JP2012509846A5 - - Google Patents
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- Publication number
- JP2012509846A5 JP2012509846A5 JP2011532298A JP2011532298A JP2012509846A5 JP 2012509846 A5 JP2012509846 A5 JP 2012509846A5 JP 2011532298 A JP2011532298 A JP 2011532298A JP 2011532298 A JP2011532298 A JP 2011532298A JP 2012509846 A5 JP2012509846 A5 JP 2012509846A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pharmaceutical composition
- group
- amino acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10640008P | 2008-10-17 | 2008-10-17 | |
| US61/106,400 | 2008-10-17 | ||
| PCT/US2009/061068 WO2010045599A1 (en) | 2008-10-17 | 2009-10-16 | Pharmaceutical compositions with attenuated release of phenolic opioids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037724A Division JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509846A JP2012509846A (ja) | 2012-04-26 |
| JP2012509846A5 true JP2012509846A5 (enExample) | 2012-12-06 |
| JP5706825B2 JP5706825B2 (ja) | 2015-04-22 |
Family
ID=41466912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532298A Active JP5706825B2 (ja) | 2008-10-17 | 2009-10-16 | フェノール性オピオイドの放出が減弱された医薬組成物 |
| JP2015037724A Pending JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037724A Pending JP2015129167A (ja) | 2008-10-17 | 2015-02-27 | フェノール性オピオイドの放出が減弱された医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8802681B2 (enExample) |
| EP (1) | EP2349241B1 (enExample) |
| JP (2) | JP5706825B2 (enExample) |
| KR (1) | KR20110081852A (enExample) |
| CN (1) | CN102186467B (enExample) |
| AU (1) | AU2009305563C1 (enExample) |
| CA (1) | CA2739936C (enExample) |
| IL (1) | IL212081A (enExample) |
| MX (1) | MX2011004095A (enExample) |
| RU (1) | RU2562583C2 (enExample) |
| WO (1) | WO2010045599A1 (enExample) |
| ZA (1) | ZA201102361B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| WO2011008636A1 (en) * | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
| JP2013503862A (ja) * | 2009-09-08 | 2013-02-04 | シグネーチャー セラピューティクス，インク． | 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物 |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US20110262359A1 (en) * | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable prodrugs of active agents and inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| CA2795222A1 (en) * | 2010-04-21 | 2011-10-27 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US20130059914A1 (en) | 2010-04-21 | 2013-03-07 | Signature Therapeutics, Inc. | Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof |
| WO2011133151A1 (en) * | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable phenol-modified opioid prodrugs and inhibitors thereof |
| AU2012205733B2 (en) * | 2011-01-11 | 2015-10-08 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| WO2012096886A1 (en) * | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| EP2683394B1 (en) * | 2011-03-09 | 2021-01-06 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| US10314839B2 (en) | 2014-10-20 | 2019-06-11 | Elysium Therapeutics, Inc. | Diversion-resistant opioid formulations |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| WO2017059459A1 (en) * | 2015-10-01 | 2017-04-06 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10335406B2 (en) * | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| CA3025268A1 (en) | 2016-05-25 | 2017-11-30 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| CA3056239C (en) | 2017-03-17 | 2023-09-12 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10717712B2 (en) | 2018-07-27 | 2020-07-21 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic TRPV1 agonists |
| WO2020181000A1 (en) | 2019-03-06 | 2020-09-10 | Ensysce Biosciences, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| KR20230174213A (ko) | 2021-03-09 | 2023-12-27 | 엔사이스 바이오사이언시즈 인크. | 나파모스타트의 변형된 방출 조성물 및 그의 사용 방법 |
| CN117715632A (zh) | 2021-03-09 | 2024-03-15 | 恩赛斯生物科学股份有限公司 | 包含酶可裂解的前药和萘莫司他的组合物及其使用方法 |
| MX2024003466A (es) | 2021-09-29 | 2024-06-04 | Ensysce Biosciences Inc | Profarmacos de metadona escindibles por enzimas y metodos de uso de los mismos. |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527371B2 (en) | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| US5109118A (en) * | 1989-07-06 | 1992-04-28 | Yutaka Mizushima | Modified biologically active proteins |
| CA2032420A1 (en) | 1989-12-22 | 1991-06-23 | Akira Okuyama | Guanidinobenzene derivatives |
| US6692766B1 (en) | 1994-06-15 | 2004-02-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Controlled release oral drug delivery system |
| US5952499A (en) * | 1995-01-16 | 1999-09-14 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound-fatty acid conjugates |
| EP0893437A4 (en) | 1996-04-10 | 2000-12-27 | Ono Pharmaceutical Co | GUANIDINO TRYPTASE INHIBITOR |
| AU781255B2 (en) | 1998-12-15 | 2005-05-12 | Applied Biosystems, Llc | Multiple enzyme assays |
| US6849263B2 (en) * | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
| EP1161226B1 (en) | 1999-02-18 | 2004-05-26 | SuperGen, Inc. | Phosphocholine linked prodrug derivatives |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| ES2364452T3 (es) | 2001-06-11 | 2011-09-02 | Medarex, Inc. | Método para diseñar compuestos profármacos activados por cd10. |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20100092562A1 (en) | 2002-11-26 | 2010-04-15 | Hollenbeck R Gary | Sustained-release drug delivery compositions and methods |
| JP4898445B2 (ja) | 2003-05-29 | 2012-03-14 | シャイア エルエルシー | 乱用抵抗性アンフェタミン化合物類 |
| EP1928881A2 (en) * | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
| JP5276982B2 (ja) | 2005-08-26 | 2013-08-28 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | オキシトシンの投与による頭痛の処置のための方法 |
| CN101309917B (zh) | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7563821B2 (en) | 2005-12-05 | 2009-07-21 | Xenoport, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| US20100144645A1 (en) | 2006-04-14 | 2010-06-10 | Shire Llc | Compositions and methods for enhancing analgesic potency of covalently bound-compounds, attenuating its adverse side effects, and preventing their abuse |
| SG172633A1 (en) | 2006-05-26 | 2011-07-28 | Pharmacofore Inc | Controlled release of phenolic opioids |
| TWI401237B (zh) | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| WO2008101187A2 (en) | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | Pro-drugs of peripheral phenolic opioid antagonists |
| WO2008101202A1 (en) | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | N-17-alkylated prodrugs of opioids |
| MX2010005680A (es) | 2007-11-23 | 2010-12-21 | Protect Pharmaceutical Corp | Composiciones de tapentadol. |
| US9023860B2 (en) | 2007-11-26 | 2015-05-05 | Signature Therapeutics, Inc. | Pro-drugs for controlled release of biologically active compounds |
| WO2009092073A2 (en) | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects |
| JP2011512360A (ja) | 2008-02-14 | 2011-04-21 | アルカーメス，インコーポレイテッド | 選択的オピオイド化合物 |
| CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| WO2010100477A2 (en) | 2009-03-03 | 2010-09-10 | Shire Llc | Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof |
| CA2756397A1 (en) | 2009-04-02 | 2010-10-07 | Shire Llc | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof |
| EP2453900A1 (en) | 2009-07-17 | 2012-05-23 | Shire LLC | Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof |
| WO2011133346A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Peripheral opioid agonists and peripheral opioid antagonists |
-
2009
- 2009-10-16 CA CA2739936A patent/CA2739936C/en active Active
- 2009-10-16 CN CN200980141547.0A patent/CN102186467B/zh active Active
- 2009-10-16 AU AU2009305563A patent/AU2009305563C1/en active Active
- 2009-10-16 EP EP09740597.1A patent/EP2349241B1/en active Active
- 2009-10-16 RU RU2011119643/15A patent/RU2562583C2/ru active
- 2009-10-16 KR KR1020117011102A patent/KR20110081852A/ko not_active Withdrawn
- 2009-10-16 US US13/121,335 patent/US8802681B2/en active Active
- 2009-10-16 WO PCT/US2009/061068 patent/WO2010045599A1/en not_active Ceased
- 2009-10-16 MX MX2011004095A patent/MX2011004095A/es not_active Application Discontinuation
- 2009-10-16 JP JP2011532298A patent/JP5706825B2/ja active Active
-
2011
- 2011-03-30 ZA ZA2011/02361A patent/ZA201102361B/en unknown
- 2011-04-03 IL IL212081A patent/IL212081A/en active IP Right Grant
-
2014
- 2014-06-30 US US14/320,351 patent/US9534014B2/en active Active
-
2015
- 2015-02-27 JP JP2015037724A patent/JP2015129167A/ja active Pending
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