JP2011505341A5 - - Google Patents
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- JP2011505341A5 JP2011505341A5 JP2010535064A JP2010535064A JP2011505341A5 JP 2011505341 A5 JP2011505341 A5 JP 2011505341A5 JP 2010535064 A JP2010535064 A JP 2010535064A JP 2010535064 A JP2010535064 A JP 2010535064A JP 2011505341 A5 JP2011505341 A5 JP 2011505341A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- nhc
- alkyl
- compound
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98955107P | 2007-11-21 | 2007-11-21 | |
| PCT/US2008/084193 WO2009067600A2 (en) | 2007-11-21 | 2008-11-20 | Biaryl pde4 inhibitors for treating inflammation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046962A Division JP2014185149A (ja) | 2007-11-21 | 2014-03-10 | 炎症を治療するためのビアリールpde4阻害薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505341A JP2011505341A (ja) | 2011-02-24 |
| JP2011505341A5 true JP2011505341A5 (https=) | 2013-03-14 |
Family
ID=41650335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535064A Pending JP2011505341A (ja) | 2007-11-21 | 2008-11-20 | 炎症性、心血管およびcns障害を治療するビアリールpde4抑制剤 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2222638A2 (https=) |
| JP (1) | JP2011505341A (https=) |
| CN (1) | CN102089279A (https=) |
| AU (1) | AU2008326381B2 (https=) |
| CA (1) | CA2722582A1 (https=) |
| WO (1) | WO2009067600A2 (https=) |
Families Citing this family (32)
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| EP2562168B1 (en) | 2006-02-28 | 2014-04-16 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as pde4 inhibitors |
| KR20100098653A (ko) | 2007-11-21 | 2010-09-08 | 디코드 제네틱스 이에이치에프 | 염증의 치료를 위한 바이아릴 pde4 억제제 |
| WO2010059838A2 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects |
| AR088020A1 (es) | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| US9617197B2 (en) | 2010-08-04 | 2017-04-11 | University Of Virginia Patent Foundation | Compositions and methods for treating inflammatory diseases |
| EP2637659B1 (en) | 2010-11-09 | 2016-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| CA2819299A1 (en) * | 2010-12-24 | 2012-06-28 | Merck Sharp & Dohme B.V. | N-substituted azetidine derivatives |
| CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
| CN103012255B (zh) * | 2011-09-21 | 2014-06-11 | 天津康鸿医药科技发展有限公司 | 罗氟司特晶型化合物、其制备方法、组合物及应用 |
| CN102603676B (zh) * | 2012-02-20 | 2014-02-12 | 徐江平 | 一种能避免呕吐反应的磷酸二酯酶4抑制剂 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| JP2016501203A (ja) | 2012-11-20 | 2016-01-18 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インドールアミン2,3−ジオキシゲナーゼの阻害剤として有用な化合物 |
| CN103012408B (zh) * | 2012-11-28 | 2015-02-04 | 中国科学院广州生物医药与健康研究院 | 依匹斯汀的合成方法 |
| MX370188B (es) * | 2013-03-14 | 2019-12-04 | Dart Neuroscience Cayman Ltd | Compuestos de piridina y pirazina sustituidos como inhibidores de pde4. |
| CN106458896A (zh) | 2014-03-14 | 2017-02-22 | 沃克哈特有限公司 | (2s,5r)‑6‑(苄氧基)‑7‑氧代‑1,6‑二氮杂二环[3.2.1]辛烷‑2‑羧酸钠的制备方法 |
| KR20200087273A (ko) | 2014-10-24 | 2020-07-20 | 란도스 바이오파마, 인크. | 란티오닌 합성효소 c-유사 2-계 치료제 |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| US11078192B2 (en) | 2016-07-05 | 2021-08-03 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
| BR112020010983A2 (pt) | 2017-11-30 | 2020-11-17 | Landos Biopharma, Inc | método in vitro para gerar células preparadas a partir de células precursoras, células isoladas e método para tratar uma afecção em um animal com as células isoladas |
| KR102666727B1 (ko) | 2017-12-29 | 2024-05-21 | 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. | 방향족 비닐 또는 방향족 에틸계 유도체, 그의 제조방법, 중간체, 약물조성물 및 용도 |
| CN110041253B (zh) * | 2018-01-17 | 2022-03-29 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
| WO2020219615A1 (en) * | 2019-04-23 | 2020-10-29 | Tetra Discovery Partners, Inc. | 3-hydroxy-2-phenyl-6-(pyrazol-4-ylmethyl)pyridine derivatives as pde4d inhibitors |
| BR112022002387A2 (pt) | 2019-12-20 | 2022-09-06 | Landos Biopharma Inc | Composto da fórmula z-y-q-y' ou um sal ou éster farmaceuticamente aceitável do mesmo |
| CN113912593A (zh) * | 2020-07-10 | 2022-01-11 | 启元生物(杭州)有限公司 | 一种氘代吡啶酮类化合物及其应用 |
| EP4215526A4 (en) | 2020-09-18 | 2024-10-16 | Shanghai Pharmaceuticals Holding Co., Ltd. | HETEROCYCLIC CARBONYL COMPOUND AND ITS USE |
| CN112374984A (zh) * | 2020-11-06 | 2021-02-19 | 苏州求索生物科技有限公司 | 一种2-溴-4-羟基苯甲醚的制备工艺 |
| KR102514860B1 (ko) * | 2020-12-01 | 2023-03-29 | 한국과학기술연구원 | 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물 |
| CN117756794B (zh) * | 2023-12-18 | 2024-07-16 | 和径医药科技(上海)有限公司 | 一种含氮杂环类化合物及其制备方法和应用 |
| WO2025240840A1 (en) * | 2024-05-17 | 2025-11-20 | Shionogi & Co., Ltd. | Aromatic heterocycle derivatives and aromatic carbocycle derivatives having pde4d inhibitory activity |
| CN118994115B (zh) * | 2024-07-29 | 2025-09-09 | 宁波大学 | 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用 |
| CN119819277B (zh) * | 2025-03-17 | 2025-05-27 | 昆明医科大学 | 一种基于BINAM的β-环糊精衍生物手性固定相及其制备方法和应用 |
Family Cites Families (34)
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| DE3778430D1 (en) * | 1986-06-20 | 1992-05-27 | Idemitsu Kosan Co | Polycarbonate. |
| GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
| CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| US5594141A (en) * | 1994-11-23 | 1997-01-14 | Neurogen Corporation | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands |
| JP2918002B2 (ja) * | 1994-11-23 | 1999-07-12 | ニューロゲン コーポレイション | アミノメチル アリール化合物;ドーパミンレセプター亜型選択性リガンド |
| AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| GB9604926D0 (en) * | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| FR2754260B1 (fr) * | 1996-10-04 | 1998-10-30 | Adir | Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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| EP1066257A2 (en) * | 1998-03-26 | 2001-01-10 | Sugen, Inc. | Heterocylic classes of compounds for the modulating tyrosine protein kinase |
| WO2000014083A1 (en) * | 1998-09-09 | 2000-03-16 | Inflazyme Pharmaceuticals Ltd. | SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO |
| WO2001030764A1 (en) * | 1999-10-22 | 2001-05-03 | Takeda Chemical Industries, Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
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| WO2003094845A2 (en) * | 2002-05-08 | 2003-11-20 | Bristol-Myers Squibb Company | Pyridine-based thyroid receptor ligands |
| AU2003277576A1 (en) * | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| WO2004084824A2 (en) * | 2003-03-24 | 2004-10-07 | Merck & Co., Inc. | Biaryl substituted 6-membered heterocyles as sodium channel blockers |
| JP2006522130A (ja) * | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール |
| US7557143B2 (en) * | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
| WO2005030206A1 (en) * | 2003-09-24 | 2005-04-07 | Imclone Systems Incorporated | Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity |
| ATE500234T1 (de) * | 2003-11-10 | 2011-03-15 | Merck Sharp & Dohme | Substituierte trialzole als blocker des natriumkanals |
| CN1882327A (zh) * | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
| AU2004309271A1 (en) * | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| PE20061124A1 (es) * | 2004-11-23 | 2006-10-13 | Pfizer Prod Inc | Compuestos y derivados de dibencil amina |
| JP5258299B2 (ja) * | 2004-12-23 | 2013-08-07 | ガルデルマ・リサーチ・アンド・デヴェロップメント | Rar受容体を調節する新規リガンド、並びにヒトの医薬品及び化粧品におけるその使用 |
| KR20070107022A (ko) * | 2005-01-07 | 2007-11-06 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| CN102775396B (zh) * | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
| CA2856037C (en) * | 2005-12-28 | 2017-03-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US7915271B2 (en) * | 2005-12-30 | 2011-03-29 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors |
| UA93548C2 (uk) * | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
| KR20090025367A (ko) * | 2006-06-28 | 2009-03-10 | 가부시키가이샤산와카가쿠켄큐쇼 | 신규 6-5계 이환식 복소환 유도체 및 그 의약용도 |
| EP2054383A2 (en) * | 2006-08-09 | 2009-05-06 | SmithKline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
| JP2010522214A (ja) * | 2007-03-21 | 2010-07-01 | アルミラル, エセ.アー. | アデノシンレセプターアンタゴニストとしての置換ピリミジン |
| KR20100098653A (ko) * | 2007-11-21 | 2010-09-08 | 디코드 제네틱스 이에이치에프 | 염증의 치료를 위한 바이아릴 pde4 억제제 |
| FR2932180B1 (fr) * | 2008-06-04 | 2012-08-10 | Centre Nat Rech Scient | Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline |
-
2008
- 2008-11-20 CA CA2722582A patent/CA2722582A1/en not_active Abandoned
- 2008-11-20 CN CN2008801251758A patent/CN102089279A/zh active Pending
- 2008-11-20 WO PCT/US2008/084193 patent/WO2009067600A2/en not_active Ceased
- 2008-11-20 EP EP08851045A patent/EP2222638A2/en not_active Withdrawn
- 2008-11-20 AU AU2008326381A patent/AU2008326381B2/en not_active Expired - Fee Related
- 2008-11-20 JP JP2010535064A patent/JP2011505341A/ja active Pending
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