JP2011521964A5 - - Google Patents
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- JP2011521964A5 JP2011521964A5 JP2011511822A JP2011511822A JP2011521964A5 JP 2011521964 A5 JP2011521964 A5 JP 2011521964A5 JP 2011511822 A JP2011511822 A JP 2011511822A JP 2011511822 A JP2011511822 A JP 2011511822A JP 2011521964 A5 JP2011521964 A5 JP 2011521964A5
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 201000006938 muscular dystrophy Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- 208000019693 Lung disease Diseases 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 206010003011 Appendicitis Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical group CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 241001317099 Dystaxia Species 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims 1
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 1
- 208000001362 Fetal Growth Retardation Diseases 0.000 claims 1
- 206010070531 Foetal growth restriction Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000022461 Glomerular disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000000203 Hyaline Membrane Disease Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 208000032571 Infant acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000008450 Intracranial aneurysm Diseases 0.000 claims 1
- 206010024238 Leptospirosis Diseases 0.000 claims 1
- 208000004852 Lung Injury Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 206010028974 Neonatal respiratory distress syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000013200 Stress disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010069363 Traumatic lung injury Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000001925 catabolic effect Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000002169 ectodermal dysplasia Diseases 0.000 claims 1
- 208000031068 ectodermal dysplasia syndrome Diseases 0.000 claims 1
- 208000030941 fetal growth restriction Diseases 0.000 claims 1
- 231100000852 glomerular disease Toxicity 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000025070 hereditary periodic fever syndrome Diseases 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 231100000515 lung injury Toxicity 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000003239 periodontal effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000010346 psychosocial stress Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 150000003456 sulfonamides Chemical group 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5671508P | 2008-05-28 | 2008-05-28 | |
| US61/056,715 | 2008-05-28 | ||
| PCT/US2009/045489 WO2009155056A2 (en) | 2008-05-28 | 2009-05-28 | Non-hormonal steroid modulators of nf-kb for treatment of disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015116880A Division JP6204408B2 (ja) | 2008-05-28 | 2015-06-09 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521964A JP2011521964A (ja) | 2011-07-28 |
| JP2011521964A5 true JP2011521964A5 (enExample) | 2012-07-12 |
| JP5780521B2 JP5780521B2 (ja) | 2015-09-16 |
Family
ID=41434650
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511822A Active JP5780521B2 (ja) | 2008-05-28 | 2009-05-28 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
| JP2015116880A Active JP6204408B2 (ja) | 2008-05-28 | 2015-06-09 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
| JP2017167132A Active JP6356888B2 (ja) | 2008-05-28 | 2017-08-31 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015116880A Active JP6204408B2 (ja) | 2008-05-28 | 2015-06-09 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
| JP2017167132A Active JP6356888B2 (ja) | 2008-05-28 | 2017-08-31 | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
Country Status (25)
| Country | Link |
|---|---|
| US (9) | US8207151B2 (enExample) |
| EP (5) | EP2805720B1 (enExample) |
| JP (3) | JP5780521B2 (enExample) |
| KR (3) | KR101749032B1 (enExample) |
| CN (3) | CN102076344B (enExample) |
| AU (1) | AU2009260471B2 (enExample) |
| BR (1) | BRPI0909564B8 (enExample) |
| CA (1) | CA2725008C (enExample) |
| CY (2) | CY1121984T1 (enExample) |
| DK (3) | DK2278978T3 (enExample) |
| ES (3) | ES2744879T3 (enExample) |
| FI (1) | FIC20240018I1 (enExample) |
| FR (1) | FR24C1021I2 (enExample) |
| HK (1) | HK1201184A1 (enExample) |
| HR (1) | HRP20191455T1 (enExample) |
| HU (4) | HUE027715T2 (enExample) |
| LT (2) | LT2805720T (enExample) |
| MX (1) | MX2010012976A (enExample) |
| NL (1) | NL301273I2 (enExample) |
| NZ (2) | NZ589444A (enExample) |
| PL (1) | PL2805720T3 (enExample) |
| PT (1) | PT2805720T (enExample) |
| SI (1) | SI2805720T1 (enExample) |
| WO (1) | WO2009155056A2 (enExample) |
| ZA (1) | ZA201008256B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5780521B2 (ja) | 2008-05-28 | 2015-09-16 | リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
| EP2556083A4 (en) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT |
| WO2013082253A2 (en) * | 2011-11-29 | 2013-06-06 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of nf-kb for treatment of disease |
| CN103509075A (zh) * | 2012-06-29 | 2014-01-15 | 中国药科大学 | 一种制备二氟泼尼酯的方法 |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| PT3319612T (pt) * | 2015-07-06 | 2021-08-24 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| IL264561A (en) * | 2019-01-31 | 2020-08-31 | Lydus Medical Ltd | device for anastomosis |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
| US20240350492A1 (en) | 2020-07-10 | 2024-10-24 | Ting Therapeutics Llc | Methods for the Prevention and Treatment of Hearing Loss |
| EP4413976B1 (en) * | 2023-02-07 | 2025-08-13 | Santhera Pharmaceuticals (Schweiz) AG | A new vamorolone preparation exhibiting improved solubility |
Family Cites Families (142)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US619456A (en) * | 1899-02-14 | Adjustable partition-frame for trunks | ||
| GB787410A (en) | 1954-05-21 | 1957-12-11 | Pfizer & Co C | Improvements in or relating to steroid compounds and the preparation thereof |
| GB843215A (en) | 1954-10-05 | 1960-08-04 | Schering Corp | Improvements in or relating to steroid compounds |
| GB843214A (en) | 1955-01-11 | 1960-08-04 | Schering Corp | Improvements in or relating to steroid compounds |
| US2957893A (en) | 1955-01-20 | 1960-10-25 | Schering Corp | delta1, 4, 9(11)-pregnatrienes |
| US2776927A (en) | 1955-12-27 | 1957-01-08 | Pfizer & Co C | Preparation of delta 1, 4-3-keto steroids from delta4 3-keto steroids by protaminobacter |
| US3164618A (en) | 1957-07-22 | 1965-01-05 | Schering Corp | Alkylated steroids |
| US2838536A (en) | 1957-11-29 | 1958-06-10 | Upjohn Co | 6-fluoro 9 alpha-halo-delta4-pregnenes and process for preparing same |
| GB912379A (en) | 1958-06-19 | 1962-12-05 | Merck & Co Inc | Steroid compounds |
| GB928302A (en) | 1958-06-20 | 1963-06-12 | Scherico Ltd | í¸-pregnene compounds |
| US2894963A (en) | 1958-06-20 | 1959-07-14 | Scherico Ltd | 9,11-dihalogeno-4-pregnenes and 1,4-pregnadienes |
| US2980713A (en) | 1958-09-05 | 1961-04-18 | Merck & Co Inc | 16-methyl-3alpha, 17alpha-dihydroxy steroids of the pregnane series |
| US3098086A (en) | 1959-01-22 | 1963-07-16 | Ciba Geigy Corp | Process for the manufacture of 11beta-hydroxy-pregnane compounds |
| US3009933A (en) | 1959-06-01 | 1961-11-21 | Schering Corp | Process for the manufacture of 9alpha, 11beta-dihalogenated steroids |
| FR1433301A (fr) | 1959-06-12 | 1966-04-01 | Merck & Co Inc | Procédé de préparation de composés de 16alpha-méthyl, 1, 4-prégnadiène |
| US3004965A (en) | 1959-08-07 | 1961-10-17 | Smith Kline French Lab | Process and intermediates for preparing steroidal 17->18 lactones |
| GB959377A (en) | 1959-10-12 | 1964-06-03 | Scherico Ltd | Dioxy steroids and processes for their preparation |
| FR1363865A (fr) | 1960-06-16 | 1964-06-19 | Roussel Uclaf | Nouveaux stéroïdes polyhydroxylés et obtention de ces composés |
| US3053866A (en) | 1961-03-02 | 1962-09-11 | Merck & Co Inc | Improved steroid dehydrogenation process |
| US3127425A (en) | 1961-05-29 | 1964-03-31 | Schering Corp | 6, 17alpha-disubstituted 9alpha, 11beta-dihalogeno derivatives of a-ring unsaturated pregnane 3, 20-diones |
| US3047468A (en) | 1961-06-06 | 1962-07-31 | American Cyanamid Co | Method of preparing delta1, 4-3-keto steroids of the pregnane series |
| US3087938A (en) | 1961-08-02 | 1963-04-30 | Schering Corp | 17alpha-chloro and 17alpha-bromo-progesterones |
| US3284477A (en) | 1963-07-10 | 1966-11-08 | Schering Corp | Diuretic 1, 4, 9(11)-pregnatrienes |
| US3463852A (en) * | 1966-01-14 | 1969-08-26 | Schering Corp | Treating allergies with steroids of the pregnane series |
| DE1938218C3 (de) | 1969-07-24 | 1978-10-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 9 a,21,21-Trichlor-ll ß-fluor- pregnene, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel |
| HU164115B (enExample) | 1971-05-07 | 1973-12-28 | ||
| BE785812A (fr) | 1971-07-05 | 1973-01-04 | Glaxo Lab Ltd | Nouveaux composes steroides |
| BE795243A (fr) | 1972-02-11 | 1973-08-09 | Schering Ag | Procede de preparation de steroides insatures en 16,17 |
| GB1440063A (en) | 1972-08-11 | 1976-06-23 | Glaxo Lab Ltd | 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids |
| FR2244530B1 (enExample) * | 1973-07-27 | 1977-07-01 | Roussel Uclaf | |
| US4041055A (en) | 1975-11-17 | 1977-08-09 | The Upjohn Company | Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes |
| ES445981A1 (es) | 1976-03-11 | 1977-06-01 | Aldo Union Calzada Y Cia S R C | Procedimiento para la preparacion de un compuesto intermedioen la sintesis de 9 alfa-halogeno-16 beta-metil-prednisolo- na. |
| GB1544642A (en) | 1976-06-04 | 1979-04-25 | Bristol Myers Co | 9,11-epoxy steroids and synthesis of corticosteroids therefrom |
| US4076708A (en) | 1976-12-22 | 1978-02-28 | Schering Corporation | Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby |
| DE2748442C3 (de) | 1977-10-26 | 1981-08-27 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel |
| US4427591A (en) | 1980-01-31 | 1984-01-24 | The Upjohn Company | Reduced A ring-Δ9(11) -corticoids |
| US4336200A (en) | 1980-01-31 | 1982-06-22 | The Upjohn Company | 17α-Acyloxy-5β-corticoids |
| US4444689A (en) | 1980-01-31 | 1984-04-24 | The Upjohn Company | 17α-Acyloxy-5β-corticoids and 17α-acyloxy-5α-corticoids |
| US4318853A (en) | 1980-01-31 | 1982-03-09 | The Upjohn Company | 9β,11β-Epoxy-5β-corticoids |
| ZA817929B (en) | 1980-12-22 | 1982-10-27 | Upjohn Co | 5alpha-and 5beta-androstane-17beta-carboxylates |
| EP0057401B1 (en) | 1981-02-02 | 1984-08-01 | Schering Corporation | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
| DE3109459A1 (de) | 1981-03-09 | 1982-09-23 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden |
| DE3373189D1 (en) | 1982-06-21 | 1987-10-01 | Dainippon Ink & Chemicals | Process for preparation of steroids |
| DE3227312A1 (de) | 1982-07-19 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung |
| DE3322120A1 (de) * | 1982-07-30 | 1984-02-02 | The Upjohn Co., 49001 Kalamazoo, Mich. | Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide |
| DE3243482A1 (de) * | 1982-11-22 | 1984-05-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6(alpha)-methylkortikoide, ihre herstellung und verwendung |
| US4994443A (en) | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| US5001116A (en) | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| DE3373782D1 (en) | 1982-12-20 | 1987-10-29 | Harvard College | Inhibition of angiogenesis |
| DE3315722A1 (de) | 1983-04-27 | 1984-10-31 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von 3-oxo-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch),(pfeil hoch)(pfeil hoch)4(pfeil hoch)-steroiden |
| DE3401680A1 (de) | 1984-01-16 | 1985-07-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6(alpha),16ss-dimethylkortikoide |
| DE3409554A1 (de) | 1984-03-13 | 1985-09-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6(alpha)-methyl-d-homo-kortikoide |
| US4948533A (en) | 1984-03-28 | 1990-08-14 | The Upjohn Company | 11a-hydroxy steroid diester |
| CA1310009C (en) | 1984-03-28 | 1992-11-10 | John Mark Braughler | Ester prodrugs of steroids |
| US4990612A (en) | 1984-06-11 | 1991-02-05 | The Upjohn Company | 16α-methylation process |
| JPS611699A (ja) | 1984-06-11 | 1986-01-07 | ジ アツプジヨン カンパニー | １６α‐メチル化法 |
| US4613463A (en) | 1984-11-01 | 1986-09-23 | The Upjohn Company | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid |
| WO1987001706A2 (en) | 1985-09-12 | 1987-03-26 | The Upjohn Company | C20 through c26 amino steroids |
| US4975537A (en) | 1985-10-23 | 1990-12-04 | The Upjohn Company | Δ9(11) -angiostatic steroids |
| US4771042A (en) | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| CN87104859A (zh) | 1986-06-19 | 1988-04-27 | Mba服务有限公司 | 带状电缆传输系统 |
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