HUE049911T2 - Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai - Google Patents

Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai

Info

Publication number
HUE049911T2
HUE049911T2 HUE17151869A HUE17151869A HUE049911T2 HU E049911 T2 HUE049911 T2 HU E049911T2 HU E17151869 A HUE17151869 A HU E17151869A HU E17151869 A HUE17151869 A HU E17151869A HU E049911 T2 HUE049911 T2 HU E049911T2
Authority
HU
Hungary
Prior art keywords
glucose dehydrogenase
pyrroloquinoline quinone
soluble glucose
dependent soluble
improved mutants
Prior art date
Application number
HUE17151869A
Other languages
English (en)
Inventor
Mara Boenitz-Dulat
Daniela Beck
Peter Kratzsch
Rainer Schmuck
Der Eltz Herbert Von
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36579921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE049911(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUE049911T2 publication Critical patent/HUE049911T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
HUE17151869A 2006-04-13 2007-04-11 Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai HUE049911T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06007779 2006-04-13

Publications (1)

Publication Number Publication Date
HUE049911T2 true HUE049911T2 (hu) 2020-11-30

Family

ID=36579921

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE07724148A HUE032804T2 (hu) 2006-04-13 2007-04-11 Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai
HUE17151869A HUE049911T2 (hu) 2006-04-13 2007-04-11 Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE07724148A HUE032804T2 (hu) 2006-04-13 2007-04-11 Pirrolokinolin-kinon-függõ, oldható glükóz-dehidrogenáz javított mutánsai

Country Status (15)

Country Link
US (1) US7732179B2 (hu)
EP (2) EP2010649B1 (hu)
JP (3) JP5683809B2 (hu)
KR (1) KR101168623B1 (hu)
CN (1) CN101421396B (hu)
AU (1) AU2007237478B2 (hu)
BR (1) BRPI0710131B1 (hu)
CA (1) CA2649135C (hu)
ES (2) ES2807530T3 (hu)
HK (1) HK1131633A1 (hu)
HU (2) HUE032804T2 (hu)
MX (1) MX2008013001A (hu)
PL (2) PL3246402T3 (hu)
PT (2) PT3246402T (hu)
WO (1) WO2007118647A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5753720B2 (ja) * 2010-04-22 2015-07-22 アークレイ株式会社 バイオセンサ
US20130092536A1 (en) 2010-07-23 2013-04-18 Roche Diagnostics Operations, Inc. Zwitterion buffer containing compositions and uses in electroanalytical methods
EP2465936A1 (en) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of statins and intermediates thereof
WO2012095244A2 (en) 2010-12-20 2012-07-19 Lek Pharmaceuticals D.D. Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof
EP3901624B1 (en) 2010-12-22 2024-01-31 Roche Diabetes Care GmbH Methods to compensate for sources of error during electrochemical testing
CN102559624B (zh) * 2012-03-05 2013-10-16 浙江德清汇宁生物科技有限公司 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法
KR101728597B1 (ko) 2012-04-19 2017-04-19 에프. 호프만-라 로슈 아게 혈액 내 분석물 농도를 결정하는 방법 및 디바이스
EP2811299A1 (en) 2013-06-07 2014-12-10 Roche Diagniostics GmbH Test element for detecting at least one analyte in a body fluid
JP6998863B2 (ja) 2015-09-25 2022-02-04 エフ．ホフマン－ラ ロシュ アーゲー 深共融溶媒におけるソルターゼａを利用したアミド基転移
JP6895953B2 (ja) 2015-09-25 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ソルターゼａを利用してチオエステルを作製するための方法
CN105331590B (zh) * 2015-10-29 2020-02-28 英科隆生物技术（杭州）有限公司 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用
CN111073866B (zh) * 2015-10-29 2024-03-19 英科隆生物技术（杭州）有限公司 PQQ-sGDH突变体、聚核苷酸及其在葡萄糖检测中的应用
EP3394252B1 (en) 2015-12-21 2020-04-29 F. Hoffmann-La Roche AG Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same
JP6989528B2 (ja) 2016-02-09 2022-01-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ロドバクター・スフェロイデス（Ｒｈｏｄｏｂａｃｔｅｒ ｓｐｈａｅｒｏｉｄｅｓ）由来の変異型３−ヒドロキシブチレート脱水素酵素及びそれを含む方法
WO2018067235A1 (en) 2016-10-05 2018-04-12 Roche Diabetes Care, Inc. Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
DE3716957A1 (de) 1987-05-20 1988-12-01 Boehringer Mannheim Gmbh Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten
DE4311464A1 (de) 1993-04-08 1994-10-13 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase
DE19639169A1 (de) 1996-09-24 1998-04-02 Boehringer Mannheim Gmbh Redoxaktive Verbindungen und deren Anwendung
JPH10243786A (ja) 1997-03-03 1998-09-14 Koji Hayade 改変型グルコース脱水素酵素
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JPH11243949A (ja) 1998-03-03 1999-09-14 Toyobo Co Ltd Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法
EP1155130A2 (de) * 1999-02-19 2001-11-21 MERCK PATENT GmbH Glucose-dehydrogenase-fusionsproteine und ihre verwendung in expressionssystemen
JP2000350588A (ja) * 1999-04-08 2000-12-19 Koji Hayade グルコース脱水素酵素
TWI224136B (en) 1999-04-30 2004-11-21 Koji Sode Glucose dehydrogenase
AU2002215966B2 (en) 2000-10-27 2006-05-04 F. Hoffmann-La Roche Ag Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase
JP2004344145A (ja) * 2002-05-27 2004-12-09 Toyobo Co Ltd 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体
JP2004173538A (ja) 2002-11-25 2004-06-24 Amano Enzyme Inc ピロロキノリンキノン依存性グルコース脱水素酵素
RU2336306C1 (ru) 2004-07-20 2008-10-20 Ф.Хоффманн-Ля Рош Аг Генетически сконструированная зависимая от пирролохинолинхинона глюкозодегидрогеназа, содержащая инсерцию аминокислоты

Also Published As

Publication number Publication date
KR20080106349A (ko) 2008-12-04
MX2008013001A (es) 2008-10-17
CN101421396A (zh) 2009-04-29
PT2010649T (pt) 2017-05-03
US20090148874A1 (en) 2009-06-11
BRPI0710131A2 (pt) 2011-08-02
CN101421396B (zh) 2016-01-20
JP2009533033A (ja) 2009-09-17
ES2624805T3 (es) 2017-07-17
EP2010649A1 (en) 2009-01-07
HUE032804T2 (hu) 2017-11-28
JP5937547B2 (ja) 2016-06-22
PL3246402T3 (pl) 2020-10-19
PT3246402T (pt) 2020-07-14
JP5683809B2 (ja) 2015-03-11
AU2007237478B2 (en) 2011-05-19
US7732179B2 (en) 2010-06-08
KR101168623B1 (ko) 2012-08-03
AU2007237478A1 (en) 2007-10-25
EP2010649B1 (en) 2017-03-08
JP2016119904A (ja) 2016-07-07
WO2007118647A1 (en) 2007-10-25
BRPI0710131B1 (pt) 2020-03-10
EP3246402B1 (en) 2020-05-20
JP2013198497A (ja) 2013-10-03
CA2649135C (en) 2013-11-19
EP3246402A1 (en) 2017-11-22
JP6185617B2 (ja) 2017-08-23
CA2649135A1 (en) 2007-10-25
PL2010649T3 (pl) 2017-08-31
ES2807530T3 (es) 2021-02-23
HK1131633A1 (zh) 2010-01-29

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