JP2012507294A5 - - Google Patents

Download PDF

Info

Publication number
JP2012507294A5
JP2012507294A5 JP2011534672A JP2011534672A JP2012507294A5 JP 2012507294 A5 JP2012507294 A5 JP 2012507294A5 JP 2011534672 A JP2011534672 A JP 2011534672A JP 2011534672 A JP2011534672 A JP 2011534672A JP 2012507294 A5 JP2012507294 A5 JP 2012507294A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
sequence shown
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011534672A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012507294A (ja
JP5291802B2 (ja
Filing date
Publication date
Priority claimed from US12/260,307 external-priority patent/US7608693B2/en
Application filed filed Critical
Publication of JP2012507294A publication Critical patent/JP2012507294A/ja
Publication of JP2012507294A5 publication Critical patent/JP2012507294A5/ja
Application granted granted Critical
Publication of JP5291802B2 publication Critical patent/JP5291802B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011534672A 2008-10-29 2009-10-27 ヒトil−4受容体に対する高親和性ヒト抗体 Active JP5291802B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/260,307 US7608693B2 (en) 2006-10-02 2008-10-29 High affinity human antibodies to human IL-4 receptor
US12/260,307 2008-10-29
PCT/US2009/062168 WO2010053751A1 (en) 2008-10-29 2009-10-27 High affinity human antibodies to human il-4 receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013097263A Division JP5844772B2 (ja) 2008-10-29 2013-05-07 ヒトil−4受容体に対する高親和性ヒト抗体

Publications (3)

Publication Number Publication Date
JP2012507294A JP2012507294A (ja) 2012-03-29
JP2012507294A5 true JP2012507294A5 (OSRAM) 2013-06-27
JP5291802B2 JP5291802B2 (ja) 2013-09-18

Family

ID=41600767

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2011534672A Active JP5291802B2 (ja) 2008-10-29 2009-10-27 ヒトil−4受容体に対する高親和性ヒト抗体
JP2013097263A Active JP5844772B2 (ja) 2008-10-29 2013-05-07 ヒトil−4受容体に対する高親和性ヒト抗体
JP2015199976A Active JP6449125B2 (ja) 2008-10-29 2015-10-08 ヒトil−4受容体に対する高親和性ヒト抗体
JP2018209345A Active JP6608505B2 (ja) 2008-10-29 2018-11-07 ヒトil−4受容体に対する高親和性ヒト抗体
JP2019191643A Active JP6843208B2 (ja) 2008-10-29 2019-10-21 ヒトil−4受容体に対する高親和性ヒト抗体
JP2021024740A Active JP7100731B2 (ja) 2008-10-29 2021-02-19 ヒトil-4受容体に対する高親和性ヒト抗体
JP2022105797A Active JP7442581B2 (ja) 2008-10-29 2022-06-30 ヒトil-4受容体に対する高親和性ヒト抗体
JP2024022482A Pending JP2024040526A (ja) 2008-10-29 2024-02-19 ヒトil-4受容体に対する高親和性ヒト抗体

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2013097263A Active JP5844772B2 (ja) 2008-10-29 2013-05-07 ヒトil−4受容体に対する高親和性ヒト抗体
JP2015199976A Active JP6449125B2 (ja) 2008-10-29 2015-10-08 ヒトil−4受容体に対する高親和性ヒト抗体
JP2018209345A Active JP6608505B2 (ja) 2008-10-29 2018-11-07 ヒトil−4受容体に対する高親和性ヒト抗体
JP2019191643A Active JP6843208B2 (ja) 2008-10-29 2019-10-21 ヒトil−4受容体に対する高親和性ヒト抗体
JP2021024740A Active JP7100731B2 (ja) 2008-10-29 2021-02-19 ヒトil-4受容体に対する高親和性ヒト抗体
JP2022105797A Active JP7442581B2 (ja) 2008-10-29 2022-06-30 ヒトil-4受容体に対する高親和性ヒト抗体
JP2024022482A Pending JP2024040526A (ja) 2008-10-29 2024-02-19 ヒトil-4受容体に対する高親和性ヒト抗体

Country Status (47)

Country Link
US (7) US7608693B2 (OSRAM)
EP (7) EP4345111A3 (OSRAM)
JP (8) JP5291802B2 (OSRAM)
KR (1) KR101599706B1 (OSRAM)
CN (3) CN103739711B (OSRAM)
AR (1) AR073978A1 (OSRAM)
AU (1) AU2009311496B9 (OSRAM)
BR (1) BRPI0919853B8 (OSRAM)
CA (1) CA2737044C (OSRAM)
CL (1) CL2009002004A1 (OSRAM)
CO (1) CO6362024A2 (OSRAM)
CR (1) CR20110148A (OSRAM)
CY (3) CY1114123T1 (OSRAM)
DK (3) DK3064511T3 (OSRAM)
EC (1) ECSP11011010A (OSRAM)
ES (4) ES2404206T3 (OSRAM)
FI (1) FI3715372T3 (OSRAM)
FR (1) FR18C1011I2 (OSRAM)
HN (1) HN2011001210A (OSRAM)
HR (3) HRP20130467T1 (OSRAM)
HU (3) HUE066473T2 (OSRAM)
IL (1) IL211726A (OSRAM)
JO (1) JO2865B1 (OSRAM)
LT (3) LT3064511T (OSRAM)
LU (1) LUC00059I2 (OSRAM)
MA (1) MA32802B1 (OSRAM)
MX (3) MX388436B (OSRAM)
MY (1) MY152448A (OSRAM)
NI (1) NI201100064A (OSRAM)
NL (1) NL300922I2 (OSRAM)
NO (2) NO2018009I2 (OSRAM)
NZ (2) NZ596093A (OSRAM)
PA (1) PA8847001A1 (OSRAM)
PE (1) PE20100738A1 (OSRAM)
PH (1) PH12014500462A1 (OSRAM)
PL (4) PL3064511T3 (OSRAM)
PT (4) PT3064511T (OSRAM)
RS (3) RS52782B (OSRAM)
RU (2) RU2539774C3 (OSRAM)
SI (3) SI3715372T1 (OSRAM)
SM (2) SMT201800362T1 (OSRAM)
SV (1) SV2011003880A (OSRAM)
TW (3) TWI658833B (OSRAM)
UA (1) UA102122C2 (OSRAM)
UY (1) UY32213A (OSRAM)
WO (1) WO2010053751A1 (OSRAM)
ZA (1) ZA201101867B (OSRAM)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2564432A1 (en) * 2004-04-27 2005-11-10 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Human anti-amyloid .beta. peptide antibody and fragment of said antibody
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
PL2069403T3 (pl) 2006-10-02 2015-08-31 Regeneron Pharma Przeciwciała ludzkie o wysokim powinowactwie wobec receptora ludzkiej IL-4
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
ES2603559T5 (es) 2010-02-08 2021-02-22 Regeneron Pharma Cadena ligera común de ratón
US20120021409A1 (en) * 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
AU2011312191B2 (en) 2010-10-06 2015-07-02 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies
UA111731C2 (uk) * 2010-10-06 2016-06-10 Рідженерон Фармасьютікалз, Інк. Стабілізована композиція, яка містить антитіло до рецептора інтерлейкіну-4 (іl-4r), варіанти
CN110711248A (zh) 2011-01-28 2020-01-21 赛诺菲生物技术公司 包含针对pcsk9的人抗体的药物组合物
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
FI3865581T3 (fi) 2011-08-05 2024-11-02 Regeneron Pharma Humanisoituja universaaleja kevytketjun hiiriä
ES2992345T3 (es) 2011-09-16 2024-12-11 Regeneron Pharma Métodos para reducir los niveles de lipoproteína(a) mediante la administración de un inhibidor de la proproteína convertasa subtilisina kexina-9 (PCSK9)
MX345019B (es) * 2011-12-22 2017-01-11 Astellas Pharma Inc Nuevo anticuerpo ctgf antihumano.
RS57118B1 (sr) 2012-03-16 2018-06-29 Regeneron Pharma Antitela sa lakim lancem konstruisanim sa histidinom i genetički modifikovani glodari za generisanje istih
NZ730271A (en) 2012-03-16 2022-09-30 Regeneron Pharma Non-human animals expressing ph-sensitive immunoglobulin sequences
SG10201912896YA (en) * 2012-08-21 2020-02-27 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
JP6306588B2 (ja) * 2012-08-21 2018-04-04 サノフィ・バイオテクノロジー Il−4rアンタゴニストを投与することにより喘息を処置又は予防するための方法
ES2981062T3 (es) * 2012-09-07 2024-10-07 Regeneron Pharma Métodos para el tratamiento de la dermatitis atópica administrando un antagonista de IL-4R
KR102284244B1 (ko) * 2012-09-07 2021-08-03 리제너론 파아마슈티컬스, 인크. Il-4r 길항제 투여로 아토피성 피부염을 치료하는 방법
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
EP3010539B1 (en) 2013-06-21 2019-07-24 Sanofi Biotechnology Methods for treating nasal polyposis by administering an il-4r antagonist
DK3010539T3 (da) * 2013-06-21 2019-10-21 Sanofi Biotechnology Fremgangsmåder til behandling af nasal polyposis ved administration af en il-4r-antagonist
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
EP3068803B1 (en) 2013-11-12 2021-01-20 Sanofi Biotechnology Dosing regimens for use with pcsk9 inhibitors
DE112014005975T5 (de) * 2013-12-17 2016-09-15 Kymab Limited Menschliche Ziele
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
NZ722120A (en) * 2014-01-16 2022-07-29 Mario Umberto Francesco Mondelli Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen
IL247290B (en) * 2014-02-21 2021-06-30 Sanofi Biotechnology Methods of treating or preventing asthma by adding an il-4r antagonist
IL315136A (en) * 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
EP3110848B1 (en) 2014-02-28 2024-02-14 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an il-4r antagonist
CA3124228C (en) 2014-03-21 2024-05-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
NO2785538T3 (OSRAM) 2014-05-07 2018-08-04
RU2735521C2 (ru) 2014-07-16 2020-11-03 Санофи Байотекнолоджи Способы лечения пациентов с гетерозиготной семейной гиперхолестеринемией (hefh)
JP6861630B2 (ja) * 2014-11-14 2021-04-21 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法
WO2016149678A1 (en) 2015-03-19 2016-09-22 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
CN107683291B (zh) 2015-04-02 2021-11-19 英特维特国际股份有限公司 针对犬白介素-4受体α的抗体
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法(一)
US10772956B2 (en) 2015-08-18 2020-09-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab
US10314904B2 (en) 2016-02-19 2019-06-11 Regeneron Pharmaceuticals, Inc. Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
CN113372446A (zh) * 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
EP3504328A1 (en) 2016-08-24 2019-07-03 Regeneron Pharmaceuticals, Inc. Host cell protein modification
CN118141914A (zh) 2016-09-01 2024-06-07 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
KR20190053250A (ko) 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
KR20190091290A (ko) 2016-11-29 2019-08-05 리제너론 파아마슈티컬스, 인크. Prlr 양성 유방암 치료 방법
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
EP3957752B1 (en) 2017-04-13 2025-08-20 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
AU2018298039B2 (en) 2017-07-06 2023-02-02 Regeneron Pharmaceuticals, Inc. Cell culture process for making a glycoprotein
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
EP4344706A3 (en) 2017-10-30 2024-05-22 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
SG11202004380QA (en) 2017-12-22 2020-06-29 Regeneron Pharma System and method for characterizing drug product impurities
CN111655722A (zh) 2018-01-31 2020-09-11 瑞泽恩制药公司 用于表征药物产品杂质的系统和方法
CN110105451B (zh) * 2018-02-01 2020-12-18 北京凯因科技股份有限公司 IL-4Rα抗体及其用途
WO2019148405A1 (zh) * 2018-02-01 2019-08-08 北京凯因科技股份有限公司 IL-4Rα抗体及其用途
TW202311746A (zh) 2018-02-02 2023-03-16 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
BR112020013426A2 (pt) 2018-02-28 2020-12-01 Regeneron Pharmaceuticals, Inc. métodos para identificação de um vírus em uma amostra e para detecção de ácidos nucleicos virais em uma amostra de cultura de células
EA202092203A1 (ru) 2018-03-19 2020-12-07 Ридженерон Фармасьютикалз, Инк. Способы анализа и реагенты для микрочипового капиллярного электрофореза
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
US12253490B2 (en) 2018-03-19 2025-03-18 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
CN120173101A (zh) 2018-03-22 2025-06-20 表面肿瘤学有限责任公司 抗il-27抗体及其用途
CN108373505B (zh) * 2018-04-20 2019-08-20 北京智仁美博生物科技有限公司 抗il-4r抗体及其用途
TW202016125A (zh) 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
MA52624A (fr) 2018-05-13 2021-03-24 Regeneron Pharma Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
CN113101364B (zh) * 2018-05-29 2023-12-01 康诺亚生物医药科技(成都)有限公司 一种自免疫抑制剂的开发和应用
TWI838388B (zh) 2018-07-10 2024-04-11 美商雷傑納榮製藥公司 修飾結合分子以最小化已存在的交互作用
MY205774A (en) 2018-08-24 2024-11-12 Shanghai hengrui pharmaceutical co ltd Human il-4r binding antibody, antigen binding fragment thereof, and medical use thereof
EA202092684A1 (ru) 2018-08-27 2021-03-11 Ридженерон Фармасьютикалз, Инк. Применение рамановской спектроскопии для последующей очистки
TWI866924B (zh) 2018-08-30 2024-12-21 美商再生元醫藥公司 用於將蛋白質複合物定特徵之方法
CN110872349A (zh) * 2018-09-04 2020-03-10 三生国健药业(上海)股份有限公司 结合人il-4r的抗体、其制备方法和用途
WO2020096381A1 (ko) * 2018-11-09 2020-05-14 아주대학교 산학협력단 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도
US11312778B2 (en) 2018-11-21 2022-04-26 Brian C. Machler Method for treating allergic contact dermatitis
CN110746507B (zh) * 2018-12-25 2020-06-26 江苏荃信生物医药有限公司 抗人白介素4受体α单克隆抗体及其应用
CN117110492A (zh) 2019-01-16 2023-11-24 瑞泽恩制药公司 鉴别蛋白质中的游离巯基的方法
WO2020180727A1 (en) 2019-03-06 2020-09-10 Regeneron Pharmaceuticals, Inc. Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
WO2020191346A1 (en) 2019-03-21 2020-09-24 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
SG11202110911RA (en) 2019-05-13 2021-10-28 Regeneron Pharma Improved competitive ligand binding assays
CN112010977B (zh) * 2019-05-29 2022-04-26 山东博安生物技术股份有限公司 抗白介素4受体(il-4r)的抗体及其应用
CN110343666B (zh) * 2019-07-10 2023-05-30 通化东宝药业股份有限公司 一种cho细胞培养的补料培养基及其制备方法和应用
EP3999114A1 (en) 2019-07-16 2022-05-25 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
SG11202113310UA (en) 2019-08-05 2021-12-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
EP4010001A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
BR112022004885A2 (pt) 2019-09-24 2022-06-07 Regeneron Pharma Sistemas e métodos para uso e regeneração de cromatografia
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN111825766B (zh) 2019-10-31 2021-05-11 上海洛启生物医药技术有限公司 抗il-4r单域抗体及其应用
IL293112A (en) 2019-11-25 2022-07-01 Regeneron Pharma Sustained release formulations using non-aqueous emulsions
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
AU2020399975A1 (en) 2019-12-09 2022-07-28 Sanofi Biotechnology Methods for treating digitally-identified IL-4/IL-13 related disorders
BR112022014212B1 (pt) 2020-01-21 2024-01-23 Regeneron Pharmaceuticals, Inc Métodos de análise de uma amostra incluindo uma proteína de interesse
BR112022016345A2 (pt) 2020-02-21 2022-12-20 Jiangsu Hengrui Pharmaceuticals Co Ltd Composição farmacêutica contendo anticorpo anti-il-4r e uso da mesma
WO2021170020A1 (en) * 2020-02-27 2021-09-02 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Antibodies binding il4r and uses thereof
WO2021195530A1 (en) 2020-03-27 2021-09-30 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
CN113549151A (zh) * 2020-04-24 2021-10-26 苏州康乃德生物医药有限公司 与人IL-4Rα中特定表位结合的抗体及其应用
US20250154267A2 (en) 2020-05-22 2025-05-15 Regeneron Pharmaceuticals, Inc. Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
KR20230058094A (ko) 2020-08-31 2023-05-02 리제너론 파아마슈티컬스, 인크. 세포 배양 성능을 개선하고 아스파라긴 서열 변이체를 완화하기 위한 아스파라긴 공급 전략
US20220169739A1 (en) 2020-10-05 2022-06-02 Sanofi Biotechnology Methods for treating asthma in pediatric subjects by administering an il-4r antagonist
WO2022115588A1 (en) 2020-11-25 2022-06-02 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
US12350374B2 (en) 2020-12-17 2025-07-08 Regeneron Pharmaceuticals, Inc. Fabrication of protein-encapsulating microgels
TW202231663A (zh) * 2020-12-22 2022-08-16 大陸商江蘇恆瑞醫藥股份有限公司 抗il-4r抗體或其抗原結合片段的複合物及醫藥用途
US20220220211A1 (en) 2021-01-08 2022-07-14 Regeneron Pharmaceuticals, Inc. Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist
JP2024503408A (ja) 2021-01-20 2024-01-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 細胞培養におけるタンパク質力価の改善方法
JP2024512299A (ja) 2021-03-03 2024-03-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質の粘度を定量及び変更するためのシステム及び方法
US20220309215A1 (en) 2021-03-26 2022-09-29 Regeneron Pharmaceuticals, Inc. Methods and systems for developing mixing protocols
CA3220848A1 (en) 2021-06-01 2022-12-08 Timothy Riehlman Microchip capillary electrophoresis assays and reagents
KR20240037321A (ko) 2021-07-26 2024-03-21 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 만성 자발성 심마진의 치료 방법
TWI876192B (zh) * 2021-08-05 2025-03-11 美商美國禮來大藥廠 人類介白素-4受體α抗體
WO2023017252A1 (en) 2021-08-10 2023-02-16 Kymab Limited Treatment of atopic dermatitis
CA3227014A1 (en) 2021-08-23 2023-03-02 Ashish Bansal Methods for treating atopic dermatitis by administering an il-4r antagonist
TW202313692A (zh) * 2021-08-26 2023-04-01 大陸商正大天晴藥業集團股份有限公司 抗il4r抗體的藥物組成物及其用途
US20230077710A1 (en) 2021-09-08 2023-03-16 Regeneron Pharmaceuticals, Inc. HIGH-THROUGHPUT AND MASS-SPECTROMETRY-BASED METHOD FOR QUANTITATING ANTIBODIES AND OTHER Fc-CONTAINING PROTEINS
CN118139881A (zh) 2021-09-20 2024-06-04 瑞泽恩制药公司 控制抗体异质性的方法
AU2022356375A1 (en) 2021-09-30 2024-03-14 Regeneron Pharmaceuticals, Inc. Reticulocalbin-3 (rcn3) variants and treatment of asthma with interleukin-4 receptor alpha (il4r) antagonists
IL311248A (en) 2021-10-07 2024-05-01 Regeneron Pharma PH meter calibration and repair
TW202323817A (zh) 2021-10-07 2023-06-16 美商再生元醫藥公司 Ph建模及控制之系統及方法
AU2022369296A1 (en) 2021-10-20 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating prurigo nodularis by administering an il-4r antagonist
TW202330104A (zh) 2021-10-26 2023-08-01 美商再生元醫藥公司 用於產生實驗室用水及分配不同溫度之實驗室用水的系統及方法
MX2024005769A (es) 2021-11-11 2024-05-24 Regeneron Pharma Tratamiento de la enfermedad pulmonar basado en la estratificacion de puntuacion de riesgo poligenico para la interleucina 33 (il-33).
WO2023085978A1 (en) * 2021-11-11 2023-05-19 Joint Stock Company «Biocad» Monoclonal antibody or antigen-binding fragment thereof that specifically binds to il-4ra, and use thereof
CA3238160A1 (en) 2021-11-18 2023-05-25 Aaron Sato Dickkopf-1 variant antibodies and methods of use
WO2023102383A1 (en) 2021-11-30 2023-06-08 Regeneron Pharmaceuticals, Inc. Treatment of lung disease based upon stratification of polygenic score relating to response to a therapeutic agent
WO2023130010A1 (en) 2021-12-30 2023-07-06 Regeneron Pharmaceuticals, Inc. Methods for attenuating atopic march by administering an il-4/il-13 antagonist
CN118678972A (zh) 2022-01-29 2024-09-20 上海盛迪医药有限公司 糖皮质激素的药物偶联物
WO2023167855A1 (en) 2022-03-02 2023-09-07 Regeneron Pharmaceuticals, Inc. Manufacturing process for high titer antibody
EP4493921A1 (en) 2022-03-18 2025-01-22 Regeneron Pharmaceuticals, Inc. Methods and systems for analyzing polypeptide variants
WO2023191665A1 (en) * 2022-03-31 2023-10-05 Milaboratory, Limited Liability Company ANTIBODIES TO HUMAN IL-4Rα HAVING REDUCED IMMUNOGENICITY AND APPLICATION THEREOF
KR20250037491A (ko) 2022-07-08 2025-03-17 리제너론 파아마슈티컬스, 인크. Il-4r 길항제 투여에 의한 소아 호산구성 식도염을 치료하는 방법
CN120091829A (zh) 2022-08-29 2025-06-03 赛诺菲生物技术公司 通过施用il-4r拮抗剂治疗慢性诱导性寒冷性荨麻疹的方法
KR20240038841A (ko) 2022-09-16 2024-03-26 연세대학교 산학협력단 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이의 용도
TW202432598A (zh) 2022-11-01 2024-08-16 美商再生元醫藥公司 藉由投予il-4r拮抗劑治療手足皮膚炎的方法
WO2024112935A1 (en) 2022-11-23 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for improving bone growth by administering an il-4r antagonist
EP4634659A1 (en) 2022-12-16 2025-10-22 Regeneron Pharmaceuticals, Inc. Methods and systems for assessing chromatographic column integrity
WO2024158880A1 (en) 2023-01-25 2024-08-02 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
EP4655595A1 (en) 2023-01-25 2025-12-03 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
WO2024163708A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis
CN120530132A (zh) * 2023-02-17 2025-08-22 顶峰疗法股份有限公司 结合白介素4受体α的抗体和使用方法
US20240280551A1 (en) 2023-02-22 2024-08-22 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
KR20250160361A (ko) 2023-03-22 2025-11-12 사노피 바이오테크놀로지 Il-4r 길항제를 투여하여 만성 폐쇄성 폐 질환(copd)을 치료하는 방법
CN121001741A (zh) 2023-03-27 2025-11-21 瑞泽恩制药公司 用于通过施用il-4r拮抗剂治疗嗜酸粒细胞性胃肠炎的方法
WO2024199665A1 (en) 2023-03-30 2024-10-03 Sandoz Ag Stable composition comprising a high protein concentration
AU2024265540A1 (en) 2023-05-01 2025-10-30 Regeneron Pharmaceuticals, Inc. Multidose antibody drug products using phenol or benzyl alcohol
KR20240170605A (ko) 2023-05-23 2024-12-04 연세대학교 산학협력단 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이를 포함하는 비강 분무 제형
TW202528736A (zh) 2023-09-08 2025-07-16 美商再生元醫藥公司 用於評估層析管柱完整性的方法及系統
WO2025064403A2 (en) 2023-09-18 2025-03-27 Regeneron Pharmaceuticals, Inc. Methods and systems for developing chromatography protocols
TW202532098A (zh) 2023-09-29 2025-08-16 美商再生元醫藥公司 使用控制成核之冷凍乾燥
WO2025075970A1 (en) 2023-10-02 2025-04-10 Regeneron Pharmaceuticals, Inc. Drug delivery device safety system
WO2025085594A1 (en) 2023-10-18 2025-04-24 Regeneron Pharmaceuticals, Inc. Rapid purification of monoclonal antibody from in-process upstream cell culture material
TW202535934A (zh) 2023-11-02 2025-09-16 美商再生元醫藥公司 利用應力來降低脂酶活性的方法
US20250179207A1 (en) 2023-11-30 2025-06-05 Genzyme Corporation Methods for treating digitally-identified cd20-related disorders
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods
CN117924490B (zh) * 2023-12-22 2024-10-22 华润生物医药有限公司 抗il-4r抗体及其用途
WO2025166234A1 (en) * 2024-01-31 2025-08-07 Apogee Therapeutics, Inc. Methods of administering antibodies that bind interleukin 4 receptor alpha
WO2025166281A1 (en) 2024-02-01 2025-08-07 Regeneron Pharmaceuticals, Inc. Platform for charge-detection mass spectrometry analysis of aavs
WO2025175164A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods
WO2025194043A1 (en) 2024-03-15 2025-09-18 Regeneron Pharmaceuticals, Inc. Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations
EP4623903A1 (en) 2024-03-28 2025-10-01 Fresenius Kabi Deutschland GmbH Pharmaceutical composition comprising dupilumab
WO2025221640A1 (en) 2024-04-15 2025-10-23 Sanofi Biotechnology Methods for treating chronic rhinosinusitis without nasal polyps by administering an il-4r antagonist
WO2025259840A1 (en) 2024-06-13 2025-12-18 Regeneron Pharmaceuticals, Inc. Methods and systems for scaled chromatography

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
GB8808015D0 (en) 1988-04-06 1988-05-05 Ritter M A Chemical compounds
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
AU643427B2 (en) 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
BR9205967A (pt) * 1991-05-03 1994-07-26 Seragen Inc Moléculas marcadas com receptor de interleucina tratamento de artrite inflamatória
US5863537A (en) * 1992-02-19 1999-01-26 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
JP3315427B2 (ja) 1992-03-05 2002-08-19 大日本除蟲菊株式会社 皮膚炎治療剤
SG48760A1 (en) 1992-07-24 2003-03-18 Abgenix Inc Generation of xenogenetic antibodies
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (en) 1992-12-29 1994-07-06 Schering-Plough Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
RU2162711C2 (ru) * 1993-09-07 2001-02-10 Смитклайн Бичам Корпорейшн Рекомбинантные il4-антитела, используемые для лечения нарушений, связанных с действием il4
US6387632B2 (en) * 1998-06-11 2002-05-14 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
AU766492B2 (en) 1998-09-18 2003-10-16 Dynavax Technologies Corporation Methods of treating IgE-associated disorders and compositions for use therein
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
MXPA02011682A (es) 2000-05-26 2003-05-14 Immunex Corp Uso de antagonistas de interleuquina-4 y composiciones de los mismos.
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
CN100496579C (zh) 2000-07-26 2009-06-10 株式会社凤凰堂 止痒性组合物和促进创伤治愈的组合物
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PL366226A1 (en) 2000-12-22 2005-01-24 Societe Des Produits Nestle S.A. Induction of tolerance
US20030103938A1 (en) 2001-05-09 2003-06-05 Alk-Abello A/S Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
JP2004529180A (ja) 2001-05-11 2004-09-24 ノバルティス アクチエンゲゼルシャフト IgE関連障害を処置するのに使用するための組成物
ATE440617T1 (de) 2001-05-23 2009-09-15 Duotol Ab Unterdrückung von allergischen reaktionen durch transkutane verabreichung von allergenen zusammen mit oder fusioniert mit toxinuntereinheiten oder deren fragmenten
CA2468733C (en) 2001-11-30 2013-06-11 Biogen Idec Ma Inc. Antibodies against monocyte chemotactic proteins
SI1527100T1 (sl) 2002-03-29 2009-12-31 Schering Corp Humana monoklonska protitelesa proti interlevkinu-5 in postopki in sestavki, ki jih obsegajo
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
EP1592777A4 (en) 2003-02-01 2008-06-04 Tanox Inc METHOD OF GENERATING HIGH-ANTIBODY ANTIBODIES
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
WO2005047331A2 (en) 2003-11-07 2005-05-26 Immunex Corporation Antibodies that bind interleukin-4 receptor
AU2004309373A1 (en) 2003-12-22 2005-07-14 Amgen Inc. Methods for identifying functional antibodies
ATE395358T1 (de) 2004-02-27 2008-05-15 Regeneron Pharma Il-4/il-13-spezifische polypetide und deren therapeutische verwendung
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
JP5234445B2 (ja) 2004-10-05 2013-07-10 源一郎 杣 薬剤
US8030003B2 (en) 2004-12-07 2011-10-04 Children's Hospital Medical Center Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
BRPI0710572A2 (pt) 2006-01-24 2013-01-08 Domantis Ltd ligante, uso do ligante, mÉtodos para o tratamento de uma doenÇa alÉrgica, de asma e de cÂncer, para a inibiÇço de uma resposta imune do tipo th2, e administraÇço de tratamento anti-il-4 e tratamento anti-il-13, composiÇço farmacÊutica, dispositivo de dispensaÇço de droga, Ácido nucleico isolado ou recombinante, vetor, cÉlula hospedeira, mÉtodos para a produÇço de um ligante e de inibiÇço da proliferaÇço de cÉlulas
PL2374818T3 (pl) 2006-06-02 2013-05-31 Regeneron Pharma Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6
JP4221018B2 (ja) 2006-08-31 2009-02-12 トヨタ自動車株式会社 頭部保護エアバッグ装置
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
PL2069403T3 (pl) 2006-10-02 2015-08-31 Regeneron Pharma Przeciwciała ludzkie o wysokim powinowactwie wobec receptora ludzkiej IL-4
RS53402B (sr) 2007-03-22 2014-10-31 Genentech, Inc. Vezivanje apoptotskih anti-ige antitela za membranski ige
EP2022507A1 (en) 2007-08-07 2009-02-11 Universität Hamburg Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy
WO2009061819A1 (en) 2007-11-05 2009-05-14 The Regents Of The University Of Colorado Minimally-invasive measurement of esophageal inflammation
EP2245064B1 (en) 2007-12-21 2014-07-23 Medimmune Limited BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha)
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
US20090264392A1 (en) 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US20120004205A1 (en) 2008-12-01 2012-01-05 Cincinnati Children's Hospital Medical Center Il-13 induced gene signature for eosinophilic esophagitis
WO2010120524A2 (en) 2009-03-31 2010-10-21 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
US8497528B2 (en) 2010-05-06 2013-07-30 Taiwan Semiconductor Manufacturing Company, Ltd. Method for fabricating a strained structure
CA2773234C (en) 2009-09-07 2017-11-28 Dbv Technologies Method of treating eosinophilic esophagitis
US8993347B2 (en) 2009-12-17 2015-03-31 Cornell University Methods for detecting antibodies in mucosal samples and device for sampling mucosal material
ES2894936T3 (es) 2010-06-24 2022-02-16 Viropharma Biologics Llc Métodos de tratamiento para la inflamación del esófago
AU2011312191B2 (en) * 2010-10-06 2015-07-02 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies
RU2453303C1 (ru) 2010-12-23 2012-06-20 Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") Фармацевтическая композиция для лечения атопического дерматита
US20130324435A1 (en) 2011-01-06 2013-12-05 Children's Hospital Medical Center Esophageal cytokine expression profiles in eosinophilic esophagitis
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
US9928344B2 (en) 2011-06-21 2018-03-27 Children's Hospital Medical Center Diagnostic methods of eosinophilic esophagitis
WO2013051928A1 (en) 2011-10-06 2013-04-11 N.V. Nutricia Treatment of eosinophilic esophagitis
SG11201402796SA (en) 2011-12-16 2014-06-27 Atopix Therapeutics Ltd Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
TW201334789A (zh) 2012-01-31 2013-09-01 Genentech Inc 抗ige抗體及其使用方法
WO2013155010A1 (en) 2012-04-09 2013-10-17 Children's Hospital Medical Center Non-invasive biomarkers for eosinophilic esophagitis
JP6306588B2 (ja) 2012-08-21 2018-04-04 サノフィ・バイオテクノロジー Il−4rアンタゴニストを投与することにより喘息を処置又は予防するための方法
ES2981062T3 (es) 2012-09-07 2024-10-07 Regeneron Pharma Métodos para el tratamiento de la dermatitis atópica administrando un antagonista de IL-4R
US10132809B2 (en) 2012-10-10 2018-11-20 Rhote Island Hospital Differential expression of protein markers for the diagnosis and treatment of eosinophilic esophagitis
US10077315B2 (en) 2013-02-05 2018-09-18 Engmab Sàrl Bispecific antibodies against CD3 and BCMA
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
EP3010539B1 (en) * 2013-06-21 2019-07-24 Sanofi Biotechnology Methods for treating nasal polyposis by administering an il-4r antagonist
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
RU2552929C1 (ru) 2013-11-14 2015-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
EP3110848B1 (en) 2014-02-28 2024-02-14 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an il-4r antagonist
JP6861630B2 (ja) * 2014-11-14 2021-04-21 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法
US10314904B2 (en) 2016-02-19 2019-06-11 Regeneron Pharmaceuticals, Inc. Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
CN118141914A (zh) 2016-09-01 2024-06-07 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
KR20190053250A (ko) 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
MX2019009552A (es) 2017-02-17 2019-10-02 Hutchinson Fred Cancer Res Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios.
EP3615068A1 (en) 2017-04-28 2020-03-04 Novartis AG Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
EP4344706A3 (en) 2017-10-30 2024-05-22 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
MA52624A (fr) 2018-05-13 2021-03-24 Regeneron Pharma Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
WO2020191346A1 (en) 2019-03-21 2020-09-24 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
EP4010001A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
SG11202113310UA (en) 2019-08-05 2021-12-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
AU2020399975A1 (en) 2019-12-09 2022-07-28 Sanofi Biotechnology Methods for treating digitally-identified IL-4/IL-13 related disorders
WO2021195530A1 (en) 2020-03-27 2021-09-30 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
US20250154267A2 (en) 2020-05-22 2025-05-15 Regeneron Pharmaceuticals, Inc. Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
US20220220211A1 (en) 2021-01-08 2022-07-14 Regeneron Pharmaceuticals, Inc. Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist

Similar Documents

Publication Publication Date Title
JP2012507294A5 (OSRAM)
HRP20190643T1 (hr) Protutijela protiv dkk-1
JP2013539361A5 (OSRAM)
HRP20192295T1 (hr) Optimizirana monoklonska protutijela protiv inhibitora faktora tkivnog puta (tfpi)
JP2012511913A5 (OSRAM)
PH12014500089A1 (en) Antibodies that bind to ox40 and their uses
EA201200277A1 (ru) Антитела против респираторного синцитиального вируса (pcb) и способы их применения
JP2017176174A5 (OSRAM)
JP2010515717A5 (OSRAM)
EA201291243A1 (ru) Антитела против респираторно-синцитиального вируса (рсв) и способы их применения
NZ709390A (en) Folate receptor 1 antibodies and immunoconjugates and uses thereof
LTPA2018010I1 (lt) Žmogaus anti-IL-23 antikūnai, kompozicijos, metodai ir panaudojimai
RU2018137842A (ru) Агонисты рецепторов глюкагона/glp-1 для лечения ожирения
RU2539774C3 (ru) Человеческие антитела с высокой аффинностью к рецепторам il-4 человека
EP3210625A3 (en) Therapeutic peptides comprising antibodies binding to mhc class 1 polypeptide related sequence a (mica)
HUE037205T2 (hu) Antitestek, amelyek IL-4-et és/vagy IL-13-at kötnek és alkalmazásaik
CY2017039I2 (el) Αντισωματα υψηλης συγγενειας στον υποδοχεα της ανθρωπινης ιl-6
JP2011219478A5 (OSRAM)
JP2019524645A5 (OSRAM)
JP2011182796A5 (OSRAM)
BRPI0815368A2 (pt) "proteinas c-fms humanas a antigeno"
HUE060029T2 (hu) Emberi antitestek, amelyek kötnek limfocita aktivációs gént-3 (LAG-3) és azok felhasználásai
ZA201208539B (en) Monoclonal antibodies against the rgm a protein and uses thereof
JP2018033454A5 (OSRAM)
JP2014518898A5 (OSRAM)