JP2012504141A5 - - Google Patents
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- Publication number
- JP2012504141A5 JP2012504141A5 JP2011529334A JP2011529334A JP2012504141A5 JP 2012504141 A5 JP2012504141 A5 JP 2012504141A5 JP 2011529334 A JP2011529334 A JP 2011529334A JP 2011529334 A JP2011529334 A JP 2011529334A JP 2012504141 A5 JP2012504141 A5 JP 2012504141A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- pyridin
- amino
- methyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000001204 N-oxides Chemical class 0.000 claims 13
- 229910052801 chlorine Inorganic materials 0.000 claims 12
- 229910052731 fluorine Inorganic materials 0.000 claims 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 10
- -1 benzyl compound Chemical class 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- DTAGOGAWTAPDIK-UHFFFAOYSA-N 2-[2-chloro-5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=C(Cl)C(CC(O)=O)=C1 DTAGOGAWTAPDIK-UHFFFAOYSA-N 0.000 claims 1
- YYXOJBMROVGLIH-UHFFFAOYSA-N 2-[5-[2-[[(2,4-dimethoxypyrimidine-5-carbonyl)-ethylamino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1N=C(OC)N=C(OC)C=1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 YYXOJBMROVGLIH-UHFFFAOYSA-N 0.000 claims 1
- WWOSOKWYMIHJBL-UHFFFAOYSA-N 2-[5-[2-[[(2-ethoxyacetyl)-ethylamino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound CCOCC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 WWOSOKWYMIHJBL-UHFFFAOYSA-N 0.000 claims 1
- YBRYCJIMXNMPHB-UHFFFAOYSA-N 2-[5-[2-[[[2-(6-chloropyridin-3-yl)acetyl]-ethylamino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=C(Cl)N=CC=1CC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 YBRYCJIMXNMPHB-UHFFFAOYSA-N 0.000 claims 1
- OOXVPQKSHQMNQM-UHFFFAOYSA-N 2-[5-[2-[[acetyl(benzyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-chloropyridin-3-yl]acetic acid Chemical compound C=1C(C(F)(F)F)=CC=C(C=2C(=NC=C(CC(O)=O)C=2)Cl)C=1CN(C(=O)C)CC1=CC=CC=C1 OOXVPQKSHQMNQM-UHFFFAOYSA-N 0.000 claims 1
- KWMMGLFULJDUCF-UHFFFAOYSA-N 2-[5-[2-[[acetyl(benzyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound COC1=NC=C(CC(O)=O)C=C1C1=CC=C(C(F)(F)F)C=C1CN(C(C)=O)CC1=CC=CC=C1 KWMMGLFULJDUCF-UHFFFAOYSA-N 0.000 claims 1
- LVLNGJFEMTWLJP-UHFFFAOYSA-N 2-[5-[2-[[acetyl(benzyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-oxo-1h-pyridin-3-yl]acetic acid Chemical compound C=1C(C(F)(F)F)=CC=C(C=2C(=NC=C(CC(O)=O)C=2)O)C=1CN(C(=O)C)CC1=CC=CC=C1 LVLNGJFEMTWLJP-UHFFFAOYSA-N 0.000 claims 1
- WBPHTXWTRIVNIJ-UHFFFAOYSA-N 2-[5-[2-[[acetyl(benzyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C(C(F)(F)F)=CC=C(C=2C=C(CC(O)=O)C=NC=2)C=1CN(C(=O)C)CC1=CC=CC=C1 WBPHTXWTRIVNIJ-UHFFFAOYSA-N 0.000 claims 1
- GIRFXFYSJNPGQO-UHFFFAOYSA-N 2-[5-[2-[[acetyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound CCN(C(C)=O)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1OC GIRFXFYSJNPGQO-UHFFFAOYSA-N 0.000 claims 1
- DAMQAXPJQBPLSA-UHFFFAOYSA-N 2-[5-[2-[[benzyl(cyclopropanecarbonyl)amino]methyl]-4-(2h-tetrazol-5-yl)phenyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CN=CC(C=2C(=CC(=CC=2)C2=NNN=N2)CN(CC=2C=CC=CC=2)C(=O)C2CC2)=C1 DAMQAXPJQBPLSA-UHFFFAOYSA-N 0.000 claims 1
- CEGLMWHDFHIXTR-UHFFFAOYSA-N 2-[5-[2-[[benzyl(cyclopropanecarbonyl)amino]methyl]-4-(methylcarbamoyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C(C(=O)NC)=CC=C(C=2C=C(CC(O)=O)C=NC=2)C=1CN(C(=O)C1CC1)CC1=CC=CC=C1 CEGLMWHDFHIXTR-UHFFFAOYSA-N 0.000 claims 1
- XZBUOLJEKMMBKM-UHFFFAOYSA-N 2-[5-[2-[[benzyl(cyclopropanecarbonyl)amino]methyl]-4-(tert-butylcarbamoyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C(C(=O)NC(C)(C)C)=CC=C(C=2C=C(CC(O)=O)C=NC=2)C=1CN(C(=O)C1CC1)CC1=CC=CC=C1 XZBUOLJEKMMBKM-UHFFFAOYSA-N 0.000 claims 1
- DLTQWNMPEBMPDU-UHFFFAOYSA-N 2-[5-[2-[[benzyl(cyclopropanecarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CN=CC(C=2C(=CC(=CC=2)C(F)(F)F)CN(CC=2C=CC=CC=2)C(=O)C2CC2)=C1 DLTQWNMPEBMPDU-UHFFFAOYSA-N 0.000 claims 1
- GHHCYMXSQWLUPR-UHFFFAOYSA-N 2-[5-[2-[[benzyl(cyclopropanecarbonyl)amino]methyl]-4-cyanophenyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CN=CC(C=2C(=CC(=CC=2)C#N)CN(CC=2C=CC=CC=2)C(=O)C2CC2)=C1 GHHCYMXSQWLUPR-UHFFFAOYSA-N 0.000 claims 1
- MQWROAXQEOBPOI-UHFFFAOYSA-N 2-[5-[2-[[benzylcarbamoyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound C=1C=CC=CC=1CNC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1OC MQWROAXQEOBPOI-UHFFFAOYSA-N 0.000 claims 1
- CQMUIBWLYBWMDY-UHFFFAOYSA-N 2-[5-[2-[[benzylcarbamoyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=CC=CC=1CNC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 CQMUIBWLYBWMDY-UHFFFAOYSA-N 0.000 claims 1
- ICYCXPQSYZGVFO-UHFFFAOYSA-N 2-[5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1OC ICYCXPQSYZGVFO-UHFFFAOYSA-N 0.000 claims 1
- URYKBIDRAIUZKO-UHFFFAOYSA-N 2-[5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-oxo-1h-pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1O URYKBIDRAIUZKO-UHFFFAOYSA-N 0.000 claims 1
- YIIDSHPRTCOKPR-UHFFFAOYSA-N 2-[5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 YIIDSHPRTCOKPR-UHFFFAOYSA-N 0.000 claims 1
- PCZNTTTWRKPDEL-UHFFFAOYSA-N 2-[5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-fluorophenyl]pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(F)=CC=C1C1=CN=CC(CC(O)=O)=C1 PCZNTTTWRKPDEL-UHFFFAOYSA-N 0.000 claims 1
- OVBZQKVNTWESEM-UHFFFAOYSA-N 2-[5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-methylsulfanylphenyl]pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(SC)=CC=C1C1=CN=CC(CC(O)=O)=C1 OVBZQKVNTWESEM-UHFFFAOYSA-N 0.000 claims 1
- SXHFECPVYZWLGK-UHFFFAOYSA-N 2-[5-[2-[[ethyl(3-phenylpropanoyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=CC=CC=1CCC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 SXHFECPVYZWLGK-UHFFFAOYSA-N 0.000 claims 1
- CWYAHUVPFPMFRG-UHFFFAOYSA-N 2-[5-[2-[[ethyl(3-pyridin-3-ylpropanoyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=CN=CC=1CCC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 CWYAHUVPFPMFRG-UHFFFAOYSA-N 0.000 claims 1
- OJYNHCQLROWNDT-UHFFFAOYSA-N 2-[5-[2-[[ethyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound C=1C=CC=CC=1COC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1OC OJYNHCQLROWNDT-UHFFFAOYSA-N 0.000 claims 1
- PIAPZCGCWAHOKS-UHFFFAOYSA-N 2-[5-[2-[[ethyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=CC=CC=1COC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 PIAPZCGCWAHOKS-UHFFFAOYSA-N 0.000 claims 1
- BPAWMONIWAETOE-UHFFFAOYSA-N 2-[5-[2-[[ethyl(pyrazine-2-carbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1N=CC=NC=1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 BPAWMONIWAETOE-UHFFFAOYSA-N 0.000 claims 1
- NYOJPBYEMKOZHH-UHFFFAOYSA-N 2-[5-[2-[[ethyl-(2-methoxyacetyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid Chemical compound COCC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1OC NYOJPBYEMKOZHH-UHFFFAOYSA-N 0.000 claims 1
- WDYMDFMTCRJNFK-UHFFFAOYSA-N 2-[5-[2-[[ethyl-(2-methoxyacetyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound COCC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 WDYMDFMTCRJNFK-UHFFFAOYSA-N 0.000 claims 1
- LJQFHYPHVXLDMB-UHFFFAOYSA-N 2-[5-[2-[[ethyl-[2-(6-methylpyridin-3-yl)acetyl]amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C=1C=C(C)N=CC=1CC(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CN=CC(CC(O)=O)=C1 LJQFHYPHVXLDMB-UHFFFAOYSA-N 0.000 claims 1
- VCVIEIWNCYTGBE-UHFFFAOYSA-N 2-[5-[4-(benzylcarbamoyl)-2-[[benzyl(cyclopropanecarbonyl)amino]methyl]phenyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CN=CC(C=2C(=CC(=CC=2)C(=O)NCC=2C=CC=CC=2)CN(CC=2C=CC=CC=2)C(=O)C2CC2)=C1 VCVIEIWNCYTGBE-UHFFFAOYSA-N 0.000 claims 1
- YFCIMWZNCHDMSH-UHFFFAOYSA-N 2-[6-chloro-5-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]pyridin-3-yl]acetic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(F)(F)F)=CC=C1C1=CC(CC(O)=O)=CN=C1Cl YFCIMWZNCHDMSH-UHFFFAOYSA-N 0.000 claims 1
- PTEWVYARVIUQIG-UHFFFAOYSA-N 4-[5-(carboxymethyl)pyridin-3-yl]-3-[[cyclopropanecarbonyl(ethyl)amino]methyl]benzoic acid Chemical compound C1CC1C(=O)N(CC)CC1=CC(C(O)=O)=CC=C1C1=CN=CC(CC(O)=O)=C1 PTEWVYARVIUQIG-UHFFFAOYSA-N 0.000 claims 1
- LMHRXIYWPNPJES-UHFFFAOYSA-N 4-[5-(carboxymethyl)pyridin-3-yl]-3-[[ethyl(phenylmethoxycarbonyl)amino]methyl]benzoic acid Chemical compound C=1C=CC=CC=1COC(=O)N(CC)CC1=CC(C(O)=O)=CC=C1C1=CN=CC(CC(O)=O)=C1 LMHRXIYWPNPJES-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003221 ear drop Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000005414 inactive ingredient Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10107408P | 2008-09-29 | 2008-09-29 | |
| US61/101,074 | 2008-09-29 | ||
| PCT/US2009/058655 WO2010037054A2 (en) | 2008-09-29 | 2009-09-28 | Heteroaryl antagonists of prostaglandin d2 receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504141A JP2012504141A (ja) | 2012-02-16 |
| JP2012504141A5 true JP2012504141A5 (OSRAM) | 2012-10-18 |
Family
ID=41327552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529334A Ceased JP2012504141A (ja) | 2008-09-29 | 2009-09-28 | プロスタグランジンｄ２受容体の三環式アンタゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8049015B2 (OSRAM) |
| EP (1) | EP2328869A4 (OSRAM) |
| JP (1) | JP2012504141A (OSRAM) |
| CN (1) | CN102164894A (OSRAM) |
| AR (1) | AR073319A1 (OSRAM) |
| CA (1) | CA2737739C (OSRAM) |
| GB (1) | GB2463788B (OSRAM) |
| PE (1) | PE20100317A1 (OSRAM) |
| TW (1) | TW201018465A (OSRAM) |
| UY (1) | UY32152A (OSRAM) |
| WO (2) | WO2010037059A2 (OSRAM) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2245002A4 (en) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| US8168678B2 (en) | 2008-02-01 | 2012-05-01 | Panmira Pharmaceuticals, Inc. | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors |
| EP2257536A4 (en) * | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| WO2009108720A2 (en) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| EP2268611A2 (en) * | 2008-04-02 | 2011-01-05 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| US8710163B2 (en) | 2008-07-25 | 2014-04-29 | Exxonmobil Chemical Patents Inc. | Pyridyldiamido transition metal complexes, production and use thereof |
| US8674040B2 (en) | 2008-07-25 | 2014-03-18 | Exxonmobil Chemical Patents Inc. | Pyridyldiamido transition metal complexes, production and use thereof |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| US20100173313A1 (en) * | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| EP2480225A4 (en) * | 2009-07-31 | 2013-05-01 | Panmira Pharmaceuticals Llc | DERMAL FORMULATIONS FROM DP2 RECEPTOR ANTAGONISTS |
| CA2768492A1 (en) | 2009-07-31 | 2011-02-03 | Panmira Pharmaceuticals, Llc | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| CN102596902A (zh) | 2009-08-05 | 2012-07-18 | 潘米拉制药公司 | Dp2拮抗剂及其用途 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
| US8835563B2 (en) | 2011-03-25 | 2014-09-16 | Exxonmobil Chemical Patents Inc. | Block copolymers from silylated vinyl terminated macromers |
| US8318998B2 (en) | 2011-03-25 | 2012-11-27 | Exxonmobil Chemical Patents Inc. | Enhanced catalyst performance for production of vinyl terminated propylene and ethylene/propylene macromers |
| US8399724B2 (en) | 2011-03-25 | 2013-03-19 | Exxonmobil Chemical Patents Inc. | Vinyl terminated higher olefin copolymers and methods to produce thereof |
| US8841397B2 (en) | 2011-03-25 | 2014-09-23 | Exxonmobil Chemical Patents Inc. | Vinyl terminated higher olefin polymers and methods to produce thereof |
| US8940839B2 (en) | 2011-03-25 | 2015-01-27 | Exxonmobil Chemical Patents Inc. | Diblock copolymers prepared by cross metathesis |
| US8623974B2 (en) | 2011-03-25 | 2014-01-07 | Exxonmobil Chemical Patents Inc. | Branched vinyl terminated polymers and methods for production thereof |
| US9371294B2 (en) | 2011-04-12 | 2016-06-21 | Chong Kun Dang Pharmaceutical Corp. | Cycloalkenyl aryl derivatives for CETP inhibitor |
| EP3382391A1 (en) | 2012-10-24 | 2018-10-03 | NYU Winthrop Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
| US9102773B2 (en) | 2013-02-06 | 2015-08-11 | Exxonmobil Chemical Patents Inc. | Process for controlling molecular weight of polyolefins prepared using pyridyl diamide catalyst systems |
| US9260552B2 (en) | 2013-11-15 | 2016-02-16 | Exxonmobil Chemical Patents Inc. | Process to produce polymers from pyridyldiamido transition metal complexes and use thereof |
| US9315593B2 (en) | 2013-11-15 | 2016-04-19 | Exxonmobil Chemical Patents Inc. | Catalyst systems comprising pyridyldiamido transition metal complexes and chain transfer agent and use thereof |
| US9290519B2 (en) | 2013-11-15 | 2016-03-22 | Exxonmobil Chemical Patents Inc. | Pyridyldiamido transition metal complexes, production and use thereof |
| WO2015073157A1 (en) | 2013-11-15 | 2015-05-21 | Exxonmobil Chemical Patents Inc. | Process to produce polymers from pyridyldiamido transition metal complexes and use thereof |
| US9315526B2 (en) | 2014-03-03 | 2016-04-19 | Exxonmobil Chemical Patents Inc. | Pyridyldiamido transition metal complexes, production and use thereof |
| US9598444B2 (en) | 2015-06-30 | 2017-03-21 | Exxonmobil Chemical Patents Inc. | Transition metal complexes of tridentate dianionic CNN ligands, production and use thereof |
| WO2017003565A1 (en) | 2015-06-30 | 2017-01-05 | Exxonmobil Chemical Patents Inc. | Transition metal complexes of tridentate dianionic cnn ligands, production and use thereof |
| US20170057943A1 (en) * | 2015-08-17 | 2017-03-02 | Japan Tobacco Inc. | Hydroxytriazine compounds and pharmaceutical use thereof |
| US10618988B2 (en) | 2015-08-31 | 2020-04-14 | Exxonmobil Chemical Patents Inc. | Branched propylene polymers produced via use of vinyl transfer agents and processes for production thereof |
| WO2017039994A1 (en) | 2015-08-31 | 2017-03-09 | Exxonmobil Chemical Patents Inc. | Aluminum alkyls with pendant olefins on clays |
| EP3344665A4 (en) | 2015-08-31 | 2019-08-14 | ExxonMobil Chemical Patents Inc. | ALUMINUM ALKYLE WITH HANGING OLEFINS FOR POLYOLEFINREACTIONS |
| JP2018525507A (ja) | 2015-08-31 | 2018-09-06 | エクソンモービル・ケミカル・パテンツ・インク | ビニル連鎖移動剤の使用によって製造されたポリマー |
| US9982067B2 (en) | 2015-09-24 | 2018-05-29 | Exxonmobil Chemical Patents Inc. | Polymerization process using pyridyldiamido compounds supported on organoaluminum treated layered silicate supports |
| US10208140B2 (en) | 2016-06-30 | 2019-02-19 | Exxonmobil Chemical Patents Inc. | Quinolinyldiamido transition metal complexes, production and use thereof |
| US10562987B2 (en) | 2016-06-30 | 2020-02-18 | Exxonmobil Chemical Patents Inc. | Polymers produced via use of quinolinyldiamido transition metal complexes and vinyl transfer agents |
| US10927196B2 (en) | 2016-06-30 | 2021-02-23 | Exxonmobil Chemical Patents Inc. | Long chain branched polypropylene via polymerization with aluminum vinyl transfer agent |
| KR20190003835A (ko) | 2016-06-30 | 2019-01-09 | 엑손모빌 케미칼 패턴츠 인코포레이티드 | 퀴놀리닐디아미도 전이 금속 착물, 제조 및 이의 용도 |
| US10150821B2 (en) | 2016-07-29 | 2018-12-11 | Exxonmobil Chemical Patents Inc. | Heterocyclic amido transition metal complexes, production and use thereof |
| WO2018022249A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Heterocyclic amido transition metal complexes, production and use thereof |
| US10882932B2 (en) | 2016-10-05 | 2021-01-05 | Exxonmobil Chemical Patents Inc. | Sterically hindered metallocenes, synthesis and use |
| US10626200B2 (en) | 2017-02-28 | 2020-04-21 | Exxonmobil Chemical Patents Inc. | Branched EPDM polymers produced via use of vinyl transfer agents and processes for production thereof |
| WO2018160278A1 (en) | 2017-03-01 | 2018-09-07 | Exxonmobil Chemical Patents Inc. | Branched ethylene copolymers produced via use of vinyl transfer agents and processes for production thereof |
| CN109485664B (zh) * | 2017-09-12 | 2022-03-08 | 北京凯莱天成医药科技有限公司 | 一种抗真菌药物他伐硼罗的制备工艺 |
| KR20200109293A (ko) | 2017-09-13 | 2020-09-22 | 프로제너티, 인크. | 자간전증 바이오마커 및 관련된 시스템 및 방법 |
| WO2019173598A1 (en) | 2018-03-08 | 2019-09-12 | Exxonmobil Chemical Patents Inc. | Ethylene-propylene linear copolymers as viscosity modifiers |
| EP3762475B1 (en) | 2018-03-08 | 2025-08-20 | ExxonMobil Chemical Patents Inc. | Ethylene-propylene branched copolymers as viscosity modifiers with enhanced fuel economy |
| CN109266735A (zh) * | 2018-06-15 | 2019-01-25 | 天津医科大学 | Crth2作为肺动脉高压免疫治疗药物靶标及其应用 |
| WO2021041406A1 (en) | 2019-08-27 | 2021-03-04 | Chevron Oronite Company Llc | Ethylene copolymers and use as viscosity modifiers |
| CN110878043B (zh) * | 2019-11-18 | 2020-08-14 | 南京哈柏医药科技有限公司 | 一种地平类降压药物中间体6-甲氧基吡啶-3-甲醛的合成方法 |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239084A (en) | 1990-06-29 | 1993-08-24 | Hoffmann-La Roche Inc. | Substituted aminoalkyl biphenyl compounds |
| US5827868A (en) | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
| US5334598A (en) | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5565485A (en) | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5391566A (en) | 1993-07-20 | 1995-02-21 | Merck & Co., Inc. | Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives |
| DE19601782A1 (de) * | 1996-01-19 | 1997-07-24 | Merck Patent Gmbh | Chinolin-2-(1H)one |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| US6617351B1 (en) | 1998-07-31 | 2003-09-09 | Eli Lilly And Company | Amide, carbamate, and urea derivatives |
| DE19937537A1 (de) | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
| US6884593B1 (en) | 1999-08-23 | 2005-04-26 | Bml, Inc. | Method of identifying properties of substance with respect to human prostaglandin D2 receptors |
| US6617361B2 (en) * | 1999-11-05 | 2003-09-09 | Be Able, Llc | Behavior chemotherapy |
| US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| WO2002094830A2 (en) | 2001-05-23 | 2002-11-28 | Merck Frosst Canada & Co. | DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS |
| WO2002098840A1 (en) | 2001-06-04 | 2002-12-12 | Eisai Co., Ltd. | Carboxylic acid derivative and medicine comprising salt or ester of the same |
| WO2003006011A1 (en) | 2001-07-09 | 2003-01-23 | Axys Pharmaceuticals, Inc. | 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors |
| AR038136A1 (es) * | 2002-01-24 | 2004-12-29 | Merck Frosst Canada Inc | Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento |
| AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| ATE327977T1 (de) | 2002-10-21 | 2006-06-15 | Warner Lambert Co | Tetrahydrochinolin-derivate als crth2 antagonisten |
| DE60334015D1 (de) | 2002-10-30 | 2010-10-14 | Merck Frosst Canada Ltd | Pyridopyrrolizin- und pyridoindolizinderivate |
| JP2004182657A (ja) | 2002-12-04 | 2004-07-02 | Eisai Co Ltd | Ｈｄｌレベル上昇促進剤 |
| ES2401079T3 (es) | 2002-12-20 | 2013-04-16 | Amgen Inc. | Moduladores del asma y de la inflamación alérgica |
| ES2257616T3 (es) | 2003-04-25 | 2006-08-01 | Actimis Pharmaceuticals, Inc. | Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2. |
| US7205329B2 (en) | 2003-05-30 | 2007-04-17 | Microbia, Inc. | Modulators of CRTH2 activity |
| AU2004266740B2 (en) | 2003-08-21 | 2010-08-26 | Merck Frosst Canada Ltd | Cathepsin cysteine protease inhibitors |
| WO2005033105A2 (en) * | 2003-09-30 | 2005-04-14 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| BRPI0415437A (pt) | 2003-10-14 | 2006-12-05 | Oxagen Ltd | composto, processo para a preparação e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, produto |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| JP4922615B2 (ja) | 2003-11-26 | 2012-04-25 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| US7019022B2 (en) | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| US20060014737A1 (en) * | 2004-03-09 | 2006-01-19 | Varghese John | Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors |
| JP4922924B2 (ja) * | 2004-04-13 | 2012-04-25 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｅｔｐ阻害薬 |
| CA2565437A1 (en) | 2004-06-18 | 2006-01-05 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| US20080312286A1 (en) | 2004-07-30 | 2008-12-18 | Pinkerton Anthony B | Indanone Potentiators of Metabotropic Glutamate Receptors |
| AU2005286718A1 (en) | 2004-09-21 | 2006-03-30 | Wyeth | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof |
| CN101124207A (zh) | 2004-09-21 | 2008-02-13 | 阿特西斯公司 | 显示出crth2受体拮抗作用的苯并咪唑乙酸类和其用途 |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| GT200500284A (es) * | 2004-10-15 | 2006-03-27 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| US20070299122A1 (en) | 2004-11-08 | 2007-12-27 | Tobert Jonathan A | Method of Treating Pathological Blushing |
| AU2005305969A1 (en) * | 2004-11-19 | 2006-05-26 | Galderma Research & Development | Compounds that modulate PPARy type receptors, and use thereof in cosmetic or pharmaceutical compositions |
| CA2589322A1 (en) | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
| ATE518834T1 (de) | 2004-12-27 | 2011-08-15 | Actelion Pharmaceuticals Ltd | 2,3,4,9-tetrahydro-1h-carbazol-derivative als crth2-rezeptorantagonisten |
| JP2008536802A (ja) | 2005-02-24 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体のベンズアゾール増強剤 |
| BRPI0607433A2 (pt) * | 2005-02-25 | 2009-09-08 | Takeda Pharmaceutical | composto ou um sal do mesmo, pró-droga, agente farmacêutico, inibidor de peptidase, uso de um composto ou de uma pró-droga do mesmo, e, métodos de prevenção ou tratamento de doenças, de inibição de peptidase em um mamìfero, e de produção de um composto |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| CA2619101A1 (en) | 2005-08-23 | 2007-03-01 | Irm Llc | Immunosuppressant compounds and compositions |
| GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| RU2405770C2 (ru) | 2005-09-27 | 2010-12-10 | Сионоги Энд Ко., Лтд. | Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2 |
| JP5155171B2 (ja) * | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| GT200600457A (es) * | 2005-10-13 | 2007-04-27 | Aventis Pharma Inc | Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2 |
| EP1963259B1 (en) | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
| GB0605743D0 (en) | 2006-03-22 | 2006-05-03 | Oxagen Ltd | Salts with CRTH2 antagonist activity |
| GB0611695D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| KR101411820B1 (ko) | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체 |
| WO2008024746A1 (en) | 2006-08-21 | 2008-02-28 | Array Biopharma, Inc. | 4-substituted phenoxyphenylacetic acid derivatives |
| WO2008033455A2 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors |
| US7629258B2 (en) * | 2006-11-22 | 2009-12-08 | Clarkson University | Method for one-to-one polishing of silicon nitride and silicon oxide |
| WO2008082567A1 (en) | 2006-12-29 | 2008-07-10 | Merck & Co., Inc. | Process for synthesizing a cetp inhibitor |
| US7960567B2 (en) | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
| RU2468012C2 (ru) | 2007-06-21 | 2012-11-27 | Актимис Фармасьютикалз, Инк. | Частицы антагониста crth2 |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| GB0719521D0 (en) | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
| WO2009061676A2 (en) | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
| WO2009061681A2 (en) | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc | Antagonists of pgd2 receptors |
| GB0722216D0 (en) | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
| GB0722203D0 (en) | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
| US20110136877A1 (en) | 2008-01-07 | 2011-06-09 | Ligand Pharmaceuticals Inc. | 2-phenyl phenoxyacetic acids useful for treating inflammatory disorders |
| DK2250161T3 (da) | 2008-01-18 | 2014-01-27 | Atopix Therapeutics Ltd | Forbindelser med CRTH2-antagonistaktivitet |
| EP2245002A4 (en) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| US8168678B2 (en) | 2008-02-01 | 2012-05-01 | Panmira Pharmaceuticals, Inc. | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors |
| EP2257536A4 (en) | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| WO2009108720A2 (en) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| EP2268611A2 (en) | 2008-04-02 | 2011-01-05 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| MX2010014172A (es) | 2008-07-03 | 2011-02-22 | Amira Pharmaceuticals Inc | Antagonistas de receptores de prostaglandina d2. |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| US20100173313A1 (en) | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| CA2768492A1 (en) | 2009-07-31 | 2011-02-03 | Panmira Pharmaceuticals, Llc | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| EP2480225A4 (en) | 2009-07-31 | 2013-05-01 | Panmira Pharmaceuticals Llc | DERMAL FORMULATIONS FROM DP2 RECEPTOR ANTAGONISTS |
| CN102596902A (zh) | 2009-08-05 | 2012-07-18 | 潘米拉制药公司 | Dp2拮抗剂及其用途 |
-
2009
- 2009-09-24 GB GB0916810A patent/GB2463788B/en not_active Expired - Fee Related
- 2009-09-28 WO PCT/US2009/058663 patent/WO2010037059A2/en not_active Ceased
- 2009-09-28 US US12/568,571 patent/US8049015B2/en not_active Expired - Fee Related
- 2009-09-28 EP EP09817014A patent/EP2328869A4/en not_active Withdrawn
- 2009-09-28 CN CN2009801381671A patent/CN102164894A/zh active Pending
- 2009-09-28 JP JP2011529334A patent/JP2012504141A/ja not_active Ceased
- 2009-09-28 WO PCT/US2009/058655 patent/WO2010037054A2/en not_active Ceased
- 2009-09-28 AR ARP090103725A patent/AR073319A1/es unknown
- 2009-09-28 US US13/121,398 patent/US20110312974A1/en not_active Abandoned
- 2009-09-28 CA CA2737739A patent/CA2737739C/en not_active Expired - Fee Related
- 2009-09-28 PE PE2009001158A patent/PE20100317A1/es not_active Application Discontinuation
- 2009-09-29 UY UY0001032152A patent/UY32152A/es unknown
- 2009-09-29 TW TW098133063A patent/TW201018465A/zh unknown
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