JP2011510984A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011510984A5 JP2011510984A5 JP2010545030A JP2010545030A JP2011510984A5 JP 2011510984 A5 JP2011510984 A5 JP 2011510984A5 JP 2010545030 A JP2010545030 A JP 2010545030A JP 2010545030 A JP2010545030 A JP 2010545030A JP 2011510984 A5 JP2011510984 A5 JP 2011510984A5
- Authority
- JP
- Japan
- Prior art keywords
- progesterone
- elastomer
- polysiloxane
- ring
- intravaginal ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 74
- 239000000186 progesterone Substances 0.000 claims 37
- 229960003387 progesterone Drugs 0.000 claims 37
- -1 polysiloxane Polymers 0.000 claims 33
- 229920001971 elastomer Polymers 0.000 claims 30
- 239000000806 elastomer Substances 0.000 claims 30
- 229920001296 polysiloxane Polymers 0.000 claims 27
- 238000000034 method Methods 0.000 claims 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 10
- 239000008240 homogeneous mixture Substances 0.000 claims 8
- 239000003921 oil Substances 0.000 claims 8
- 239000004215 Carbon black (E152) Substances 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 229930195733 hydrocarbon Natural products 0.000 claims 6
- 150000002430 hydrocarbons Chemical class 0.000 claims 6
- 238000001727 in vivo Methods 0.000 claims 6
- 229920005645 diorganopolysiloxane polymer Polymers 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 231100000545 luteal phase defect Toxicity 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000002480 mineral oil Substances 0.000 claims 2
- 235000010446 mineral oil Nutrition 0.000 claims 2
- 229940044953 vaginal ring Drugs 0.000 claims 2
- 239000006213 vaginal ring Substances 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 1
- 150000002314 glycerols Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2611508P | 2008-02-04 | 2008-02-04 | |
| US61/026,115 | 2008-02-04 | ||
| US13945408P | 2008-12-19 | 2008-12-19 | |
| US61/139,454 | 2008-12-19 | ||
| PCT/US2009/000672 WO2009099586A2 (en) | 2008-02-04 | 2009-02-03 | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014055994A Division JP6124411B2 (ja) | 2008-02-04 | 2014-03-19 | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510984A JP2011510984A (ja) | 2011-04-07 |
| JP2011510984A5 true JP2011510984A5 (enExample) | 2012-03-22 |
| JP5507467B2 JP5507467B2 (ja) | 2014-05-28 |
Family
ID=40939073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545030A Active JP5507467B2 (ja) | 2008-02-04 | 2009-02-03 | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
| JP2014055994A Active JP6124411B2 (ja) | 2008-02-04 | 2014-03-19 | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014055994A Active JP6124411B2 (ja) | 2008-02-04 | 2014-03-19 | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US8580293B2 (enExample) |
| EP (2) | EP2359807B1 (enExample) |
| JP (2) | JP5507467B2 (enExample) |
| KR (3) | KR20100133969A (enExample) |
| CN (2) | CN104146948B (enExample) |
| AR (1) | AR070561A1 (enExample) |
| AU (1) | AU2009210779B2 (enExample) |
| BR (1) | BRPI0905946B8 (enExample) |
| CA (2) | CA2713943C (enExample) |
| CL (1) | CL2009000242A1 (enExample) |
| DK (2) | DK2359807T3 (enExample) |
| EA (2) | EA021615B1 (enExample) |
| ES (2) | ES2645630T3 (enExample) |
| HR (1) | HRP20171319T1 (enExample) |
| HU (1) | HUE035634T2 (enExample) |
| IL (2) | IL207376A (enExample) |
| LT (1) | LT2249757T (enExample) |
| MX (2) | MX385981B (enExample) |
| NZ (3) | NZ596844A (enExample) |
| PL (2) | PL2249757T3 (enExample) |
| PT (2) | PT2359807T (enExample) |
| SG (2) | SG10201605171QA (enExample) |
| SI (2) | SI2359807T1 (enExample) |
| TW (3) | TWI599359B (enExample) |
| WO (1) | WO2009099586A2 (enExample) |
| ZA (2) | ZA201307321B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2249757T (lt) | 2008-02-04 | 2017-09-25 | Ferring B.V. | Vientisi intravaginaliniai žiedai, apimantys progesteroną, ir jų gamybos bei panaudojimo būdai |
| JP2013535992A (ja) * | 2010-06-22 | 2013-09-19 | テバ ウィメンズ ヘルス インコーポレイテッド | 抗コリン作動剤を含む膣内用デバイスおよびそれを作る方法 |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| EP2641602A1 (en) * | 2012-03-23 | 2013-09-25 | PregLem S.A. | Method for treating gynecological diseases |
| WO2014122563A1 (en) * | 2013-02-08 | 2014-08-14 | Qpharma Ab | An intra vaginal device, and a method of reducing the rate of diffusion of active ingredients in said intra vaginal device |
| CN103394127A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有中西医药的阴道模具材料 |
| CN103431930A (zh) * | 2013-08-02 | 2013-12-11 | 苏州市马尔泰新材料有限公司 | 一种含有甲酯树脂的阴道模具 |
| CN103394128A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有川芎的模具材料 |
| CN103405810A (zh) * | 2013-08-02 | 2013-11-27 | 苏州市马尔泰新材料有限公司 | 一种含有甲基丙烯酸甲酯树脂的阴道模具 |
| CN103445892A (zh) * | 2013-08-02 | 2013-12-18 | 苏州市马尔泰新材料有限公司 | 一种含有甲酯树脂和雌酚的阴道模具 |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| CN112494195A (zh) | 2014-04-01 | 2021-03-16 | 保利医学公司 | 避孕装置及相关装置 |
| ES2699003T3 (es) * | 2014-06-28 | 2019-02-06 | Laboratorios Andromaco S A | Pesario de cerclaje que contiene progesterona de liberación prolongada, sostenida y continua, usado para la prevención de partos prematuros |
| CN104546267B (zh) * | 2015-01-13 | 2017-01-04 | 安徽农业大学 | 一种犬用宫外节育装置及其节育方法 |
| BR112018012744A2 (pt) * | 2015-12-21 | 2018-12-04 | Bayer Oy | método de fabricação de um anel vaginal |
| EP3542786A1 (en) * | 2018-03-21 | 2019-09-25 | ITF Research Pharma, S.L.U. | Progesterone intravaginal devices |
| CN114126710A (zh) * | 2019-03-29 | 2022-03-01 | B·马特尔 | 含有孕酮的eva分段式阴道内环 |
| US10918649B2 (en) | 2019-06-21 | 2021-02-16 | The Population Council, Inc. | System for providing birth control |
| US11439588B2 (en) * | 2019-10-12 | 2022-09-13 | National Research Institute For Family Planning | Vaginal sustained-release drug delivery system for luteal support, method for preparation and use thereof |
| TWI791347B (zh) * | 2020-12-11 | 2023-02-01 | 酷氏基因生物科技股份有限公司 | 一種用於評估胚胎植入成功率的預測方法 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE494972A (enExample) | 1949-04-07 | |||
| US2863846A (en) | 1950-05-04 | 1958-12-09 | Dow Corning | Organo silyl-silica filled siloxane elastomers and process for producing same |
| US2890188A (en) | 1951-12-17 | 1959-06-09 | Dow Corning | Siloxane elastomers compounded with hydroxylated silanes |
| NL91756C (enExample) | 1953-11-19 | |||
| US3022951A (en) | 1957-05-14 | 1962-02-27 | Ibm | Full adder |
| US3545439A (en) | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| DE3040978A1 (de) * | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| US4629449A (en) * | 1982-07-29 | 1986-12-16 | Alza Corporation | Vaginal dispenser for dispensing beneficial hormone |
| US4816257A (en) * | 1985-09-20 | 1989-03-28 | Research & Education Institute, Harbor-Ucla Medical Center Inc. | Method for producing an in vivo environment suitable for human embryo transfer |
| SE8602666D0 (sv) * | 1986-06-16 | 1986-06-16 | Leo Ab | Intravaginal devices |
| US5188835A (en) * | 1986-06-16 | 1993-02-23 | Kabi Pharmacia Ab | Intravaginal devices |
| FR2618329B1 (fr) | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
| US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
| US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
| DE3838815A1 (de) * | 1988-11-17 | 1990-05-23 | Hoechst Ag | Verfahren zum herstellen eines intravaginalen applikationssystems |
| US6264638B1 (en) * | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
| US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| US5393528A (en) * | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
| IT1256393B (it) | 1992-11-17 | 1995-12-04 | Inverni Della Beffa Spa | Forme matriciali multistrato per il rilascio controllato di principi attivi |
| FI95768C (fi) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Emättimensisäinen antosysteemi |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| US6586006B2 (en) * | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| EP0836473B1 (en) * | 1995-07-04 | 2001-10-31 | Akzo Nobel N.V. | Ring-shaped devices |
| GB9522403D0 (en) * | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
| US5744463A (en) * | 1996-06-03 | 1998-04-28 | Bair; Glenn O. | Treatment of side effects of progestins and progesterone analogues used for birth control |
| US5869081A (en) * | 1996-06-28 | 1999-02-09 | The Population Council | Progesterone vaginal ring for treatment of infertility |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| US6028064A (en) * | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US5985861A (en) * | 1996-11-04 | 1999-11-16 | Columbia Laboratories, Inc. | Progesterone for treating or reducing ischemia |
| US5814329A (en) * | 1996-11-12 | 1998-09-29 | Polytherapeutics, Inc. | Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents |
| US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
| US5993856A (en) * | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| US6056972A (en) * | 1997-02-26 | 2000-05-02 | Dimera, Llc | Method for reducing coronary artery reactivity |
| NZ501236A (en) * | 1997-05-07 | 2002-02-01 | Galen Chemicals Ltd | Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors in a polymer matrix and surrounded by a sheath |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6039968A (en) | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US6245757B1 (en) * | 1997-10-03 | 2001-06-12 | Research Corporation Technologies, Inc. | Use of progestins to treat ischemic event |
| US6306914B1 (en) * | 1997-10-21 | 2001-10-23 | Columbia Laboratories, Inc. | Progestin therapy for maintaining amenorrhea |
| NZ330596A (en) * | 1998-06-05 | 2001-02-23 | Dec Res | Intravaginal devices allowing for increased uptake of active ingredients |
| AU748653B2 (en) * | 1998-05-01 | 2002-06-06 | John F. Cline | Method for injection molding manufacture of controlled release devices |
| JP2002518351A (ja) | 1998-06-19 | 2002-06-25 | オキシバイオ・インコーポレイテッド | 抗感染および避妊特性を有する医療装置 |
| US7001609B1 (en) * | 1998-10-02 | 2006-02-21 | Regents Of The University Of Minnesota | Mucosal originated drug delivery systems and animal applications |
| US6056976A (en) | 1998-11-12 | 2000-05-02 | Leiras Oy | Elastomer, its preparation and use |
| US6063395A (en) | 1998-11-12 | 2000-05-16 | Leiras Oy | Drug delivery device especially for the delivery of progestins and estrogens |
| US20050197651A1 (en) * | 2001-04-25 | 2005-09-08 | Chen Hai L. | Vaginal ring preparation and its application |
| CN1210079C (zh) * | 2001-04-25 | 2005-07-13 | 上海市计划生育科学研究所 | 阴道环制剂及其应用 |
| AU2002313517B2 (en) * | 2001-08-31 | 2007-09-06 | Bayer Schering Pharma Oy | Drug delivery system |
| AU2003208679A1 (en) * | 2002-02-08 | 2003-09-02 | Advanced Animal Technology Limited | Control of a biological function |
| EP1494646B2 (en) * | 2002-03-27 | 2017-10-04 | Warner Chilcott (Ireland) Limited | Intravaginal matrix drug delivery devices |
| CA2504283A1 (en) * | 2002-10-31 | 2004-05-21 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| US20040089308A1 (en) * | 2002-11-13 | 2004-05-13 | Welch Robert A. | Cervical ring to deliver medication |
| FR2849380A1 (fr) * | 2002-12-27 | 2004-07-02 | Ernest Loumaye | NOUVELLE UTILISATION D'UN AGONISTE DU GnRH |
| ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| US8404272B2 (en) * | 2003-06-26 | 2013-03-26 | Poly-Med, Inc. | Fiber-reinforced composite rings for intravaginal controlled drug delivery |
| CA2531640C (en) * | 2003-07-10 | 2013-06-18 | Galen (Chemicals) Limited | Intravaginal drug delivery devices |
| US20050255157A1 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
| US7707169B2 (en) | 2004-06-10 | 2010-04-27 | Siemens Corporation | Specification-based automation methods for medical content extraction, data aggregation and enrichment |
| KR101229701B1 (ko) * | 2004-07-09 | 2013-02-05 | 라보라토이레 에이치알에이 파르마 | 프로게스테론 수용체 조절제를 함유하는 서방형 조성물 |
| AR043476A1 (es) * | 2004-09-09 | 2005-08-03 | Dvoskin Victor Oscar | Dispositivo de administracion regulada de sustancias para la insercion en una cavidad corporal y procedimiento para fabricar un medio de soporte de dichas sustancias |
| US7517914B2 (en) * | 2005-04-04 | 2009-04-14 | Boston Scientificscimed, Inc. | Controlled degradation materials for therapeutic agent delivery |
| US8399012B2 (en) * | 2006-04-17 | 2013-03-19 | Kimberly-Clark Worldwide, Inc. | Degradable therapeutic delivery device |
| JP2009536164A (ja) * | 2006-05-10 | 2009-10-08 | エボニック デグサ ゲーエムベーハー | ロール圧密成形した熱分解法二酸化ケイ素の医薬組成物での使用 |
| US8828981B2 (en) * | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
| US20080214512A1 (en) * | 2007-03-01 | 2008-09-04 | Christian Seitz | Pharmaceutical preparation containing a gestagen, and kit and method for treating endometriosis using the preparation |
| CA2823407C (en) * | 2007-03-22 | 2016-10-18 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
| WO2008140794A1 (en) | 2007-05-11 | 2008-11-20 | The Texas A & M University System | Hormone normalization therapy and uses thereof |
| LT2249757T (lt) | 2008-02-04 | 2017-09-25 | Ferring B.V. | Vientisi intravaginaliniai žiedai, apimantys progesteroną, ir jų gamybos bei panaudojimo būdai |
-
2009
- 2009-02-03 LT LTEP09707504.8T patent/LT2249757T/lt unknown
- 2009-02-03 PT PT101876860T patent/PT2359807T/pt unknown
- 2009-02-03 NZ NZ596844A patent/NZ596844A/en not_active IP Right Cessation
- 2009-02-03 CA CA2713943A patent/CA2713943C/en active Active
- 2009-02-03 CA CA3016642A patent/CA3016642A1/en not_active Abandoned
- 2009-02-03 BR BRPI0905946A patent/BRPI0905946B8/pt not_active IP Right Cessation
- 2009-02-03 NZ NZ61126809A patent/NZ611268A/en not_active IP Right Cessation
- 2009-02-03 SI SI200931723T patent/SI2359807T1/sl unknown
- 2009-02-03 CN CN201410380175.XA patent/CN104146948B/zh active Active
- 2009-02-03 ES ES09707504.8T patent/ES2645630T3/es active Active
- 2009-02-03 CN CN200980112513.9A patent/CN102098991B/zh active Active
- 2009-02-03 US US12/364,990 patent/US8580293B2/en active Active
- 2009-02-03 MX MX2016003140A patent/MX385981B/es unknown
- 2009-02-03 AU AU2009210779A patent/AU2009210779B2/en active Active
- 2009-02-03 KR KR1020107019899A patent/KR20100133969A/ko not_active Ceased
- 2009-02-03 WO PCT/US2009/000672 patent/WO2009099586A2/en not_active Ceased
- 2009-02-03 HR HRP20171319TT patent/HRP20171319T1/hr unknown
- 2009-02-03 DK DK10187686.0T patent/DK2359807T3/en active
- 2009-02-03 DK DK09707504.8T patent/DK2249757T3/en active
- 2009-02-03 MX MX2010008545A patent/MX337634B/es active IP Right Grant
- 2009-02-03 PL PL09707504T patent/PL2249757T3/pl unknown
- 2009-02-03 SG SG10201605171QA patent/SG10201605171QA/en unknown
- 2009-02-03 KR KR1020167012312A patent/KR101730517B1/ko active Active
- 2009-02-03 JP JP2010545030A patent/JP5507467B2/ja active Active
- 2009-02-03 PT PT97075048T patent/PT2249757T/pt unknown
- 2009-02-03 ES ES10187686.0T patent/ES2648640T3/es active Active
- 2009-02-03 SG SG2013008289A patent/SG187529A1/en unknown
- 2009-02-03 HU HUE09707504A patent/HUE035634T2/en unknown
- 2009-02-03 EA EA201070919A patent/EA021615B1/ru unknown
- 2009-02-03 PL PL10187686T patent/PL2359807T3/pl unknown
- 2009-02-03 NZ NZ587758A patent/NZ587758A/en unknown
- 2009-02-03 EA EA201491815A patent/EA031017B1/ru unknown
- 2009-02-03 SI SI200931722T patent/SI2249757T1/sl unknown
- 2009-02-03 EP EP10187686.0A patent/EP2359807B1/en active Active
- 2009-02-03 KR KR1020147006224A patent/KR20140048321A/ko not_active Ceased
- 2009-02-03 EP EP09707504.8A patent/EP2249757B1/en active Active
- 2009-02-04 TW TW104111334A patent/TWI599359B/zh not_active IP Right Cessation
- 2009-02-04 TW TW105113785A patent/TWI655947B/zh active
- 2009-02-04 CL CL2009000242A patent/CL2009000242A1/es unknown
- 2009-02-04 AR ARP090100365A patent/AR070561A1/es not_active Application Discontinuation
- 2009-02-04 TW TW098103540A patent/TWI549681B/zh not_active IP Right Cessation
-
2010
- 2010-08-03 IL IL207376A patent/IL207376A/en active IP Right Grant
-
2012
- 2012-09-19 IL IL221988A patent/IL221988A/en active IP Right Grant
-
2013
- 2013-10-01 ZA ZA2013/07321A patent/ZA201307321B/en unknown
- 2013-10-01 ZA ZA2013/07320A patent/ZA201307320B/en unknown
- 2013-10-03 US US14/045,311 patent/US10548904B2/en active Active
-
2014
- 2014-03-19 JP JP2014055994A patent/JP6124411B2/ja active Active
-
2016
- 2016-06-08 US US15/176,169 patent/US10537584B2/en active Active
-
2020
- 2020-01-31 US US16/778,526 patent/US11413294B2/en active Active
-
2022
- 2022-07-05 US US17/857,959 patent/US20230158044A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011510984A5 (enExample) | ||
| HRP20171319T1 (hr) | Monolitni intravaginalni prsten koji sadrži progesteron i metode njegove izrade i uporabe | |
| CN1270718C (zh) | 表别孕烷醇酮在制备治疗甾族化合物诱导的疾病的药物中的应用 | |
| JP2006104221A5 (enExample) | ||
| JP2008535850A5 (enExample) | ||
| HRP20131073T1 (hr) | Organski spojevi | |
| JPH01221318A (ja) | ダナゾール含有の局所投与製剤 | |
| JP2013529665A5 (enExample) | ||
| CN1522147B (zh) | 含有15-酮基-前列腺素类化合物的用于治疗药物诱导的便秘的组合物 | |
| JP2016510041A5 (enExample) | ||
| TW200521117A (en) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| WO1999017737A1 (fr) | Composition de suppositoire | |
| Samborski et al. | Intra‐articular treatment of arthritides and activated osteoarthritis with the 5‐HT3 receptor antagonist tropisetron. A double‐blind study compared with methylprednisolone | |
| JP2011195430A (ja) | 低収縮性セメント組成物 | |
| CN110141653B (zh) | 一种含总姜酚的组合物及其制备方法 | |
| CN102872026A (zh) | 一种化合物的新用途 | |
| JP2008001688A (ja) | 痔疾治療用組成物 | |
| KR20200135443A (ko) | 프로게스테론 질내 장치 | |
| RU2018134045A (ru) | Пролекарства селективного модулятора рецептора прогестерона (sprm) (11.бета.,17.бета.)-17-гидрокси-11-[4-(метилсульфонил)фенил]-17-(пентафторэтил))эстра-4,9-диен-3-она | |
| RU2009115643A (ru) | Модуляторы прогестеронового рецептора на основе пиридооксазепина | |
| US20130172306A1 (en) | Use of an estrogen derivative for the manufacture of pharmaceutical compositions useful for the treatment and/or prevention of psychiatric diseases and for the treatment and prevention of said diseases | |
| JP2014024768A (ja) | 皮膚外用剤組成物 | |
| Park et al. | Changes in awake cystometry and expression of bladder β-adrenoceptors after partial bladder outlet obstruction in male rats | |
| JP2007008871A (ja) | 経皮吸収促進組成物 | |
| CN101007091B (zh) | 一种治疗妇女原发性痛经的中药复方制剂 |