JP2012149073A - 医薬組成物 - Google Patents
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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Abstract
【解決手段】オメガ−3多価不飽和脂肪酸の遊離酸型又は薬理学的に許容されるその誘導体の少なくとも一つを含む医薬製剤が、長期に亘り顕著に硬くなることが無く、有効期限がより長くなることを特徴とする、コラーゲン源の酸による前処理工程を含む抽出プロセスによって抽出されたゼラチンを含む軟ゼラチンカプセル。
【選択図】なし
Description
Claims (22)
- 遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含む医薬製剤を有する軟ゼラチンカプセルであって、該軟ゼラチンカプセルが、該軟ゼラチンカプセルの有効期限を改善するのに十分な量のAタイプ(ブタ)ゼラチンを含有するものにおいて、
該有効期限が、遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含み、かつ、本質的にBタイプゼラチンからなるものである医薬製剤を含む軟ゼラチンカプセルのそれよりも長いものである、
ことを特徴とする軟ゼラチンカプセル。 - 該製剤が5,8,11,14,17−エイコサペンタエン酸(すなわち「EPA」)を含む、請求項1に記載の軟ゼラチンカプセル。
- EPAが該製剤の少なくとも50重量%の量存在する、請求項2に記載の軟ゼラチンカプセル。
- EPAが該製剤の50重量%〜60重量%の間の量存在する、請求項2又は3に記載の軟ゼラチンカプセル。
- EPAが該製剤の少なくとも90重量%の量存在する、請求項2又は3に記載の軟ゼラチンカプセル。
- 該製剤が4,7,10,13,16,19−ドコサヘキサエン酸(すなわちDHA」)を含む、請求項1〜5のいずれか1項に記載の軟ゼラチンカプセル。
- 請求項1〜4のいずれか1項から依存する範囲で、DHAが該製剤の20重量%〜30重量%の間の量存在する、請求項6に記載の軟ゼラチンカプセル。
- 該製剤の100mg〜2000mgを含む、請求項1〜7のいずれか1項に記載の軟ゼラチンカプセル。
- 該製剤の500mgを含む、請求項1〜8のいずれか1項に記載の軟ゼラチンカプセル。
- 該製剤の1000mgを含む、請求項1〜8のいずれか1項に記載の軟ゼラチンカプセル。
- 該カプセルの壁膜が単層からなる、請求項1〜10のいずれか1項に記載の軟ゼラチンカプセル。
- 胃を通過するまで、該カプセルが該製剤の放出を遅延させる、請求項1〜11のいずれか1項に記載の軟ゼラチンカプセル。
- 十二指腸内の膵管を超えるまで、該カプセルが該製剤の放出を遅延させる、請求項1〜12のいずれか1項に記載の軟ゼラチンカプセル。
- 該カプセルが腸溶性材料の少なくとも一つで被覆されている、請求項12又は13に記載の軟ゼラチンカプセル。
- 該腸溶性材料の少なくとも一つが該カプセルの該ゼラチン内に溶け込んでいる、請求項12〜14のいずれか1項に記載の軟ゼラチンカプセル。
- 該腸溶性材料の一つ又は少なくとも一つが中性のポリアクリル酸ポリマーである、請求項14又は15に記載の軟ゼラチンカプセル。
- 該腸溶性材料の一つ又は少なくとも一つがポリ(アクリル酸エチル−メタクリル酸メチル)である、請求項14〜16のいずれか1項に記載の軟ゼラチンカプセル。
- 該軟ゼラチンカプセルのゼラチンがAタイプ(ブタ)ゼラチンである請求項1〜17のいずれか1項に記載の軟ゼラチンカプセル。
- 慢性的な炎症状態、高脂血症、高トリグリセリド血症、喘息、双極性障害及び腫瘍性疾患から選択される状態を経口的に治療又は予防するための、請求項1〜18のいずれかに記載された軟ゼラチンカプセル。
- 遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含む医薬製剤を含む軟ゼラチンカプセルを製造するための方法であって、Aタイプ(ブタ)ゼラチン内に該医薬製剤を封入する工程を含む該方法。
- 製剤との化学的相互作用に対する軟ゼラチンカプセルの抵抗性を改善するための、遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含む医薬製剤を含む軟ゼラチンカプセルにおける、Aタイプ(ブタ)ゼラチンの使用であって、
該抵抗性が、遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含み、かつ、本質的にBタイプゼラチンからなるものである医薬製剤を含む軟ゼラチンカプセルのそれよりも大きいものである、Aタイプ(ブタ)ゼラチンの使用。 - 軟ゼラチンカプセルの有効期限を改善するための、遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含む医薬製剤を含む軟ゼラチンカプセル内での、Aタイプ(ブタ)ゼラチンの使用であって、
該有効期限が、遊離酸形態のオメガ−3多価不飽和脂肪酸の少なくとも一つを含み、かつ、本質的にBタイプゼラチンからなるものである医薬製剤を含む軟ゼラチンカプセルのそれよりも長いものである、Aタイプ(ブタ)ゼラチンの使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0403247.0 | 2004-02-13 | ||
GB0403247A GB0403247D0 (en) | 2004-02-13 | 2004-02-13 | A pharmaceutical composition |
Related Parent Applications (1)
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JP2006552677A Division JP5435842B2 (ja) | 2004-02-13 | 2005-02-07 | 医薬組成物 |
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JP2014059433A Division JP2014139216A (ja) | 2004-02-13 | 2014-03-24 | 医薬組成物 |
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JP2012149073A true JP2012149073A (ja) | 2012-08-09 |
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Application Number | Title | Priority Date | Filing Date |
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JP2006552677A Expired - Fee Related JP5435842B2 (ja) | 2004-02-13 | 2005-02-07 | 医薬組成物 |
JP2012059540A Pending JP2012149073A (ja) | 2004-02-13 | 2012-03-16 | 医薬組成物 |
JP2014059433A Pending JP2014139216A (ja) | 2004-02-13 | 2014-03-24 | 医薬組成物 |
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JP2006552677A Expired - Fee Related JP5435842B2 (ja) | 2004-02-13 | 2005-02-07 | 医薬組成物 |
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JP2014059433A Pending JP2014139216A (ja) | 2004-02-13 | 2014-03-24 | 医薬組成物 |
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US (6) | US7960370B2 (ja) |
EP (1) | EP1755565B2 (ja) |
JP (3) | JP5435842B2 (ja) |
KR (1) | KR101198458B1 (ja) |
CN (1) | CN1929824B (ja) |
AR (1) | AR047799A1 (ja) |
AT (1) | ATE457720T2 (ja) |
AU (1) | AU2005215198B2 (ja) |
BR (1) | BRPI0507473B8 (ja) |
CA (1) | CA2555064C (ja) |
CY (1) | CY1110030T1 (ja) |
DE (1) | DE602005019402D1 (ja) |
DK (1) | DK1755565T4 (ja) |
ES (1) | ES2344208T5 (ja) |
GB (1) | GB0403247D0 (ja) |
IL (1) | IL177462A (ja) |
MX (1) | MXPA06008352A (ja) |
NO (1) | NO341821B1 (ja) |
PL (1) | PL1755565T5 (ja) |
PT (1) | PT1755565E (ja) |
SI (1) | SI1755565T2 (ja) |
WO (1) | WO2005079853A2 (ja) |
ZA (1) | ZA200606229B (ja) |
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