JP2022531801A5 - - Google Patents
Info
- Publication number
- JP2022531801A5 JP2022531801A5 JP2021566469A JP2021566469A JP2022531801A5 JP 2022531801 A5 JP2022531801 A5 JP 2022531801A5 JP 2021566469 A JP2021566469 A JP 2021566469A JP 2021566469 A JP2021566469 A JP 2021566469A JP 2022531801 A5 JP2022531801 A5 JP 2022531801A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- propyl
- pyrimidine
- phenyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024202910A JP2025028915A (ja) | 2019-05-10 | 2024-11-21 | フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962846251P | 2019-05-10 | 2019-05-10 | |
| US201962846258P | 2019-05-10 | 2019-05-10 | |
| US62/846,258 | 2019-05-10 | ||
| US62/846,251 | 2019-05-10 | ||
| US201962911730P | 2019-10-07 | 2019-10-07 | |
| US201962911728P | 2019-10-07 | 2019-10-07 | |
| US62/911,730 | 2019-10-07 | ||
| US62/911,728 | 2019-10-07 | ||
| PCT/US2020/032087 WO2020231806A1 (en) | 2019-05-10 | 2020-05-08 | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024202910A Division JP2025028915A (ja) | 2019-05-10 | 2024-11-21 | フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022531801A JP2022531801A (ja) | 2022-07-11 |
| JP2022531801A5 true JP2022531801A5 (https=) | 2023-05-15 |
| JP7593947B2 JP7593947B2 (ja) | 2024-12-03 |
Family
ID=73046797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566469A Active JP7593947B2 (ja) | 2019-05-10 | 2020-05-08 | フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
| JP2024202910A Pending JP2025028915A (ja) | 2019-05-10 | 2024-11-21 | フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024202910A Pending JP2025028915A (ja) | 2019-05-10 | 2024-11-21 | フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US11530206B2 (https=) |
| EP (2) | EP4342469A3 (https=) |
| JP (2) | JP7593947B2 (https=) |
| KR (1) | KR20220008873A (https=) |
| CN (4) | CN118930524A (https=) |
| AU (3) | AU2020275392B2 (https=) |
| BR (1) | BR112021022504A2 (https=) |
| CA (1) | CA3139708A1 (https=) |
| CL (1) | CL2021002952A1 (https=) |
| CO (1) | CO2021016768A2 (https=) |
| DK (1) | DK3966207T3 (https=) |
| ES (1) | ES2966807T3 (https=) |
| FI (1) | FI3966207T3 (https=) |
| HR (1) | HRP20231730T1 (https=) |
| HU (1) | HUE065486T2 (https=) |
| IL (2) | IL287787B2 (https=) |
| LT (1) | LT3966207T (https=) |
| MX (2) | MX2021013661A (https=) |
| PE (1) | PE20220597A1 (https=) |
| PH (1) | PH12021552848A1 (https=) |
| PL (1) | PL3966207T3 (https=) |
| PT (1) | PT3966207T (https=) |
| RS (1) | RS65019B1 (https=) |
| SG (1) | SG11202112336PA (https=) |
| SI (1) | SI3966207T1 (https=) |
| SM (1) | SMT202300469T1 (https=) |
| TW (2) | TW202540081A (https=) |
| WO (1) | WO2020231806A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118416236A (zh) | 2018-01-31 | 2024-08-02 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| EP3849535A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス, インコーポレイテッド | 組み合わせ療法 |
| EA202190749A1 (ru) | 2018-09-10 | 2021-07-09 | Мирати Терапьютикс, Инк. | Способы комбинированной терапии |
| EP3849537B1 (en) | 2018-09-10 | 2024-10-23 | Mirati Therapeutics, Inc. | Combination therapies |
| MX2021002804A (es) | 2018-12-05 | 2021-07-15 | Mirati Therapeutics Inc | Terapias de combinacion. |
| BR112021012812A2 (pt) | 2018-12-28 | 2021-12-07 | Deciphera Pharmaceuticals Llc | Csf1r inhibitors para uso e tratamento de câncer |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
| US11518758B2 (en) | 2019-05-10 | 2022-12-06 | Deciphera Pharmaceuticals, Llc | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PE20221083A1 (es) | 2019-06-17 | 2022-07-05 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso |
| EP4013412B1 (en) | 2019-08-12 | 2026-01-28 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| MX2022002465A (es) | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| WO2021061749A1 (en) | 2019-09-24 | 2021-04-01 | Mirati Therapeutics, Inc. | Combination therapies |
| IL326597A (en) | 2019-10-07 | 2026-04-01 | Contineum Therapeutics Inc | Muscarinic M1 acetylcholine receptor antagonists |
| US11752149B2 (en) | 2019-12-02 | 2023-09-12 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| KR20220153582A (ko) | 2020-02-14 | 2022-11-18 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 마크로시클릭 ulk1/2 억제제 |
| EP4210833A4 (en) | 2020-09-11 | 2024-09-11 | Mirati Therapeutics, Inc. | CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR |
| IL302807A (en) | 2020-11-18 | 2023-07-01 | Deciphera Pharmaceuticals Llc | Gcn2 and perk kinase inhibitors and methods of use thereof |
| JP2023553492A (ja) | 2020-12-15 | 2023-12-21 | ミラティ セラピューティクス, インコーポレイテッド | アザキナゾリン汎KRas阻害剤 |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| US20240208934A1 (en) * | 2021-04-07 | 2024-06-27 | Lifearc | Ulk1/2 inhibitors and their use thereof |
| EP4433059A4 (en) * | 2021-11-15 | 2025-06-18 | Erasca, Inc. | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE |
| PE20250609A1 (es) | 2021-12-03 | 2025-02-26 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| AU2023334055A1 (en) * | 2022-09-02 | 2025-03-06 | Deciphera Pharmaceuticals, Llc | Combination of dcc-3116 and mapkap pathway inhibitors for use in the treatment of cancer |
| WO2024099225A1 (zh) * | 2022-11-08 | 2024-05-16 | 微境生物医药科技(上海)有限公司 | Ulk抑制剂 |
| WO2024140401A1 (zh) * | 2022-12-30 | 2024-07-04 | 捷思英达控股有限公司 | 作为激酶抑制剂的杂环化合物以及包括其的组合物 |
| TW202509027A (zh) * | 2023-05-04 | 2025-03-01 | 美商艾瑞斯卡公司 | 噻吩ulk1/2抑制劑及其用途 |
| WO2025045203A1 (zh) * | 2023-09-01 | 2025-03-06 | 葆元生物医药科技(杭州)有限公司 | 杂环化合物及其中间体和应用 |
| WO2025045182A1 (zh) * | 2023-09-01 | 2025-03-06 | 深圳众格生物科技有限公司 | Ulk1抑制剂及其制备方法和用途 |
| WO2025117886A1 (en) * | 2023-12-01 | 2025-06-05 | Casma Therapeutics, Inc. | Ulk complex modulators and uses thereof |
| WO2025122952A1 (en) | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| US20250206720A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Solid forms of an ulk inhibitor |
| WO2025166161A1 (en) * | 2024-02-02 | 2025-08-07 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
| WO2025166180A1 (en) * | 2024-02-02 | 2025-08-07 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
| WO2025166124A1 (en) * | 2024-02-02 | 2025-08-07 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
| WO2025194599A1 (en) * | 2024-03-18 | 2025-09-25 | Galixir Technologies (Beijing) Limited | Heterocycle ulk1/2 inhibitors and methods of use thereof |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
| WO2025250391A1 (en) * | 2024-05-28 | 2025-12-04 | Biomed Valley Discoveries, Inc. | Compositions and methods for solid forms of ulixertinib |
| WO2026076328A1 (en) * | 2024-10-04 | 2026-04-09 | Deciphera Pharmaceuticals, Llc | Solid state forms of ulk inhibitors |
| WO2026076312A1 (en) * | 2024-10-04 | 2026-04-09 | Deciphera Pharmaceuticals, Llc | Solid state forms of a ulk inhibitor |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19824922A1 (de) | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| GB9910807D0 (en) | 1999-05-10 | 1999-07-07 | Prometic Biosciences Limited | Novel detoxification agents and their use |
| US6906067B2 (en) | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
| AU783981C (en) | 2000-05-08 | 2007-05-03 | Janssen Pharmaceutica N.V. | HIV replication inhibitors |
| CA2450934A1 (en) | 2001-06-19 | 2002-12-27 | Marco Dodier | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| AU2002316421B2 (en) | 2001-06-26 | 2008-05-15 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-ALPHA expression |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| WO2003032994A2 (de) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
| ATE407678T1 (de) | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| JP4072615B2 (ja) | 2002-03-05 | 2008-04-09 | 独立行政法人産業技術総合研究所 | 配位子を有する複素環化合物及びその製造方法、及びこの複素環化合物を用いる金属元素の固定化膜 |
| JP2006508997A (ja) * | 2002-11-28 | 2006-03-16 | シエーリング アクチエンゲゼルシャフト | Chk−、Pdk−およびAkt−阻害性ピリミジン、それらの製造および薬剤としての使用 |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| CL2004000306A1 (es) | 2003-02-20 | 2005-04-08 | Tibotec Pharm Ltd | Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa. |
| EP1781659B1 (en) | 2003-07-16 | 2008-11-05 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| ATE506953T1 (de) | 2003-08-07 | 2011-05-15 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
| US7754714B2 (en) | 2004-05-18 | 2010-07-13 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| PL1756084T3 (pl) | 2004-06-04 | 2009-06-30 | Arena Pharm Inc | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie zaburzeń z metabolizmem związanych |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| US20070032493A1 (en) | 2005-05-26 | 2007-02-08 | Synta Pharmaceuticals Corp. | Method for treating B cell regulated autoimmune disorders |
| WO2006128129A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating cancer |
| US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| CN101484433A (zh) | 2006-02-15 | 2009-07-15 | 艾博特公司 | 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用 |
| MX2008014618A (es) | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| RU2008152195A (ru) | 2006-06-15 | 2010-07-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | 2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа |
| US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| CA2673965A1 (en) | 2006-12-28 | 2008-07-10 | Taisho Pharmaceutical Co., Ltd. | Pyrazolopyrimidine compound |
| WO2008131276A1 (en) | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| AU2008317057B8 (en) | 2007-10-22 | 2014-02-13 | Merck Sharp & Dohme Corp. | Bicyclic Heterocycle Derivatives and their use as modulators of the activity of GPR119 |
| US20100056524A1 (en) * | 2008-04-02 | 2010-03-04 | Mciver Edward Giles | Compound |
| PE20100087A1 (es) | 2008-06-25 | 2010-02-08 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| NZ603525A (en) | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| JP5444365B2 (ja) | 2008-10-29 | 2014-03-19 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗癌活性および抗増殖活性を示すシクロプロパンアミドおよび類似物質 |
| WO2010111406A2 (en) | 2009-03-24 | 2010-09-30 | Myriad Pharmaceuticals, Inc. | Compounds and therapeutic uses thereof |
| US8410126B2 (en) | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| PH12012500097A1 (en) | 2009-07-21 | 2011-01-27 | Shanghai Inst Organic Chem | Potent small molecule inhibitors of autophagy, and methods of use thereof |
| KR101445012B1 (ko) | 2009-12-17 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | Syk 억제제로서의 아미노피리미딘 |
| JP2013516422A (ja) | 2009-12-30 | 2013-05-13 | アビラ セラピューティクス, インコーポレイテッド | タンパク質のリガンド−指向性共有的修飾 |
| CA2800998A1 (en) | 2010-04-29 | 2011-11-10 | Deciphera Pharmaceuticals, Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| SG185073A1 (en) | 2010-04-29 | 2012-12-28 | Deciphera Pharmaceuticals Llc | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activites |
| ES2577829T3 (es) | 2010-06-04 | 2016-07-19 | F. Hoffmann-La Roche Ag | Derivados de aminopirimidina como moduladores de la LRRK2 |
| US20130324532A1 (en) | 2011-02-17 | 2013-12-05 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| EP2736901A1 (en) | 2011-07-28 | 2014-06-04 | Cellzome Limited | Heterocyclyl pyrimidine analogues as jak inhibitors |
| JP2015507606A (ja) | 2011-11-22 | 2015-03-12 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗癌および抗増殖作用を示すピリドンアミドおよび類似体 |
| MX348920B (es) | 2011-11-29 | 2017-07-04 | Genentech Inc | Derivados de 2-(fenil o pirid-3-il)aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2) para el tratamiento de la enfermedad de parkinson. |
| US9145402B2 (en) | 2011-11-29 | 2015-09-29 | Genentech, Inc. | Aminopyrimidine derivatives as LRRK2 modulators |
| EP2785381B1 (en) | 2011-11-30 | 2016-05-18 | F.Hoffmann-La Roche Ag | Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (pet) imaging for lrrk2 |
| CN103159736B (zh) | 2011-12-10 | 2015-05-13 | 通化济达医药有限公司 | 取代的吡唑激酶抑制剂 |
| WO2013134298A1 (en) | 2012-03-07 | 2013-09-12 | Deciphera Pharmaceuticals, Llc | Raf inhibitor compounds |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| WO2014031928A2 (en) | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| WO2014086102A1 (zh) | 2012-12-06 | 2014-06-12 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| DK2968286T3 (en) | 2013-03-15 | 2018-01-02 | Deciphera Pharmaceuticals Llc | 2-AMINOPYRIMIDIN-6-ONES AND ANALOGS THAT HAVE ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES |
| WO2014145015A2 (en) | 2013-03-15 | 2014-09-18 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2014145023A1 (en) | 2013-03-15 | 2014-09-18 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2014145029A2 (en) | 2013-03-15 | 2014-09-18 | Deciphera Pharmaceuticals, Llc | N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
| US9012635B2 (en) | 2013-03-15 | 2015-04-21 | Deciphera Pharmaceuticals, Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| JP6364472B2 (ja) | 2013-03-15 | 2018-07-25 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
| CN103242341B (zh) | 2013-04-19 | 2015-12-09 | 中国科学院广州生物医药与健康研究院 | 噻吩并2,4取代嘧啶类化合物及其药物组合物与应用 |
| US9783504B2 (en) | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| WO2015039613A1 (zh) | 2013-09-18 | 2015-03-26 | 北京韩美药品有限公司 | 抑制btk和/或jak3激酶活性的化合物 |
| KR101879422B1 (ko) | 2013-09-18 | 2018-07-17 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물 |
| PH12016500676B1 (en) | 2013-10-18 | 2022-07-20 | Eisai R&D Man Co Ltd | Pyrimidine fgfr4 inhibitors |
| BR112016008632A8 (pt) | 2013-10-21 | 2020-03-17 | Merck Patent Gmbh | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
| US9457019B2 (en) | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| WO2015123722A1 (en) | 2014-02-19 | 2015-08-27 | Bionomics Limited | Inhibitors |
| US20150284341A1 (en) | 2014-04-07 | 2015-10-08 | Catylix, Inc. | Fluoroalkyl-substituted derivatives of pyridine, pyrimidine, and pyrazine |
| US10266549B2 (en) | 2014-08-25 | 2019-04-23 | Salk Institute For Biological Studies | ULK1 inhibitors and methods using same |
| EP3056202A1 (en) | 2015-02-16 | 2016-08-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Benzopyrrolidone derivatives possessing antiviral and anticancer properties |
| CN108348779A (zh) | 2015-08-02 | 2018-07-31 | H·李·莫菲特癌症中心研究有限公司 | Ack1/tnk2酪氨酸激酶的抑制剂 |
| WO2017066428A1 (en) | 2015-10-13 | 2017-04-20 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Brd4-kinase inhibitors as cancer therapeutics |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| CN108239069B (zh) | 2016-12-26 | 2021-01-05 | 南京药捷安康生物科技有限公司 | 一种用于成纤维细胞生长因子受体的抑制剂及其用途 |
| AU2018226771B2 (en) | 2017-02-28 | 2023-11-23 | Dana-Farber Cancer Institute, Inc. | Uses of pyrimidopyrimidinones as SIK inhibitors |
| MY205552A (en) | 2017-05-30 | 2024-10-25 | Deciphera Pharmaceuticals Inc | Use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl ]-3-phenylurea and analogs for the treatment of cancers associated with genetic abnormalities in platelet derived growth factor receptor alpha |
| CN109535132B (zh) | 2017-09-21 | 2021-07-20 | 北京赛特明强医药科技有限公司 | 2-取代吡唑氨基-4-取代氨基-5-嘧啶甲酰胺类化合物、组合物及其应用 |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| KR102803762B1 (ko) | 2018-04-10 | 2025-05-09 | 뉴로포레 테라피스, 인코포레이티드 | Pi3-키나제 및 오토파지 경로의 조절인자로서의 트리-치환된 아릴 및 헤테로아릴 유도체 |
| BR112021012812A2 (pt) | 2018-12-28 | 2021-12-07 | Deciphera Pharmaceuticals Llc | Csf1r inhibitors para uso e tratamento de câncer |
| BR112021022237A2 (pt) | 2019-05-10 | 2022-03-29 | Janssen Biotech Inc | Queladores macrocíclicos e métodos de uso dos mesmos |
| PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
| SG11202110561XA (en) | 2019-05-10 | 2021-10-28 | Cersci Therapeutics Inc | Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent |
| US11518758B2 (en) | 2019-05-10 | 2022-12-06 | Deciphera Pharmaceuticals, Llc | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PE20221083A1 (es) | 2019-06-17 | 2022-07-05 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| US12458630B2 (en) | 2020-01-14 | 2025-11-04 | The Regents Of The University Of California | Combination therapy for cancer |
| WO2023108110A2 (en) | 2021-12-10 | 2023-06-15 | Verastem, Inc. | Combination therapy for treating abnormal cell growth |
-
2020
- 2020-05-08 PE PE2021001870A patent/PE20220597A1/es unknown
- 2020-05-08 MX MX2021013661A patent/MX2021013661A/es unknown
- 2020-05-08 SI SI202030312T patent/SI3966207T1/sl unknown
- 2020-05-08 TW TW113145915A patent/TW202540081A/zh unknown
- 2020-05-08 CA CA3139708A patent/CA3139708A1/en active Pending
- 2020-05-08 EP EP23206773.6A patent/EP4342469A3/en active Pending
- 2020-05-08 PT PT207294208T patent/PT3966207T/pt unknown
- 2020-05-08 HR HRP20231730TT patent/HRP20231730T1/hr unknown
- 2020-05-08 PL PL20729420.8T patent/PL3966207T3/pl unknown
- 2020-05-08 BR BR112021022504A patent/BR112021022504A2/pt unknown
- 2020-05-08 WO PCT/US2020/032087 patent/WO2020231806A1/en not_active Ceased
- 2020-05-08 DK DK20729420.8T patent/DK3966207T3/da active
- 2020-05-08 CN CN202410819165.5A patent/CN118930524A/zh active Pending
- 2020-05-08 LT LTEPPCT/US2020/032087T patent/LT3966207T/lt unknown
- 2020-05-08 HU HUE20729420A patent/HUE065486T2/hu unknown
- 2020-05-08 CN CN202080049700.3A patent/CN114127057B/zh active Active
- 2020-05-08 EP EP20729420.8A patent/EP3966207B1/en active Active
- 2020-05-08 CN CN202410819167.4A patent/CN118878520A/zh active Pending
- 2020-05-08 FI FIEP20729420.8T patent/FI3966207T3/fi active
- 2020-05-08 TW TW109115468A patent/TWI865526B/zh active
- 2020-05-08 PH PH1/2021/552848A patent/PH12021552848A1/en unknown
- 2020-05-08 SG SG11202112336PA patent/SG11202112336PA/en unknown
- 2020-05-08 SM SM20230469T patent/SMT202300469T1/it unknown
- 2020-05-08 RS RS20231266A patent/RS65019B1/sr unknown
- 2020-05-08 JP JP2021566469A patent/JP7593947B2/ja active Active
- 2020-05-08 ES ES20729420T patent/ES2966807T3/es active Active
- 2020-05-08 AU AU2020275392A patent/AU2020275392B2/en active Active
- 2020-05-08 CN CN202410819161.7A patent/CN118878519A/zh active Pending
- 2020-05-08 IL IL287787A patent/IL287787B2/en unknown
- 2020-05-08 US US16/870,384 patent/US11530206B2/en active Active
- 2020-05-08 KR KR1020217040559A patent/KR20220008873A/ko active Pending
-
2021
- 2021-11-08 MX MX2025004367A patent/MX2025004367A/es unknown
- 2021-11-09 CL CL2021002952A patent/CL2021002952A1/es unknown
- 2021-12-10 CO CONC2021/0016768A patent/CO2021016768A2/es unknown
-
2022
- 2022-06-06 US US17/833,272 patent/US12071432B2/en active Active
-
2023
- 2023-10-17 AU AU2023251416A patent/AU2023251416B2/en active Active
-
2024
- 2024-07-11 US US18/770,318 patent/US20250084073A1/en active Pending
- 2024-11-21 JP JP2024202910A patent/JP2025028915A/ja active Pending
-
2025
- 2025-10-26 IL IL324234A patent/IL324234A/en unknown
- 2025-12-03 AU AU2025275164A patent/AU2025275164A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022531801A5 (https=) | ||
| HRP20231730T1 (hr) | Fenilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene | |
| JP2022531932A5 (https=) | ||
| JP5823518B2 (ja) | ブルトン型チロシンキナーゼの阻害剤 | |
| AU2013207205B2 (en) | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of Hepatitis B | |
| JP2025028915A5 (https=) | ||
| AU2019323035B2 (en) | Pyrazine compounds and uses thereof | |
| JP2020505454A5 (https=) | ||
| JP2012525395A5 (https=) | ||
| HRP20231310T1 (hr) | Heteroarilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene | |
| RU2009125897A (ru) | Ингибиторы фосфоинозитид-3-киназы и способы их применения | |
| TW201919640A (zh) | 作為rsv抑制劑的組合藥劑 | |
| JP2010512338A5 (https=) | ||
| JP2019508384A (ja) | 5−置換2−(モルホリン−4−イル)−1,7−ナフチリジン | |
| AU2015242975A1 (en) | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators | |
| KR20130043175A (ko) | 헤테로사이클릭 알키닐 벤젠 화합물 및 의약 조성물 및 그들의 용도 | |
| US20170173026A1 (en) | Aminoquinazoline and pyridopyrimidine derivatives | |
| JP2019535689A5 (https=) | ||
| IL310330A (en) | Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling | |
| EP4267137A1 (en) | Lactam (hetero)arylfusedpyrimidine derivatives as inhibitors of erbb2 | |
| JP2024506047A5 (https=) | ||
| JP7681116B2 (ja) | カルボニル置換ジアザスピロ化合物及びその使用 | |
| WO2023139085A1 (en) | New benzimidazole pyridine derivatives | |
| TH2101006978A (th) | สารยับยั้งการกินตัวเองของเซลล์ชนิดเฮเทอโรแอริลอะมิโนไพริดีนเอไมด์และวิธีการใช้สารนั้น | |
| JP2022545019A5 (https=) |