JP2011088902A5 - - Google Patents

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JP2011088902A5
JP2011088902A5 JP2010265830A JP2010265830A JP2011088902A5 JP 2011088902 A5 JP2011088902 A5 JP 2011088902A5 JP 2010265830 A JP2010265830 A JP 2010265830A JP 2010265830 A JP2010265830 A JP 2010265830A JP 2011088902 A5 JP2011088902 A5 JP 2011088902A5
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alkyl
hydrogen
composition
hormone
stereoisomer
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JP2010265830A
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JP5226760B2 (ja
JP2011088902A (ja
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JP2010265830A 2003-07-07 2010-11-29 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体 Expired - Lifetime JP5226760B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48543403P 2003-07-07 2003-07-07
US60/485,434 2003-07-07

Related Parent Applications (1)

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JP2006518842A Division JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

Publications (3)

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JP2011088902A JP2011088902A (ja) 2011-05-06
JP2011088902A5 true JP2011088902A5 (OSRAM) 2012-01-19
JP5226760B2 JP5226760B2 (ja) 2013-07-03

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JP2006518842A Expired - Lifetime JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体
JP2010265830A Expired - Lifetime JP5226760B2 (ja) 2003-07-07 2010-11-29 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

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JP2006518842A Expired - Lifetime JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

Country Status (24)

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US (3) US7056927B2 (OSRAM)
EP (1) EP1646389B1 (OSRAM)
JP (2) JP4722844B2 (OSRAM)
KR (1) KR101139148B1 (OSRAM)
CN (1) CN100424078C (OSRAM)
AT (1) ATE407679T1 (OSRAM)
AU (1) AU2004257639B2 (OSRAM)
BR (1) BRPI0412314B8 (OSRAM)
CA (1) CA2531508C (OSRAM)
CY (1) CY1108656T1 (OSRAM)
DE (1) DE602004016516D1 (OSRAM)
DK (1) DK1646389T3 (OSRAM)
EA (1) EA010370B1 (OSRAM)
ES (1) ES2314448T3 (OSRAM)
HR (1) HRP20080646T3 (OSRAM)
IL (1) IL172833A (OSRAM)
MX (1) MXPA06000297A (OSRAM)
NO (1) NO334897B1 (OSRAM)
NZ (1) NZ544747A (OSRAM)
PL (1) PL1646389T3 (OSRAM)
PT (1) PT1646389E (OSRAM)
SI (1) SI1646389T1 (OSRAM)
WO (1) WO2005007165A1 (OSRAM)
ZA (1) ZA200600475B (OSRAM)

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CN107935863A (zh) * 2017-11-30 2018-04-20 厦门海乐景生化有限公司 Elagolix的关键原料化合物C的合成方法
CN110938037A (zh) * 2018-09-21 2020-03-31 苏州鹏旭医药科技有限公司 一种依拉戈利钠盐药物中间体的制备方法
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CN109970663B (zh) * 2017-12-27 2023-04-11 上海科胜药物研发有限公司 一种制备噁拉戈利中间体的方法
CN108129400B (zh) * 2017-12-29 2021-10-15 安帝康(无锡)生物科技有限公司 氘代噁拉戈利衍生物及其用途
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CN112469417A (zh) * 2018-07-23 2021-03-09 艾伯维公司 恶拉戈利钠组合物和方法
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CN109810065B (zh) * 2019-02-16 2022-07-15 安徽华胜医药科技有限公司 一种恶拉戈利的合成方法
CN109651265A (zh) * 2019-02-16 2019-04-19 安徽诺全药业有限公司 一种Elagolix的制备方法
CN110041232A (zh) * 2019-04-10 2019-07-23 丽珠集团新北江制药股份有限公司 一种制备GnRHR药物关键中间体化合物的方法
CN109956906B (zh) * 2019-04-19 2021-01-29 奥锐特药业股份有限公司 一种噁拉戈利关键中间体的制备方法
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CN110204498B (zh) * 2019-06-14 2020-11-27 奥锐特药业股份有限公司 一种高效合成噁拉戈利中间体的方法
CN110372608A (zh) * 2019-07-09 2019-10-25 丽珠集团新北江制药股份有限公司 一种促性腺激素释放激素拮抗剂的制备方法
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CN110372609B (zh) * 2019-07-25 2021-04-09 奥锐特药业股份有限公司 一种噁拉戈利钠盐的纯化方法
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IT201900015458A1 (it) 2019-09-03 2021-03-03 Ind Chimica Srl Processo per la preparazione del sale sodico dell’acido 4-[[(1r)-2-[5-(2-fluoro-3-metossifenil)-3-[[2-fluoro-6-(trifluorometil)fenil]metil]-3,6-diidro-4-metil-2,6-diosso-1(2h)-pirimidinil]-1-feniletil]ammino]-butanoico (elagolix sale sodico) e intermedi di detto processo
TWI755055B (zh) * 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
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CN112694445B (zh) * 2019-10-22 2023-07-28 成都倍特药业股份有限公司 一种噁拉戈利钠中间体的纯化方法
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CN113125575B (zh) * 2019-12-31 2023-04-18 济南尚博生物科技有限公司 一种1-(2-氟-6-(三氟甲基)苄基)-6-甲基嘧啶-二酮的定量分析方法
CN111116490A (zh) * 2020-01-15 2020-05-08 奥锐特药业股份有限公司 一种噁拉戈利中间体水杨酸盐的制备与纯化方法
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