|
WO2005105814A1
(en)
*
|
2004-04-28 |
2005-11-10 |
Incyte Corporation |
Tetracyclic inhibitors of janus kinases
|
|
EP2455382B1
(en)
|
2005-12-13 |
2016-10-26 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
EP2121692B1
(en)
*
|
2006-12-22 |
2013-04-10 |
Incyte Corporation |
Substituted heterocycles as janus kinase inhibitors
|
|
EP3070090B1
(en)
|
2007-06-13 |
2018-12-12 |
Incyte Holdings Corporation |
Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
FR2938537B1
(fr)
|
2008-11-14 |
2012-10-26 |
Sanofi Aventis |
Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
|
|
CA3121743A1
(en)
|
2009-01-15 |
2010-07-22 |
Incyte Holdings Corporation |
Processes for preparing jak inhibitors and related intermediate compounds
|
|
SG176111A1
(en)
|
2009-05-22 |
2011-12-29 |
Incyte Corp |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
JP5775070B2
(ja)
|
2009-05-22 |
2015-09-09 |
インサイト・コーポレイションIncyte Corporation |
ヤヌスキナーゼ阻害剤としてのピラゾール−4−イル−ピロロ[2,3−d]ピリミジンおよびピロール−3−イル−ピロロ[2,3−d]ピリミジンのN−(ヘテロ)アリール−ピロリジン誘導体
|
|
AR078012A1
(es)
|
2009-09-01 |
2011-10-05 |
Incyte Corp |
Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
|
|
US20110207736A1
(en)
|
2009-12-23 |
2011-08-25 |
Gatekeeper Pharmaceuticals, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
EP2534258B1
(en)
*
|
2010-02-10 |
2017-09-20 |
Genon Biotechnologies OY |
Dual activity kinase domains and uses thereof
|
|
EP2536729A1
(en)
*
|
2010-02-18 |
2012-12-26 |
Incyte Corporation |
Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
|
|
PT3354652T
(pt)
|
2010-03-10 |
2020-07-20 |
Incyte Holdings Corp |
Derivados de piperidin-4-ilazetidina como inibidores de jak1
|
|
GB201007286D0
(en)
*
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
RS54824B1
(sr)
|
2010-05-21 |
2016-10-31 |
Incyte Holdings Corp |
Topikalna formulacija za inhibiciju jak-a
|
|
PT2576541T
(pt)
|
2010-06-04 |
2016-07-08 |
Hoffmann La Roche |
Derivados de aminopirimidina como moduladores de lrrk2
|
|
AU2011328237A1
(en)
*
|
2010-11-09 |
2013-05-23 |
Cellzome Limited |
Pyridine compounds and aza analogues thereof as TYK2 inhibitors
|
|
HRP20172006T1
(hr)
|
2010-11-10 |
2018-02-09 |
Genentech, Inc. |
Derivati pirazol-aminopiridina kao lrrk2-modulatori
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
CA2827673C
(en)
|
2011-02-18 |
2020-10-27 |
Novartis Pharma Ag |
Mtor/jak inhibitor combination therapy
|
|
WO2012139930A1
(en)
*
|
2011-04-11 |
2012-10-18 |
Nerviano Medical Sciences S.R.L. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
MY165963A
(en)
|
2011-06-20 |
2018-05-18 |
Incyte Holdings Corp |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
WO2013041042A1
(en)
*
|
2011-09-22 |
2013-03-28 |
Merck Sharp & Dohme Corp. |
Pyrazole carboxamides as janus kinase inhibitors
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
CN103102359B
(zh)
*
|
2011-11-15 |
2016-11-09 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
EP4556010A3
(en)
|
2011-11-30 |
2025-07-23 |
Emory University |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はahi1の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
US8809359B2
(en)
*
|
2012-06-29 |
2014-08-19 |
Ym Biosciences Australia Pty Ltd |
Phenyl amino pyrimidine bicyclic compounds and uses thereof
|
|
EP2911675A4
(en)
|
2012-10-23 |
2016-06-01 |
Merck Sharp & Dohme |
2-PYRIDYLOXY-3-SUBSTITUTED 4-NITRIL-OREXINE RECEPTOR ANTAGONISTS
|
|
CN104918945B
(zh)
|
2012-11-01 |
2018-01-05 |
因赛特公司 |
作为jak抑制剂的三环稠合噻吩衍生物
|
|
CA2890002A1
(en)
*
|
2012-11-05 |
2014-05-08 |
Nant Holdings Ip, Llc |
Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway
|
|
CN113384546A
(zh)
|
2012-11-15 |
2021-09-14 |
因赛特公司 |
鲁索利替尼的缓释剂型
|
|
WO2014075318A1
(zh)
*
|
2012-11-19 |
2014-05-22 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
KR20220143164A
(ko)
|
2012-11-21 |
2022-10-24 |
피티씨 테라퓨틱스, 인크. |
치환된 리버스 피리미딘 bmi-1 저해제
|
|
WO2014138168A1
(en)
|
2013-03-06 |
2014-09-12 |
Incyte Corporation |
Processes and intermediates for making a jak inhibitor
|
|
WO2014146249A1
(en)
*
|
2013-03-19 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
SMT201900223T1
(it)
|
2013-05-17 |
2019-07-11 |
Incyte Corp |
Sale di bipirazolo come inibitore di jak
|
|
AU2014275643B2
(en)
*
|
2013-06-05 |
2018-08-09 |
C&C Research Laboratories |
Heterocyclic derivatives and use thereof
|
|
SG10201801069QA
(en)
|
2013-08-07 |
2018-03-28 |
Incyte Corp |
Sustained release dosage forms for a jak1 inhibitor
|
|
AR093580A1
(es)
|
2013-08-30 |
2015-06-10 |
Ptc Therapeutics Inc |
Inhibidores bmi-1 de pirimidina sustituidos
|
|
CN105980381A
(zh)
|
2013-11-08 |
2016-09-28 |
拜耳医药股份有限公司 |
取代的尿嘧啶及其用途
|
|
WO2015076800A1
(en)
|
2013-11-21 |
2015-05-28 |
Ptc Therapeutics, Inc. |
Substituted pyridine and pyrazine bmi-1 inhibitors
|
|
CN104860941B
(zh)
*
|
2014-02-25 |
2017-03-22 |
上海海雁医药科技有限公司 |
2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
|
|
JP6752715B2
(ja)
|
2014-03-26 |
2020-09-09 |
アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited |
組合せ
|
|
MX373150B
(es)
|
2014-03-26 |
2020-04-21 |
Astex Therapeutics Ltd |
Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r).
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
CN106687462A
(zh)
|
2014-04-30 |
2017-05-17 |
因赛特公司 |
Jak1抑制剂的制备方法以及其新形式
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
CN113563332B
(zh)
*
|
2014-12-23 |
2024-12-17 |
达纳-法伯癌症研究所公司 |
作为egfr抑制剂的新的嘧啶和治疗病症的方法
|
|
TWI719960B
(zh)
|
2015-02-10 |
2021-03-01 |
英商阿斯迪克治療公司 |
新穎組成物
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
WO2017016463A1
(zh)
*
|
2015-07-24 |
2017-02-02 |
上海海雁医药科技有限公司 |
Egfr抑制剂及其药学上可接受的盐和多晶型物及其应用
|
|
AU2016328693B2
(en)
|
2015-09-23 |
2021-03-11 |
Janssen Pharmaceutica Nv |
Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
|
|
DK3353177T3
(da)
|
2015-09-23 |
2020-08-24 |
Janssen Pharmaceutica Nv |
Tricykliske heterocykler til behandling af cancer
|
|
US10793542B2
(en)
|
2016-11-22 |
2020-10-06 |
Development Center For Biotechnology |
Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof
|
|
KR20240152947A
(ko)
|
2017-10-18 |
2024-10-22 |
인사이트 코포레이션 |
Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
EA202091830A1
(ru)
|
2018-01-30 |
2020-12-29 |
Инсайт Корпорейшн |
Способы и промежуточные соединения для получения ингибитора jak
|
|
IL311485B1
(en)
|
2018-02-16 |
2026-01-01 |
Incyte Corp |
JAK1 pathway inhibitors for the treatment of cytokine-related disorders
|
|
WO2019191679A1
(en)
|
2018-03-30 |
2019-10-03 |
Incyte Corporation |
Biomarkers for inflammatory skin disease
|
|
MD3773593T2
(ro)
|
2018-03-30 |
2024-10-31 |
Incyte Corp |
Tratament hidradenitei supurative utilizând inhibitori ai JAK
|
|
CA3097025A1
(en)
|
2018-04-13 |
2019-10-17 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
CN113164479A
(zh)
|
2018-08-17 |
2021-07-23 |
Ptc医疗公司 |
用于治疗胰腺癌的方法
|
|
CR20250050A
(es)
|
2018-09-05 |
2025-03-19 |
Incyte Corp |
Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
JP7186874B2
(ja)
*
|
2018-10-26 |
2022-12-09 |
アーリーン ファーマシューティカルズ エルエルシー |
ピラゾリル化合物およびその使用方法
|
|
CA3117969A1
(en)
|
2018-10-31 |
2020-05-07 |
Incyte Corporation |
Combination therapy for treatment of hematological diseases
|
|
WO2020118683A1
(en)
*
|
2018-12-14 |
2020-06-18 |
Lynk Pharmaceuticals Co. Ltd. |
Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
WO2020180959A1
(en)
|
2019-03-05 |
2020-09-10 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
NZ780966A
(en)
|
2019-04-18 |
2026-02-27 |
Univ Johns Hopkins |
Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
CN112142731B
(zh)
*
|
2019-06-28 |
2022-07-22 |
成都赜灵生物医药科技有限公司 |
一种2,4-二取代嘧啶衍生物及其制备方法和用途
|
|
EP3985000B1
(en)
*
|
2019-06-28 |
2024-09-25 |
Chengdu Zenitar Biomedical Technology Co., Ltd. |
2,4-disubstituted pyrimidine derivative, preparation method for same, and uses thereof
|
|
TW202115024A
(zh)
|
2019-08-14 |
2021-04-16 |
美商英塞特公司 |
作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
|
|
CN114761013A
(zh)
|
2019-09-27 |
2022-07-15 |
迪斯克医药公司 |
治疗骨髓纤维化和相关病症的方法
|
|
US12360120B2
(en)
|
2019-10-10 |
2025-07-15 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
EP4041204A1
(en)
|
2019-10-10 |
2022-08-17 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
AU2020364007A1
(en)
|
2019-10-11 |
2022-04-28 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CN115038443A
(zh)
|
2019-11-22 |
2022-09-09 |
因西特公司 |
包含alk2抑制剂和jak2抑制剂的组合疗法
|
|
BR112022018477A2
(pt)
*
|
2020-03-23 |
2022-11-01 |
Whan In Pharmaceutical Co Ltd |
Composto derivado de pirimidina, composição compreendendo o mesmo, e seus usos na prevenção ou tratamento de doenças neurodegenerativas e câncer
|
|
WO2021231798A1
(en)
|
2020-05-13 |
2021-11-18 |
Disc Medicine, Inc. |
Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
|
|
FI4157831T3
(fi)
|
2020-06-02 |
2024-12-02 |
Incyte Corp |
Menetelmiä jak1-estäjän valmistamiseksi
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
CA3192099A1
(en)
|
2020-08-18 |
2022-02-24 |
Incyte Corporation |
Process and intermediates for preparing a jak inhibitor
|
|
CR20230130A
(es)
|
2020-08-18 |
2023-07-13 |
Incyte Corp |
Proceso e intermedios para preparar un inhibidor de jak1
|
|
CN114181199B
(zh)
*
|
2020-09-15 |
2023-09-26 |
成都赜灵生物医药科技有限公司 |
2,4-二取代嘧啶衍生物及其制备方法和用途
|
|
CN112142675B
(zh)
*
|
2020-10-09 |
2021-11-30 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
CN112159394B
(zh)
*
|
2020-10-09 |
2021-10-22 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
WO2022125670A1
(en)
|
2020-12-08 |
2022-06-16 |
Incyte Corporation |
Jak1 pathway inhibitors for the treatment of vitiligo
|
|
CN114874189B
(zh)
*
|
2021-02-05 |
2023-09-29 |
深圳市塔吉瑞生物医药有限公司 |
取代的杂芳基衍生物及其组合物及用途
|
|
RS67455B1
(sr)
|
2021-05-03 |
2025-12-31 |
Incyte Corp |
Inhibitori jak1 puta za lečenje prurigo nodularisa
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
CN118317946A
(zh)
|
2021-07-12 |
2024-07-09 |
因赛特公司 |
用于制备巴瑞替尼的方法和中间体
|
|
WO2023060202A1
(en)
*
|
2021-10-06 |
2023-04-13 |
Aerie Pharmaceuticals, Inc. |
Janus kinase inhibiting pyrazole compounds and uses thereof
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
EP4577535A1
(en)
*
|
2022-08-22 |
2025-07-02 |
Hangzhou Highlightll Pharmaceutical Co., Ltd. |
Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases
|
|
CN115594664B
(zh)
*
|
2022-11-25 |
2023-02-24 |
英矽智能科技(上海)有限公司 |
一类螺环衍生物作为kif18a抑制剂
|