JP2014501524A5 - - Google Patents
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- JP2014501524A5 JP2014501524A5 JP2013545306A JP2013545306A JP2014501524A5 JP 2014501524 A5 JP2014501524 A5 JP 2014501524A5 JP 2013545306 A JP2013545306 A JP 2013545306A JP 2013545306 A JP2013545306 A JP 2013545306A JP 2014501524 A5 JP2014501524 A5 JP 2014501524A5
- Authority
- JP
- Japan
- Prior art keywords
- dehydrogenase
- pqq
- formula
- aldose
- reaction system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10015774.2 | 2010-12-20 | ||
| EP10015774A EP2465936A1 (en) | 2010-12-20 | 2010-12-20 | Enzymatic synthesis of statins and intermediates thereof |
| EP11168227.4 | 2011-05-31 | ||
| EP11168227 | 2011-05-31 | ||
| PCT/EP2011/073412 WO2012095244A2 (en) | 2010-12-20 | 2011-12-20 | Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501524A JP2014501524A (ja) | 2014-01-23 |
| JP2014501524A5 true JP2014501524A5 (https=) | 2016-06-30 |
| JP6194251B2 JP6194251B2 (ja) | 2017-09-06 |
Family
ID=45529045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545306A Expired - Fee Related JP6194251B2 (ja) | 2010-12-20 | 2011-12-20 | 医薬品有効成分およびこれの中間体の酵素的合成 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130337485A1 (https=) |
| EP (1) | EP2655650B1 (https=) |
| JP (1) | JP6194251B2 (https=) |
| CN (1) | CN103403174B (https=) |
| AU (1) | AU2011355209B2 (https=) |
| CA (1) | CA2822331A1 (https=) |
| WO (1) | WO2012095244A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2210935A1 (en) * | 2009-01-19 | 2010-07-28 | Deinove | Methods for isolating bacteria |
| CN110592249A (zh) * | 2019-10-29 | 2019-12-20 | 山东省果树研究所 | 一种快速鉴定果园高效解磷细菌的特异性引物及其试剂盒、分离鉴定方法 |
| CN113373187B (zh) * | 2021-05-26 | 2023-11-10 | 江苏阿尔法药业股份有限公司 | 一种氮杂环化合物c27h30fno6的酶催化合成方法 |
| CN114045243B (zh) * | 2021-12-03 | 2023-12-26 | 山东天力药业有限公司 | 一种缩短生黑葡萄糖酸杆菌发酵周期的方法 |
| CN116903543A (zh) * | 2023-09-08 | 2023-10-20 | 重庆普佑生物医药有限公司 | 一种瑞舒伐他汀钙的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3863170A (en) | 1973-02-21 | 1975-01-28 | Bendix Corp | Thermally stable power amplifier |
| DE2401055A1 (de) | 1974-01-10 | 1975-07-24 | Horst Lindenmann | Spielgeraet |
| US5567605A (en) | 1994-11-21 | 1996-10-22 | Uop | Assay for D-allose using a NAD cofactor coupled D-allose dehydrogenase |
| EP1332216B1 (en) | 2000-10-27 | 2011-08-17 | Roche Diagnostics GmbH | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| AU2003263031A1 (en) | 2002-09-20 | 2004-04-08 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| JP4415282B2 (ja) | 2003-03-24 | 2010-02-17 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| MXPA06014090A (es) | 2004-06-04 | 2007-03-07 | Dsm Ip Assets Bv | 2-desoxi-d-ribosa 5-fosfato aldolasas mejoradas, y para uso en la produccion de 2,4,6-tridesoxihexosas y derivados 6-halogeno o 6-ciano-sustituidos de los mismos. |
| BRPI0513691A (pt) | 2004-07-20 | 2008-03-25 | Roche Diagnostics Gmbh | glicose desidrogenase dependente de pirroloquinolina quinona transformada geneticamente compreendendo uma inserção de aminoácido |
| CA2581226C (en) | 2004-10-15 | 2011-06-14 | Mara Boenitz-Dulat | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
| JP2006217811A (ja) | 2005-02-08 | 2006-08-24 | Toyobo Co Ltd | 基質特異性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| WO2006134482A1 (en) | 2005-06-16 | 2006-12-21 | Pfizer Inc. | Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof |
| EP1969131A1 (en) * | 2005-12-15 | 2008-09-17 | Isobionics B.V. | Process for the preparation of delta lactones |
| MX2008013001A (es) | 2006-04-13 | 2008-10-17 | Hoffmann La Roche | Mutantes mejorados de glucosa deshidrogenasa soluble dependiente de pirroloquinolina quinona. |
| EP2134696B1 (en) | 2007-04-03 | 2017-05-17 | LEK Pharmaceuticals d.d. | Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof |
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| US8404870B2 (en) * | 2008-01-23 | 2013-03-26 | Lek Pharmaceuticals D.D. | ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylate and process for the production thereof |
| DE102008030435A1 (de) | 2008-06-26 | 2010-01-07 | Bayer Technology Services Gmbh | Neuartige Varianten PQQ-abhängiger Glukosehydrogenase mit verbesserter Substratspezifität |
| WO2013068917A1 (en) * | 2011-11-07 | 2013-05-16 | Dr. Reddy's Laboratories Limited | Processes for the production of a lactone statin intermediate by enzymatic oxidation |
-
2011
- 2011-12-20 WO PCT/EP2011/073412 patent/WO2012095244A2/en not_active Ceased
- 2011-12-20 EP EP11811536.9A patent/EP2655650B1/en not_active Not-in-force
- 2011-12-20 US US13/995,420 patent/US20130337485A1/en not_active Abandoned
- 2011-12-20 AU AU2011355209A patent/AU2011355209B2/en not_active Ceased
- 2011-12-20 CA CA2822331A patent/CA2822331A1/en not_active Abandoned
- 2011-12-20 CN CN201180067928.6A patent/CN103403174B/zh not_active Expired - Fee Related
- 2011-12-20 JP JP2013545306A patent/JP6194251B2/ja not_active Expired - Fee Related
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