JP2011522913A - オキアミ油加工方法 - Google Patents
オキアミ油加工方法 Download PDFInfo
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- JP2011522913A JP2011522913A JP2011509430A JP2011509430A JP2011522913A JP 2011522913 A JP2011522913 A JP 2011522913A JP 2011509430 A JP2011509430 A JP 2011509430A JP 2011509430 A JP2011509430 A JP 2011509430A JP 2011522913 A JP2011522913 A JP 2011522913A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
- A23D9/013—Other fatty acid esters, e.g. phosphatides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B7/00—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
- C11B7/0083—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils with addition of auxiliary substances, e.g. cristallisation promotors, filter aids, melting point depressors
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Insects & Arthropods (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
Abstract
Description
本発明の主たる目的は,不飽和の程度にしたがって作用する分離技術(尿素分画)を用いることなく,あるいはそのような技術を少しだけ用いることにより,高濃度のオメガ−3脂肪酸を含む組成物を製造する方法を提供することである。
本発明にしたがえば,高濃度のオメガ−3脂肪酸を含む組成物を製造する方法が提供され,この方法は,上述の国際出願PCT/NO2007/000402にしたがって得られたオキアミ脂質画分を短行程蒸留,または超臨界流体抽出,クロマトグラフィー,またはこれらの組み合わせの1またはそれ以上の工程に供する工程を含む。
Claims (38)
- 高濃度のオメガ−3脂肪酸を含む組成物を製造する方法であって,
a)オキアミ生材料の含水量を低下させ;および
b)脂質画分を単離して新鮮なオキアミからの実質的に総脂質画分を取得し;そして
前記脂質画分を短行程蒸留に供し;または超臨界流体抽出,クロマトグラフィー,またはこれらの組み合わせの1またはそれ以上の工程に供する,
の各工程を含む方法。 - 工程a)は,オキアミ原料を1:0.5から1:5の重量比のエタノール,メタノール,プロパノールまたはイソプロパノールで洗浄することを含み;および工程b)はアルコールから脂質画分を単離することを含む,請求項1記載の方法。
- 工程a)はオキアミ原料をエタノールで洗浄することを含み,および工程b)はエタノールから脂質画分を単離することを含む,請求項1または2記載の方法。
- a−1)工程a)からの水分減少オキアミ材料を,エタノール,メタノール,プロパノールまたはイソプロパノールを含むCO2で超臨界圧で抽出する追加の工程を含む,請求項1−3のいずれかに記載の方法。
- オキアミ原料を洗浄する前に60−100℃に加熱する,請求項1−4のいずれかに記載の方法。
- オキアミ原料を洗浄する前に70−100℃に加熱する,請求項5記載の方法。
- オキアミ原料を洗浄する前に80−95℃に加熱する,請求項5または6記載の方法。
- オキアミ原料を洗浄する前にマイクロ波を用いて前処理する,請求項1−4のいずれかに記載の方法。
- 2種類の抽出物,すなわち,第1に工程a)におけるオキアミの洗浄からの溶媒からオメガ−3脂肪酸の豊富な抽出物,および第2に工程b)における残留オキアミ材料からの残留溶媒の除去によりオメガ−3脂肪酸の少ない抽出物が得られる,請求項1−8のいずれかに記載の方法。
- 工程b)におけるオキアミ材料からの残留溶媒の除去は,プレスまたは遠心分離によって行われる,請求項9記載の方法。
- 短行程蒸留は1工程または2工程短行程蒸留である,請求項1−10のいずれかに記載の方法。
- 得られた組成物を温和な尿素分画に供する追加の工程を含む,請求項1−11のいずれかに記載の方法。
- 尿素/エチルエステルの比率は0.1−1.5である,請求項12記載の方法。
- 尿素/エチルエステルの比率は0.5−1.0である,請求項13記載の方法。
- 得られた組成物を最終短行程蒸留に供する追加の工程を含む,請求項12記載の方法。
- 請求項1−15のいずれかに記載の方法により得ることができる高濃度のオメガ−3脂肪酸を含む組成物。
- 脂質組成物は,少なくとも80重量%のエイコサペンタエン酸(EPA)および/またはドコサヘキサエン酸(DHA)を含む,請求項16記載の組成物。
- 脂質組成物は,少なくとも90重量%のオメガ−3脂肪酸を含む,請求項16または17記載の組成物。
- エイコサペンタエン酸(EPA)対ドコサヘキサエン酸(DHA)の重量比は1:2から2:1である,請求項16−18のいずれかに記載の組成物。
- 組成物は,EPAおよびDHAの組み合わせを含む,請求項16−19のいずれかに記載の組成物。
- EPAおよび/またはDHAは,酸またはエステルの形で,好ましくはエチルエステルとして存在する,請求項16−20のいずれかに記載の組成物。
- 脂質組成物は,Lovaza(商標)またはOmacor(登録商標)の製品ラベルで定義される脂肪酸組成物と類似するものである,請求項16−21のいずれかに記載の組成物。
- 主要活性成分は,Lovaza(商標)またはOmacor(登録商標)の製品ラベルで定義されるとおりである,請求項22記載の組成物。
- 組成物は,高濃度のオメガ−3脂肪酸および低濃度のオメガ−6脂肪酸を含む,請求項16記載の組成物。
- オメガ−3/オメガ−6の比率は30より多い,請求項24記載の組成物。
- オメガ−3/オメガ−6の比率は40より多い,請求項25記載の組成物。
- オメガ−3/オメガ−6の比率は50より多い,請求項26記載の組成物。
- 脂肪酸C22:5n−6の濃度は0.8%未満である,請求項16記載の組成物。
- 鎖長C14およびC16の:脂肪酸を25重量%より多い量で含み;およびEPAおよび/またはDHAを30重量%より多い量で含む,オキアミからの脂質画分。
- EPAおよび/またはDHAの量は35重量%より多い,請求項29記載の脂質画分。
- EPAおよび/またはDHAの量は40重量%より多い,請求項29記載の脂質画分。
- 脂肪酸C22:5n−6を実質的に含まない,請求項29記載の脂質画分。
- 前記画分はオキアミ油サプリメント製品である,請求項29−32のいずれかに記載の脂質画分。
- 前記画分は,高濃度オメガ−3酸またはエステル製品を製造するために,追加の工程において出発材料として用いられる,請求項29−32のいずれかに記載の脂質画分。
- オメガ−3サプリメント製品または医薬組成物を製造するための出発材料としての,請求項29−34のいずれかに記載の脂質画分の使用。
- 請求項1−15のいずれかに記載の方法により得ることができる脂質画分。
- 前記画分は医薬組成物である,請求項36記載の脂質画分。
- 脂肪酸C22:5n−6を実質的に含まない,請求項36記載の脂質画分。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5345508P | 2008-05-15 | 2008-05-15 | |
US61/053,455 | 2008-05-15 | ||
PCT/NO2009/000184 WO2009139641A1 (en) | 2008-05-15 | 2009-05-15 | Krill oil process |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2011522913A true JP2011522913A (ja) | 2011-08-04 |
Family
ID=41318881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011509430A Pending JP2011522913A (ja) | 2008-05-15 | 2009-05-15 | オキアミ油加工方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8829215B2 (ja) |
EP (1) | EP2291499B1 (ja) |
JP (1) | JP2011522913A (ja) |
KR (1) | KR20110021886A (ja) |
CN (1) | CN102099451B (ja) |
BR (1) | BRPI0912749A2 (ja) |
CA (1) | CA2724463C (ja) |
MX (1) | MX2010012482A (ja) |
WO (1) | WO2009139641A1 (ja) |
Cited By (2)
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WO2013172346A1 (ja) * | 2012-05-14 | 2013-11-21 | 日本水産株式会社 | 環境汚染物質を低減させた高度不飽和脂肪酸又は高度不飽和脂肪酸エチルエステル及びその製造方法 |
US11330817B2 (en) | 2013-12-04 | 2022-05-17 | Nippon Suisan Kaisha, Ltd. | Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil |
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WO2013172346A1 (ja) * | 2012-05-14 | 2013-11-21 | 日本水産株式会社 | 環境汚染物質を低減させた高度不飽和脂肪酸又は高度不飽和脂肪酸エチルエステル及びその製造方法 |
JPWO2013172346A1 (ja) * | 2012-05-14 | 2016-01-12 | 日本水産株式会社 | 環境汚染物質を低減させた高度不飽和脂肪酸又は高度不飽和脂肪酸エチルエステル及びその製造方法 |
US9540306B2 (en) | 2012-05-14 | 2017-01-10 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
US10399922B2 (en) | 2012-05-14 | 2019-09-03 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
US10399923B2 (en) | 2012-05-14 | 2019-09-03 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
US11034643B2 (en) | 2012-05-14 | 2021-06-15 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
EP2851361B1 (en) | 2012-05-14 | 2021-11-24 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
US11603347B2 (en) | 2012-05-14 | 2023-03-14 | Nippon Suisan Kaisha, Ltd. | Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same |
US11330817B2 (en) | 2013-12-04 | 2022-05-17 | Nippon Suisan Kaisha, Ltd. | Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil |
US11856952B2 (en) | 2013-12-04 | 2024-01-02 | Nippon Suisan Kaisha, Ltd. | Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil |
Also Published As
Publication number | Publication date |
---|---|
CN102099451B (zh) | 2015-07-15 |
KR20110021886A (ko) | 2011-03-04 |
WO2009139641A1 (en) | 2009-11-19 |
MX2010012482A (es) | 2010-12-01 |
BRPI0912749A2 (pt) | 2017-05-23 |
CN102099451A (zh) | 2011-06-15 |
EP2291499B1 (en) | 2020-02-12 |
CA2724463A1 (en) | 2009-11-19 |
EP2291499A4 (en) | 2017-05-24 |
EP2291499A1 (en) | 2011-03-09 |
US20110130458A1 (en) | 2011-06-02 |
CA2724463C (en) | 2017-10-03 |
US8829215B2 (en) | 2014-09-09 |
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