ATE223902T1 - Chinolinderivate als gnrh antagonisten - Google Patents
Chinolinderivate als gnrh antagonistenInfo
- Publication number
- ATE223902T1 ATE223902T1 AT96935360T AT96935360T ATE223902T1 AT E223902 T1 ATE223902 T1 AT E223902T1 AT 96935360 T AT96935360 T AT 96935360T AT 96935360 T AT96935360 T AT 96935360T AT E223902 T1 ATE223902 T1 AT E223902T1
- Authority
- AT
- Austria
- Prior art keywords
- agent
- cancer
- controlling agent
- animals
- agents
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 7
- 241001465754 Metazoa Species 0.000 abstract 3
- 230000001419 dependent effect Effects 0.000 abstract 2
- 230000027758 ovulation cycle Effects 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 201000000736 Amenorrhea Diseases 0.000 abstract 1
- 206010001928 Amenorrhoea Diseases 0.000 abstract 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
- 201000004458 Myoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 abstract 1
- 201000005746 Pituitary adenoma Diseases 0.000 abstract 1
- 206010061538 Pituitary tumour benign Diseases 0.000 abstract 1
- 206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 231100000540 amenorrhea Toxicity 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124566 female contraceptive agent Drugs 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 239000003163 gonadal steroid hormone Substances 0.000 abstract 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 208000021310 pituitary gland adenoma Diseases 0.000 abstract 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
- 208000006155 precocious puberty Diseases 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 230000001739 rebound effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27164095 | 1995-10-19 | ||
| PCT/JP1996/003019 WO1997014682A1 (en) | 1995-10-19 | 1996-10-18 | Quinoline derivatives as gnrh antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223902T1 true ATE223902T1 (de) | 2002-09-15 |
Family
ID=17502876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96935360T ATE223902T1 (de) | 1995-10-19 | 1996-10-18 | Chinolinderivate als gnrh antagonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5807869A (de) |
| EP (1) | EP0876349B1 (de) |
| CN (1) | CN1200114A (de) |
| AT (1) | ATE223902T1 (de) |
| AU (1) | AU7333496A (de) |
| CA (1) | CA2229201A1 (de) |
| DE (1) | DE69623655T2 (de) |
| WO (1) | WO1997014682A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0781774B1 (de) * | 1995-12-08 | 2002-07-31 | Takeda Chemical Industries, Ltd. | Hemmer der Prolaktinsynthese |
| WO1997044037A1 (en) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6150522A (en) * | 1996-05-20 | 2000-11-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| CA2254769A1 (en) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6147088A (en) * | 1996-05-20 | 2000-11-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| ATE305007T1 (de) | 1997-12-26 | 2005-10-15 | Takeda Pharmaceutical | Stickstoffhaltige heterocyclische verbindungen, ihre herstellung und verwendung |
| JP2002510631A (ja) * | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| WO1999051233A1 (en) * | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002510629A (ja) * | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| EP1067929A1 (de) * | 1998-04-02 | 2001-01-17 | Merck & Co., Inc. | Gonadotropin-releasing-hormon antagonisten |
| US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| US6248736B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
| AU6762400A (en) | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EP1255738B1 (de) | 2000-01-25 | 2012-03-07 | Neurocrine Biosciences, Inc. | Gonadotropin freisetzende hormon rezeptor antagonisten und ihre verwandten verfahren |
| US6583153B2 (en) * | 2000-12-12 | 2003-06-24 | Ortho-Mcneil Pharmaceutical, Inc. | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
| DE10108271A1 (de) | 2001-02-21 | 2002-08-22 | Schering Ag | Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons |
| AU2002247737B2 (en) * | 2001-02-21 | 2006-05-18 | Zentaris Gmbh | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone |
| EP1411941A2 (de) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Pyridinon- und pyridazinonderivate als antagonisten des gonadotropin-freisetzungshormon-rezeptors |
| KR20040030893A (ko) | 2001-08-02 | 2004-04-09 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 치환된 피리딘-4-온 및 고나도트로핀 분비 호르몬 수용체길항제로서의 이의 용도 |
| AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
| KR20040023712A (ko) | 2001-08-02 | 2004-03-18 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀 분비 호르몬 수용체(ｇｎｒｈ) 길항제로서의1,2,4-트리아진-3,5-디온 |
| EP1412363A1 (de) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Rezeptor antagonisten für gonadotropin-freisetzende hormone |
| US7569570B2 (en) | 2002-01-30 | 2009-08-04 | Takeda Pharmaceutical Company Limited | Thienopyrimidines, process for preparing the same and use thereof |
| US20050250793A1 (en) * | 2002-04-12 | 2005-11-10 | Masami Kusaka | Preventives/remedies for hot flash |
| EP1644342B1 (de) | 2003-07-07 | 2012-05-09 | Neurocrine Biosciences, Inc. | Arylpyrimidine geeignet zur Behandlung von sexualhormonbedingten Zuständen wie Endometriose, Prostatakrebs und dergleichen |
| WO2005007165A1 (en) | 2003-07-07 | 2005-01-27 | Neurocrine Biosciences, Inc. | Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
| CN100376246C (zh) | 2003-07-07 | 2008-03-26 | 纽罗克里生物科学有限公司 | 作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物 |
| CN1964950A (zh) * | 2004-06-04 | 2007-05-16 | 安斯泰来制药有限公司 | 丙烷－1,3－二酮衍生物或其盐 |
| US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| MX341797B (es) * | 2004-06-24 | 2016-09-02 | Vertex Pharmaceuticals Incorporated * | Moduladores de transportadores con casete de union con atp. |
| BRPI0512397A (pt) | 2004-06-25 | 2008-03-04 | Takeda Pharmaceutical | composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexual |
| DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
| EP1864976B1 (de) * | 2005-03-31 | 2012-10-10 | Astellas Pharma Inc. | Propan-1,3-dionderivat oder salz davon |
| DE602005027002D1 (en) * | 2005-05-04 | 2011-04-28 | Organon Nv | Dihydropyridinderivate |
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| EP1979367A2 (de) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Chinolin-4-on-derivate als modulatoren von abc-transportern |
| LT1993360T (lt) * | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| EP2095818A1 (de) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| MX384179B (es) | 2009-03-20 | 2025-03-14 | Vertex Pharma | Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística. |
| TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| EP3204358B1 (de) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Cokristalle von modulatoren des transmembrankonduktanzregulators bei zystischer fibrose |
| US10299702B2 (en) | 2015-11-11 | 2019-05-28 | Zwift, Inc. | Devices and methods for determining step characteristics |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5488276A (en) * | 1977-12-21 | 1979-07-13 | Grelan Pharmaceut Co Ltd | 6- and 7-carbamoylquinoline derivative |
| US4659691A (en) * | 1985-02-08 | 1987-04-21 | Merck & Co., Inc. | Novel cyclic Hexapeptide LHRH antagonists |
| US5140009A (en) * | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
| US5171835A (en) * | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
| WO1994020460A1 (en) * | 1993-03-11 | 1994-09-15 | Smithkline Beecham Corporation | Chemical compounds |
| TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
-
1996
- 1996-10-18 CN CN96197676.4A patent/CN1200114A/zh active Pending
- 1996-10-18 AT AT96935360T patent/ATE223902T1/de not_active IP Right Cessation
- 1996-10-18 WO PCT/JP1996/003019 patent/WO1997014682A1/en not_active Ceased
- 1996-10-18 AU AU73334/96A patent/AU7333496A/en not_active Abandoned
- 1996-10-18 CA CA002229201A patent/CA2229201A1/en not_active Abandoned
- 1996-10-18 DE DE69623655T patent/DE69623655T2/de not_active Expired - Fee Related
- 1996-10-18 EP EP96935360A patent/EP0876349B1/de not_active Expired - Lifetime
-
1997
- 1997-01-07 US US08/779,609 patent/US5807869A/en not_active Expired - Fee Related
-
1998
- 1998-09-14 US US09/152,514 patent/US6087503A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69623655T2 (de) | 2003-04-24 |
| WO1997014682A1 (en) | 1997-04-24 |
| US6087503A (en) | 2000-07-11 |
| DE69623655D1 (de) | 2002-10-17 |
| EP0876349A1 (de) | 1998-11-11 |
| US5807869A (en) | 1998-09-15 |
| AU7333496A (en) | 1997-05-07 |
| EP0876349B1 (de) | 2002-09-11 |
| CA2229201A1 (en) | 1997-04-24 |
| CN1200114A (zh) | 1998-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |