JP2011512848A5 - - Google Patents
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- JP2011512848A5 JP2011512848A5 JP2010549897A JP2010549897A JP2011512848A5 JP 2011512848 A5 JP2011512848 A5 JP 2011512848A5 JP 2010549897 A JP2010549897 A JP 2010549897A JP 2010549897 A JP2010549897 A JP 2010549897A JP 2011512848 A5 JP2011512848 A5 JP 2011512848A5
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- JP
- Japan
- Prior art keywords
- coa
- dehydrogenase
- naturally occurring
- item
- organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 244000005700 microbiome Species 0.000 claims description 87
- 108090000623 proteins and genes Proteins 0.000 claims description 86
- 102000004190 Enzymes Human genes 0.000 claims description 63
- 108090000790 Enzymes Proteins 0.000 claims description 63
- 108020004707 nucleic acids Proteins 0.000 claims description 62
- 150000007523 nucleic acids Chemical class 0.000 claims description 62
- 102000039446 nucleic acids Human genes 0.000 claims description 62
- 230000037361 pathway Effects 0.000 claims description 56
- 230000004136 fatty acid synthesis Effects 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 48
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims description 41
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 238000004519 manufacturing process Methods 0.000 claims description 27
- 125000002252 acyl group Chemical group 0.000 claims description 23
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 20
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 20
- 150000003138 primary alcohols Chemical class 0.000 claims description 17
- 102000052553 3-Hydroxyacyl CoA Dehydrogenase Human genes 0.000 claims description 16
- 108700020831 3-Hydroxyacyl-CoA Dehydrogenase Proteins 0.000 claims description 16
- 108090001018 hexadecanal dehydrogenase (acylating) Proteins 0.000 claims description 16
- 108010087894 Fatty acid desaturases Proteins 0.000 claims description 14
- 102000009114 Fatty acid desaturases Human genes 0.000 claims description 14
- 108700016155 Acyl transferases Proteins 0.000 claims description 13
- 102000057234 Acyl transferases Human genes 0.000 claims description 13
- 102000004316 Oxidoreductases Human genes 0.000 claims description 13
- 108090000854 Oxidoreductases Proteins 0.000 claims description 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 13
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 13
- 108060008225 Thiolase Proteins 0.000 claims description 13
- 102000002932 Thiolase Human genes 0.000 claims description 13
- 210000003470 mitochondria Anatomy 0.000 claims description 13
- 102000008146 Acetate-CoA ligase Human genes 0.000 claims description 12
- 108010049926 Acetate-CoA ligase Proteins 0.000 claims description 12
- 210000000172 cytosol Anatomy 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 12
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 10
- 101710088194 Dehydrogenase Proteins 0.000 claims description 9
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims description 9
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 150000001298 alcohols Chemical class 0.000 claims description 8
- 238000012258 culturing Methods 0.000 claims description 8
- 230000002438 mitochondrial effect Effects 0.000 claims description 8
- 241000206602 Eukaryota Species 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 230000001086 cytosolic effect Effects 0.000 claims description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical class CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 6
- 102000000587 Glycerolphosphate Dehydrogenase Human genes 0.000 claims description 6
- 108010041921 Glycerolphosphate Dehydrogenase Proteins 0.000 claims description 6
- 108010086428 NADH Dehydrogenase Proteins 0.000 claims description 6
- 102000006746 NADH Dehydrogenase Human genes 0.000 claims description 6
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims description 6
- 101000636911 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial Proteins 0.000 claims description 6
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims description 6
- 238000012217 deletion Methods 0.000 claims description 6
- 230000037430 deletion Effects 0.000 claims description 6
- 125000004050 enoyl group Chemical group 0.000 claims description 6
- -1 fatty acid ester Chemical class 0.000 claims description 6
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 6
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 5
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims description 5
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 5
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 5
- 241000235527 Rhizopus Species 0.000 claims description 5
- 244000253911 Saccharomyces fragilis Species 0.000 claims description 5
- 235000018368 Saccharomyces fragilis Nutrition 0.000 claims description 5
- 229940031154 kluyveromyces marxianus Drugs 0.000 claims description 5
- 101710185553 Malate dehydrogenase, cytoplasmic Proteins 0.000 claims description 4
- 102100026475 Malate dehydrogenase, cytoplasmic Human genes 0.000 claims description 4
- 240000005384 Rhizopus oryzae Species 0.000 claims description 4
- 235000013752 Rhizopus oryzae Nutrition 0.000 claims description 4
- 241000235070 Saccharomyces Species 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 108010092060 Acetate kinase Proteins 0.000 claims description 3
- 241000228212 Aspergillus Species 0.000 claims description 3
- 241000228245 Aspergillus niger Species 0.000 claims description 3
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims description 3
- 108090000698 Formate Dehydrogenases Proteins 0.000 claims description 3
- 108010036781 Fumarate Hydratase Proteins 0.000 claims description 3
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims description 3
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims description 3
- 241001138401 Kluyveromyces lactis Species 0.000 claims description 3
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 3
- 102000004317 Lyases Human genes 0.000 claims description 3
- 108090000856 Lyases Proteins 0.000 claims description 3
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 claims description 3
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims description 3
- 102000001253 Protein Kinase Human genes 0.000 claims description 3
- 108010042687 Pyruvate Oxidase Proteins 0.000 claims description 3
- 108010031852 Pyruvate Synthase Proteins 0.000 claims description 3
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims description 3
- 102000019259 Succinate Dehydrogenase Human genes 0.000 claims description 3
- 108010012901 Succinate Dehydrogenase Proteins 0.000 claims description 3
- 108010065064 acetaldehyde dehydrogenase (acylating) Proteins 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 3
- CNNRFBWVTKFGRE-UHFFFAOYSA-N formic acid;2-oxopropanoic acid Chemical compound OC=O.CC(=O)C(O)=O CNNRFBWVTKFGRE-UHFFFAOYSA-N 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 3
- 101710082056 Ethanol acetyltransferase 1 Proteins 0.000 claims description 2
- 150000002185 fatty acyl-CoAs Chemical class 0.000 claims description 2
- 108010062385 long-chain-alcohol O-fatty-acyltransferase Proteins 0.000 claims description 2
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 description 8
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 6
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 6
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 6
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 6
- ZWRUINPWMLAQRD-UHFFFAOYSA-N nonan-1-ol Chemical compound CCCCCCCCCO ZWRUINPWMLAQRD-UHFFFAOYSA-N 0.000 description 6
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 6
- 101150040763 PDC3 gene Proteins 0.000 description 4
- 101100054948 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH4 gene Proteins 0.000 description 4
- 101100054950 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH5 gene Proteins 0.000 description 4
- 101100393304 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GPD1 gene Proteins 0.000 description 4
- 101100393309 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GPD2 gene Proteins 0.000 description 4
- 101100069218 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GUT2 gene Proteins 0.000 description 4
- 101100290494 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) MDH2 gene Proteins 0.000 description 4
- 101100348117 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NDE1 gene Proteins 0.000 description 4
- 101100348120 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NDE2 gene Proteins 0.000 description 4
- 101100459997 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NDI1 gene Proteins 0.000 description 4
- 101100082596 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC5 gene Proteins 0.000 description 4
- 101100519200 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC6 gene Proteins 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 101100434411 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH1 gene Proteins 0.000 description 3
- 101100082579 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC1 gene Proteins 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- 241001465318 Aspergillus terreus Species 0.000 description 2
- 101100433695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) AAD16 gene Proteins 0.000 description 2
- 101100054940 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH3 gene Proteins 0.000 description 2
- 101100001024 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH6 gene Proteins 0.000 description 2
- 101100001028 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADH7 gene Proteins 0.000 description 2
- 101100493787 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BDH2 gene Proteins 0.000 description 2
- 101100462087 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) LAT1 gene Proteins 0.000 description 2
- 101100009692 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) LPD1 gene Proteins 0.000 description 2
- 101100350214 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDA1 gene Proteins 0.000 description 2
- 101100027944 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDB1 gene Proteins 0.000 description 2
- 101100518193 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDX1 gene Proteins 0.000 description 2
- 101100502339 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SFA1 gene Proteins 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 1
- 230000009331 reductive pathway Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3414608P | 2008-03-05 | 2008-03-05 | |
| US61/034,146 | 2008-03-05 | ||
| US9017108P | 2008-08-19 | 2008-08-19 | |
| US61/090,171 | 2008-08-19 | ||
| US11050008P | 2008-10-31 | 2008-10-31 | |
| US61/110,500 | 2008-10-31 | ||
| PCT/US2009/036242 WO2009111672A1 (en) | 2008-03-05 | 2009-03-05 | Primary alcohol producing organisms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014042892A Division JP2014100147A (ja) | 2008-03-05 | 2014-03-05 | 第一級アルコールを産生する生物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011512848A JP2011512848A (ja) | 2011-04-28 |
| JP2011512848A5 true JP2011512848A5 (https=) | 2012-04-05 |
| JP5755884B2 JP5755884B2 (ja) | 2015-07-29 |
Family
ID=41056374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549897A Expired - Fee Related JP5755884B2 (ja) | 2008-03-05 | 2009-03-05 | 第一級アルコールを産生する生物 |
| JP2014042892A Withdrawn JP2014100147A (ja) | 2008-03-05 | 2014-03-05 | 第一級アルコールを産生する生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014042892A Withdrawn JP2014100147A (ja) | 2008-03-05 | 2014-03-05 | 第一級アルコールを産生する生物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7977084B2 (https=) |
| EP (2) | EP2262901B1 (https=) |
| JP (2) | JP5755884B2 (https=) |
| BR (1) | BRPI0909690A2 (https=) |
| CA (2) | CA3081506A1 (https=) |
| DK (1) | DK2262901T3 (https=) |
| ES (1) | ES2703775T3 (https=) |
| PL (1) | PL2262901T3 (https=) |
| SI (1) | SI2262901T1 (https=) |
| WO (1) | WO2009111672A1 (https=) |
| ZA (1) | ZA201007065B (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| DK2262901T3 (en) | 2008-03-05 | 2019-01-21 | Genomatica Inc | ORGANISMS PRODUCING PRIMARY ALCOHOL |
| CA3101888A1 (en) | 2008-05-16 | 2009-11-19 | REG Life Sciences, LLC | Methods and compositions for producing hydrocarbons |
| BRPI0913901A2 (pt) | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| KR101717569B1 (ko) | 2008-10-07 | 2017-03-17 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알데히드를 생산하기 위한 방법과 조성물들 |
| KR101636403B1 (ko) | 2008-10-28 | 2016-07-05 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| WO2010057022A1 (en) * | 2008-11-14 | 2010-05-20 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
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| EP2277989A1 (en) | 2009-07-24 | 2011-01-26 | Technische Universiteit Delft | Fermentative glycerol-free ethanol production |
| KR20120120493A (ko) | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
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| WO2014016328A1 (en) * | 2012-07-25 | 2014-01-30 | Total Marketing Services | Genetically engineered micro-organisms for production of fatty acids |
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| KR20210118216A (ko) * | 2012-10-15 | 2021-09-29 | 게노마티카 인코포레이티드 | 특정 길이의 지방 알콜 및 관련 화합물의 생산을 위한 미생물 및 방법 |
| HK1216547A1 (zh) | 2012-12-21 | 2016-11-18 | Greenlight Biosciences Inc. | 用於將甲烷轉化成燃料、丙酮酸或異丁醇的無細胞系統 |
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