JP2012107256A - 乳酸重合体及びその製造方法 - Google Patents
乳酸重合体及びその製造方法 Download PDFInfo
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/89—Recovery of the polymer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Abstract
【解決手段】高分子量の乳酸重合体を加水分解し、得られた加水分解生成物を含む溶液を、そこに含有される目的とする乳酸重合体が析出し得る条件下に置き、析出物を分離、取得することを特徴とする、重量平均分子量約5000以下の重合体含有量が約5重量%以下である、重量平均分子量15000〜50000の乳酸重合体の製造方法、重量平均分子量5000以下の重合体含有量が約5重量%以下である、重量平均分子量15000〜50000の乳酸重合体、当該乳酸重合体を含んで成る徐放性製剤用基材、及び当該乳酸重合体の徐放性製剤用基材としての用途。
【選択図】なし
Description
加水分解反応温度は、通常0〜150℃、好ましくは20〜80℃である。
(i)O/W法
本方法においては、まず本発明の乳酸重合体(以下、本発明の生体内分解性ポリマーと記載する場合がある。)の有機溶媒溶液を作製する。本発明の徐放性製剤の製造の際に使用する有機溶媒は、沸点が120℃以下であることが好ましい。
まず、本発明の生体内分解性ポリマーの有機溶媒溶液を作る。
本法によってマイクロカプセルを製造する場合には,前記(I)の水中乾燥法に記載した生理活性物質及び本発明の生体内分解性ポリマーから成る組成物を含む有機溶媒溶液にコアセルベーション剤を撹拌下徐々に加えてマイクロカプセルを析出,固化させる。該コアセルベーション剤は油相体積の約0.01〜1,000倍、好ましくは約0.05〜500倍、特に好ましくは約0.1〜200倍から選ばれる。
本法によってマイクロカプセルを製造する場合には,前記(I)の水中乾燥法に記載した生理活性物質及び本発明の生体内分解性ポリマーの2者から成る組成物を含有する有機溶媒溶液または分散液をノズルを用いてスプレードライヤー(噴霧乾燥器)の乾燥室内に噴霧し、極めて短時間内に微粒化液滴内の有機溶媒を揮発させ、マイクロカプセルを調製する。該ノズルとしては、例えば、二流体ノズル型,圧力ノズル型,回転ディスク型等がある。この後、必要であれば、前記(I)の水中乾燥法で記載と同様の方法で洗浄を行った後に凍結乾燥、さらには加温乾燥してもよい。
脱水キシレン230mLに1.0mol/Lジエチル亜鉛ヘキサン溶液4.1mL、乳酸tert−ブチル1.35g及びDL−ラクチド230gを加え、120〜130℃で約2時間重合反応させた。反応終了後、反応液にジクロロメタン120mLを注入し、トリフルオロ酢酸230mLを加え脱保護反応させた。反応終了後、反応液にジクロロメタン300mLを加えた後、該反応液をイソプロピルエーテル2800mL中に注ぎ、目的物を沈殿させ、次いでジクロロメタン/イソプロピルエーテルで再沈殿操作を繰り返し、重量平均分子量約40000の乳酸重合体を得た。
合成例1で得られた重合体をジクロロメタン600mLに溶解し、該溶液の液性が中性となるまで水洗した後、90%乳酸水溶液70gを添加し、40℃で反応させた。反応液中に溶解している重合体の重量平均分子量が約20,000となったところで室温まで冷却し、ジクロロメタン600mLを注入して反応を停止させ、反応液の液性が中性となるまで水洗した。水洗後、反応液を濃縮、乾燥させて乳酸重合体を得た。得られた乳酸重合体の末端カルボキシル基は重合体1g当たり約80μmolであり、重量平均分子量5000以下の重合体含有量は7.29重量%であった。
合成例1で得られた重合体をジクロロメタン600mLに溶解し、該溶液の液性が中性となるまで水洗した後、90%乳酸水溶液70gを添加し、40℃で反応させた。反応液中に溶解している重合体の重量平均分子量が約20,000となったところで室温まで冷却し、ジクロロメタン600mLを注入して反応を停止させ、反応液の液性が中性となるまで水洗した後、反応液をイソプロピルエーテル2800mL中に滴下し、目的とする乳酸重合体を沈殿させた。デカンテーションにより得られた沈殿物をジクロロメタン600mLに溶解した後、溶液を濃縮、乾燥して乳酸重合体160gを得た。得られた乳酸重合体の末端カルボキシル基量は重合体1g当たり約70μmolであった。また、使用した高分子量乳酸重合体の重量平均分子量、加水分解処理後の乳酸重合体の重量平均分子量、得られた目的の乳酸重合体の重量平均分子量及びその分子量分画を表1に示す。
実施例1と同様な操作を行い、本発明の乳酸重合体を得た。使用した高分子量乳酸重合体の重量平均分子量、加水分解処理後の乳酸重合体の重量平均分子量、得られた目的の乳酸重合体の重量平均分子量及びその分子量分画を表1に併せて示す。
Claims (7)
- 重量平均分子量5000以下の重合体含有量が5重量%以下である、重量平均分子量15000〜50000の乳酸重合体。
- 重量平均分子量3000以下の重合体含有量が1.5重量%以下である請求項1に記載の乳酸重合体。
- 重量平均分子量1000以下の重合体含有量が0.1重量%以下である請求項2に記載の乳酸重合体。
- 重量平均分子量が15000〜30000である請求項1〜3の何れかに記載の乳酸重合体。
- 重量平均分子量が20000〜25000である請求項1〜3の何れかに記載の乳酸重合体。
- 請求項1〜5の何れかに記載の乳酸重合体を含んで成る、徐放性製剤用基材。
- 請求項1〜5の何れかに記載の乳酸重合体の徐放性製剤用基材としての用途。
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US (3) | US7019106B2 (ja) |
EP (2) | EP1693054B1 (ja) |
JP (2) | JP5046447B2 (ja) |
KR (1) | KR100772950B1 (ja) |
CN (1) | CN1269870C (ja) |
AT (1) | ATE322513T1 (ja) |
AU (1) | AU2001276733A1 (ja) |
CA (1) | CA2419065C (ja) |
CY (1) | CY1117889T1 (ja) |
DE (1) | DE60118575T3 (ja) |
DK (1) | DK1310517T4 (ja) |
ES (2) | ES2256276T5 (ja) |
HK (1) | HK1095526A1 (ja) |
PT (2) | PT1693054T (ja) |
WO (1) | WO2002012369A1 (ja) |
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