|
US7646707B2
(en)
*
|
2003-12-23 |
2010-01-12 |
At&T Intellectual Property I, L.P. |
Method and system for automatically renaming logical circuit identifiers for rerouted logical circuits in a data network
|
|
EP1718300A4
(en)
*
|
2004-01-16 |
2008-05-14 |
Univ Michigan |
CONFORMATIVELY IMPROVED SMAC MIMETIKA AND ITS USES
|
|
CA2553871A1
(en)
*
|
2004-01-16 |
2005-08-04 |
The Regents Of The University Of Michigan |
Smac peptidomimetics and the uses thereof
|
|
WO2005097791A1
(en)
|
2004-04-07 |
2005-10-20 |
Novartis Ag |
Inhibitors of iap
|
|
WO2006014361A1
(en)
|
2004-07-02 |
2006-02-09 |
Genentech, Inc. |
Inhibitors of iap
|
|
US7674787B2
(en)
*
|
2004-07-09 |
2010-03-09 |
The Regents Of The University Of Michigan |
Conformationally constrained Smac mimetics and the uses thereof
|
|
US20100190688A1
(en)
*
|
2004-07-12 |
2010-07-29 |
Bin Chao |
Tetrapeptide analogs
|
|
JP5230865B2
(ja)
|
2004-07-15 |
2013-07-10 |
テトラロジック ファーマシューティカルズ コーポレーション |
Iap結合性化合物
|
|
EA019420B1
(ru)
|
2004-12-20 |
2014-03-31 |
Дженентех, Инк. |
Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
|
|
DK1851200T3
(da)
|
2005-02-25 |
2014-04-14 |
Tetralogic Pharm Corp |
Dimere iap-inhibitorer
|
|
CA2607940C
(en)
|
2005-05-18 |
2009-12-15 |
Aegera Therapeutics Inc. |
Bir domain binding compounds
|
|
US20100256046A1
(en)
*
|
2009-04-03 |
2010-10-07 |
Tetralogic Pharmaceuticals Corporation |
Treatment of proliferative disorders
|
|
AU2006279929A1
(en)
*
|
2005-08-09 |
2007-02-22 |
Tetralogic Pharmaceuticals Corporation |
Treatment of proliferative disorders
|
|
WO2007048224A1
(en)
*
|
2005-10-25 |
2007-05-03 |
Aegera Therapeutics Inc. |
Iap bir domain binding compounds
|
|
CN101374829A
(zh)
|
2005-12-19 |
2009-02-25 |
健泰科生物技术公司 |
Iap的抑制剂
|
|
TWI543988B
(zh)
|
2006-03-16 |
2016-08-01 |
科學製藥股份有限公司 |
結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物
|
|
MY159563A
(en)
*
|
2006-05-16 |
2017-01-13 |
Pharmascience Inc |
Iap bir domain binding compounds
|
|
JP5452223B2
(ja)
|
2006-07-24 |
2014-03-26 |
テトラロジック ファーマシューティカルズ コーポレーション |
Iap阻害剤
|
|
US20100144650A1
(en)
*
|
2006-07-24 |
2010-06-10 |
Tetralogic Pharmaceuticals Corporation |
Dimeric iap inhibitors
|
|
WO2008014238A2
(en)
*
|
2006-07-24 |
2008-01-31 |
Tetralogic Pharmaceuticals Corporation |
Dimeric iap inhibitors
|
|
EP2049563B1
(en)
*
|
2006-07-24 |
2014-03-12 |
Tetralogic Pharmaceuticals Corporation |
Dimeric iap antagonists
|
|
US20100113326A1
(en)
*
|
2006-07-24 |
2010-05-06 |
Tetralogic Pharmaceuticals Corporation |
Dimeric iap inhibitors
|
|
US20100056495A1
(en)
*
|
2006-07-24 |
2010-03-04 |
Tetralogic Pharmaceuticals Corporation |
Dimeric iap inhibitors
|
|
PE20110224A1
(es)
|
2006-08-02 |
2011-04-05 |
Novartis Ag |
PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO
|
|
CN101506203B
(zh)
*
|
2006-08-24 |
2013-10-16 |
诺瓦提斯公司 |
治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
|
|
JP5351025B2
(ja)
*
|
2006-09-22 |
2013-11-27 |
ノバルティス アーゲー |
ヘテロ環式有機化合物
|
|
JP5190062B2
(ja)
*
|
2006-10-12 |
2013-04-24 |
ノバルティス アーゲー |
Iap阻害剤としてのピロリジン誘導体
|
|
JP2010513561A
(ja)
*
|
2006-12-19 |
2010-04-30 |
ジェネンテック, インコーポレイテッド |
Iapのイミダゾピリジンインヒビター
|
|
JP2010513403A
(ja)
*
|
2006-12-20 |
2010-04-30 |
ノバルティス アーゲー |
Scd阻害剤としての2−置換5員ヘテロ環
|
|
EP2079309B1
(en)
*
|
2007-04-12 |
2015-11-11 |
Joyant Pharmaceuticals Inc |
SMAC MIMEE DIMERS AND TRIMERS USEFUL AS ANTICANCER AGENTS
|
|
AR066348A1
(es)
*
|
2007-04-30 |
2009-08-12 |
Genentech Inc |
Inhibidores de las iap
|
|
JP2010528587A
(ja)
*
|
2007-05-07 |
2010-08-26 |
テトラロジック ファーマシューティカルズ コーポレーション |
アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてTNFα遺伝子の発現を用いる方法
|
|
WO2008144925A1
(en)
*
|
2007-05-30 |
2008-12-04 |
Aegera Therapeutics Inc. |
Iap bir domain binding compounds
|
|
PL2240506T3
(pl)
*
|
2008-01-11 |
2013-05-31 |
Genentech Inc |
Inhibitory IAP
|
|
WO2009136290A1
(en)
*
|
2008-05-05 |
2009-11-12 |
Aegera Therapeutics, Inc. |
Functionalized pyrrolidines and use thereof as iap inhibitors
|
|
EP2310402A1
(en)
*
|
2008-06-27 |
2011-04-20 |
Aegera Therapeutics Inc. |
Bridged secondary amines and use thereof as iap bir domain binding compounds
|
|
NZ590550A
(en)
*
|
2008-08-02 |
2013-05-31 |
Genentech Inc |
Inhibitors of Apoptosis (IAP) for treating cancer
|
|
NZ590500A
(en)
*
|
2008-08-16 |
2012-06-29 |
Genentech Inc |
Azaindole inhibitors of iap
|
|
AU2009293403A1
(en)
|
2008-09-17 |
2010-03-25 |
Tetralogic Pharmaceuticals Corp. |
IAP inhibitors
|
|
FR2939073B1
(fr)
|
2008-12-03 |
2010-12-31 |
Sidel Participations |
Formage des recipients avec contre-pression localisee
|
|
US20100317593A1
(en)
*
|
2009-06-12 |
2010-12-16 |
Astrazeneca Ab |
2,3-dihydro-1h-indene compounds
|
|
US8283372B2
(en)
|
2009-07-02 |
2012-10-09 |
Tetralogic Pharmaceuticals Corp. |
2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
|
|
CN102612651A
(zh)
|
2009-09-18 |
2012-07-25 |
诺瓦提斯公司 |
Iap抑制剂化合物的生物标志物
|
|
US8551955B2
(en)
|
2009-10-28 |
2013-10-08 |
Joyant Pharmaceuticals, Inc. |
Dimeric Smac mimetics
|
|
CN102050867A
(zh)
*
|
2009-11-10 |
2011-05-11 |
上海艾力斯医药科技有限公司 |
四肽类似物、制备方法及其应用
|
|
NZ602368A
(en)
|
2010-02-12 |
2014-10-31 |
Pharmascience Inc |
Iap bir domain binding compounds
|
|
EP2558458B1
(de)
|
2010-04-16 |
2017-09-06 |
Bayer Intellectual Property GmbH |
Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel
|
|
GB201106817D0
(en)
|
2011-04-21 |
2011-06-01 |
Astex Therapeutics Ltd |
New compound
|
|
WO2013043591A1
(en)
*
|
2011-09-21 |
2013-03-28 |
Albert Einstein College Of Medicine Of Yeshiva University |
Combination therapy for cancer
|
|
US20140243276A1
(en)
|
2011-09-30 |
2014-08-28 |
Tetralogic Pharmaceuticals Corporation |
Smac mimetic (birinapant) for use in the treatment of proliferative diseases (cancer)
|
|
NO2755614T3
(OSRAM)
*
|
2012-01-03 |
2018-03-31 |
|
|
|
US9353419B2
(en)
|
2012-05-04 |
2016-05-31 |
Novartis Ag |
Biomarkers for IAP inhibitor therapy
|
|
JP6382831B2
(ja)
|
2012-11-30 |
2018-08-29 |
サンフォード−バーンハム メディカル リサーチ インスティテュート |
アポトーシス阻害タンパク質(iap)のアンタゴニスト
|
|
US9498532B2
(en)
|
2013-03-13 |
2016-11-22 |
Novartis Ag |
Antibody drug conjugates
|
|
MX366978B
(es)
|
2013-03-15 |
2019-08-01 |
Novartis Ag |
Conjugados de anticuerpo - farmaco.
|
|
ES2982449T3
(es)
|
2013-06-25 |
2024-10-16 |
Walter & Eliza Hall Inst Medical Res |
Miméticos Smac para su uso en el tratamiento de una infección persistente por VIH
|
|
GB201311891D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compound
|
|
GB201311888D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
LT3083616T
(lt)
|
2013-12-20 |
2021-09-10 |
Astex Therapeutics Limited |
Bicikinių heterociklų junginiai ir jų panaudojimas terapijoje
|
|
CA2974651A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
US9811383B2
(en)
*
|
2014-05-05 |
2017-11-07 |
Empire Technology Development Llc |
Processing a composite task based on a semantic relation graph
|
|
US10300074B2
(en)
|
2014-06-04 |
2019-05-28 |
Sanford Burnham Prebys Medical Discovery Institute |
Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy
|
|
WO2016020791A1
(en)
|
2014-08-05 |
2016-02-11 |
Novartis Ag |
Ckit antibody drug conjugates
|
|
KR20170040249A
(ko)
|
2014-08-12 |
2017-04-12 |
노파르티스 아게 |
항-cdh6 항체 약물 접합체
|
|
GB201414730D0
(en)
|
2014-08-19 |
2014-10-01 |
Tpp Global Dev Ltd |
Pharmaceutical compound
|
|
WO2016079527A1
(en)
|
2014-11-19 |
2016-05-26 |
Tetralogic Birinapant Uk Ltd |
Combination therapy
|
|
WO2016097773A1
(en)
|
2014-12-19 |
2016-06-23 |
Children's Cancer Institute |
Therapeutic iap antagonists for treating proliferative disorders
|
|
US11352351B2
(en)
|
2015-01-20 |
2022-06-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
US12312316B2
(en)
|
2015-01-20 |
2025-05-27 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
WO2016197114A1
(en)
|
2015-06-05 |
2016-12-08 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
|
EP3310813A1
(en)
|
2015-06-17 |
2018-04-25 |
Novartis AG |
Antibody drug conjugates
|
|
US10772962B2
(en)
|
2015-08-19 |
2020-09-15 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
|
MX392422B
(es)
|
2016-06-21 |
2025-03-24 |
Orion Ophthalmology LLC |
Derivados de prolinamida heterociclica
|
|
JP7164521B2
(ja)
|
2016-06-21 |
2022-11-01 |
オリオン・オフサルモロジー・エルエルシー |
炭素環式プロリンアミド誘導体
|
|
KR20230127371A
(ko)
|
2016-11-01 |
2023-08-31 |
아비나스 오퍼레이션스, 인코포레이티드 |
타우(Tau)-단백질 표적화 프로탁(PROTAC) 및 관련 사용 방법
|
|
IL297717A
(en)
|
2016-12-01 |
2022-12-01 |
Arvinas Operations Inc |
History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists
|
|
MX2019007649A
(es)
|
2016-12-23 |
2019-09-10 |
Arvinas Operations Inc |
Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente.
|
|
WO2018118598A1
(en)
|
2016-12-23 |
2018-06-28 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
WO2018119441A1
(en)
|
2016-12-23 |
2018-06-28 |
Arvinas, Inc. |
Egfr proteolysis targeting chimeric molecules and associated methods of use
|
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
|
IL300417A
(en)
|
2017-01-26 |
2023-04-01 |
Arvinas Operations Inc |
Bifunctional benzothiophene compounds, preparations containing them and their use in therapy
|
|
JOP20190187A1
(ar)
|
2017-02-03 |
2019-08-01 |
Novartis Ag |
مترافقات عقار جسم مضاد لـ ccr7
|
|
US11179413B2
(en)
|
2017-03-06 |
2021-11-23 |
Novartis Ag |
Methods of treatment of cancer with reduced UBB expression
|
|
WO2018185618A1
(en)
|
2017-04-03 |
2018-10-11 |
Novartis Ag |
Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
WO2018215937A1
(en)
|
2017-05-24 |
2018-11-29 |
Novartis Ag |
Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
|
|
IL322309A
(en)
|
2017-05-24 |
2025-09-01 |
Novartis Ag |
IL2 antibody grafted proteins and methods of use in cancer treatment
|
|
US20200362058A1
(en)
|
2017-05-24 |
2020-11-19 |
Novartis Ag |
Antibody-cytokine engrafted proteins and methods of use
|
|
CN114685602A
(zh)
|
2017-11-13 |
2022-07-01 |
正大天晴药业集团股份有限公司 |
用作iap抑制剂的smac模拟物及其用途
|
|
US11065231B2
(en)
|
2017-11-17 |
2021-07-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
|
|
JP7161849B2
(ja)
*
|
2018-01-24 |
2022-10-27 |
株式会社クラレ |
第一級アミンの製造方法
|
|
WO2019154053A1
(zh)
*
|
2018-02-09 |
2019-08-15 |
广东东阳光药业有限公司 |
Iap抑制剂及其在药物中的应用
|
|
JP7720698B2
(ja)
|
2018-04-04 |
2025-08-08 |
アルビナス・オペレーションズ・インコーポレイテッド |
タンパク質分解の調節因子および関連する使用方法
|
|
CA3103385A1
(en)
|
2018-07-10 |
2020-01-16 |
Novartis Ag |
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
WO2020023851A1
(en)
|
2018-07-26 |
2020-01-30 |
Yale University |
Bifunctional substitued pyrimidines as modulators of fak proteolyse
|
|
CN112912376A
(zh)
|
2018-08-20 |
2021-06-04 |
阿尔维纳斯运营股份有限公司 |
用于治疗神经变性疾病的具有E3泛素连接酶结合活性并靶向α-突触核蛋白的蛋白水解靶向嵌合(PROTAC)化合物
|
|
MX2021002559A
(es)
|
2018-09-07 |
2021-07-21 |
Arvinas Operations Inc |
Compuestos policiclicos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma rapidamente acelerado.
|
|
WO2020089811A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody drug conjugates
|
|
WO2020128972A1
(en)
|
2018-12-20 |
2020-06-25 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
KR20210107731A
(ko)
|
2018-12-21 |
2021-09-01 |
노파르티스 아게 |
Pmel17에 대한 항체 및 이의 접합체
|
|
ES3032659T3
(en)
|
2019-02-15 |
2025-07-23 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
ES2982474T3
(es)
|
2019-02-15 |
2024-10-16 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
|
|
EP3936126A4
(en)
*
|
2019-03-07 |
2022-12-21 |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
COMBINATION OF IAP INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR
|
|
PT3967702T
(pt)
*
|
2019-05-10 |
2024-04-09 |
Chia Tai Tianqing Pharmaceutical Group Co Ltd |
Cristalização de miméticos de smac utilizados como inibidores de iap e método para a sua preparação
|
|
US11912699B2
(en)
|
2019-07-17 |
2024-02-27 |
Arvinas Operations, Inc. |
Tau-protein targeting compounds and associated
|
|
US20220257698A1
(en)
|
2019-08-02 |
2022-08-18 |
Lanthiopep B.V. |
Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer
|
|
EP4021450B1
(en)
|
2019-08-26 |
2025-11-05 |
Arvinas Operations, Inc. |
Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
|
|
MX2022007759A
(es)
|
2019-12-20 |
2022-07-19 |
Novartis Ag |
Combinacion del anticuerpo anti tim-3 mbg453 y anticuerpo anti tgf-beta nis793, con o sin decitabina o el anticuerpo anti pd-1 spartalizumab, para el tratamiento de mielofibrosis y sindrome mielodisplasico.
|
|
AU2021211871A1
(en)
|
2020-01-20 |
2022-09-08 |
Astrazeneca Ab |
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
|
CN111205232B
(zh)
*
|
2020-02-26 |
2022-07-01 |
浙江天宇药业股份有限公司 |
一种替格瑞洛中间体的合成方法
|
|
US20230181756A1
(en)
|
2020-04-30 |
2023-06-15 |
Novartis Ag |
Ccr7 antibody drug conjugates for treating cancer
|
|
US20230332104A1
(en)
|
2020-06-11 |
2023-10-19 |
Novartis Ag |
Zbtb32 inhibitors and uses thereof
|
|
MX2022015852A
(es)
|
2020-06-23 |
2023-01-24 |
Novartis Ag |
Regimen de dosificacion que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
|
|
EP4188549A1
(en)
|
2020-08-03 |
2023-06-07 |
Novartis AG |
Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
EP4204418A1
(en)
|
2020-08-28 |
2023-07-05 |
Arvinas Operations, Inc. |
Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use
|
|
EP4211128A1
(en)
|
2020-09-14 |
2023-07-19 |
Arvinas Operations, Inc. |
Crystalline forms of a compound for the targeted degradation of estrogen receptor
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
CA3216880A1
(en)
|
2021-04-16 |
2022-10-20 |
Novartis Ag |
Antibody drug conjugates and methods for making thereof
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
WO2023214325A1
(en)
|
2022-05-05 |
2023-11-09 |
Novartis Ag |
Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
|
|
EP4562010A1
(en)
|
2022-07-26 |
2025-06-04 |
Novartis AG |
Crystalline forms of an akr1c3 dependent kars inhibitor
|
|
TW202432544A
(zh)
|
2022-09-07 |
2024-08-16 |
美商亞文納營運公司 |
快速加速纖維肉瘤降解化合物及相關使用方法
|
|
TW202444727A
(zh)
|
2023-01-26 |
2024-11-16 |
美商艾維納斯手術有限公司 |
基於cereblon之kras降解protac及其相關用途
|