JP2012505896A5 - - Google Patents
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- Publication number
- JP2012505896A5 JP2012505896A5 JP2011532190A JP2011532190A JP2012505896A5 JP 2012505896 A5 JP2012505896 A5 JP 2012505896A5 JP 2011532190 A JP2011532190 A JP 2011532190A JP 2011532190 A JP2011532190 A JP 2011532190A JP 2012505896 A5 JP2012505896 A5 JP 2012505896A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- compound according
- compound
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 168
- 125000000217 alkyl group Chemical group 0.000 claims 130
- 125000003342 alkenyl group Chemical group 0.000 claims 85
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 58
- 125000000623 heterocyclic group Chemical group 0.000 claims 33
- 125000005842 heteroatom Chemical group 0.000 claims 19
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 18
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 12
- 208000017169 kidney disease Diseases 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 201000001320 Atherosclerosis Diseases 0.000 claims 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims 6
- 206010048768 Dermatosis Diseases 0.000 claims 6
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 6
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 6
- 208000032928 Dyslipidaemia Diseases 0.000 claims 6
- 208000002705 Glucose Intolerance Diseases 0.000 claims 6
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 6
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 6
- 206010020772 Hypertension Diseases 0.000 claims 6
- 208000013016 Hypoglycemia Diseases 0.000 claims 6
- 206010022489 Insulin Resistance Diseases 0.000 claims 6
- 206010023379 Ketoacidosis Diseases 0.000 claims 6
- 208000007976 Ketosis Diseases 0.000 claims 6
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 6
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 6
- 206010030113 Oedema Diseases 0.000 claims 6
- 201000001880 Sexual dysfunction Diseases 0.000 claims 6
- 208000007536 Thrombosis Diseases 0.000 claims 6
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 208000033679 diabetic kidney disease Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 201000006549 dyspepsia Diseases 0.000 claims 6
- 201000001421 hyperglycemia Diseases 0.000 claims 6
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 6
- 201000008980 hyperinsulinism Diseases 0.000 claims 6
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 6
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 6
- 230000002218 hypoglycaemic effect Effects 0.000 claims 6
- 235000020824 obesity Nutrition 0.000 claims 6
- 201000009104 prediabetes syndrome Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 231100000872 sexual dysfunction Toxicity 0.000 claims 6
- 208000017520 skin disease Diseases 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- -1 wherein Chemical group 0.000 claims 6
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims 3
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 2
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 2
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 2
- 229940123464 Thiazolidinedione Drugs 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000455 heteroaryl-fused-cycloalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
- 229960003105 metformin Drugs 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 241000257303 Hymenoptera Species 0.000 claims 1
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 1
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 claims 1
- 125000001374 aryl-fused-cycloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 0 CC1C(C)(C)*CC1 Chemical compound CC1C(C)(C)*CC1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19627108P | 2008-10-15 | 2008-10-15 | |
| US61/196,271 | 2008-10-15 | ||
| PCT/US2009/060549 WO2010045258A2 (en) | 2008-10-15 | 2009-10-13 | Spirocyclic gpr40 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505896A JP2012505896A (ja) | 2012-03-08 |
| JP2012505896A5 true JP2012505896A5 (enExample) | 2012-11-22 |
| JP5551707B2 JP5551707B2 (ja) | 2014-07-16 |
Family
ID=41835743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532190A Expired - Fee Related JP5551707B2 (ja) | 2008-10-15 | 2009-10-13 | スピロ環ｇｐｒ４０調節因子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8748462B2 (enExample) |
| EP (1) | EP2358656B1 (enExample) |
| JP (1) | JP5551707B2 (enExample) |
| AU (1) | AU2009303475B2 (enExample) |
| CA (1) | CA2739888C (enExample) |
| ES (1) | ES2450567T3 (enExample) |
| MX (1) | MX2011003917A (enExample) |
| WO (1) | WO2010045258A2 (enExample) |
Families Citing this family (43)
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| EP2716636A4 (en) | 2011-04-28 | 2014-11-26 | Mochida Pharm Co Ltd | CYCLIC AMIDE DERIVATIVE |
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| EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| CN105001212B (zh) * | 2014-04-16 | 2018-01-16 | 江苏柯菲平医药股份有限公司 | 稠环化合物及其制备方法和应用 |
| WO2015176267A1 (en) | 2014-05-22 | 2015-11-26 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| EP3177287B1 (en) | 2014-08-08 | 2022-02-23 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| EP3177282B1 (en) | 2014-08-08 | 2021-10-06 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2016022446A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [5,6]-fused bicyclic antidiabetic compounds |
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| US10676458B2 (en) | 2016-03-29 | 2020-06-09 | Merch Sharp & Dohne Corp. Rahway | Antidiabetic bicyclic compounds |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| CN110177773B (zh) | 2017-01-26 | 2023-08-25 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途 |
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| JP7049349B2 (ja) | 2017-01-26 | 2022-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルアミノピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
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| JP7049353B2 (ja) | 2017-02-08 | 2022-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病の治療のためのインダニルアミノアザジヒドロベンゾフラニル酢酸、医薬組成物 |
| AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
| EP3709995A4 (en) | 2017-11-16 | 2021-04-14 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
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| CN112010881B (zh) * | 2019-05-30 | 2021-09-03 | 中国科学院兰州化学物理研究所 | 一种烯基硼化合物及其制备方法与应用 |
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| DE102006021878A1 (de) | 2006-05-11 | 2007-11-15 | Sanofi-Aventis | Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5271895B2 (ja) * | 2006-05-15 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | 抗糖尿病性の二環式化合物 |
| RU2444521C2 (ru) | 2006-06-27 | 2012-03-10 | Такеда Фармасьютикал Компани Лимитед | Конденсированные циклические соединения |
| WO2008030618A1 (en) * | 2006-09-07 | 2008-03-13 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| EP2064193A1 (en) * | 2006-09-07 | 2009-06-03 | Amgen, Inc | Heterocyclic gpr40 modulators |
| JP2010508268A (ja) | 2006-10-31 | 2010-03-18 | メルク エンド カムパニー インコーポレーテッド | 抗糖尿病二環式化合物 |
| WO2008130514A1 (en) | 2007-04-16 | 2008-10-30 | Amgen Inc. | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| KR20100090249A (ko) * | 2007-10-10 | 2010-08-13 | 암젠 인크 | 치환된 비페닐 ｇｒｐ４０ 조절제 |
-
2009
- 2009-10-13 CA CA2739888A patent/CA2739888C/en not_active Expired - Fee Related
- 2009-10-13 EP EP09741123.5A patent/EP2358656B1/en active Active
- 2009-10-13 US US13/119,951 patent/US8748462B2/en active Active
- 2009-10-13 ES ES09741123.5T patent/ES2450567T3/es active Active
- 2009-10-13 MX MX2011003917A patent/MX2011003917A/es active IP Right Grant
- 2009-10-13 AU AU2009303475A patent/AU2009303475B2/en not_active Ceased
- 2009-10-13 WO PCT/US2009/060549 patent/WO2010045258A2/en not_active Ceased
- 2009-10-13 JP JP2011532190A patent/JP5551707B2/ja not_active Expired - Fee Related
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