JP2019535689A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535689A5 JP2019535689A5 JP2019522867A JP2019522867A JP2019535689A5 JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5 JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- oxo
- triazolo
- benzamide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZAXQHZSTRFLUMJ-UHFFFAOYSA-N CCCCCCC(N1)=NN(C(C)CS=C)C1=O Chemical compound CCCCCCC(N1)=NN(C(C)CS=C)C1=O ZAXQHZSTRFLUMJ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022103480A JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| PCT/EP2017/077301 WO2018077944A2 (en) | 2016-10-27 | 2017-10-25 | 4,5-annulated 1,2,4-triazolones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Division JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535689A JP2019535689A (ja) | 2019-12-12 |
| JP2019535689A5 true JP2019535689A5 (https=) | 2020-12-03 |
| JP7680184B2 JP7680184B2 (ja) | 2025-05-20 |
Family
ID=60293935
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522867A Active JP7680184B2 (ja) | 2016-10-27 | 2017-10-25 | ４，５－縮環１，２，４－トリアゾロン |
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10968216B2 (https=) |
| EP (1) | EP3532474B1 (https=) |
| JP (3) | JP7680184B2 (https=) |
| CN (2) | CN114921391B (https=) |
| CA (1) | CA3041650A1 (https=) |
| TW (1) | TW201827430A (https=) |
| UY (1) | UY37460A (https=) |
| WO (1) | WO2018077944A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114921391B (zh) | 2016-10-27 | 2024-01-02 | 拜耳股份有限公司 | 4,5-环状1,2,4-三唑酮 |
| JOP20190094A1 (ar) | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| TW201945346A (zh) | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
| TW202043208A (zh) * | 2019-01-11 | 2020-12-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| CA3152836A1 (en) * | 2019-08-29 | 2021-03-04 | Janssen Biotech, Inc. | Substituted urea dihydroorotate dehydrogenase inhibitors |
| WO2021070132A1 (en) * | 2019-10-10 | 2021-04-15 | Janssen Biotech, Inc. | Bi-aryl dihydroorotate dehydrogenase inhibitors |
| US12606540B2 (en) | 2020-05-29 | 2026-04-21 | Medshine Discovery Inc. | Triazolone compound |
| EP4185577A4 (en) * | 2020-07-14 | 2024-08-07 | Nanjing Zenshine Pharmaceuticals Co., Ltd. | Compounds as dhodh inhibitors |
| CN111773214B (zh) * | 2020-07-17 | 2021-04-20 | 中国人民解放军军事科学院军事医学研究院 | 2,4,5-三取代的1,2,4-三唑酮在制备抗病毒药物中的用途 |
| WO2022070069A1 (en) * | 2020-09-30 | 2022-04-07 | Janssen Biotech, Inc. | Dihydroorotate dehydrogenase inhibitors |
| BR112023021068A2 (pt) * | 2021-04-16 | 2024-01-23 | Hotspot Therapeutics Inc | Compostos, composições e métodos para tratar câncer |
| WO2023280181A1 (zh) * | 2021-07-05 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | 用作dhodh抑制剂的1,2,4-三唑酮衍生物及其制备方法和用途 |
| CN118284603A (zh) * | 2021-11-26 | 2024-07-02 | 南京明德新药研发有限公司 | 三氮唑酮类化合物的晶型及其应用 |
| JP2025523057A (ja) * | 2022-07-12 | 2025-07-17 | ホットスポット セラピューティクス インコーポレイテッド | がん処置における使用のためのｃｂｌ－ｂ阻害剤及び抗ｐｄ１／抗ｐｄ－ｌ１ |
| EP4554582A1 (en) * | 2022-07-12 | 2025-05-21 | Hotspot Therapeutics, Inc. | Cbl-b inhibitor, compositions comprising a cbl-b inhibitor in a method of treating a disease associated with cell proliferation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19627901A1 (de) | 1996-07-11 | 1998-01-15 | Bayer Ag | Substituierte aromatische Carbonylverbindungen und ihre Derivate |
| DE19901846A1 (de) | 1999-01-19 | 2000-07-20 | Bayer Ag | Substituierte Arylheterocyclen |
| US6444613B1 (en) | 1999-03-12 | 2002-09-03 | Hoechst Schering Agrevo Gmbh | Defoliant |
| JP2005512502A (ja) * | 2000-10-30 | 2005-05-12 | ファルマシア・コーポレーション | アスペルギルス・オクラセウス（Ａｓｐｅｒｇｉｌｌｕｓｏｃｈｒａｃｅｕｓ）１１アルファ水酸化酵素および酸化還元酵素 |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| EP2373645A4 (en) | 2008-12-08 | 2012-05-02 | Sirtris Pharmaceuticals Inc | ISOINDOLINONE AND RELATED ANALOGUES AS SIRTUIN MODULATORS |
| WO2010115736A2 (en) | 2009-04-02 | 2010-10-14 | Merck Serono S.A. | Dihydroorotate dehydrogenase inhibitors |
| US8686048B2 (en) * | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
| AU2011343222B2 (en) * | 2010-12-16 | 2016-09-29 | Pharmazell Gmbh | Novel 7B-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid |
| WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| TWI568722B (zh) * | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| ES2911701T3 (es) * | 2012-11-01 | 2022-05-20 | Univ British Columbia | Polipéptidos de citocromo P450 y citocromo P450 reductasa, moléculas de ácido nucleico codificantes y usos de los mismos |
| HRP20181908T1 (hr) | 2013-02-25 | 2019-01-11 | Aurigene Discovery Technologies Limited | Derivati trosupstituiranog benzotriazola kao inhibitori dihidroorotat oksigenaze |
| CN104561093A (zh) * | 2014-12-25 | 2015-04-29 | 华东师范大学 | 一种重组人源CYP3A4/CPR/cyt b5蛋白共转染共表达的方法 |
| US20160251341A1 (en) | 2015-02-27 | 2016-09-01 | Verseon Corporation | Substituted triazole compounds as serine protease inhibitors |
| CN106543139B (zh) | 2015-09-17 | 2020-03-17 | 沈阳中化农药化工研发有限公司 | 一种三唑酮类化合物及其用途 |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| CN114921391B (zh) | 2016-10-27 | 2024-01-02 | 拜耳股份有限公司 | 4,5-环状1,2,4-三唑酮 |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| TW201945346A (zh) * | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| US20190307728A1 (en) * | 2018-04-10 | 2019-10-10 | Bayer Pharma Aktiengesellschaft | Methods of treatment with a 2,4,5-trisubstituted 1,2,4-triazolone |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
-
2017
- 2017-10-25 CN CN202210298141.0A patent/CN114921391B/zh active Active
- 2017-10-25 CN CN201780067556.4A patent/CN110248937B/zh active Active
- 2017-10-25 US US16/345,178 patent/US10968216B2/en active Active
- 2017-10-25 WO PCT/EP2017/077301 patent/WO2018077944A2/en not_active Ceased
- 2017-10-25 JP JP2019522867A patent/JP7680184B2/ja active Active
- 2017-10-25 EP EP17797091.0A patent/EP3532474B1/en active Active
- 2017-10-25 CA CA3041650A patent/CA3041650A1/en active Pending
- 2017-10-27 UY UY0001037460A patent/UY37460A/es unknown
- 2017-10-27 TW TW106137268A patent/TW201827430A/zh unknown
-
2021
- 2021-01-28 US US17/161,615 patent/US11787797B2/en active Active
-
2022
- 2022-06-28 JP JP2022103480A patent/JP2022130571A/ja active Pending
-
2024
- 2024-02-29 JP JP2024030029A patent/JP7747799B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019535689A5 (https=) | ||
| JP7001682B2 (ja) | 置換１Ｈ－イミダゾ［４，５－ｂ］ピリジン－２（３Ｈ）－オン及びＧＬＵＮ２Ｂ受容体調節因子としてのそれらの使用 | |
| RU2717238C2 (ru) | Соединения 1-циано-пирролидинов в качестве ингибиторов USP30 | |
| US9216999B2 (en) | Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors | |
| KR102650565B1 (ko) | Pde9 억제제 및 이의 용도 | |
| JP4814783B2 (ja) | ピラゾロピリジン誘導体 | |
| TWI850648B (zh) | 作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物 | |
| RU2689777C1 (ru) | Конденсированные трициклические производные бензимидазолов в качестве модуляторов активности tnf | |
| KR102319857B1 (ko) | P2x7 조절제 | |
| AU2020348675B2 (en) | Azole-fused pyridazin-3(2H)-one derivatives | |
| CA3198809A1 (en) | Heterocyclic spiro compounds and methods of use | |
| AU2019280356A1 (en) | ERK inhibitor and use thereof | |
| WO2013088257A1 (en) | Substituted heterocyclic compounds as tropomyosin receptor kinase a (trka) inhibitors | |
| EA025520B1 (ru) | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ | |
| TW202115075A (zh) | 咪唑并[1,2-a]吡啶基衍生物及其在疾病治療中之用途 | |
| JP2013533868A (ja) | タンパク質チロシンキナーゼ阻害剤としての新規ホモピペラジン誘導体およびそれらの医薬使用 | |
| CN116262739A (zh) | 含氮芳基衍生物调节剂、其制备方法和应用 | |
| US20240383875A1 (en) | Benzimidazole Pyridine Derivatives | |
| CN120418238A (zh) | 新颖苯并咪唑衍生物 | |
| WO2025017078A1 (en) | New pyrazolopyridine derivatives | |
| JP2025523848A (ja) | チロシンキナーゼ２阻害剤及びその使用 | |
| JP2025523507A (ja) | チロシンキナーゼ２阻害剤及びその使用 | |
| JP2024504788A (ja) | ピラゾールアミド誘導体 | |
| HK40008526B (zh) | P2x7调节剂 | |
| OA18225A (en) | Aminopyrimidinyl compounds as Jak inhibitors. |