ZA201004055B - 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors - Google Patents

4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

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Publication number
ZA201004055B
ZA201004055B ZA2010/04055A ZA201004055A ZA201004055B ZA 201004055 B ZA201004055 B ZA 201004055B ZA 2010/04055 A ZA2010/04055 A ZA 2010/04055A ZA 201004055 A ZA201004055 A ZA 201004055A ZA 201004055 B ZA201004055 B ZA 201004055B
Authority
ZA
South Africa
Prior art keywords
pyrazolyl
amines
heteroarylpyrimidin
arylpyrimidin
kinase inhibitors
Prior art date
Application number
ZA2010/04055A
Other languages
English (en)
Inventor
Yun-Long Li
Wenqing Yao
James D Rodgers
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40380038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201004055(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ZA201004055B publication Critical patent/ZA201004055B/en

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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ZA2010/04055A 2007-11-16 2010-06-07 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors ZA201004055B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98860607P 2007-11-16 2007-11-16
PCT/US2008/083319 WO2009064835A1 (en) 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

Publications (1)

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ZA201004055B true ZA201004055B (en) 2012-09-26

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ZA2010/04055A ZA201004055B (en) 2007-11-16 2010-06-07 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

Country Status (20)

Country Link
US (1) US8309718B2 (https=)
EP (1) EP2220068B1 (https=)
JP (1) JP5480813B2 (https=)
KR (1) KR101580482B1 (https=)
CN (1) CN101910152B (https=)
AU (1) AU2008321046B2 (https=)
BR (1) BRPI0820544A2 (https=)
CA (1) CA2704599C (https=)
CO (1) CO6280420A2 (https=)
CR (1) CR11430A (https=)
EA (1) EA020777B1 (https=)
EC (1) ECSP10010263A (https=)
ES (1) ES2569528T3 (https=)
IL (1) IL205571A (https=)
MX (1) MX2010005300A (https=)
MY (1) MY152948A (https=)
NZ (1) NZ585139A (https=)
UA (1) UA104849C2 (https=)
WO (1) WO2009064835A1 (https=)
ZA (1) ZA201004055B (https=)

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WO2005105814A1 (en) * 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
EP2455382B1 (en) 2005-12-13 2016-10-26 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
EP2121692B1 (en) * 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
FR2938537B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
CA3121743A1 (en) 2009-01-15 2010-07-22 Incyte Holdings Corporation Processes for preparing jak inhibitors and related intermediate compounds
SG176111A1 (en) 2009-05-22 2011-12-29 Incyte Corp 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
JP5775070B2 (ja) 2009-05-22 2015-09-09 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体
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