|
US20060106020A1
(en)
*
|
2004-04-28 |
2006-05-18 |
Rodgers James D |
Tetracyclic inhibitors of Janus kinases
|
|
DK3184526T3
(en)
|
2005-12-13 |
2019-01-14 |
Incyte Holdings Corp |
PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
|
|
US8513270B2
(en)
*
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
EP2740731B1
(en)
|
2007-06-13 |
2016-03-23 |
Incyte Holdings Corporation |
Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
FR2938537B1
(fr)
|
2008-11-14 |
2012-10-26 |
Sanofi Aventis |
Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
|
|
JOP20190231A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
WO2010135621A1
(en)
|
2009-05-22 |
2010-11-25 |
Incyte Corporation |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
ES2487542T3
(es)
|
2009-05-22 |
2014-08-21 |
Incyte Corporation |
Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus
|
|
WO2011028685A1
(en)
|
2009-09-01 |
2011-03-10 |
Incyte Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
US20110207736A1
(en)
|
2009-12-23 |
2011-08-25 |
Gatekeeper Pharmaceuticals, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
EP2534258B1
(en)
*
|
2010-02-10 |
2017-09-20 |
Genon Biotechnologies OY |
Dual activity kinase domains and uses thereof
|
|
AU2011217961B2
(en)
*
|
2010-02-18 |
2016-05-05 |
Incyte Holdings Corporation |
Cyclobutane and methylcyclobutane derivatives as Janus kinase inhibitors
|
|
SMT201800137T1
(it)
|
2010-03-10 |
2018-07-17 |
Incyte Holdings Corp |
Derivati di piperidin-4-il azetidina come inibitori di jak1
|
|
GB201007286D0
(en)
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
PH12012502296B1
(en)
|
2010-05-21 |
2017-10-06 |
Incyte Holdings Corp |
Topical formulation for a jak inhibitor
|
|
MX2012014158A
(es)
|
2010-06-04 |
2013-02-07 |
Hoffmann La Roche |
Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2).
|
|
JP2014500254A
(ja)
*
|
2010-11-09 |
2014-01-09 |
セルゾーム リミティッド |
Tyk2阻害剤としてのピリジン化合物およびそのアザ類似体
|
|
PH12013500880A1
(en)
|
2010-11-10 |
2013-07-01 |
Hoffmann La Roche |
Pyrazole aminopyrimidine derivatives as lrrk2 modulators
|
|
SG190839A1
(en)
|
2010-11-19 |
2013-07-31 |
Incyte Corp |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
ES2536415T3
(es)
|
2010-11-19 |
2015-05-25 |
Incyte Corporation |
Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
ES2547916T3
(es)
|
2011-02-18 |
2015-10-09 |
Novartis Pharma Ag |
Terapia de combinación de inhibidores de mTOR/JAK
|
|
US9284298B2
(en)
*
|
2011-04-11 |
2016-03-15 |
Nerviano Medical Sciences S.R.L. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
WO2012177606A1
(en)
|
2011-06-20 |
2012-12-27 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
JP2014521725A
(ja)
|
2011-08-10 |
2014-08-28 |
ノバルティス・ファルマ・アクチェンゲゼルシャフト |
JAKPI3K/mTOR併用療法
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
ES2640911T3
(es)
*
|
2011-09-22 |
2017-11-07 |
Merck Sharp & Dohme Corp. |
Cicloalquilnitrilpirazolcarboxamidas como inhibidores de la quinasa Janus
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
CN103102359B
(zh)
*
|
2011-11-15 |
2016-11-09 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
EP4556010A3
(en)
|
2011-11-30 |
2025-07-23 |
Emory University |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
WO2013173720A1
(en)
|
2012-05-18 |
2013-11-21 |
Incyte Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
SG11201408679XA
(en)
|
2012-06-26 |
2015-01-29 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
US8809359B2
(en)
*
|
2012-06-29 |
2014-08-19 |
Ym Biosciences Australia Pty Ltd |
Phenyl amino pyrimidine bicyclic compounds and uses thereof
|
|
WO2014066196A1
(en)
*
|
2012-10-23 |
2014-05-01 |
Merck Sharp & Dohme Corp. |
2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
|
|
US9181271B2
(en)
|
2012-11-01 |
2015-11-10 |
Incyte Holdings Corporation |
Tricyclic fused thiophene derivatives as JAK inhibitors
|
|
JP6293770B2
(ja)
*
|
2012-11-05 |
2018-03-14 |
ナント ホールディングス アイピー,エルエルシー |
ヘッジホッグシグナル伝達経路阻害剤としての環状スルホンアミド含有誘導体
|
|
PE20151157A1
(es)
|
2012-11-15 |
2015-08-19 |
Incyte Corp |
Formas de dosificacion de ruxolitinib de liberacion sostenida
|
|
WO2014075318A1
(zh)
*
|
2012-11-19 |
2014-05-22 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
KR20220143164A
(ko)
|
2012-11-21 |
2022-10-24 |
피티씨 테라퓨틱스, 인크. |
치환된 리버스 피리미딘 bmi-1 저해제
|
|
LT3489239T
(lt)
|
2013-03-06 |
2022-03-10 |
Incyte Holdings Corporation |
Jak inhibitoriaus gamybos būdai ir tarpiniai junginiai
|
|
WO2014146249A1
(en)
*
|
2013-03-19 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
HRP20231048T1
(hr)
|
2013-05-17 |
2023-12-22 |
Incyte Holdings Corporation |
Derivati bipirazola kao jak inhibitori
|
|
AU2014275643B2
(en)
*
|
2013-06-05 |
2018-08-09 |
C&C Research Laboratories |
Heterocyclic derivatives and use thereof
|
|
UA120499C2
(uk)
|
2013-08-07 |
2019-12-26 |
Інсайт Корпорейшн |
Лікування захворювань із застосуванням лікарських форм з уповільненим вивільненням для інгібітора jak1
|
|
MX370588B
(es)
|
2013-08-30 |
2019-12-16 |
Ptc Therapeutics Inc |
Inhibidores de la bmi-1 de pirimidina sustituida.
|
|
CN105980381A
(zh)
|
2013-11-08 |
2016-09-28 |
拜耳医药股份有限公司 |
取代的尿嘧啶及其用途
|
|
WO2015076800A1
(en)
|
2013-11-21 |
2015-05-28 |
Ptc Therapeutics, Inc. |
Substituted pyridine and pyrazine bmi-1 inhibitors
|
|
CN104860941B
(zh)
*
|
2014-02-25 |
2017-03-22 |
上海海雁医药科技有限公司 |
2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
BR112016022062B1
(pt)
|
2014-03-26 |
2023-04-11 |
Astex Therapeutics Limited |
Combinação, composição farmacêutica, uso de uma combinação ou de uma composição farmacêutica, e, produto farmacêutico
|
|
PL3122358T3
(pl)
|
2014-03-26 |
2021-06-14 |
Astex Therapeutics Ltd. |
Połączenia inhibitorów fgfr i cmet w leczeniu nowotworu
|
|
MA39987A
(fr)
|
2014-04-30 |
2017-03-08 |
Incyte Corp |
Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
CN113563332B
(zh)
|
2014-12-23 |
2024-12-17 |
达纳-法伯癌症研究所公司 |
作为egfr抑制剂的新的嘧啶和治疗病症的方法
|
|
JOP20200201A1
(ar)
|
2015-02-10 |
2017-06-16 |
Astex Therapeutics Ltd |
تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
US10561646B2
(en)
|
2015-07-24 |
2020-02-18 |
Shanghai Haiyan Pharmaceutical Technology Co. Ltd. |
EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof
|
|
BR112018005637B1
(pt)
|
2015-09-23 |
2023-11-28 |
Janssen Pharmaceutica Nv |
Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos
|
|
HRP20220012T1
(hr)
|
2015-09-23 |
2022-04-01 |
Janssen Pharmaceutica Nv |
Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka
|
|
TWI720269B
(zh)
*
|
2016-11-22 |
2021-03-01 |
財團法人生物技術開發中心 |
用於調節刺蝟途徑之雜芳基胺化合物及其製法及用途
|
|
SI3697789T1
(sl)
|
2017-10-18 |
2022-04-29 |
Incyte Corporation |
Kondenzirani imidazolni derivati, substituirani s terciarnimi hidroksi skupinami, kot zaviralci PI3K-gama
|
|
WO2019113487A1
(en)
|
2017-12-08 |
2019-06-13 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
IL276302B2
(en)
|
2018-01-30 |
2023-11-01 |
Incyte Corp |
Procedures for preparing [1-(3-fluoro-2-(trifluoromethyl(isonicotinyl}piperidine-4-one)
|
|
CN118490690A
(zh)
|
2018-02-16 |
2024-08-16 |
因赛特公司 |
用于治疗细胞因子相关的病症的jak1通路抑制剂
|
|
US11584961B2
(en)
|
2018-03-30 |
2023-02-21 |
Incyte Corporation |
Biomarkers for inflammatory skin disease
|
|
SMT202400306T1
(it)
|
2018-03-30 |
2024-09-16 |
Incyte Corp |
Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
|
|
AU2019252259A1
(en)
|
2018-04-13 |
2020-12-03 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
WO2020055544A2
(en)
|
2018-08-17 |
2020-03-19 |
Ptc Therapeutics, Inc. |
Method for treating pancreatic cancer
|
|
CR20250050A
(es)
|
2018-09-05 |
2025-03-19 |
Incyte Corp |
Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
JP7186874B2
(ja)
*
|
2018-10-26 |
2022-12-09 |
アーリーン ファーマシューティカルズ エルエルシー |
ピラゾリル化合物およびその使用方法
|
|
CN113490484B
(zh)
|
2018-10-31 |
2024-08-23 |
因赛特公司 |
治疗血液疾病的组合疗法
|
|
WO2020118683A1
(en)
*
|
2018-12-14 |
2020-06-18 |
Lynk Pharmaceuticals Co. Ltd. |
Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
US11472791B2
(en)
|
2019-03-05 |
2022-10-18 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
US20230086702A1
(en)
|
2019-04-18 |
2023-03-23 |
The Johns Hopkins University |
Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a]pyridine derivatives and use thereof
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
CN114423750B
(zh)
*
|
2019-06-28 |
2024-04-19 |
成都赜灵生物医药科技有限公司 |
2,4-二取代嘧啶衍生物及其制备方法和用途
|
|
CN112142731B
(zh)
*
|
2019-06-28 |
2022-07-22 |
成都赜灵生物医药科技有限公司 |
一种2,4-二取代嘧啶衍生物及其制备方法和用途
|
|
BR112022002698A2
(pt)
|
2019-08-14 |
2022-07-19 |
Incyte Corp |
Compostos de imidazolil pirimidinilamina como inibidores de cdk2
|
|
US20220372135A1
(en)
|
2019-09-27 |
2022-11-24 |
Disc Medicine, Inc. |
Methods for treating myelofibrosis and related conditions
|
|
US12203942B2
(en)
|
2019-10-10 |
2025-01-21 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
US12360120B2
(en)
|
2019-10-10 |
2025-07-15 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
AU2020364007A1
(en)
|
2019-10-11 |
2022-04-28 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CR20220280A
(es)
|
2019-11-22 |
2022-09-02 |
Incyte Corp |
Terapia de combinación que comprende un inhibidor de alk2 y un inhibidor de jak2
|
|
CA3172750A1
(en)
*
|
2020-03-23 |
2021-09-30 |
Ge Hyeong Lee |
Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same
|
|
IL297437A
(en)
|
2020-05-13 |
2022-12-01 |
Disc Medicine Inc |
Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
|
|
PE20231102A1
(es)
|
2020-06-02 |
2023-07-19 |
Incyte Corp |
Procesos para preparar un inhibidor de jak1
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
AU2021329301A1
(en)
|
2020-08-18 |
2023-04-13 |
Incyte Corporation |
Process and intermediates for preparing a JAK1 inhibitor
|
|
KR20230096973A
(ko)
|
2020-08-18 |
2023-06-30 |
인사이트 코포레이션 |
Jak 저해제를 제조하기 위한 방법 및 중간체
|
|
CN114181199B
(zh)
*
|
2020-09-15 |
2023-09-26 |
成都赜灵生物医药科技有限公司 |
2,4-二取代嘧啶衍生物及其制备方法和用途
|
|
CN112142675B
(zh)
*
|
2020-10-09 |
2021-11-30 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
CN112159394B
(zh)
*
|
2020-10-09 |
2021-10-22 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
US11957661B2
(en)
|
2020-12-08 |
2024-04-16 |
Incyte Corporation |
JAK1 pathway inhibitors for the treatment of vitiligo
|
|
CN114874189B
(zh)
*
|
2021-02-05 |
2023-09-29 |
深圳市塔吉瑞生物医药有限公司 |
取代的杂芳基衍生物及其组合物及用途
|
|
IL308216A
(en)
|
2021-05-03 |
2024-01-01 |
Incyte Corp |
Jak1 pathway inhibitors for the treatment of prurigo nodularis
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
CN118317946A
(zh)
|
2021-07-12 |
2024-07-09 |
因赛特公司 |
用于制备巴瑞替尼的方法和中间体
|
|
CA3234554A1
(en)
*
|
2021-10-06 |
2023-04-13 |
Aerie Pharmaceuticals, Inc. |
Janus kinase inhibiting pyrazole compounds and uses thereof
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
KR20250051678A
(ko)
*
|
2022-08-22 |
2025-04-17 |
항저우 하이라이트엘엘 파마슈티컬 씨오., 엘티디. |
피부과 질환의 국소 치료를 위한 jak1/jak2/tyk2 억제제
|
|
CN115594664B
(zh)
*
|
2022-11-25 |
2023-02-24 |
英矽智能科技(上海)有限公司 |
一类螺环衍生物作为kif18a抑制剂
|