BRPI1015108A2 - pró-fármacos de aminoácidos e peptídios ligados a ácido dicarboxílico de opiáceos e seus usos - Google Patents

pró-fármacos de aminoácidos e peptídios ligados a ácido dicarboxílico de opiáceos e seus usos

Info

Publication number
BRPI1015108A2
BRPI1015108A2 BRPI1015108A BRPI1015108A BRPI1015108A2 BR PI1015108 A2 BRPI1015108 A2 BR PI1015108A2 BR PI1015108 A BRPI1015108 A BR PI1015108A BR PI1015108 A BRPI1015108 A BR PI1015108A BR PI1015108 A2 BRPI1015108 A2 BR PI1015108A2
Authority
BR
Brazil
Prior art keywords
opioid
amino acid
linked amino
dicarboxylic acid
peptide prodrugs
Prior art date
Application number
BRPI1015108A
Other languages
English (en)
Inventor
Bernard T Golding
Richard Franklin
Robert G Tyson
Original Assignee
Shire Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Llc filed Critical Shire Llc
Publication of BRPI1015108A2 publication Critical patent/BRPI1015108A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
BRPI1015108A 2009-04-02 2010-04-01 pró-fármacos de aminoácidos e peptídios ligados a ácido dicarboxílico de opiáceos e seus usos BRPI1015108A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21183109P 2009-04-02 2009-04-02
US22771609P 2009-07-22 2009-07-22
PCT/GB2010/050584 WO2010112942A1 (en) 2009-04-02 2010-04-01 Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof

Publications (1)

Publication Number Publication Date
BRPI1015108A2 true BRPI1015108A2 (pt) 2016-04-26

Family

ID=42238240

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015108A BRPI1015108A2 (pt) 2009-04-02 2010-04-01 pró-fármacos de aminoácidos e peptídios ligados a ácido dicarboxílico de opiáceos e seus usos

Country Status (11)

Country Link
US (1) US20100286186A1 (pt)
EP (1) EP2413937A1 (pt)
JP (1) JP2013523599A (pt)
KR (1) KR20110134510A (pt)
CN (1) CN102573845A (pt)
AU (1) AU2010231126A1 (pt)
BR (1) BRPI1015108A2 (pt)
CA (1) CA2756397A1 (pt)
IL (1) IL215348A0 (pt)
MX (1) MX2011010448A (pt)
WO (1) WO2010112942A1 (pt)

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US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
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US9238020B2 (en) 2010-04-21 2016-01-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug
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WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
WO2011141488A2 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
DK2663187T3 (en) 2011-01-11 2016-08-29 Signature Therapeutics Inc Compositions comprising enzyme-cleavable oxycodone prodrug
US8497237B2 (en) 2011-01-11 2013-07-30 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
AU2012211204B2 (en) 2011-01-26 2014-04-24 Nico Worldwide, Inc. Remedy for migraine headache
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RU2608305C2 (ru) 2011-03-09 2017-01-17 Сигничер Терапьютикс, Инк. Пролекарства действующих веществ гетероциклическими линкерами
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CN104136031B (zh) 2011-10-26 2016-05-04 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
WO2014031403A1 (en) * 2012-08-22 2014-02-27 Phoenix Pharmalabs, Inc. Use of morphine analogs for animal health
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
AU2014350135B2 (en) 2013-11-13 2017-08-31 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
EP3082816B1 (en) 2013-12-20 2019-03-20 Indivior UK Limited Intranasal naloxone compositions and methods of making and using same
SG11201704309YA (en) 2014-12-02 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof
US10017519B2 (en) * 2015-04-27 2018-07-10 3St Research Llc Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
US9987269B2 (en) * 2015-04-27 2018-06-05 3St Research Llc Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of oxymorphone and uses thereof
US10449190B2 (en) 2015-04-27 2019-10-22 John K. Thottathil Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof
US10226456B2 (en) 2015-04-27 2019-03-12 3St Research Llc Methods and compositions for preventing opioid abuse
CA2998528A1 (en) 2015-09-22 2017-03-30 The Regents Of The University Of California Modified cytotoxins and their therapeutic use
US10286079B2 (en) 2015-09-22 2019-05-14 The Regents Of The University Of California Modified cytotoxins and their therapeutic use
CN106866733B (zh) * 2015-12-11 2020-11-20 凯瑞康宁生物工程（武汉）有限公司 左旋美普他酚前药及其制备方法和用途
US10414718B2 (en) * 2016-01-04 2019-09-17 Shandong Danhong Pharmaceutical Co., Ltd. Dezocine analogue
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WO2018183264A1 (en) * 2017-03-29 2018-10-04 Thottathil John K Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof
US11214544B2 (en) 2017-04-14 2022-01-04 Kempharm, Inc. Dextrorphan prodrugs and processes for making and using them
WO2018191474A1 (en) * 2017-04-14 2018-10-18 Kempharm, Inc. Levorphanol prodrugs and processes for making and using them
US11234975B2 (en) 2017-04-14 2022-02-01 Kempharm, Inc. Levorphanol prodrugs and processes for making and using them
WO2019007285A1 (zh) * 2017-07-03 2019-01-10 山东丹红制药有限公司 地佐辛类似物盐酸盐的晶型及无定型
MX2020008706A (es) 2018-02-23 2020-09-25 Rhodes Tech Nuevos compuestos de opioides y sus usos.
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
CN109096191B (zh) * 2018-10-25 2022-03-08 西北工业大学 氟比洛芬美普他酚酯药用化合物及其制备方法
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US20090186832A1 (en) * 2008-01-18 2009-07-23 Shire Llc Amino acid peptide pro-drugs of phenolic analgesics and uses thereof

Also Published As

Publication number Publication date
US20100286186A1 (en) 2010-11-11
CA2756397A1 (en) 2010-10-07
WO2010112942A1 (en) 2010-10-07
EP2413937A1 (en) 2012-02-08
JP2013523599A (ja) 2013-06-17
KR20110134510A (ko) 2011-12-14
AU2010231126A1 (en) 2011-10-13
CN102573845A (zh) 2012-07-11
IL215348A0 (en) 2011-12-29
MX2011010448A (es) 2011-10-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]