|
US20060106020A1
(en)
*
|
2004-04-28 |
2006-05-18 |
Rodgers James D |
Tetracyclic inhibitors of Janus kinases
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
CA2673038C
(en)
*
|
2006-12-22 |
2015-12-15 |
Incyte Corporation |
Substituted tricyclic heteroaryl compounds as janus kinase inhibitors
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
KR20150036210A
(ko)
|
2007-06-13 |
2015-04-07 |
인사이트 코포레이션 |
야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
|
|
FR2938537B1
(fr)
|
2008-11-14 |
2012-10-26 |
Sanofi Aventis |
Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
|
|
TWI720517B
(zh)
|
2009-01-15 |
2021-03-01 |
美商英塞特公司 |
製造ｊａｋ抑制劑之方法及相關中間化合物
|
|
AR076794A1
(es)
|
2009-05-22 |
2011-07-06 |
Incyte Corp |
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
|
|
SI2432472T1
(sl)
|
2009-05-22 |
2019-11-29 |
Incyte Holdings Corp |
3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
WO2011079231A1
(en)
*
|
2009-12-23 |
2011-06-30 |
Gatekeeper Pharmaceutical, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
AU2011214254B2
(en)
*
|
2010-02-10 |
2016-06-09 |
Genon Biotechnologies Oy |
Dual activity kinase domains and uses thereof
|
|
JP5858434B2
(ja)
*
|
2010-02-18 |
2016-02-10 |
インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｊａｎｕｓキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体
|
|
EP3354652B1
(en)
|
2010-03-10 |
2020-05-06 |
Incyte Holdings Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
GB201007286D0
(en)
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
PE20130216A1
(es)
|
2010-05-21 |
2013-02-27 |
Incyte Corp |
Formulacion topica para un inhibidor de jak
|
|
ES2577829T3
(es)
|
2010-06-04 |
2016-07-19 |
F. Hoffmann-La Roche Ag |
Derivados de aminopirimidina como moduladores de la LRRK2
|
|
JP2014500254A
(ja)
*
|
2010-11-09 |
2014-01-09 |
セルゾーム リミティッド |
Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
|
|
NO2638031T3
(https=)
|
2010-11-10 |
2018-03-10 |
|
|
|
US9034884B2
(en)
|
2010-11-19 |
2015-05-19 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
|
|
PE20140146A1
(es)
|
2010-11-19 |
2014-02-06 |
Incyte Corp |
Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
ES2547916T3
(es)
|
2011-02-18 |
2015-10-09 |
Novartis Pharma Ag |
Terapia de combinación de inhibidores de mTOR/JAK
|
|
EP2702055A1
(en)
*
|
2011-04-11 |
2014-03-05 |
Nerviano Medical Sciences S.r.l. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
CN103797010B
(zh)
|
2011-06-20 |
2016-02-24 |
因塞特控股公司 |
作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
|
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
CA2849168A1
(en)
*
|
2011-09-22 |
2013-03-28 |
Merck Sharp & Dohme Corp. |
Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
CN103102359B
(zh)
*
|
2011-11-15 |
2016-11-09 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
ES3018133T3
(en)
|
2011-11-30 |
2025-05-14 |
Univ Emory |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
US8809359B2
(en)
*
|
2012-06-29 |
2014-08-19 |
Ym Biosciences Australia Pty Ltd |
Phenyl amino pyrimidine bicyclic compounds and uses thereof
|
|
EP2911675A4
(en)
*
|
2012-10-23 |
2016-06-01 |
Merck Sharp & Dohme |
2-PYRIDYLOXY-3-SUBSTITUTED 4-NITRIL-OREXINE RECEPTOR ANTAGONISTS
|
|
TWI646099B
(zh)
|
2012-11-01 |
2019-01-01 |
英塞特控股公司 |
作爲ｊａｋ抑制劑之三環稠合噻吩衍生物
|
|
EP2914253B1
(en)
|
2012-11-05 |
2018-01-03 |
NantBioScience, Inc. |
Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway
|
|
PH12020551186B1
(en)
|
2012-11-15 |
2024-03-20 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
WO2014075318A1
(zh)
*
|
2012-11-19 |
2014-05-22 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
NZ746607A
(en)
|
2012-11-21 |
2019-11-29 |
Ptc Therapeutics Inc |
Substituted reverse pyrimidine bmi-1 inhibitors
|
|
RS62867B1
(sr)
|
2013-03-06 |
2022-02-28 |
Incyte Holdings Corp |
Postupci i intermedijeri za dobijanje inhibitora jak
|
|
WO2014146249A1
(en)
*
|
2013-03-19 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
HUE033587T2
(hu)
|
2013-05-17 |
2017-12-28 |
Incyte Corp |
Bipirazol-származékok mint JAK inhibitorok
|
|
WO2014196793A1
(en)
*
|
2013-06-05 |
2014-12-11 |
C&C Research Laboratories |
Heterocyclic derivatives and use thereof
|
|
SMT202000315T1
(it)
|
2013-08-07 |
2020-07-08 |
Incyte Corp |
Forme di dosaggio a rilascio prolungato per un inibitore di jak1
|
|
EA034866B1
(ru)
|
2013-08-30 |
2020-03-31 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Замещенные пиримидиновые ингибиторы bmi-1
|
|
CN105980381A
(zh)
|
2013-11-08 |
2016-09-28 |
拜耳医药股份有限公司 |
取代的尿嘧啶及其用途
|
|
WO2015076800A1
(en)
|
2013-11-21 |
2015-05-28 |
Ptc Therapeutics, Inc. |
Substituted pyridine and pyrazine bmi-1 inhibitors
|
|
CN104860941B
(zh)
*
|
2014-02-25 |
2017-03-22 |
上海海雁医药科技有限公司 |
2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
|
|
RU2715236C2
(ru)
|
2014-03-26 |
2020-02-26 |
Астекс Терапьютикс Лтд |
Комбинации
|
|
HRP20210319T1
(hr)
|
2014-03-26 |
2021-04-30 |
Astex Therapeutics Ltd. |
Kombinacije inhibitora fgfr i inhibitora igf1r
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
MA39987A
(fr)
|
2014-04-30 |
2017-03-08 |
Incyte Corp |
Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
WO2016105525A2
(en)
*
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Novel pyrimidines as egfr inhibitors and methods of treating disorders
|
|
TWI719960B
(zh)
|
2015-02-10 |
2021-03-01 |
英商阿斯迪克治療公司 |
新穎組成物
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
CN107531678B
(zh)
*
|
2015-07-24 |
2020-12-22 |
上海海雁医药科技有限公司 |
Egfr抑制剂及其药学上可接受的盐和多晶型物及其应用
|
|
EP3353164B1
(en)
|
2015-09-23 |
2021-11-03 |
Janssen Pharmaceutica, N.V. |
Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
|
|
US11155555B2
(en)
|
2015-09-23 |
2021-10-26 |
Janssen Pharmaceutica Nv |
Compounds
|
|
US10793542B2
(en)
|
2016-11-22 |
2020-10-06 |
Development Center For Biotechnology |
Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof
|
|
KR102717072B1
(ko)
|
2017-10-18 |
2024-10-15 |
인사이트 코포레이션 |
Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
|
|
WO2019113487A1
(en)
|
2017-12-08 |
2019-06-13 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
SG11202007164UA
(en)
|
2018-01-30 |
2020-08-28 |
Incyte Corp |
Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
|
|
KR102925957B1
(ko)
|
2018-02-16 |
2026-02-11 |
인사이트 코포레이션 |
사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제
|
|
SMT202400306T1
(it)
|
2018-03-30 |
2024-09-16 |
Incyte Corp |
Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
|
|
MA52655A
(fr)
|
2018-03-30 |
2021-02-17 |
Incyte Corp |
Biomarqueurs pour maladie cutanée inflammatoire
|
|
CA3097025A1
(en)
|
2018-04-13 |
2019-10-17 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
EP3836932A2
(en)
|
2018-08-17 |
2021-06-23 |
PTC Therapeutics, Inc. |
Method for treating pancreatic cancer
|
|
CR20250050A
(es)
|
2018-09-05 |
2025-03-19 |
Incyte Corp |
Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
CN113226321B
(zh)
*
|
2018-10-26 |
2024-12-17 |
阿利安制药有限责任公司 |
吡唑基化合物及其使用方法
|
|
CA3117969A1
(en)
|
2018-10-31 |
2020-05-07 |
Incyte Corporation |
Combination therapy for treatment of hematological diseases
|
|
WO2020118683A1
(en)
*
|
2018-12-14 |
2020-06-18 |
Lynk Pharmaceuticals Co. Ltd. |
Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
|
|
US11384083B2
(en)
|
2019-02-15 |
2022-07-12 |
Incyte Corporation |
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
CA3137152A1
(en)
|
2019-04-18 |
2020-10-22 |
The Johns Hopkins University |
Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof
|
|
WO2020223469A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
CN112142731B
(zh)
*
|
2019-06-28 |
2022-07-22 |
成都赜灵生物医药科技有限公司 |
一种2，4-二取代嘧啶衍生物及其制备方法和用途
|
|
WO2020259683A1
(zh)
*
|
2019-06-28 |
2020-12-30 |
成都赜灵生物医药科技有限公司 |
2，4-二取代嘧啶衍生物及其制备方法和用途
|
|
CA3150681A1
(en)
|
2019-08-14 |
2021-02-18 |
Incyte Corporation |
Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
US20220372135A1
(en)
|
2019-09-27 |
2022-11-24 |
Disc Medicine, Inc. |
Methods for treating myelofibrosis and related conditions
|
|
WO2021072098A1
(en)
|
2019-10-10 |
2021-04-15 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
EP4041204A1
(en)
|
2019-10-10 |
2022-08-17 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
US11851426B2
(en)
|
2019-10-11 |
2023-12-26 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
JP7717065B2
(ja)
|
2019-11-22 |
2025-08-01 |
インサイト コーポレーション |
Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法
|
|
AU2021243887A1
(en)
*
|
2020-03-23 |
2022-11-03 |
Korea Research Institute Of Chemical Technology |
Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same
|
|
KR20230012539A
(ko)
|
2020-05-13 |
2023-01-26 |
디스크 메디슨, 인크. |
골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
|
|
MX2022015221A
(es)
|
2020-06-02 |
2023-03-08 |
Incyte Corp |
Procesos para preparar un inhibidor de cinasa jano 1 (jak1).
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
IL300557A
(en)
|
2020-08-18 |
2023-04-01 |
Incyte Corp |
Process and intermediates for preparing a JAK1 inhibitor
|
|
PE20231743A1
(es)
|
2020-08-18 |
2023-10-31 |
Incyte Corp |
Proceso e intermediarios para preparar un inhibidor de jak
|
|
CN114181199B
(zh)
*
|
2020-09-15 |
2023-09-26 |
成都赜灵生物医药科技有限公司 |
2，4-二取代嘧啶衍生物及其制备方法和用途
|
|
CN112142675B
(zh)
*
|
2020-10-09 |
2021-11-30 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
CN112159394B
(zh)
|
2020-10-09 |
2021-10-22 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
AU2021362678A1
(en)
|
2020-10-13 |
2023-05-04 |
The Johns Hopkins University |
SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
|
|
CA3204374A1
(en)
|
2020-12-08 |
2022-06-16 |
Incyte Corporation |
Jak1 pathway inhibitors for the treatment of vitiligo
|
|
WO2022166916A1
(zh)
*
|
2021-02-05 |
2022-08-11 |
深圳市塔吉瑞生物医药有限公司 |
取代的杂芳基衍生物及其组合物及用途
|
|
UA129643C2
(uk)
|
2021-05-03 |
2025-06-18 |
Інсайт Корпорейшн |
Інгібітори шляху jak1 для лікування вузлуватого свербця
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
US12071439B2
(en)
|
2021-07-12 |
2024-08-27 |
Incyte Corporation |
Process and intermediates for preparing a JAK inhibitor
|
|
AU2022361055A1
(en)
*
|
2021-10-06 |
2024-04-04 |
Alcon Inc. |
Janus kinase inhibiting pyrazole compounds and uses thereof
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CA3263043A1
(en)
*
|
2022-08-22 |
2024-02-29 |
Hangzhou Highlightll Pharmaceutical Co., Ltd |
JAK1/JAK2/TYK2 INHIBITORS FOR THE TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES
|
|
CN115594664B
(zh)
*
|
2022-11-25 |
2023-02-24 |
英矽智能科技(上海)有限公司 |
一类螺环衍生物作为kif18a抑制剂
|