CN102089279A - 用于治疗炎症的联芳基pde4抑制剂 - Google Patents

用于治疗炎症的联芳基pde4抑制剂 Download PDF

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CN102089279A
CN102089279A CN2008801251758A CN200880125175A CN102089279A CN 102089279 A CN102089279 A CN 102089279A CN 2008801251758 A CN2008801251758 A CN 2008801251758A CN 200880125175 A CN200880125175 A CN 200880125175A CN 102089279 A CN102089279 A CN 102089279A
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alkyl
nhc
amino
mmol
salt
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J·辛格
M·E.·格尼
A·布尔金
V·桑达纳亚卡
A·吉谢廖夫
A·莫塔
G·舒尔茨
G·哈泰干
T·哈根
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Decode Genetics ehf
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012408A (zh) * 2012-11-28 2013-04-03 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN110041253A (zh) * 2018-01-17 2019-07-23 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺
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CN117756794A (zh) * 2023-12-18 2024-03-26 和径医药科技(上海)有限公司 一种含氮杂环类化合物及其制备方法和应用
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0708337A2 (pt) 2006-02-28 2011-05-24 Helicon Therapeutics Inc pipirazinas terapêutica como inibidores pde4
JP2011504505A (ja) 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールpde4抑制剤
WO2010059838A2 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects
EP2588465B1 (en) 2010-06-30 2017-01-25 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9617197B2 (en) 2010-08-04 2017-04-11 University Of Virginia Patent Foundation Compositions and methods for treating inflammatory diseases
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
CA2819299A1 (en) * 2010-12-24 2012-06-28 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
CN102617457A (zh) * 2011-01-28 2012-08-01 天津药物研究院 一种制备罗氟司特的新方法
CN103012255B (zh) * 2011-09-21 2014-06-11 天津康鸿医药科技发展有限公司 罗氟司特晶型化合物、其制备方法、组合物及应用
CN102603676B (zh) * 2012-02-20 2014-02-12 徐江平 一种能避免呕吐反应的磷酸二酯酶4抑制剂
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
KR20150087400A (ko) 2012-11-20 2015-07-29 버텍스 파마슈티칼스 인코포레이티드 인돌아민 2,3-디옥시게나제의 억제제로서 유용한 화합물
JP6282721B2 (ja) * 2013-03-14 2018-02-21 ダート・ニューロサイエンス・(ケイマン)・リミテッド Pde4阻害剤としての置換ピリジン及びピラジン化合物
MX2016011903A (es) 2014-03-14 2016-12-05 Wockhardt Ltd Un procedimiento para la preparacion de (2s, 5r) -6- (benciloxi) -7-oxo-1,6-diazabiciclo [3.2.1] octan-2-carboxilato de sodio.
DK3209655T3 (da) 2014-10-24 2020-09-28 Landos Biopharma Inc Lanthioninsyntease C-lignende 2-baserede Therapeutica
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
KR102482673B1 (ko) 2016-07-05 2022-12-30 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. 방향족 아세틸렌 또는 방향족 에틸렌계 화합물, 그의 중간체, 제조 방법, 약물 조성물 및 용도
KR20200090873A (ko) 2017-11-30 2020-07-29 란도스 바이오파마, 인크. 란티오닌 c-유사 단백질 2 리간드 및 이와 함께 제조된 세포를 이용한 치료법
CN109988144B (zh) 2017-12-29 2024-07-05 广州再极医药科技有限公司 芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用
EP3959203A1 (en) * 2019-04-23 2022-03-02 Tetra Discovery Partners, Inc. 3-hydroxy-2-phenyl-6-(pyrazol-4-ylmethyl)pyridine derivatives as pde4d inhibitors
KR20230026522A (ko) 2019-12-20 2023-02-24 란도스 바이오파마, 인크. 란티오닌 c-유사 단백질 2 리간드, 이로 제조된 세포, 및 이를 사용하는 치료법
US20240101552A1 (en) 2020-09-18 2024-03-28 Shanghai Pharmaceuticals Holding Co., Ltd. Carbonyl heterocyclic compound and application thereof
KR102514860B1 (ko) * 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
WO2025240840A1 (en) * 2024-05-17 2025-11-20 Shionogi & Co., Ltd. Aromatic heterocycle derivatives and aromatic carbocycle derivatives having pde4d inhibitory activity
CN119819277B (zh) * 2025-03-17 2025-05-27 昆明医科大学 一种基于BINAM的β-环糊精衍生物手性固定相及其制备方法和应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249963B1 (en) * 1986-06-20 1992-04-22 Idemitsu Kosan Company Limited Polycarbonates
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
CA2144669A1 (en) * 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
WO1996016058A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Aminomethyl aryl compounds; dopamine receptor subtype selective ligands
AU6526896A (en) * 1995-07-22 1997-02-18 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
GB9604926D0 (en) * 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU1504599A (en) * 1997-12-17 1999-07-05 Shionogi & Co., Ltd. Novel pyridine compounds
WO1999048868A2 (en) * 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
DE69919179T2 (de) * 1998-09-09 2005-07-28 Inflazyme Pharmaceuticals, Ltd., Richmond Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
AU7950100A (en) * 1999-10-22 2001-05-08 Takeda Chemical Industries Ltd. 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
AU2002252227A1 (en) * 2001-03-07 2002-09-24 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
WO2003094845A2 (en) * 2002-05-08 2003-11-20 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
CA2505322A1 (en) * 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Receptor function regulator
JP2006521357A (ja) * 2003-03-24 2006-09-21 メルク エンド カムパニー インコーポレーテッド ナトリウムチャンネル遮断薬としてのビアリール置換6員複素環化合物
US7589116B2 (en) * 2003-04-03 2009-09-15 Merck & Co. Inc. Biaryl substituted pyrazoles as sodium channel blockers
US7557143B2 (en) * 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
WO2005030206A1 (en) * 2003-09-24 2005-04-07 Imclone Systems Incorporated Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity
CN1922156A (zh) * 2003-11-10 2007-02-28 默克公司 作为钠通道阻断剂的取代的三唑
CN1882327A (zh) * 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
AU2004309271A1 (en) * 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
JP2008520645A (ja) * 2004-11-23 2008-06-19 ファイザー・プロダクツ・インク ジベンジルアミン化合物および誘導体
PL1831149T3 (pl) * 2004-12-23 2012-06-29 Galderma Res & Dev Nowe ligandy, które modulują receptory RAR, i ich zastosowanie w medycynie i kosmetyce
KR20140018997A (ko) * 2005-01-07 2014-02-13 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
EP1945632B1 (en) * 2005-11-08 2013-09-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
AU2006336504C9 (en) * 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
NZ568904A (en) * 2005-12-30 2011-05-27 Merck Sharp & Dohme 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors
UA93548C2 (uk) * 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
AU2007265940A1 (en) * 2006-06-28 2008-01-03 Sanwa Kagaku Kenkyusho Co., Ltd. Novel 6-5 System Bicyclic Heterocyclic Derivative And Its Pharmaceutical Utility
WO2008021849A2 (en) * 2006-08-09 2008-02-21 Smithkline Beecham Corporation Novel compounds as antagonists or inverse agonists at opioid receptors
WO2008116185A2 (en) * 2007-03-21 2008-09-25 Neurocrine Biosciences, Inc. Substituted pyrimidines as adenosine receptor antagonists
JP2011504505A (ja) * 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールpde4抑制剤
FR2932180B1 (fr) * 2008-06-04 2012-08-10 Centre Nat Rech Scient Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline

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CN103012408A (zh) * 2012-11-28 2013-04-03 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN103012408B (zh) * 2012-11-28 2015-02-04 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN110041253A (zh) * 2018-01-17 2019-07-23 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN110041253B (zh) * 2018-01-17 2022-03-29 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN113912593A (zh) * 2020-07-10 2022-01-11 启元生物(杭州)有限公司 一种氘代吡啶酮类化合物及其应用
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺
CN117756794A (zh) * 2023-12-18 2024-03-26 和径医药科技(上海)有限公司 一种含氮杂环类化合物及其制备方法和应用
CN117756794B (zh) * 2023-12-18 2024-07-16 和径医药科技(上海)有限公司 一种含氮杂环类化合物及其制备方法和应用
CN118994115A (zh) * 2024-07-29 2024-11-22 宁波大学 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用
CN118994115B (zh) * 2024-07-29 2025-09-09 宁波大学 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用

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Application publication date: 20110608