JP2012107057A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012107057A5 JP2012107057A5 JP2012040330A JP2012040330A JP2012107057A5 JP 2012107057 A5 JP2012107057 A5 JP 2012107057A5 JP 2012040330 A JP2012040330 A JP 2012040330A JP 2012040330 A JP2012040330 A JP 2012040330A JP 2012107057 A5 JP2012107057 A5 JP 2012107057A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- following formula
- salt
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 4
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68172305P | 2005-05-17 | 2005-05-17 | |
| US68177205P | 2005-05-17 | 2005-05-17 | |
| US68172205P | 2005-05-17 | 2005-05-17 | |
| US68168405P | 2005-05-17 | 2005-05-17 | |
| US60/681,723 | 2005-05-17 | ||
| US60/681,722 | 2005-05-17 | ||
| US60/681,684 | 2005-05-17 | ||
| US60/681,772 | 2005-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Division JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012107057A JP2012107057A (ja) | 2012-06-07 |
| JP2012107057A5 true JP2012107057A5 (show.php) | 2012-10-25 |
Family
ID=37431594
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Active JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
| JP2012040330A Pending JP2012107057A (ja) | 2005-05-17 | 2012-02-27 | 眼障害の治療のための組成物および方法 |
| JP2012225028A Active JP6288907B2 (ja) | 2005-05-17 | 2012-10-10 | 眼障害の治療のための組成物および方法 |
| JP2015137500A Withdrawn JP2015187165A (ja) | 2005-05-17 | 2015-07-09 | 眼障害の治療のための組成物および方法 |
| JP2017099005A Withdrawn JP2017141297A (ja) | 2005-05-17 | 2017-05-18 | 眼障害の治療のための組成物および方法 |
| JP2019022433A Active JP6816180B2 (ja) | 2005-05-17 | 2019-02-12 | 眼障害の治療のための組成物および方法 |
| JP2020030710A Pending JP2020079312A (ja) | 2005-05-17 | 2020-02-26 | 眼障害の治療のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Active JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012225028A Active JP6288907B2 (ja) | 2005-05-17 | 2012-10-10 | 眼障害の治療のための組成物および方法 |
| JP2015137500A Withdrawn JP2015187165A (ja) | 2005-05-17 | 2015-07-09 | 眼障害の治療のための組成物および方法 |
| JP2017099005A Withdrawn JP2017141297A (ja) | 2005-05-17 | 2017-05-18 | 眼障害の治療のための組成物および方法 |
| JP2019022433A Active JP6816180B2 (ja) | 2005-05-17 | 2019-02-12 | 眼障害の治療のための組成物および方法 |
| JP2020030710A Pending JP2020079312A (ja) | 2005-05-17 | 2020-02-26 | 眼障害の治療のための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (34) | US8168655B2 (show.php) |
| EP (3) | EP1881823B1 (show.php) |
| JP (7) | JP5794721B2 (show.php) |
| CN (2) | CN102617557A (show.php) |
| AU (1) | AU2006247136C1 (show.php) |
| CA (3) | CA2609053C (show.php) |
| CY (1) | CY1118660T1 (show.php) |
| DK (2) | DK1881823T3 (show.php) |
| ES (2) | ES2530780T3 (show.php) |
| HU (1) | HUE031979T2 (show.php) |
| LT (1) | LT2444079T (show.php) |
| PL (2) | PL2444079T3 (show.php) |
| PT (2) | PT1881823E (show.php) |
| SI (2) | SI2444079T1 (show.php) |
| WO (1) | WO2006125119A1 (show.php) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE551339T1 (de) * | 2003-11-05 | 2012-04-15 | Sarcode Bioscience Inc | Modulatoren der zellulären adhäsion |
| PT2332909E (pt) | 2005-04-13 | 2014-12-17 | Astex Therapeutics Ltd | Derivados de hidroxibenzamida e sua utilização como inibidores de hsp90 |
| AU2006247136C1 (en) | 2005-05-17 | 2020-01-16 | Bausch + Lomb Ireland Limited | Compositions and methods for treatment of eye disorders |
| US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| KR100930467B1 (ko) * | 2007-06-07 | 2009-12-08 | 동아제약주식회사 | 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도 |
| ES2830024T3 (es) * | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
| JP2011521896A (ja) * | 2008-04-15 | 2011-07-28 | サーコード コーポレイション | 免疫関連障害に対する局部治療に使用するための局所ｌｆａ−１アンタゴニスト |
| CN102065694A (zh) * | 2008-04-15 | 2011-05-18 | 萨可德公司 | 用于局部治疗免疫相关疾病的雾化的lfa-1拮抗剂 |
| CN105943534A (zh) * | 2008-04-15 | 2016-09-21 | 萨可德生物科学公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| EP2297112B1 (en) | 2008-05-06 | 2013-04-03 | Boehringer Ingelheim International GmbH | Pyrazole compounds as ccr1 antagonists |
| US8506944B2 (en) * | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
| SI2915529T1 (sl) | 2008-05-07 | 2017-09-29 | The Regents Of The University Of California | Terapevtska regeneracija in obogatitev lubrikacije okularne površine |
| AP2739A (en) * | 2008-09-26 | 2013-09-30 | Boehringer Ingelheim Int | Azaindazole compounds as CCRI receptor antagonists |
| CN102459249A (zh) | 2009-05-22 | 2012-05-16 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧氮杂环庚三烯以及它们使用与制造方法 |
| CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
| PL2491028T3 (pl) | 2009-10-21 | 2014-05-30 | Boehringer Ingelheim Int | Związki indazolowe i pirazolopirydynowe jako antagoniści receptora CCR1 |
| US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2493875B1 (en) | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
| PH12012501153A1 (en) * | 2009-12-08 | 2012-10-22 | Boehringer Ingelheim Int | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| NZ604478A (en) | 2010-07-02 | 2014-12-24 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators |
| US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
| US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US10640464B2 (en) | 2011-01-03 | 2020-05-05 | The William M. Yarbrough Foundation | Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases |
| US10647668B2 (en) | 2011-01-03 | 2020-05-12 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US11407713B2 (en) | 2011-01-03 | 2022-08-09 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US11279674B2 (en) | 2011-01-03 | 2022-03-22 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US8933119B2 (en) | 2011-01-03 | 2015-01-13 | The William M. Yarbrough Foundation | Method for treating phytophotodermatitis |
| US10308599B2 (en) | 2011-01-03 | 2019-06-04 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US10273205B2 (en) | 2011-01-03 | 2019-04-30 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms |
| US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
| US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
| BR112013028886A2 (pt) | 2011-05-10 | 2016-08-09 | Gilead Sciences Inc | compostos heterocíclicos fundidos como moduladores dde canal de sódio |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (show.php) | 2011-07-01 | 2018-04-28 | ||
| US20130197059A1 (en) * | 2012-01-27 | 2013-08-01 | Hoffmann-La Roche Inc. | Integrin antagonist conjugates for targeted delivery to cells expressing lfa-1 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| WO2014018748A1 (en) | 2012-07-25 | 2014-01-30 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
| US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
| US8865772B2 (en) | 2012-07-26 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating skin cancer |
| US9839621B2 (en) | 2012-07-26 | 2017-12-12 | The William M. Yarbrough Foundation | Method for treating bladder cancer |
| US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
| US10080734B2 (en) | 2012-07-26 | 2018-09-25 | The William M. Yarbrough Foundation | Method for treating autism and other neurodevelopmental disorders |
| US9949943B2 (en) | 2012-07-26 | 2018-04-24 | The William M. Yarbrough Foundation | Method for treating neurodegenerative diseases |
| US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| WO2014092958A1 (en) * | 2012-12-10 | 2014-06-19 | Molecular Targeting Technologies, Inc. | Compositions and methods of diagnosing ocular diseases |
| KR101891144B1 (ko) * | 2012-12-19 | 2018-08-23 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 제형 |
| US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP3244851B1 (en) | 2015-01-12 | 2024-10-16 | Bausch + Lomb Ireland Limited | Micro-droplet delivery device |
| HK1247120A1 (zh) | 2015-07-08 | 2018-09-21 | 艾克瑟罗视觉股份有限公司 | 用於治疗眼部炎性病症含有整联蛋白α4拮抗剂的药物组合物 |
| CN106995439B (zh) * | 2016-01-26 | 2019-09-20 | 镇江圣安医药有限公司 | 氘取代3-(甲磺酰基)-l-苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
| US10799447B2 (en) | 2016-03-04 | 2020-10-13 | James M. Rynerson | Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation |
| WO2018031973A1 (en) | 2016-08-12 | 2018-02-15 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| JP2019524892A (ja) | 2016-08-19 | 2019-09-05 | アクリビスタ エルエルシーＡｋｒｉｖｉｓｔａ，Ｌｌｃ | ドライアイ症候群を診断及び治療する方法ならびにヒト眼を治療するための組成物 |
| US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
| NZ751690A (en) * | 2016-09-07 | 2022-02-25 | Glia Llc | Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves |
| KR102412086B1 (ko) | 2017-01-20 | 2022-06-22 | 켄달리온 테라퓨틱스 인코포레이티드 | 압전 유체 분배기 |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技（上海）有限公司 | 一种含磷化合物及其制备和应用 |
| WO2019020580A1 (en) | 2017-07-24 | 2019-01-31 | Interquim, S.A. | PROCESS FOR PREPARING AND PURIFYING LIFITEGRAST ANTAGONIST OF LFA-1 |
| WO2019036625A1 (en) | 2017-08-18 | 2019-02-21 | Akrivista, LLC | METHODS FOR DIAGNOSING AND TREATING DRY-LIKE SYNDROME AND COMPOSITIONS FOR TREATING A HUMAN EYE |
| JP7065951B2 (ja) | 2017-09-22 | 2022-05-12 | ジュビラント エピパッド エルエルシー | Ｐａｄ阻害剤としての複素環式化合物 |
| EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| WO2019097547A1 (en) | 2017-11-15 | 2019-05-23 | Cipla Limited | An improved process for the preparation of lifitegrast or salts thereof |
| WO2019096996A1 (en) | 2017-11-17 | 2019-05-23 | Medichem, S.A. | A process to obtain a tetrahydroisoquinoline derivative |
| IL274762B2 (en) | 2017-11-24 | 2023-10-01 | Jubilant Episcribe Llc | Novel heterocyclic compounds as prmt5 inhibitors |
| CN111712219A (zh) | 2017-12-08 | 2020-09-25 | 科达莱昂治疗公司 | 流体递送对准系统 |
| WO2019175897A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| US20190314198A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| CN119954787A (zh) | 2018-04-18 | 2025-05-09 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| US11919912B2 (en) | 2018-05-21 | 2024-03-05 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3817696B8 (en) | 2018-07-03 | 2024-12-11 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices |
| US11166910B2 (en) * | 2019-01-25 | 2021-11-09 | Nordiccan A/S | Cannabinoid chewing gum with sugar alcohols |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| JP7700045B2 (ja) | 2019-04-18 | 2025-06-30 | アズーラ オフサルミックス エルティーディー． | 眼障害を処置するための化合物および方法 |
| CN114040783A (zh) * | 2019-04-22 | 2022-02-11 | 阿雷格罗眼科有限责任公司 | 可用于治疗干眼症的组合物和方法 |
| JP2022541840A (ja) * | 2019-07-25 | 2022-09-27 | ノース カロライナ ステート ユニバーシティ | 架橋化化合物及びそれを使用する方法 |
| WO2021212038A1 (en) | 2020-04-17 | 2021-10-21 | Kedalion Therapeutics, Inc. | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11925577B2 (en) | 2020-04-17 | 2024-03-12 | Bausch + Lomb Ireland Limted | Hydrodynamically actuated preservative free dispensing system |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11459351B1 (en) | 2021-04-05 | 2022-10-04 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
| US11213551B1 (en) | 2021-04-05 | 2022-01-04 | Korb Research, Llc. | Ocular treatment compositions and methods of use thereof |
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| EP4507786A2 (en) * | 2022-04-13 | 2025-02-19 | The Regents Of The University Of California | Methods of producing plasma or serum and uses thereof |
| CN119895319A (zh) * | 2022-09-15 | 2025-04-25 | 日油株式会社 | 用于接触镜片的溶液 |
| WO2024215778A1 (en) * | 2023-04-10 | 2024-10-17 | Insitu Biologics, Inc. | Sustained release stable emulsion pharmaceutical formulations |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US423439A (en) * | 1890-03-18 | Stove-pipe guard and register | ||
| US744A (en) * | 1838-05-17 | Mode of cutting off steam in steam-engines | ||
| GB138135A (en) * | 1918-08-13 | 1920-02-05 | Hugh William Gabbett Fairfax | Improvements in automatic firearms |
| US1680610A (en) * | 1926-09-16 | 1928-08-14 | Mary Y Harmon | Batik-frame support |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3876444A (en) * | 1970-04-24 | 1975-04-08 | Gen Electric | Method of treating high strength carbon fibers |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) * | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| GB2209937B (en) | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| EP0314863B1 (en) | 1987-11-02 | 1994-12-07 | Baylor College Of Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation |
| EP0326151B1 (en) | 1988-01-29 | 1993-06-16 | Sumitomo Pharmaceuticals Company, Limited | Improved controlled release formulation |
| DE3802996A1 (de) * | 1988-02-02 | 1989-08-10 | Cassella Ag | Verwendung von 2-oxo-pyrrolidin-1-acetamid zur bestimmung der glomerulaeren filtrationsrate beim menschen |
| US5424399A (en) * | 1988-06-28 | 1995-06-13 | The Children's Medical Center Corporation | Human CR3α/β heterodimers |
| EP0362526B1 (en) | 1988-08-23 | 1995-06-14 | Dana Farber Cancer Institute | The Alpha-subunit of the LFA-1 leukocyte adhesion receptor |
| DE68929096T2 (de) | 1988-09-01 | 2000-05-11 | Bayer Corp., Pittsburgh | Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt |
| HU218904B (hu) | 1988-09-28 | 2000-12-28 | Dana-Farber Cancer Institute | Eljárás ICAM-1-et kódoló rekombináns DNS előállítására, ICAM-1-et kifejező sejtek vagy ezzel kapcsolatos betegségek diagnosztizálására és a specifikus védekező rendszer válaszából eredő gyulladások kezelésére szolgáló gyógyszerkészítmények előállítására |
| US5149780A (en) * | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| JPH04505009A (ja) | 1989-03-09 | 1992-09-03 | ダナ・ファーバー・キャンサー・インスティチュート | クローニングｌｆａ―１ |
| AU5553290A (en) | 1989-04-28 | 1990-11-29 | Baylor College Of Medicine | Dissemination of hiv-1 infected cells |
| CH679207A5 (show.php) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| WO1991019511A1 (en) | 1990-06-18 | 1991-12-26 | The General Hospital Corporation | CONTROLLING CELLULAR IMMUNE/INFLAMMATORY RESPONSES WITH β2 INTEGRINS |
| CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
| US5318965A (en) | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
| WO1992003473A1 (en) * | 1990-08-27 | 1992-03-05 | Cetus Corporation | Cd18 peptide medicaments for the treatment of disease |
| JP2995860B2 (ja) | 1990-11-27 | 1999-12-27 | 味の素株式会社 | 新規ペプチド |
| US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
| CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| DE69229275T2 (de) * | 1991-10-04 | 1999-12-30 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen |
| GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| US5298492A (en) * | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
| EP0656789B1 (en) * | 1992-08-21 | 1997-12-17 | Genentech, Inc. | Method for treating a lfa-1-mediated disorder |
| WO1994011400A1 (en) | 1992-11-18 | 1994-05-26 | Helsinki University Licensing Ltd. Oy | Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis |
| DE69432459T2 (de) | 1993-01-06 | 2003-11-27 | Kinerton Ltd., Blanchardstown | Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden |
| US5672659A (en) | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| US5424289A (en) * | 1993-07-30 | 1995-06-13 | Alza Corporation | Solid formulations of therapeutic proteins for gastrointestinal delivery |
| US5397791A (en) | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| PT656348E (pt) * | 1993-12-03 | 2000-10-31 | Hoffmann La Roche | Derivados do acido acetico como medicamentos |
| US5470953A (en) * | 1993-12-23 | 1995-11-28 | Icos Corporation | Human β2 integrin α subunit |
| EP0762886A4 (en) | 1994-04-19 | 1999-03-31 | Univ Kansas | ICAM-1 / LFA-1 SHORT CHAIN PEPTIDES AND METHODS FOR USE THEREOF |
| US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
| US5585359A (en) | 1994-09-29 | 1996-12-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0710657B1 (de) * | 1994-11-02 | 1998-08-26 | MERCK PATENT GmbH | Adhäsionsrezeptor-Antagonisten |
| US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
| FI974368A0 (fi) * | 1995-05-29 | 1997-11-28 | Pfizer | Kasvuhormonin vapautumista edistäviä dipeptidejä |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| US5980945A (en) * | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| DE69731623D1 (de) | 1996-04-23 | 2004-12-23 | Ipsen Mfg Ireland Ltd | Saure Polymilchsäure Polymere |
| HRP970493A2 (en) | 1996-09-23 | 1998-08-31 | Wienman E. Phlips | Oral delayed immediate release medical formulation and method for preparing the same |
| CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| DK0944619T3 (da) * | 1996-11-27 | 2007-02-05 | Bristol Myers Squibb Pharma Co | Hidtil ukendte integrinreceptorantagonister |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| US5893985A (en) | 1997-03-14 | 1999-04-13 | The Lincoln Electric Company | Plasma arc torch |
| AR012443A1 (es) | 1997-04-16 | 2000-10-18 | Uriach & Cia Sa J | Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos |
| PT1007033E (pt) | 1997-08-28 | 2008-07-22 | Novartis Ag | Antagonistas do antigénio-1 da função de linfócitos |
| HUP0101587A3 (en) * | 1998-03-27 | 2003-03-28 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| CN1114401C (zh) | 1998-07-14 | 2003-07-16 | 阿尔康实验室公司 | 11－(3－二甲氨基亚丙基)－6,11－二氢二苯并[b,e]噁庚英－2－乙酸用于制药的新用途 |
| US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| CA2352389C (en) | 1998-11-27 | 2009-01-20 | Kanji Takada | An oral formulation for gastrointestinal drug delivery |
| IT1304152B1 (it) | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato |
| US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
| WO2000040262A1 (en) * | 1999-01-05 | 2000-07-13 | The Flinders University Of South Australia | Novel agents and methods for treatment and diagnosis of ocular disorders |
| AU2847200A (en) | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
| EP1028114A1 (en) * | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
| EP1169024B1 (en) * | 1999-03-31 | 2005-12-21 | Janssen Pharmaceutica N.V. | Pregelatinized starch in a controlled release formulation |
| AU1186401A (en) | 1999-06-23 | 2001-01-22 | Sedum Laboratories, Inc. | Ionically formulated biomolecule microcarriers |
| IL147802A0 (en) | 1999-08-18 | 2002-08-14 | Sod Conseils Rech Applic | Sustained release formulation of a peptide |
| ECSP003707A (es) | 1999-10-13 | 2002-05-23 | Novartis Ag | Diazepanes |
| HK1049785A1 (zh) | 1999-10-22 | 2003-05-30 | Biogen, Inc. | Cd40:cd154结合阻断剂在治疗眼睛免疫并发症的用途 |
| US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
| US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
| IL149890A0 (en) * | 1999-12-14 | 2002-11-10 | Genentech Inc | Tnt-alpha antagonist and lfa-1 antagonist for treating lfa-1 or tnf-alpha mediated |
| AU784226B2 (en) | 1999-12-31 | 2006-02-23 | Rutgers, The State University | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| US7521061B2 (en) * | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| CA2395892C (en) | 1999-12-31 | 2014-06-03 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| US6630447B2 (en) | 2000-01-14 | 2003-10-07 | University Of New Mexico | Peptide inhibitors of LFA-1/ICAM-1 interaction |
| US20030064105A1 (en) * | 2000-08-25 | 2003-04-03 | Myung-Jin Kim | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
| US6515124B2 (en) | 2000-02-09 | 2003-02-04 | Hoffman-La Roche Inc. | Dehydroamino acids |
| WO2001085677A1 (fr) * | 2000-05-05 | 2001-11-15 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derives d'aminoacides et leur application a titre de medicaments |
| GB0011817D0 (en) | 2000-05-16 | 2000-07-05 | Pharmacia & Upjohn Spa | Antagonists of integrin receptors |
| NZ523445A (en) * | 2000-06-29 | 2004-10-29 | Abbott Lab | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
| AR030817A1 (es) | 2000-10-02 | 2003-09-03 | Novartis Ag | Derivados de diazacicloalcanodiona |
| GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
| US6653478B2 (en) * | 2000-10-27 | 2003-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators |
| DE10055857A1 (de) | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | Neue pharmazeutische Depotformulierung |
| GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
| IL155683A0 (en) | 2000-11-28 | 2003-11-23 | Genentech Inc | Lfa-1 antagonist compounds |
| WO2002050080A1 (en) | 2000-12-19 | 2002-06-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| CA2435415A1 (en) | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Microparticles of biodegradable polymer encapsulating a biologically active substance |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| AU2002250236A1 (en) * | 2001-03-02 | 2002-09-19 | Medimmune, Inc. | Cd2 antagonists for treatment of autoimmune or inflammatory disease |
| US20020176841A1 (en) * | 2001-03-19 | 2002-11-28 | Praecis Pharmaceuticals Inc. | Pharmaceutical formulations for sustained release |
| US6872382B1 (en) * | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
| WO2002098426A1 (en) * | 2001-06-06 | 2002-12-12 | Aventis Pharma Limtied | Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases |
| NZ533060A (en) | 2001-12-19 | 2006-03-31 | Alza Corp | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
| CA2474613A1 (en) | 2002-03-04 | 2003-09-18 | Jacques-Pierre Moreau | Sustained release drug formulations containing a carrier peptide |
| WO2004014365A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
| CA2497977A1 (en) | 2002-09-20 | 2004-04-01 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| US7785578B2 (en) * | 2002-10-11 | 2010-08-31 | Aciont, Inc. | Non-invasive ocular drug delivery |
| CN1832920A (zh) | 2003-08-08 | 2006-09-13 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物,组合物及其使用方法 |
| WO2005014532A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| WO2005042710A1 (en) | 2003-10-28 | 2005-05-12 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of statin to kill ebv-transformed b cells |
| ATE551339T1 (de) * | 2003-11-05 | 2012-04-15 | Sarcode Bioscience Inc | Modulatoren der zellulären adhäsion |
| GT200500139A (es) | 2004-06-08 | 2005-07-25 | Metodo para la preparacion de acidos hidroxamicos | |
| AU2006247136C1 (en) * | 2005-05-17 | 2020-01-16 | Bausch + Lomb Ireland Limited | Compositions and methods for treatment of eye disorders |
| US7541420B2 (en) * | 2006-06-30 | 2009-06-02 | Sabic Innovative Plastics Ip B.V. | Method for making molded polycarbonate articles with improved color |
| JP4193895B2 (ja) | 2006-10-12 | 2008-12-10 | 横河電機株式会社 | 欠陥検査装置 |
| ES2830024T3 (es) * | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| JP2011521896A (ja) * | 2008-04-15 | 2011-07-28 | サーコード コーポレイション | 免疫関連障害に対する局部治療に使用するための局所ｌｆａ−１アンタゴニスト |
| WO2009139817A2 (en) * | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| US8337942B2 (en) * | 2009-08-28 | 2012-12-25 | Minsek David W | Light induced plating of metals on silicon photovoltaic cells |
| US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2014018748A1 (en) * | 2012-07-25 | 2014-01-30 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
-
2006
- 2006-05-17 AU AU2006247136A patent/AU2006247136C1/en active Active
- 2006-05-17 CA CA2609053A patent/CA2609053C/en active Active
- 2006-05-17 CA CA2985444A patent/CA2985444C/en active Active
- 2006-05-17 EP EP06770607.7A patent/EP1881823B1/en active Active
- 2006-05-17 ES ES06770607T patent/ES2530780T3/es active Active
- 2006-05-17 PT PT06770607T patent/PT1881823E/pt unknown
- 2006-05-17 DK DK06770607.7T patent/DK1881823T3/en active
- 2006-05-17 WO PCT/US2006/019327 patent/WO2006125119A1/en not_active Ceased
- 2006-05-17 CN CN2012100314315A patent/CN102617557A/zh active Pending
- 2006-05-17 ES ES11181066.9T patent/ES2614080T3/es active Active
- 2006-05-17 CA CA2960117A patent/CA2960117C/en active Active
- 2006-05-17 HU HUE11181066A patent/HUE031979T2/en unknown
- 2006-05-17 PL PL11181066T patent/PL2444079T3/pl unknown
- 2006-05-17 EP EP16201157.1A patent/EP3195861A1/en not_active Withdrawn
- 2006-05-17 JP JP2008512519A patent/JP5794721B2/ja active Active
- 2006-05-17 EP EP11181066.9A patent/EP2444079B1/en active Active
- 2006-05-17 LT LTEP11181066.9T patent/LT2444079T/lt unknown
- 2006-05-17 PT PT111810669T patent/PT2444079T/pt unknown
- 2006-05-17 PL PL06770607T patent/PL1881823T3/pl unknown
- 2006-05-17 CN CN2006800171884A patent/CN101175488B/zh not_active Ceased
- 2006-05-17 SI SI200632151A patent/SI2444079T1/sl unknown
- 2006-05-17 DK DK11181066.9T patent/DK2444079T3/en active
- 2006-05-17 SI SI200631898T patent/SI1881823T1/sl unknown
- 2006-05-17 US US11/436,906 patent/US8168655B2/en active Active
-
2009
- 2009-07-23 US US12/508,311 patent/US20100092541A1/en not_active Abandoned
- 2009-07-23 US US12/508,367 patent/US8084047B2/en active Active
-
2011
- 2011-01-21 US US13/011,760 patent/US8771715B2/en active Active
- 2011-01-21 US US13/011,775 patent/US8758776B2/en active Active
-
2012
- 2012-02-16 US US13/398,542 patent/US8592450B2/en active Active
- 2012-02-27 JP JP2012040330A patent/JP2012107057A/ja active Pending
- 2012-10-10 JP JP2012225028A patent/JP6288907B2/ja active Active
-
2013
- 2013-08-08 US US13/962,369 patent/US20140073666A1/en not_active Abandoned
- 2013-08-08 US US13/962,440 patent/US20140099387A1/en not_active Abandoned
- 2013-10-03 US US14/045,131 patent/US9045457B2/en active Active
- 2013-10-03 US US14/045,159 patent/US10188641B2/en active Active
-
2014
- 2014-05-12 US US14/275,159 patent/US9045458B2/en active Active
- 2014-05-12 US US14/275,241 patent/US9051297B2/en active Active
-
2015
- 2015-01-30 US US14/610,401 patent/US20150140082A1/en not_active Abandoned
- 2015-01-30 US US14/610,338 patent/US20150140081A1/en not_active Abandoned
- 2015-01-30 US US14/610,251 patent/US20150152090A1/en not_active Abandoned
- 2015-01-30 US US14/609,795 patent/US20150216857A1/en not_active Abandoned
- 2015-01-30 US US14/610,043 patent/US20150140078A1/en not_active Abandoned
- 2015-01-30 US US14/610,346 patent/US20150175578A1/en not_active Abandoned
- 2015-01-30 US US14/610,464 patent/US20150174119A1/en not_active Abandoned
- 2015-01-30 US US14/610,182 patent/US20150140079A1/en not_active Abandoned
- 2015-01-30 US US14/609,743 patent/US20150140075A1/en not_active Abandoned
- 2015-01-30 US US14/610,291 patent/US20150140080A1/en not_active Abandoned
- 2015-01-30 US US14/610,414 patent/US20150175580A1/en not_active Abandoned
- 2015-01-30 US US14/609,967 patent/US20150182520A1/en not_active Abandoned
- 2015-01-30 US US14/610,318 patent/US20150175577A1/en not_active Abandoned
- 2015-01-30 US US14/610,465 patent/US20150175581A1/en not_active Abandoned
- 2015-01-30 US US14/610,370 patent/US20150175579A1/en not_active Abandoned
- 2015-01-30 US US14/609,998 patent/US20150140077A1/en not_active Abandoned
- 2015-01-30 US US14/609,770 patent/US20150140076A1/en not_active Abandoned
- 2015-07-09 JP JP2015137500A patent/JP2015187165A/ja not_active Withdrawn
-
2016
- 2016-11-21 US US15/357,237 patent/US20170143690A1/en not_active Abandoned
- 2016-11-30 US US15/364,935 patent/US20170143691A1/en not_active Abandoned
- 2016-12-08 US US15/372,863 patent/US20170143692A1/en not_active Abandoned
- 2016-12-09 US US15/373,604 patent/US20170143693A1/en not_active Abandoned
-
2017
- 2017-02-24 CY CY20171100257T patent/CY1118660T1/el unknown
- 2017-05-18 JP JP2017099005A patent/JP2017141297A/ja not_active Withdrawn
-
2019
- 2019-02-12 JP JP2019022433A patent/JP6816180B2/ja active Active
-
2020
- 2020-02-26 JP JP2020030710A patent/JP2020079312A/ja active Pending
-
2022
- 2022-07-27 US US17/815,256 patent/US20230233551A1/en active Pending