ATE305007T1 - Stickstoffhaltige heterocyclische verbindungen, ihre herstellung und verwendung - Google Patents

Stickstoffhaltige heterocyclische verbindungen, ihre herstellung und verwendung

Info

Publication number
ATE305007T1
ATE305007T1 AT98961503T AT98961503T ATE305007T1 AT E305007 T1 ATE305007 T1 AT E305007T1 AT 98961503 T AT98961503 T AT 98961503T AT 98961503 T AT98961503 T AT 98961503T AT E305007 T1 ATE305007 T1 AT E305007T1
Authority
AT
Austria
Prior art keywords
sup
bound via
group bound
nitrogen
production
Prior art date
Application number
AT98961503T
Other languages
English (en)
Inventor
Shuichi Furuya
Toshihiro Imaeda
Satoshi Sasaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE305007T1 publication Critical patent/ATE305007T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT98961503T 1997-12-26 1998-12-24 Stickstoffhaltige heterocyclische verbindungen, ihre herstellung und verwendung ATE305007T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP35899897 1997-12-26
JP5402298 1998-03-05
PCT/JP1998/005841 WO1999033831A1 (en) 1997-12-26 1998-12-24 Nitrogen-containing heterocyclic compounds, their production and use

Publications (1)

Publication Number Publication Date
ATE305007T1 true ATE305007T1 (de) 2005-10-15

Family

ID=26394763

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961503T ATE305007T1 (de) 1997-12-26 1998-12-24 Stickstoffhaltige heterocyclische verbindungen, ihre herstellung und verwendung

Country Status (8)

Country Link
US (3) US6194419B1 (de)
EP (1) EP1042325B1 (de)
CN (1) CN1277612A (de)
AT (1) ATE305007T1 (de)
AU (1) AU1687199A (de)
CA (1) CA2300479A1 (de)
DE (1) DE69831690T2 (de)
WO (1) WO1999033831A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346534B1 (en) 1998-09-23 2002-02-12 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
EP1185530A1 (de) * 1999-05-14 2002-03-13 Neurocrine Biosciences, Inc. Imidazo- und pyrrolo[1,2-a]pyrimid-4-one als antagonisten des rezeptors für das gonadotropin freisetzende hormon
US20020077327A1 (en) * 1999-09-23 2002-06-20 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6537998B1 (en) 1999-10-15 2003-03-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
DE60022769T2 (de) * 1999-10-15 2006-07-06 Neurocrine Biosciences, Inc., San Diego Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen
PT1255738E (pt) 2000-01-25 2012-06-19 Neurocrine Biosciences Inc Antagonistas do receptor da hormona de libertação da gonadotrofina e métodos relacionados com os mesmos
JP2004531475A (ja) * 2001-01-26 2004-10-14 ブリストル−マイヤーズ　スクイブ　カンパニー コルチコトロピン放出因子阻害剤としてのイミダゾリル誘導体
US6750350B2 (en) 2001-08-02 2004-06-15 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
US6740656B2 (en) 2001-08-02 2004-05-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
WO2003013528A1 (en) 2001-08-02 2003-02-20 Neurocrine Biosciences, Inc. Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists.
KR20040023712A (ko) 2001-08-02 2004-03-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 고나도트로핀 분비 호르몬 수용체(ｇｎｒｈ) 길항제로서의1,2,4-트리아진-3,5-디온
WO2003064429A1 (fr) 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, procedes de fabrication et d'utilisation correspondants
WO2003086464A1 (fr) * 2002-04-12 2003-10-23 Takeda Pharmaceutical Company Limited. Agents pour prevenir/traiter les bouffees de chaleur
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
US8013006B2 (en) * 2004-07-14 2011-09-06 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1781289A1 (de) * 2004-07-22 2007-05-09 PTC Therapeutics, Inc. Thienopyridine zur behandlung von hepatitis c
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (en) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Pyridinone derivatives and pharmaceutical compositions thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246387A (ja) * 1984-05-22 1985-12-06 Yoshitomi Pharmaceut Ind Ltd ジヒドロイミダゾ〔１，２−ａ〕ピリミジン誘導体
MC1673A1 (fr) * 1984-06-27 1986-06-03 Wellcome Found Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments
IT1214644B (it) 1985-12-10 1990-01-18 Consiglio Nazionale Ricerche Composti eterociclici dotati di attivita' terapeutica.
US5208141A (en) * 1990-10-09 1993-05-04 Konica Corporation Silver halide color photographic light-sensitive material
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
EP0876349B1 (de) * 1995-10-19 2002-09-11 Takeda Chemical Industries, Ltd. Chinolinderivate als gnrh antagonisten
EP0862573A1 (de) * 1995-10-19 1998-09-09 Takeda Chemical Industries, Ltd. Thienopyridinderivate als gonadotropin-releasing hormonantagoniste

Also Published As

Publication number Publication date
WO1999033831A1 (en) 1999-07-08
CA2300479A1 (en) 1999-07-08
AU1687199A (en) 1999-07-19
EP1042325B1 (de) 2005-09-21
DE69831690T2 (de) 2006-06-29
US6962919B2 (en) 2005-11-08
EP1042325A1 (de) 2000-10-11
DE69831690D1 (de) 2006-02-02
CN1277612A (zh) 2000-12-20
US20020103210A1 (en) 2002-08-01
US6413972B1 (en) 2002-07-02
US6194419B1 (en) 2001-02-27

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Legal Events

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