CN105434393B - 一种包含高含量ω-3多不饱和脂肪酸的软胶囊药物组合物 - Google Patents
一种包含高含量ω-3多不饱和脂肪酸的软胶囊药物组合物 Download PDFInfo
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- CN105434393B CN105434393B CN201410494152.1A CN201410494152A CN105434393B CN 105434393 B CN105434393 B CN 105434393B CN 201410494152 A CN201410494152 A CN 201410494152A CN 105434393 B CN105434393 B CN 105434393B
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Landscapes
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Abstract
Description
胶液 | 重量 | 百分含量 |
B型明胶 | 1664g | 32% |
阿拉伯胶 | 312g | 6% |
羟丙甲纤维素 | 78g | 1.5% |
甘露醇 | 124.8g | 2.4% |
甘油 | 603.2g | 11.6% |
水 | 2418g | 46.5% |
Claims (10)
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CN201410494152.1A CN105434393B (zh) | 2014-09-25 | 2014-09-25 | 一种包含高含量ω-3多不饱和脂肪酸的软胶囊药物组合物 |
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CN201410494152.1A CN105434393B (zh) | 2014-09-25 | 2014-09-25 | 一种包含高含量ω-3多不饱和脂肪酸的软胶囊药物组合物 |
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CN105434393A CN105434393A (zh) | 2016-03-30 |
CN105434393B true CN105434393B (zh) | 2019-07-09 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108208685A (zh) * | 2017-12-18 | 2018-06-29 | 丁玉琴 | 一种鱼油软胶囊的制备方法 |
CN109105607A (zh) * | 2018-07-16 | 2019-01-01 | 嘉必优生物技术(武汉)股份有限公司 | 含有pufa的夹心糖、含有夹心糖的食品及制备方法 |
CN113559079B (zh) * | 2020-04-28 | 2023-10-20 | 江苏恒瑞医药股份有限公司 | 一种软胶囊及其制备方法和用途 |
CN112641121B (zh) * | 2020-10-10 | 2022-04-19 | 广州玖洲胶囊生物科技有限公司 | 一种羟丙甲基纤维素和卡拉胶的填充空心胶囊制备方法 |
CN112451501B (zh) * | 2020-12-25 | 2022-07-26 | 北京达因高科儿童药物研究院有限公司 | 一种含有水合氯醛的软胶囊及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1498117A1 (en) * | 2003-07-15 | 2005-01-19 | Pfizer GmbH Arzneimittelwerk Gödecke | A pharmaceutical gelatin-capsule or gelatin containing capsule preparation showing an improved stability, a process for making the capsules and a process for improving the stability of gelatin-capsules |
CN1621031A (zh) * | 2003-11-26 | 2005-06-01 | 上海医药工业研究院 | 软胶囊囊壳胶状乳液的组成及制备方法 |
CN1929824A (zh) * | 2004-02-13 | 2007-03-14 | 狄洛特医药有限公司 | 包含ω-3多不饱和脂肪酸的软明胶胶囊 |
-
2014
- 2014-09-25 CN CN201410494152.1A patent/CN105434393B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1498117A1 (en) * | 2003-07-15 | 2005-01-19 | Pfizer GmbH Arzneimittelwerk Gödecke | A pharmaceutical gelatin-capsule or gelatin containing capsule preparation showing an improved stability, a process for making the capsules and a process for improving the stability of gelatin-capsules |
CN1621031A (zh) * | 2003-11-26 | 2005-06-01 | 上海医药工业研究院 | 软胶囊囊壳胶状乳液的组成及制备方法 |
CN1929824A (zh) * | 2004-02-13 | 2007-03-14 | 狄洛特医药有限公司 | 包含ω-3多不饱和脂肪酸的软明胶胶囊 |
Non-Patent Citations (1)
Title |
---|
软胶囊剂稳定性研究进展;黄敏等;《中国医药工业杂志》;20001231;第31卷(第3期);第137-140页 |
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