|
DE19824922A1
(de)
|
1998-06-04 |
1999-12-09 |
Boehringer Ingelheim Pharma |
Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6262088B1
(en)
|
1998-11-19 |
2001-07-17 |
Berlex Laboratories, Inc. |
Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
|
|
GB9910807D0
(en)
|
1999-05-10 |
1999-07-07 |
Prometic Biosciences Limited |
Novel detoxification agents and their use
|
|
US6906067B2
(en)
|
1999-12-28 |
2005-06-14 |
Bristol-Myers Squibb Company |
N-heterocyclic inhibitors of TNF-α expression
|
|
WO2001085700A2
(en)
|
2000-05-08 |
2001-11-15 |
Janssen Pharmaceutica N.V. |
Hiv replication inhibiting pyrimidines and triazines
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
JP2005500294A
(ja)
|
2001-06-19 |
2005-01-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
ホスホジエステラーゼ７に対するピリミジン阻害剤
|
|
US20030139435A1
(en)
|
2001-06-26 |
2003-07-24 |
Gulzar Ahmed |
N-heterocyclic inhibitors of TNF-alpha expression
|
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
|
EP1453516A2
(de)
|
2001-10-17 |
2004-09-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
|
|
ATE407678T1
(de)
*
|
2001-10-17 |
2008-09-15 |
Boehringer Ingelheim Pharma |
Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
|
|
JP4072615B2
(ja)
|
2002-03-05 |
2008-04-09 |
独立行政法人産業技術総合研究所 |
配位子を有する複素環化合物及びその製造方法、及びこの複素環化合物を用いる金属元素の固定化膜
|
|
BR0316680A
(pt)
*
|
2002-11-28 |
2005-10-18 |
Schering Ag |
Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos
|
|
US7202257B2
(en)
|
2003-12-24 |
2007-04-10 |
Deciphera Pharmaceuticals, Llc |
Anti-inflammatory medicaments
|
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
|
US7279576B2
(en)
|
2002-12-31 |
2007-10-09 |
Deciphera Pharmaceuticals, Llc |
Anti-cancer medicaments
|
|
CL2004000303A1
(es)
|
2003-02-20 |
2005-04-08 |
Tibotec Pharm Ltd |
Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
|
|
EP1781659B1
(en)
|
2003-07-16 |
2008-11-05 |
Janssen Pharmaceutica N.V. |
Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors
|
|
BRPI0413018B8
(pt)
|
2003-07-30 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, e, uso de um composto
|
|
WO2005013996A2
(en)
|
2003-08-07 |
2005-02-17 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds and uses as anti-proliferative agents
|
|
EP1763514A2
(en)
|
2004-05-18 |
2007-03-21 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
EA011671B1
(ru)
|
2004-06-04 |
2009-04-28 |
Арена Фармасьютикалз, Инк. |
Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
WO2006071940A2
(en)
|
2004-12-23 |
2006-07-06 |
Deciphera Pharmaceuticals, Llc |
Enzyme modulators and treatments
|
|
WO2006128172A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating b cell regulated autoimmune disorders
|
|
WO2006128129A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating cancer
|
|
US8193206B2
(en)
|
2005-06-14 |
2012-06-05 |
Taigen Biotechnology Co., Ltd. |
Pyrimidine compounds
|
|
US8748627B2
(en)
|
2006-02-15 |
2014-06-10 |
Abbvie Inc. |
Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
|
|
US20090312321A1
(en)
|
2006-05-15 |
2009-12-17 |
Irm Llc |
Compositions and methods for fgf receptor kinases inhibitors
|
|
RU2008152195A
(ru)
|
2006-06-15 |
2010-07-20 |
БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) |
2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа
|
|
US7897762B2
(en)
|
2006-09-14 |
2011-03-01 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of proliferative diseases
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US7790756B2
(en)
|
2006-10-11 |
2010-09-07 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
|
|
US20100298557A1
(en)
|
2006-12-28 |
2010-11-25 |
Taisho Pharmaceutical Co., Ltd |
Pyrazolopyrimidine compound
|
|
KR20100014811A
(ko)
|
2007-04-20 |
2010-02-11 |
데시페라 파마슈티칼스, 엘엘씨. |
골수증식성 질환 및 기타 증식성 질환의 치료에 유용한 키나제 억제제
|
|
CN101910151A
(zh)
|
2007-10-22 |
2010-12-08 |
先灵公司 |
双环杂环衍生物及其作为gpr119活性调节剂的用途
|
|
WO2009122180A1
(en)
|
2008-04-02 |
2009-10-08 |
Medical Research Council |
Pyrimidine derivatives capable of inhibiting one or more kinases
|
|
UY31929A
(es)
|
2008-06-25 |
2010-01-05 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
TWI546290B
(zh)
|
2008-06-27 |
2016-08-21 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
CN102256493A
(zh)
|
2008-10-29 |
2011-11-23 |
迪赛孚尔制药有限公司 |
表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物
|
|
WO2010111406A2
(en)
|
2009-03-24 |
2010-09-30 |
Myriad Pharmaceuticals, Inc. |
Compounds and therapeutic uses thereof
|
|
US8410126B2
(en)
|
2009-05-29 |
2013-04-02 |
Boehringer Ingelheim International Gmbh |
Pyrimidine inhibitors of PKTK2
|
|
TW201100441A
(en)
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
PH12012500097A1
(en)
|
2009-07-21 |
2011-01-27 |
Shanghai Inst Organic Chem |
Potent small molecule inhibitors of autophagy, and methods of use thereof
|
|
WO2011075517A1
(en)
|
2009-12-17 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
EP2519664A4
(en)
|
2009-12-30 |
2014-03-12 |
Avila Therapeutics Inc |
LIGAND-RELATED COVALENTS MODIFYING A PROTEIN
|
|
BR112012027743A2
(pt)
|
2010-04-29 |
2017-03-14 |
Deciphera Pharmaceuticals Llc |
ciclopropil dicarboxamidas e análogos exibindo atividades anticâncer e antiproliferativas
|
|
EP2563773A1
(en)
|
2010-04-29 |
2013-03-06 |
Deciphera Pharmaceuticals, LLC |
Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
|
|
PT2576541T
(pt)
|
2010-06-04 |
2016-07-08 |
Hoffmann La Roche |
Derivados de aminopirimidina como moduladores de lrrk2
|
|
EP2675793B1
(en)
|
2011-02-17 |
2018-08-08 |
Cancer Therapeutics Crc Pty Limited |
Fak inhibitors
|
|
CN103781780B
(zh)
|
2011-07-28 |
2015-11-25 |
赛尔佐姆有限公司 |
作为jak抑制剂的杂环基嘧啶类似物
|
|
BR112014012407A2
(pt)
|
2011-11-22 |
2017-06-06 |
Deciphera Pharmaceuticals Llc |
amidas de piridona e análogos exibindo propriedades anti-câncer e anti-proliferativas
|
|
BR112014009717B1
(pt)
|
2011-11-29 |
2022-06-14 |
Genentech, Inc |
Derivados de 2-(fenil ou pirid-3-il)aminopirimidina, seus usos, e composição farmacêutica
|
|
CN103958482B
(zh)
|
2011-11-29 |
2017-06-09 |
健泰科生物技术公司 |
作为lrrk2调节剂的氨基嘧啶衍生物
|
|
EP2785381B1
(en)
|
2011-11-30 |
2016-05-18 |
F.Hoffmann-La Roche Ag |
Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (pet) imaging for lrrk2
|
|
CN103159736B
(zh)
|
2011-12-10 |
2015-05-13 |
通化济达医药有限公司 |
取代的吡唑激酶抑制剂
|
|
AR090151A1
(es)
|
2012-03-07 |
2014-10-22 |
Lilly Co Eli |
Compuestos inhibidores de raf
|
|
US9187474B2
(en)
|
2012-03-07 |
2015-11-17 |
Deciphera Pharmaceuticals, Llc |
Raf inhibitor compounds
|
|
GB201204384D0
(en)
|
2012-03-13 |
2012-04-25 |
Univ Dundee |
Anti-flammatory agents
|
|
US8461179B1
(en)
|
2012-06-07 |
2013-06-11 |
Deciphera Pharmaceuticals, Llc |
Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20140073634A1
(en)
|
2012-08-24 |
2014-03-13 |
Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center |
Heterocyclic modulators of hif activity for treatment of disease
|
|
DK2930167T3
(en)
|
2012-12-06 |
2019-02-25 |
Kbp Biosciences Co Ltd |
INDOLINO DERIVATIVE AS A TYROSINKINASE INHIBITOR
|
|
US9133183B2
(en)
|
2013-03-15 |
2015-09-15 |
Deciphera Pharmaceuticals, Llc |
Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
US9309224B2
(en)
|
2013-03-15 |
2016-04-12 |
Deciphera Pharmaceuticals, Llc. |
N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
WO2014145004A1
(en)
|
2013-03-15 |
2014-09-18 |
Deciphera Pharmaceuticals, Llc |
Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
RU2769607C2
(ru)
|
2013-03-15 |
2022-04-04 |
ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность
|
|
US9193719B2
(en)
|
2013-03-15 |
2015-11-24 |
Deciphera Pharmaceuticals, Llc |
1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
CA2903285C
(en)
|
2013-03-15 |
2021-05-11 |
Deciphera Pharmaceuticals, Llc |
2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
CN103242341B
(zh)
|
2013-04-19 |
2015-12-09 |
中国科学院广州生物医药与健康研究院 |
噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
|
|
EP3019491A4
(en)
|
2013-07-09 |
2016-12-21 |
Dana Farber Cancer Inst Inc |
KINASEHEMMER FOR THE TREATMENT OF DISEASES
|
|
WO2015039613A1
(zh)
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
|
KR101879422B1
(ko)
|
2013-09-18 |
2018-07-17 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
|
|
MX378288B
(es)
|
2013-10-18 |
2025-03-10 |
Eisai R&D Man Co Ltd |
Inhibidores de pirimidina del fgfr4.
|
|
BR112016008632A8
(pt)
|
2013-10-21 |
2020-03-17 |
Merck Patent Gmbh |
compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica
|
|
US9457019B2
(en)
|
2013-11-07 |
2016-10-04 |
Deciphera Pharmaceuticals, Llc |
Methods for inhibiting tie-2 kinase useful in the treatment of cancer
|
|
WO2015123722A1
(en)
|
2014-02-19 |
2015-08-27 |
Bionomics Limited |
Inhibitors
|
|
US20150284341A1
(en)
|
2014-04-07 |
2015-10-08 |
Catylix, Inc. |
Fluoroalkyl-substituted derivatives of pyridine, pyrimidine, and pyrazine
|
|
DK3185868T3
(da)
*
|
2014-08-25 |
2022-05-23 |
Salk Inst For Biological Studi |
Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme
|
|
EP3056202A1
(en)
|
2015-02-16 |
2016-08-17 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Benzopyrrolidone derivatives possessing antiviral and anticancer properties
|
|
WO2017023899A1
(en)
|
2015-08-02 |
2017-02-09 |
H. Lee Moffitt Cancer Center & Research Institute |
Inhibitors of ack1/tnk2 tyrosine kinase
|
|
US10738016B2
(en)
|
2015-10-13 |
2020-08-11 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
BRD4-kinase inhibitors as cancer therapeutics
|
|
US11028080B2
(en)
|
2016-03-11 |
2021-06-08 |
Denali Therapeutics Inc. |
Substituted pyrimidines as LRKK2 inhibitors
|
|
CN108239069B
(zh)
|
2016-12-26 |
2021-01-05 |
南京药捷安康生物科技有限公司 |
一种用于成纤维细胞生长因子受体的抑制剂及其用途
|
|
BR112019017741A2
(pt)
|
2017-02-28 |
2020-04-07 |
Dana Farber Cancer Inst Inc |
usos de pirimidopirimidinonas como inibidores de sik
|
|
CA3065365C
(en)
|
2017-05-30 |
2025-09-16 |
Deciphera Pharmaceuticals, Llc |
USE OF 1-[4-BROMO-5-[1-ETHYL-7-(METHYLAMINO)-2-OXO-1,2-DIHYDRO-1,6-NAPHTHYRIDINE-3-YL]-2-FLUOROPHENYL]-3-PHENYLUREA AND ITS ANALOGUES FOR THE TREATMENT OF CANCERS ASSOCIATED WITH GENETIC ABNORMALITIES IN THE PLATELET-DERIVED GROWTH FACTOR ALPHA RECEPTOR
|
|
CN109535132B
(zh)
|
2017-09-21 |
2021-07-20 |
北京赛特明强医药科技有限公司 |
2-取代吡唑氨基-4-取代氨基-5-嘧啶甲酰胺类化合物、组合物及其应用
|
|
IL276398B2
(en)
|
2018-01-31 |
2026-03-01 |
Deciphera Pharmaceuticals Llc |
Combination therapy for mastocytosis
|
|
ES3032793T3
(en)
|
2018-04-10 |
2025-07-24 |
Neuropore Therapies Inc |
Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways
|
|
SMT202500389T1
(it)
|
2018-12-28 |
2025-11-10 |
Deciphera Pharmaceuticals Llc |
Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti
|
|
EP3966200A1
(en)
|
2019-05-10 |
2022-03-16 |
Cersci Therapeutics, Inc. |
Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent
|
|
MX2021013662A
(es)
|
2019-05-10 |
2022-03-11 |
Deciphera Pharmaceuticals Llc |
Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos.
|
|
CR20210556A
(es)
|
2019-05-10 |
2021-12-17 |
Janssen Biotech Inc |
Quelantes macrocíclicos y métodos de uso de estos
|
|
EP3966207B1
(en)
|
2019-05-10 |
2023-11-01 |
Deciphera Pharmaceuticals, LLC |
Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
IL325201A
(en)
|
2019-06-17 |
2026-02-01 |
Deciphera Pharmaceuticals Llc |
Aminopyrimidine amide autophagy inhibitors and methods of using them
|
|
JP2022552655A
(ja)
|
2019-10-07 |
2022-12-19 |
キャリーオペ，インク． |
Ｇｐｒ１１９アゴニスト
|
|
US12458630B2
(en)
|
2020-01-14 |
2025-11-04 |
The Regents Of The University Of California |
Combination therapy for cancer
|
|
WO2023108110A2
(en)
|
2021-12-10 |
2023-06-15 |
Verastem, Inc. |
Combination therapy for treating abnormal cell growth
|