JP JP2015037724A patent/JP2015129167A/ja active Pending