PT2010649T - Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolina quinona - Google Patents

Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolina quinona

Info

Publication number
PT2010649T
PT2010649T PT77241487T PT07724148T PT2010649T PT 2010649 T PT2010649 T PT 2010649T PT 77241487 T PT77241487 T PT 77241487T PT 07724148 T PT07724148 T PT 07724148T PT 2010649 T PT2010649 T PT 2010649T
Authority
PT
Portugal
Prior art keywords
glucose dehydrogenase
pyrroloquinoline quinone
soluble glucose
dependent soluble
improved mutants
Prior art date
Application number
PT77241487T
Other languages
English (en)
Inventor
Boenitz-Dulat Mara
Beck Daniela
Kratzsch Peter
Schmuck Rainer
Von Der Eltz Herbert
Original Assignee
Hoffmann La Roche
Roche Diabetes Care Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36579921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2010649(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Roche Diabetes Care Gmbh filed Critical Hoffmann La Roche
Publication of PT2010649T publication Critical patent/PT2010649T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PT77241487T 2006-04-13 2007-04-11 Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolina quinona PT2010649T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06007779 2006-04-13

Publications (1)

Publication Number Publication Date
PT2010649T true PT2010649T (pt) 2017-05-03

Family

ID=36579921

Family Applications (2)

Application Number Title Priority Date Filing Date
PT171518699T PT3246402T (pt) 2006-04-13 2007-04-11 Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolinaquinona
PT77241487T PT2010649T (pt) 2006-04-13 2007-04-11 Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolina quinona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT171518699T PT3246402T (pt) 2006-04-13 2007-04-11 Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolinaquinona

Country Status (15)

Country Link
US (1) US7732179B2 (pt)
EP (2) EP2010649B1 (pt)
JP (3) JP5683809B2 (pt)
KR (1) KR101168623B1 (pt)
CN (1) CN101421396B (pt)
AU (1) AU2007237478B2 (pt)
BR (1) BRPI0710131B1 (pt)
CA (1) CA2649135C (pt)
ES (2) ES2807530T3 (pt)
HK (1) HK1131633A1 (pt)
HU (2) HUE049911T2 (pt)
MX (1) MX2008013001A (pt)
PL (2) PL3246402T3 (pt)
PT (2) PT3246402T (pt)
WO (1) WO2007118647A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5753720B2 (ja) * 2010-04-22 2015-07-22 アークレイ株式会社 バイオセンサ
WO2012010308A1 (en) 2010-07-23 2012-01-26 Roche Diagnostics Gmbh Zwitterion buffer containing compositions and uses in electroanalytical devices and methods
EP2655650B1 (en) 2010-12-20 2017-12-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof
EP2465936A1 (en) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of statins and intermediates thereof
WO2012084194A1 (en) 2010-12-22 2012-06-28 Roche Diagnostics Gmbh Systems and methods to compensate for sources of error during electrochemical testing
CN102559624B (zh) * 2012-03-05 2013-10-16 浙江德清汇宁生物科技有限公司 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法
KR101728597B1 (ko) 2012-04-19 2017-04-19 에프. 호프만-라 로슈 아게 혈액 내 분석물 농도를 결정하는 방법 및 디바이스
EP2811299A1 (en) 2013-06-07 2014-12-10 Roche Diagniostics GmbH Test element for detecting at least one analyte in a body fluid
WO2017050872A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Transamidation employing sortase a in deep eutectic solvents
JP6895953B2 (ja) 2015-09-25 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ソルターゼａを利用してチオエステルを作製するための方法
CN105331591B (zh) * 2015-10-29 2020-02-28 英科隆生物技术（杭州）有限公司 PQQ-sGDH突变体、聚核苷酸及葡萄糖检测装置
CN105331590B (zh) * 2015-10-29 2020-02-28 英科隆生物技术（杭州）有限公司 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用
CN108350439A (zh) 2015-12-21 2018-07-31 豪夫迈·罗氏有限公司 来自粪产碱菌的突变体3-羟基丁酸脱氢酶及其相关方法和用途
WO2017137491A1 (en) 2016-02-09 2017-08-17 Roche Diabetes Care Gmbh Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
CN109804240A (zh) 2016-10-05 2019-05-24 豪夫迈·罗氏有限公司 用于多分析物诊断测试元件的检测试剂和电极布置以及其使用方法
CN115820608B (zh) * 2022-08-31 2024-06-04 中国海洋大学 λ-卡拉胶酶突变体OUC-CglA-DPQQ及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3716957A1 (de) 1987-05-20 1988-12-01 Boehringer Mannheim Gmbh Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten
DE4311464A1 (de) 1993-04-08 1994-10-13 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase
DE19639169A1 (de) 1996-09-24 1998-04-02 Boehringer Mannheim Gmbh Redoxaktive Verbindungen und deren Anwendung
JPH10243786A (ja) 1997-03-03 1998-09-14 Koji Hayade 改変型グルコース脱水素酵素
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JPH11243949A (ja) 1998-03-03 1999-09-14 Toyobo Co Ltd Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法
KR20010103017A (ko) * 1999-02-19 2001-11-17 플레믹 크리스티안 글루코스 데히드로게나제 융합 단백질 및 발현계에서의그의 용도
JP2000350588A (ja) 1999-04-08 2000-12-19 Koji Hayade グルコース脱水素酵素
TWI224136B (en) 1999-04-30 2004-11-21 Koji Sode Glucose dehydrogenase
ATE520777T1 (de) * 2000-10-27 2011-09-15 Hoffmann La Roche Varianten der löslichen pyrroloquinolin quinon- abhängigen glukose dehydrogenase
JP2004344145A (ja) * 2002-05-27 2004-12-09 Toyobo Co Ltd 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体
JP2004173538A (ja) * 2002-11-25 2004-06-24 Amano Enzyme Inc ピロロキノリンキノン依存性グルコース脱水素酵素
KR100879491B1 (ko) * 2004-07-20 2009-01-20 에프. 호프만-라 로슈 아게 아미노산 삽입을 포함하는 유전자 엔지니어링된피롤로퀴놀린 퀴논 의존성 글루코오스 디히드로게나아제

Also Published As

Publication number Publication date
CN101421396B (zh) 2016-01-20
ES2624805T3 (es) 2017-07-17
HK1131633A1 (zh) 2010-01-29
EP2010649B1 (en) 2017-03-08
PT3246402T (pt) 2020-07-14
MX2008013001A (es) 2008-10-17
JP5937547B2 (ja) 2016-06-22
JP2016119904A (ja) 2016-07-07
PL3246402T3 (pl) 2020-10-19
CA2649135C (en) 2013-11-19
JP6185617B2 (ja) 2017-08-23
US7732179B2 (en) 2010-06-08
BRPI0710131A2 (pt) 2011-08-02
JP2013198497A (ja) 2013-10-03
PL2010649T3 (pl) 2017-08-31
HUE049911T2 (hu) 2020-11-30
AU2007237478B2 (en) 2011-05-19
EP3246402A1 (en) 2017-11-22
JP2009533033A (ja) 2009-09-17
BRPI0710131B1 (pt) 2020-03-10
JP5683809B2 (ja) 2015-03-11
EP3246402B1 (en) 2020-05-20
WO2007118647A1 (en) 2007-10-25
ES2807530T3 (es) 2021-02-23
CN101421396A (zh) 2009-04-29
AU2007237478A1 (en) 2007-10-25
HUE032804T2 (en) 2017-11-28
CA2649135A1 (en) 2007-10-25
US20090148874A1 (en) 2009-06-11
EP2010649A1 (en) 2009-01-07
KR20080106349A (ko) 2008-12-04
KR101168623B1 (ko) 2012-08-03

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