JP2011505013A5 - - Google Patents
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- Publication number
- JP2011505013A5 JP2011505013A5 JP2010536104A JP2010536104A JP2011505013A5 JP 2011505013 A5 JP2011505013 A5 JP 2011505013A5 JP 2010536104 A JP2010536104 A JP 2010536104A JP 2010536104 A JP2010536104 A JP 2010536104A JP 2011505013 A5 JP2011505013 A5 JP 2011505013A5
- Authority
- JP
- Japan
- Prior art keywords
- estradiol
- test sample
- liquid chromatography
- ions
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 44
- 229960005309 estradiol Drugs 0.000 claims 27
- 229930182833 estradiol Natural products 0.000 claims 27
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 22
- 150000002500 ions Chemical class 0.000 claims 22
- 210000001124 body fluid Anatomy 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 238000004811 liquid chromatography Methods 0.000 claims 9
- -1 estradiol ion Chemical class 0.000 claims 8
- 239000010839 body fluid Substances 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 238000004128 high performance liquid chromatography Methods 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 5
- 238000004885 tandem mass spectrometry Methods 0.000 claims 5
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical group 0.000 claims 4
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical group COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical group N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims 2
- 235000019253 formic acid Nutrition 0.000 claims 2
- 238000011002 quantification Methods 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/946,017 US20090134325A1 (en) | 2007-11-27 | 2007-11-27 | Methods for detecting estradiol by mass spectrometry |
| US11/946,017 | 2007-11-27 | ||
| PCT/US2008/084561 WO2009070539A1 (en) | 2007-11-27 | 2008-11-24 | Methods for detecting estradiol by mass spectrometry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167359A Division JP6176735B2 (ja) | 2007-11-27 | 2014-08-20 | 質量分析によってエストラジオールを検出するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011505013A JP2011505013A (ja) | 2011-02-17 |
| JP2011505013A5 true JP2011505013A5 (enExample) | 2012-01-19 |
| JP5602636B2 JP5602636B2 (ja) | 2014-10-08 |
Family
ID=40668902
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536104A Active JP5602636B2 (ja) | 2007-11-27 | 2008-11-24 | 質量分析によってエストラジオールを検出するための方法 |
| JP2014167359A Active JP6176735B2 (ja) | 2007-11-27 | 2014-08-20 | 質量分析によってエストラジオールを検出するための方法 |
| JP2017132534A Active JP6673875B2 (ja) | 2007-11-27 | 2017-07-06 | 質量分析によってエストラジオールを検出するための方法 |
| JP2020037829A Active JP7199392B2 (ja) | 2007-11-27 | 2020-03-05 | 質量分析によってエストラジオールを検出するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167359A Active JP6176735B2 (ja) | 2007-11-27 | 2014-08-20 | 質量分析によってエストラジオールを検出するための方法 |
| JP2017132534A Active JP6673875B2 (ja) | 2007-11-27 | 2017-07-06 | 質量分析によってエストラジオールを検出するための方法 |
| JP2020037829A Active JP7199392B2 (ja) | 2007-11-27 | 2020-03-05 | 質量分析によってエストラジオールを検出するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20090134325A1 (enExample) |
| EP (4) | EP4250336A3 (enExample) |
| JP (4) | JP5602636B2 (enExample) |
| CN (2) | CN101918098B (enExample) |
| CA (1) | CA2706847C (enExample) |
| WO (1) | WO2009070539A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US8399829B2 (en) * | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
| EP2381947A4 (en) | 2008-12-23 | 2012-08-22 | Quest Diagnostics Invest Inc | MASS SPECTROMETRY ASSAY FOR STROGENIC COMPOUNDS |
| CN102175792B (zh) * | 2010-12-24 | 2012-04-25 | 北京师范大学 | 一种水环境中雌激素及壬基酚、辛基酚和双酚a的共检测方法 |
| WO2012095948A1 (ja) * | 2011-01-11 | 2012-07-19 | 株式会社島津製作所 | 質量分析データ解析方法、質量分析データ解析装置、及び質量分析データ解析用プログラム |
| EP3702774B1 (en) * | 2011-02-07 | 2025-10-01 | Laboratory Corporation of America Holdings | Method for determining the presence or amount of testosterone in a sample |
| CN102183606B (zh) * | 2011-03-02 | 2012-04-25 | 北京师范大学 | 一种水体沉积物中雌激素及壬基酚、辛基酚、双酚a的共检测方法 |
| US8669519B2 (en) * | 2011-12-05 | 2014-03-11 | Quest Diagnostics Investments, Inc. | Methods for detecting reverse triiodothyronine by mass spectrometry |
| US9404900B2 (en) * | 2012-12-21 | 2016-08-02 | Thermo Finnigan Llc | System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis |
| WO2015162426A1 (en) * | 2014-04-23 | 2015-10-29 | Micromass Uk Limited | Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences |
| EP3143392B1 (en) * | 2014-05-12 | 2023-02-22 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen metabolites by mass spectrometry |
| CN105572238B (zh) * | 2014-10-16 | 2017-11-10 | 无锡市寰创环境科技发展有限公司 | 一种检测养殖废物中雌激素的方法 |
| CN104678022A (zh) * | 2015-03-09 | 2015-06-03 | 黑龙江省乳品工业技术开发中心 | 一种产后奶牛泌乳中β-雌二醇含量消退的预测方法及应用 |
| US11360098B2 (en) * | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| CN108459104A (zh) * | 2017-12-26 | 2018-08-28 | 华南师范大学 | 一种检测鱼类胆汁中个人护理品的方法 |
| CN110243917A (zh) * | 2018-03-09 | 2019-09-17 | 中国科学院天津工业生物技术研究所 | 一种快速检测小分子化合物的方法 |
| JP2022528979A (ja) * | 2019-04-16 | 2022-06-16 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｌｃ－ｍｓ／ｍｓによる１１－オキソアンドロゲンの検出のための方法およびシステム |
| CN111103380A (zh) * | 2019-12-25 | 2020-05-05 | 南京希麦迪医药科技有限公司 | 一种液质联用测定人血浆中内源性雌二醇浓度的方法 |
| GB2700086A (en) * | 2023-07-21 | 2025-09-17 | Thermo Fisher Scient Bremen Gmbh | Compound assembly |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| ATE242485T1 (de) * | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5772874A (en) * | 1995-11-02 | 1998-06-30 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
| DK0840893T3 (da) * | 1996-01-19 | 2000-04-03 | Cohesive Tech Inc | Fremgangsmåde og apparat til højeffektiv væskekromatografi |
| GB9717926D0 (en) * | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| US6600155B1 (en) * | 1998-01-23 | 2003-07-29 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
| JP2000088834A (ja) * | 1998-09-16 | 2000-03-31 | Sumika Chemical Analysis Service Ltd | 分析方法 |
| JP2001116736A (ja) * | 1999-10-21 | 2001-04-27 | Sumika Chemical Analysis Service Ltd | エストロゲンの分析方法 |
| DE10028974A1 (de) * | 2000-06-16 | 2002-01-03 | Henkel Kgaa | Thixotrope Mund- und Zahnpflegemittel |
| US6680203B2 (en) * | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
| JP2002056040A (ja) * | 2000-08-14 | 2002-02-20 | Nec Corp | ３次元ｃａｄによるケーブルクランプとケーブルの形状設計方法およびコンピュータ読み取り可能な記録媒体 |
| US6635173B2 (en) * | 2000-12-28 | 2003-10-21 | Cohesive Technologies, Inc. | Multi column chromatography system |
| US7223552B2 (en) * | 2001-01-02 | 2007-05-29 | The Cleveland Clinic Foundation | Myeloperoxidase, a risk indicator for cardiovascular disease |
| JP2003090839A (ja) * | 2001-09-18 | 2003-03-28 | Toru Ueda | 内分泌攪乱物質群およびそれらの活性を指標とした生物系廃棄物処理物の評価方法 |
| JP2003098169A (ja) * | 2001-09-25 | 2003-04-03 | Toru Ueda | 内分泌攪乱作用を指標とした穀類・青果物等の評価方法とその応用方法 |
| AU2003239333A1 (en) * | 2002-01-31 | 2003-09-02 | Centre National De La Recherche Scientifique (Cnrs) | The ligand binding pocket peptide fragment of estrogen-related receptor 3 (err3), its crystal structure, and uses thereof |
| JP2003342291A (ja) * | 2002-05-27 | 2003-12-03 | Sumika Chemical Analysis Service Ltd | エストラジオール抱合体 |
| JP3844741B2 (ja) * | 2003-03-03 | 2006-11-15 | 株式会社荏原製作所 | 女性ホルモン分解細菌及びその用途 |
| WO2004090525A1 (en) * | 2003-04-14 | 2004-10-21 | Georgetown University | Steroid hormone analysis by mass spectrometry |
| US6977143B1 (en) * | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| US8480742B2 (en) * | 2005-08-02 | 2013-07-09 | Perumala Corporation | Total artificial disc |
| JP2005283380A (ja) * | 2004-03-30 | 2005-10-13 | Teikoku Hormone Mfg Co Ltd | バイオアベイラブルステロイドホルモンの測定方法 |
| JP4667832B2 (ja) * | 2004-11-15 | 2011-04-13 | あすか製薬株式会社 | 生体内微量エストラジオールの新規測定法 |
| JP2008534955A (ja) * | 2005-03-31 | 2008-08-28 | ジョージタウン ユニバーシティ | 質量分析法による有利サイロキシンおよび遊離トリヨードサイロニン分析 |
| JPWO2007029668A1 (ja) * | 2005-09-08 | 2009-03-19 | 国立大学法人金沢大学 | ソフトイオン化法のための誘導体化試薬 |
| JP4634913B2 (ja) * | 2005-11-09 | 2011-02-16 | あすか製薬株式会社 | ステロイドの測定方法 |
| CN1834641A (zh) * | 2006-04-14 | 2006-09-20 | 清华大学 | 水环境中极性内分泌干扰物采样监测方法及装置 |
| US7935921B2 (en) * | 2006-05-26 | 2011-05-03 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US8202736B2 (en) * | 2009-02-26 | 2012-06-19 | The Governing Council Of The University Of Toronto | Method of hormone extraction using digital microfluidics |
-
2007
- 2007-11-27 US US11/946,017 patent/US20090134325A1/en not_active Abandoned
-
2008
- 2008-11-24 EP EP23186684.9A patent/EP4250336A3/en active Pending
- 2008-11-24 WO PCT/US2008/084561 patent/WO2009070539A1/en not_active Ceased
- 2008-11-24 CN CN2008801251512A patent/CN101918098B/zh active Active
- 2008-11-24 EP EP14169040.4A patent/EP2777792B1/en active Active
- 2008-11-24 CN CN201310193851.8A patent/CN103323561B/zh active Active
- 2008-11-24 CA CA2706847A patent/CA2706847C/en active Active
- 2008-11-24 EP EP18176001.8A patent/EP3388127B1/en active Active
- 2008-11-24 JP JP2010536104A patent/JP5602636B2/ja active Active
- 2008-11-24 EP EP08855326.8A patent/EP2231297B2/en active Active
-
2014
- 2014-08-20 JP JP2014167359A patent/JP6176735B2/ja active Active
-
2015
- 2015-03-02 US US14/635,586 patent/US20150309055A1/en not_active Abandoned
-
2017
- 2017-07-06 JP JP2017132534A patent/JP6673875B2/ja active Active
-
2020
- 2020-03-05 JP JP2020037829A patent/JP7199392B2/ja active Active
-
2022
- 2022-05-03 US US17/735,879 patent/US20220326260A1/en active Pending
-
2025
- 2025-01-15 US US19/021,914 patent/US20250237668A1/en active Pending
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