JP2011184449A - 新規栄養補助食品組成物及びその使用 - Google Patents
新規栄養補助食品組成物及びその使用 Download PDFInfo
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- JP2011184449A JP2011184449A JP2011103767A JP2011103767A JP2011184449A JP 2011184449 A JP2011184449 A JP 2011184449A JP 2011103767 A JP2011103767 A JP 2011103767A JP 2011103767 A JP2011103767 A JP 2011103767A JP 2011184449 A JP2011184449 A JP 2011184449A
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- vitamin
- resveratrol
- egcg
- genistein
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Abstract
【解決手段】活性成分として、レスベラトロール又はその誘導体、代謝産物若しくは類似体を含み、さらに、EGCG、ゲニステイン、ビタミンE、多価不飽和脂肪酸、γ−リノレン酸及びビタミンKから選択される少なくとも1種の付加的な成分を含む組成物。この組成物は、抗炎症効果を示し、食物若しくは飲料であり得るか、又は、食物用若しくは飲料用のサプリメントであり得るか、又は、医薬組成物であり得る。
【選択図】なし
Description
に含まれる化合物を包含する。記号Aで表される上記炭素−炭素二重結合はトランス又はシスであり得るが、当然のことながら、上記式Iには、シス/トランス混合物も包含される。しかしながら、Aがトランス炭素−炭素結合である式Iの化合物が好ましい。
レスベラトロール、及び、EGCG;
レスベラトロール、及び、ビタミンE;
レスベラトロール、及び、PUFA(EPA;DHA;GLA);
レスベラトロール、及び、ビタミンE、EGCG;
レスベラトロール、及び、ビタミンK、EGCG;
レスベラトロール、及び、ビタミンE、PUFA(EPA;DHA;GLA);
レスベラトロール、及び、EGCG、ビタミンE、PUFA(EPA;DHA;GLA);
レスベラトロール、及び、ビタミンE、PUFA(EPA;DHA;GLA)、ゲニステイン;
レスベラトロール、及び、EGCG、ビタミンE、ゲニステイン、PUFA(EPA;DHA;GLA)。
ソフトゼラチンカプセル
以下に挙げてある成分を用いて、慣習的な方法によりソフトゼラチンカプセルを調製した。
活性成分:レスベラトロール 10mg、EPA 200mg、ビタミンE 50mg;
他の成分:グリセロール、水、ゼラチン、植物油
ハードゼラチンカプセル
以下に挙げてある成分を用いて、慣習的な方法によりハードゼラチンカプセルを調製した。
活性成分:レスベラトロール 10mg、EGCG 100mg、ゲニステイン、5mg、ビタミンE 50mg、ビタミンK 1mg;
他の成分:
増量剤:ラクトース又はセルロース又はセルロース誘導体 充分量
滑沢剤:必要な場合には、ステアリン酸マグネシウム(0.5%)
錠剤
以下に挙げてある成分を用いて、慣習的な方法により錠剤を調製した。
活性成分:レスベラトロール 5mg、EGCG 50mg、ビタミンE 20mg
他の成分:微晶質セルロース、二酸化ケイ素(SiO2)、ステアリン酸マグネシウム、クロスカルメロースナトリウム
30%のジュースを含んでいるソフトドリンク
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜200mg/1回摂取分
EGCG:2〜200mg/1回摂取分
PUFA (EPA;DHA;GLA):5〜500mg/1回摂取分
ゲニステイン:0.2〜50mg/1回摂取分
ビタミンE:5〜100mg/1回摂取分
ビタミンK:0.01〜5mg/1回摂取分
標準的1回摂取量:240mL
オレンジ濃縮物
60.3°Brix, 5.15%酸性度 657.99
レモン濃縮物
43.5°Brix, 32.7%酸性度 95.96
オレンジフレーバー(水溶性) 13.43
アプリコットフレーバー(水溶性) 6.71
水 26.46
1.2 着色剤
β−カロテン 10%CWS 0.89
水 67.65
1.3 酸及び酸化防止剤
アスコルビン酸 4.11
無水クエン酸 0.69
水 43.18
1.4 安定剤
ペクチン 0.20
安息香酸ナトリウム 2.74
水 65.60
1.5 油溶性フレーバー
オレンジフレーバー(油溶性) 0.34
オレンジ蒸留油 0.34
1.6 活性成分
上記濃縮物に含ませた活性成分(これは、上記活性成分を意味する:レスベラトロール並びにEGCG、PUFA (EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKの内の1種以上)
[g]
ソフトドリンク混合物 74.50
水 50.00
糖シロップ 60°Brix 150.00
安息香酸ナトリウムを用いる変わりに、上記飲料を低温殺菌してもよい。該飲料は、炭素処理することもできる。
5セリアルブレッド
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取分
EGCG:2〜100mg/1回摂取分
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取分
ゲニステイン:0.2〜20mg/1回摂取分
ビタミンE:5〜100mg/1回摂取分
ビタミンK:0.01〜5mg/1回摂取分
標準的1回摂取量:50g
5セリアル粉 56.8
水 39.8
酵母 2.3
塩 1.1
螺旋状混練システム 4分間 第1ギア
5分間 第2ギア
ドウプルーフィング 60分間
ドウ温度 22℃〜24℃
プルーフィング時間 30分間
オーブン オランダ型オーブン
ベーキング温度: 250/220℃
ベーキング時間 50〜60分
クッキータイプMilano
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取分
EGCG:2〜100mg/1回摂取分
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取分
ゲニステイン:0.2〜20mg/1回摂取分
ビタミンE:5〜100mg/1回摂取分
ビタミンK:0.01〜5mg/1回摂取分
標準的1回摂取量:30g
小麦粉、タイプ550 56.8
砂糖 20.5
脂肪/バター 20.5
全卵(液体) 18.0
レモンフレーバー 充分量
ベーキング剤 充分量
オーブン ファンオーブン
ベーキング温度: 180℃
ベーキング時間 15分
トースト
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取量
EGCG:2〜100mg/1回摂取量
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取量
ゲニステイン:0.2〜20mg/1回摂取量
ビタミンE:5〜100mg/1回摂取量
ビタミンK:0.01〜5mg/1回摂取量
標準的1回摂取量:100g
小麦粉、タイプ550 55.4
水 33.2
酵母 2.8
塩 1.1
脂肪/バター 5.5
麦芽 0.6
乳化ベーキング剤 1.4
螺旋状混練システム 5〜6分間 第1ギア
3〜4分間 第2ギア
ドウプルーフィング 無
ドウ温度 22℃〜24℃
プルーフィング時間 40分間
オーブン オランダ型オーブン
ベーキング温度: 220℃
ベーキング時間 35〜40分
セット型ヨーグルト
3.5%脂肪
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取量
EGCG:2〜100mg/1回摂取量
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取量
ゲニステイン:0.2〜20mg/1回摂取量
ビタミンE:5〜100mg/1回摂取量
ビタミンK:0.01〜5mg/1回摂取量
標準的1回摂取量:225g
フルファットミルク(3.8%脂肪) 90.5
脱脂粉乳 2.0
砂糖 5.0
培養 2.5
撹拌型ヨーグルト
3.5%脂肪
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取量
EGCG:2〜100mg/1回摂取量
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取量
ゲニステイン:0.2〜20mg/1回摂取量
ビタミンE:5〜100mg/1回摂取量
ビタミンK:0.01〜5mg/1回摂取量
標準的1回摂取量:225g
フルファットミルク(3.8%脂肪) 90.2
脱脂粉乳 2.0
安定剤 0.3
砂糖 5.0
培養 2.5
アイスクリーム
8%脂肪
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜100mg/1回摂取量
EGCG:2〜100mg/1回摂取量
PUFA(EPA;DHA;GLA):5〜200mg/1回摂取量
ゲニステイン:0.2〜20mg/1回摂取量
ビタミンE:5〜100mg/1回摂取量
ビタミンK:0.01〜5mg/1回摂取量
標準的1回摂取量:85g
ミルク(3.7%脂肪) 600.00
クリーム(35%脂肪) 166.00
脱脂粉乳 49.10
砂糖 109.00
グルコースシロップ 80% 70.00
アイスクリーム安定剤 5.00
フレーバー 充分量
着色剤 充分量
ワインガム
活性成分:レスベラトロール、並びに、EGCG、PUFA(EPA;DHA;GLA)、ゲニステイン、ビタミンE及びビタミンKから選択される1種以上の付加的な成分を該食品に組み入れた。
レスベラトロール:0.2〜50mg/1回摂取量
EGCG:2〜50mg/1回摂取量
PUFA(EPA;DHA;GLA):5〜100mg/1回摂取量
ゲニステイン:0.2〜10mg/1回摂取量
ビタミンE:5〜10mg/1回摂取量
ビタミンK:0.01〜5mg/1回摂取量
標準的1回摂取量:30g
ゼラチン 200 Bloom 80.0
水(I) 125.0
糖結晶 290.0
水(II) 120.0
グルコースシロップ DE 38 390.0
クエン酸 10.0
フレーバー 2.0
着色剤 充分量
生成物 約1000.0
Claims (30)
- 活性成分として、レスベラトロール又はその誘導体、代謝産物若しくは類似体を含み、さらに、EGCG、ゲニステイン、ビタミンE、多価不飽和脂肪酸、γ−リノレン酸及びビタミンKから選択される少なくとも1種の付加的な成分を含む組成物。
- レスベラトロール、EGCG及び多価不飽和脂肪酸が存在している、請求項1に記載の組成物。
- ビタミンEが存在している、請求項2に記載の組成物。
- ゲニステインが存在している、請求項2又は3に記載の組成物。
- レスベラトロールが約0.5mg〜約2000mgの1日投与量を投与するのに充分な量で存在している、請求項1〜4のいずれか1項に記載の組成物。
- EGCGが約10mg〜約2000mgの1日投与量をヒト成人に投与するのに充分な量で存在している、請求項1〜5のいずれか1項に記載の組成物。
- 多価不飽和脂肪酸が約10mg〜約4000mgの1日投与量をヒト成人に投与するのに充分な量で存在している、請求項1〜4のいずれか1項に記載の組成物。
- ゲニステインが約0.5mg〜約2000mgの1日投与量をヒト成人に投与するのに充分な量で存在している、請求項1〜4のいずれか1項に記載の組成物。
- ビタミンKが約0.01mg〜約50mgの1日投与量をヒト成人に投与するのに充分な量で存在している、請求項1〜4のいずれか1項に記載の組成物。
- 投与単位形態にある、請求項1〜9のいずれか1項に記載の組成物。
- 前記投与形態が固体投与単位形態である、請求項10に記載の組成物。
- 前記投与単位形態が約0.5mg〜約500mgのレスベラトロールを含んでいる、請求項11に記載の組成物。
- 前記投与単位形態が約5mg〜約500mgのEGCGを含んでいる、請求項11に記載の組成物。
- 前記投与単位形態が約5mg〜約1000mgのビタミンEを含んでいる、請求項11に記載の組成物。
- 前記投与単位形態が約10mg〜約1000mgの多価不飽和脂肪酸を含んでいる、請求項11に記載の組成物。
- 前記投与単位形態が約0.5mg〜約500mgのゲニステインを含んでいる、請求項11に記載の組成物。
- 前記投与単位形態が約0.01mg〜約25mgのビタミンKを含んでいる、請求項11に記載の組成物。
- 食物若しくは飲料であるか又は食物用若しくは飲料用のサプリメント組成物である、請求項1〜9のいずれか1項に記載の組成物。
- レスベラトロールが1回摂取量当たり約0.2mg〜約500mgの量で存在している、請求項18に記載の組成物。
- EGCGが1回摂取量当たり約2mg〜約500mgの量で存在している、請求項18に記載の組成物。
- 多価不飽和脂肪酸が1回摂取量当たり約5mg〜約1000mgの量で存在している、請求項18に記載の組成物。
- ゲニステインが1回摂取量当たり約0.2mg〜約500mgの量で存在している、請求項18に記載の組成物。
- ビタミンEが1回摂取量当たり約2mg〜約500mgの量で存在している、請求項18に記載の組成物。
- ビタミンKが1回摂取量当たり約0.002mg〜約20mgの量で存在している、請求項18に記載の組成物。
- EGCG、ゲニステイン、ビタミンE、多価不飽和脂肪酸、γ−リノレン酸及びビタミンKから選択される少なくとも1種の付加的な成分と組み合わせた、レスベラトロール又はその誘導体、代謝産物若しくは類似体の、栄養補助食品組成物の調製における使用。
- レスベラトロール、EGCG及び多価不飽和脂肪酸の組合せ;又は、レスベラトロール、EGCG、多価不飽和脂肪酸及びビタミンEの組合せ;又は、レスベラトロール、EGCG、多価不飽和脂肪酸、ビタミンE及びゲニステインの組合せの、請求項25に記載の使用において、該レスベラトロールは投与される対象の体重1kg当たり0.3mg〜約30mgの1日投与量を提供するのに充分な量で使用され;該EGCGは投与される対象の体重1kg当たり0.3mg〜約30mgの1日投与量を提供するのに充分な量で使用され;該多価不飽和脂肪酸は投与される対象の体重1kg当たり1.0mg〜約50mgの1日投与量を提供するのに充分な量で使用され;該ゲニステインは投与される対象の体重1kg当たり1.0mg〜約100mgの1日投与量を提供するのに充分な量で使用され;該ビタミンKは投与される対象の体重1kg当たり0.15μg〜約7mgの1日投与量を提供するのに充分な量で使用され;及び、該ビタミンEは投与される対象の体重1kg当たり1.0mg〜約100mgの1日投与量を提供するのに充分な量で使用される、前記使用。
- 前記栄養補助食品組成物が、食物若しくは飲料であるか、又は、食物用若しくは飲料用のサプリメント組成物である、請求項25に記載の使用。
- 前記栄養補助食品組成物が、炎症性疾患の治療又は予防を意図している、請求項25に記載の使用。
- 前記栄養補助食品組成物が医薬組成物である、請求項28に記載の使用。
- 炎症性疾患を治療又は予防する方法であって、そのような処置が必要な対象に対して、EGCG、ゲニステイン、ビタミンE、多価不飽和脂肪酸、γ−リノレン酸及びビタミンKから選択される少なくとも1種の付加的な成分と組み合わせて、レスベラトロール又はその誘導体、代謝産物若しくは類似体を投与することを含む、前記方法。
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Also Published As
Publication number | Publication date |
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WO2004105517A1 (en) | 2004-12-09 |
DK2218342T3 (en) | 2018-10-22 |
KR20120034228A (ko) | 2012-04-10 |
CN102125538A (zh) | 2011-07-20 |
CN103211806A (zh) | 2013-07-24 |
KR101254454B1 (ko) | 2013-04-12 |
CN102125538B (zh) | 2014-05-07 |
EP2218342A2 (en) | 2010-08-18 |
CN103211806B (zh) | 2015-09-09 |
US20060287256A1 (en) | 2006-12-21 |
JP5335192B2 (ja) | 2013-11-06 |
JP2006528950A (ja) | 2006-12-28 |
ES2687657T3 (es) | 2018-10-26 |
EP2218342B1 (en) | 2018-07-04 |
KR20060015737A (ko) | 2006-02-20 |
KR101143719B1 (ko) | 2012-05-09 |
EP1633208A1 (en) | 2006-03-15 |
US7582674B2 (en) | 2009-09-01 |
JP2011184450A (ja) | 2011-09-22 |
PL2218342T3 (pl) | 2019-01-31 |
CN1794925A (zh) | 2006-06-28 |
JP5566946B2 (ja) | 2014-08-06 |
EP2218342A3 (en) | 2011-01-05 |
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