PL2805720T3 - Niehormonalne steroidowe modulatory nf-kb do leczenia choroby - Google Patents

Niehormonalne steroidowe modulatory nf-kb do leczenia choroby

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Publication number
PL2805720T3
PL2805720T3 PL14173342T PL14173342T PL2805720T3 PL 2805720 T3 PL2805720 T3 PL 2805720T3 PL 14173342 T PL14173342 T PL 14173342T PL 14173342 T PL14173342 T PL 14173342T PL 2805720 T3 PL2805720 T3 PL 2805720T3
Authority
PL
Poland
Prior art keywords
disease
treatment
hormonal steroid
steroid modulators
modulators
Prior art date
Application number
PL14173342T
Other languages
English (en)
Inventor
John M Mccall
Eric Hoffman
Nagaraju Kanneboyina
Original Assignee
Reveragen Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reveragen Biopharma Inc filed Critical Reveragen Biopharma Inc
Publication of PL2805720T3 publication Critical patent/PL2805720T3/pl

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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PL14173342T 2008-05-28 2009-05-28 Niehormonalne steroidowe modulatory nf-kb do leczenia choroby PL2805720T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5671508P 2008-05-28 2008-05-28
PCT/US2009/045489 WO2009155056A2 (en) 2008-05-28 2009-05-28 Non-hormonal steroid modulators of nf-kb for treatment of disease
EP09767367.7A EP2278978B1 (en) 2008-05-28 2009-05-28 Non-hormonal steroid modulators of nf-kb for treatment of disease
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CN103739647A (zh) 2014-04-23
CN103536599A (zh) 2014-01-29
LT2805720T (lt) 2019-09-25
EP2805720B1 (en) 2019-08-07
JP2015172072A (ja) 2015-10-01
US20190125763A1 (en) 2019-05-02
US8207151B2 (en) 2012-06-26
DK2444092T3 (en) 2015-09-28
SI2805720T1 (sl) 2019-11-29
US9649320B2 (en) 2017-05-16
US20140142078A1 (en) 2014-05-22
US20120094970A1 (en) 2012-04-19
WO2009155056A2 (en) 2009-12-23
CA2725008C (en) 2017-09-05
JP6356888B2 (ja) 2018-07-11
KR101749032B1 (ko) 2017-06-20
DK2805720T3 (da) 2019-09-02
BRPI0909564B8 (pt) 2021-05-25
US20170027959A1 (en) 2017-02-02
US10857161B2 (en) 2020-12-08
CN102076344A (zh) 2011-05-25
HUE027463T2 (en) 2016-09-28
EP2444092B1 (en) 2015-09-02
US20180015104A1 (en) 2018-01-18
EP2444092A1 (en) 2012-04-25
ES2548138T3 (es) 2015-10-14
EP2278978B1 (en) 2015-09-02
EP2278978A2 (en) 2011-02-02
US8334279B2 (en) 2012-12-18
AU2009260471A1 (en) 2009-12-23
US20100087408A1 (en) 2010-04-08
US11833159B2 (en) 2023-12-05
BRPI0909564B1 (pt) 2021-03-09
CN102076344B (zh) 2013-11-13
MX2010012976A (es) 2011-05-31
HK1201184A1 (en) 2015-08-28
EP3656385A1 (en) 2020-05-27
ZA201008256B (en) 2011-07-27
HUE046243T2 (hu) 2020-02-28
KR20170013406A (ko) 2017-02-06
HUE027715T2 (en) 2016-10-28
EP2805720A1 (en) 2014-11-26
JP2017206563A (ja) 2017-11-24
US10206933B2 (en) 2019-02-19

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