CN102089279A - 用于治疗炎症的联芳基pde4抑制剂 - Google Patents
用于治疗炎症的联芳基pde4抑制剂 Download PDFInfo
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- CN102089279A CN102089279A CN2008801251758A CN200880125175A CN102089279A CN 102089279 A CN102089279 A CN 102089279A CN 2008801251758 A CN2008801251758 A CN 2008801251758A CN 200880125175 A CN200880125175 A CN 200880125175A CN 102089279 A CN102089279 A CN 102089279A
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- JQWHZXXYXSGYTH-UHFFFAOYSA-N COc1cccc(OC)c1-c1cc([N+]([O-])=O)ccc1 Chemical compound COc1cccc(OC)c1-c1cc([N+]([O-])=O)ccc1 JQWHZXXYXSGYTH-UHFFFAOYSA-N 0.000 description 1
- KJNMRIQGYBKDAN-UHFFFAOYSA-N Cc(cc1)cc(-c2cccc(Cl)c2)c1OC Chemical compound Cc(cc1)cc(-c2cccc(Cl)c2)c1OC KJNMRIQGYBKDAN-UHFFFAOYSA-N 0.000 description 1
- CSVKZOZMPSRLTC-UHFFFAOYSA-N Cc(cc1)cc(B(O)O)c1OC Chemical compound Cc(cc1)cc(B(O)O)c1OC CSVKZOZMPSRLTC-UHFFFAOYSA-N 0.000 description 1
- JMLWXCJXOYDXRN-UHFFFAOYSA-N Clc1cccc(I)c1 Chemical compound Clc1cccc(I)c1 JMLWXCJXOYDXRN-UHFFFAOYSA-N 0.000 description 1
- KNINFIYIAATMMF-UHFFFAOYSA-N NC(Nc1ccc(Cc(cc2)cc(-c3cc(Cl)ccc3)c2O)cc1)=O Chemical compound NC(Nc1ccc(Cc(cc2)cc(-c3cc(Cl)ccc3)c2O)cc1)=O KNINFIYIAATMMF-UHFFFAOYSA-N 0.000 description 1
- BJRATIDAIAYLRC-UHFFFAOYSA-N NC(Oc(ccc(CC(C=C1)=NNC1=O)c1)c1-c1cccc(N[O-])c1)=O Chemical compound NC(Oc(ccc(CC(C=C1)=NNC1=O)c1)c1-c1cccc(N[O-])c1)=O BJRATIDAIAYLRC-UHFFFAOYSA-N 0.000 description 1
- IEECODMSQVOYRW-UHFFFAOYSA-N NCCOc(ccc(Cc(cc1)ccc1NC(N)=O)c1)c1-c1cc(Cl)ccc1 Chemical compound NCCOc(ccc(Cc(cc1)ccc1NC(N)=O)c1)c1-c1cc(Cl)ccc1 IEECODMSQVOYRW-UHFFFAOYSA-N 0.000 description 1
- AKSXQPCIAOIJGP-UHFFFAOYSA-N NS(c1ccc(B(O)O)cc1)(=O)=O Chemical compound NS(c1ccc(B(O)O)cc1)(=O)=O AKSXQPCIAOIJGP-UHFFFAOYSA-N 0.000 description 1
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N O=C(CCC1)NC1=O Chemical compound O=C(CCC1)NC1=O KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 description 1
- SJSABZBUTDSWMJ-UHFFFAOYSA-N O=C(c1ccncc11)NC1=O Chemical compound O=C(c1ccncc11)NC1=O SJSABZBUTDSWMJ-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N O=C1NCCC1 Chemical compound O=C1NCCC1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- SDEAGACSNFSZCU-UHFFFAOYSA-N OB(c1cc(Cl)ccc1)O Chemical compound OB(c1cc(Cl)ccc1)O SDEAGACSNFSZCU-UHFFFAOYSA-N 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N Oc1ncccc1 Chemical compound Oc1ncccc1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- IUDUFNIFPSKLBK-UHFFFAOYSA-N SOCCN1CCCC1 Chemical compound SOCCN1CCCC1 IUDUFNIFPSKLBK-UHFFFAOYSA-N 0.000 description 1
- AHTMPIXXFHRJMK-UHFFFAOYSA-N SOCCN1CCOCC1 Chemical compound SOCCN1CCOCC1 AHTMPIXXFHRJMK-UHFFFAOYSA-N 0.000 description 1
- DOKONVRRDFDOKU-UHFFFAOYSA-N [O-]Nc1cc(-c(cc(CC(C=C2)=NNC2=O)cc2)c2O)ccc1 Chemical compound [O-]Nc1cc(-c(cc(CC(C=C2)=NNC2=O)cc2)c2O)ccc1 DOKONVRRDFDOKU-UHFFFAOYSA-N 0.000 description 1
- UWWHDODMRXLXCA-UHFFFAOYSA-N [O-]Nc1cc(B(O)O)ccc1 Chemical compound [O-]Nc1cc(B(O)O)ccc1 UWWHDODMRXLXCA-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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| US7915271B2 (en) * | 2005-12-30 | 2011-03-29 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors |
| UA93548C2 (uk) * | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
| KR20090025367A (ko) * | 2006-06-28 | 2009-03-10 | 가부시키가이샤산와카가쿠켄큐쇼 | 신규 6-5계 이환식 복소환 유도체 및 그 의약용도 |
| EP2054383A2 (en) * | 2006-08-09 | 2009-05-06 | SmithKline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
| JP2010522214A (ja) * | 2007-03-21 | 2010-07-01 | アルミラル, エセ.アー. | アデノシンレセプターアンタゴニストとしての置換ピリミジン |
| KR20100098653A (ko) * | 2007-11-21 | 2010-09-08 | 디코드 제네틱스 이에이치에프 | 염증의 치료를 위한 바이아릴 pde4 억제제 |
| FR2932180B1 (fr) * | 2008-06-04 | 2012-08-10 | Centre Nat Rech Scient | Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline |
-
2008
- 2008-11-20 CA CA2722582A patent/CA2722582A1/en not_active Abandoned
- 2008-11-20 CN CN2008801251758A patent/CN102089279A/zh active Pending
- 2008-11-20 WO PCT/US2008/084193 patent/WO2009067600A2/en not_active Ceased
- 2008-11-20 EP EP08851045A patent/EP2222638A2/en not_active Withdrawn
- 2008-11-20 AU AU2008326381A patent/AU2008326381B2/en not_active Expired - Fee Related
- 2008-11-20 JP JP2010535064A patent/JP2011505341A/ja active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103012408A (zh) * | 2012-11-28 | 2013-04-03 | 中国科学院广州生物医药与健康研究院 | 依匹斯汀的合成方法 |
| CN103012408B (zh) * | 2012-11-28 | 2015-02-04 | 中国科学院广州生物医药与健康研究院 | 依匹斯汀的合成方法 |
| CN110041253A (zh) * | 2018-01-17 | 2019-07-23 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
| CN110041253B (zh) * | 2018-01-17 | 2022-03-29 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
| CN113912593A (zh) * | 2020-07-10 | 2022-01-11 | 启元生物(杭州)有限公司 | 一种氘代吡啶酮类化合物及其应用 |
| CN112374984A (zh) * | 2020-11-06 | 2021-02-19 | 苏州求索生物科技有限公司 | 一种2-溴-4-羟基苯甲醚的制备工艺 |
| CN117756794A (zh) * | 2023-12-18 | 2024-03-26 | 和径医药科技(上海)有限公司 | 一种含氮杂环类化合物及其制备方法和应用 |
| CN117756794B (zh) * | 2023-12-18 | 2024-07-16 | 和径医药科技(上海)有限公司 | 一种含氮杂环类化合物及其制备方法和应用 |
| CN118994115A (zh) * | 2024-07-29 | 2024-11-22 | 宁波大学 | 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用 |
| CN118994115B (zh) * | 2024-07-29 | 2025-09-09 | 宁波大学 | 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2722582A1 (en) | 2009-05-28 |
| WO2009067600A3 (en) | 2009-07-30 |
| WO2009067600A2 (en) | 2009-05-28 |
| AU2008326381B2 (en) | 2014-10-23 |
| EP2222638A2 (en) | 2010-09-01 |
| JP2011505341A (ja) | 2011-02-24 |
| AU2008326381A1 (en) | 2009-05-28 |
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