JP2010539952A5 - - Google Patents
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- JP2010539952A5 JP2010539952A5 JP2010527257A JP2010527257A JP2010539952A5 JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5 JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 239000000758 substrate Substances 0.000 claims 16
- 150000001413 amino acids Chemical group 0.000 claims 12
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 5
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 5
- 239000004474 valine Substances 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- LVJARDSTTGGMSM-UHFFFAOYSA-N methyl 2-(benzamidomethyl)-3-oxobutanoate Chemical compound COC(=O)C(C(C)=O)CNC(=O)C1=CC=CC=C1 LVJARDSTTGGMSM-UHFFFAOYSA-N 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 235000014304 histidine Nutrition 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- NQUVCRCCRXRJCK-UHFFFAOYSA-N 4-methylbenzoyl chloride Chemical compound CC1=CC=C(C(Cl)=O)C=C1 NQUVCRCCRXRJCK-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- ATBIFOORFZTUKF-UHFFFAOYSA-N methyl 2-(benzamidomethyl)-3-hydroxybutanoate Chemical compound COC(=O)C(C(C)O)CNC(=O)C1=CC=CC=C1 ATBIFOORFZTUKF-UHFFFAOYSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 0 C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O Chemical compound C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O 0.000 description 8
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O Chemical compound C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 3
- JUZNIMUFDBIJCM-GATUNPTCSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O JUZNIMUFDBIJCM-GATUNPTCSA-N 0.000 description 2
- XFPGUZAJZDKQEC-VFCYFNJJSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O XFPGUZAJZDKQEC-VFCYFNJJSA-N 0.000 description 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O Chemical compound C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 2
- HOYUMWJOTCLELZ-OLNVJHKFSA-N C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O Chemical compound C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O HOYUMWJOTCLELZ-OLNVJHKFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97655507P | 2007-10-01 | 2007-10-01 | |
| US60/976,555 | 2007-10-01 | ||
| PCT/US2008/078513 WO2009046153A1 (en) | 2007-10-01 | 2008-10-01 | Ketoreductase polypeptides for the production of azetidinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539952A JP2010539952A (ja) | 2010-12-24 |
| JP2010539952A5 true JP2010539952A5 (enExample) | 2011-11-10 |
| JP5646328B2 JP5646328B2 (ja) | 2014-12-24 |
Family
ID=40262027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527257A Active JP5646328B2 (ja) | 2007-10-01 | 2008-10-01 | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US7883879B2 (enExample) |
| EP (1) | EP2205727B1 (enExample) |
| JP (1) | JP5646328B2 (enExample) |
| KR (1) | KR20100065387A (enExample) |
| CN (1) | CN101883846A (enExample) |
| ES (1) | ES2547528T3 (enExample) |
| HU (1) | HUE027683T2 (enExample) |
| IL (2) | IL204379A (enExample) |
| SI (1) | SI2205727T1 (enExample) |
| WO (1) | WO2009046153A1 (enExample) |
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|---|---|---|---|---|
| JP5362359B2 (ja) | 2005-10-12 | 2013-12-11 | モルフォシス アーゲー | ヒトＣＤ３８に特異的な完全ヒトＨｕＣＡＬＧＯＬＤ由来の治療抗体の生成とプロファイリング |
| JP2010517574A (ja) | 2007-02-08 | 2010-05-27 | コデクシス， インコーポレイテッド | ケトレダクターゼおよびその使用 |
| CN101784669B (zh) | 2007-08-24 | 2015-02-18 | 科德克希思公司 | 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽 |
| CN101855342B (zh) | 2007-09-13 | 2013-07-10 | 科德克希思公司 | 用于还原苯乙酮的酮还原酶多肽 |
| CN101889081B (zh) | 2007-09-28 | 2014-06-18 | 科德克希思公司 | 酮还原酶多肽及其用途 |
| SI2205727T1 (sl) | 2007-10-01 | 2015-09-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za izdelavo azetidinona |
| SI2329013T1 (sl) | 2008-08-27 | 2016-03-31 | Codexis, Inc. | Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina |
| US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8288131B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| EP2329014B1 (en) | 2008-08-29 | 2014-10-22 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| EP2510089B1 (en) | 2009-12-08 | 2015-10-21 | Codexis, Inc. | Synthesis of prazole compounds |
| US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| US9040262B2 (en) | 2010-05-04 | 2015-05-26 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| DK2697662T3 (en) | 2011-04-13 | 2018-07-30 | Codexis Inc | BIOCATALYTIC PROCEDURE FOR PREPARING ESLICARBAZEPIN AND ANALOGUES THEREOF |
| CN104053771B (zh) | 2011-11-18 | 2016-11-09 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| US9193957B2 (en) | 2012-05-11 | 2015-11-24 | Codexis, Inc. | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds |
| CN103045504B (zh) * | 2012-12-05 | 2014-06-04 | 浙江工业大学 | 微生物催化制备(2s, 3r)-2-苯甲酰氨甲基-3-羟基丁酸酯及菌株 |
| WO2014150633A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| CN103373934A (zh) * | 2013-06-14 | 2013-10-30 | 苏州汇和药业有限公司 | 碳青霉烯和青霉烯类药物的手性中间体的催化合成方法 |
| AU2014306149B2 (en) | 2013-08-06 | 2019-09-19 | Imago Biosciences Inc. | KDM1A inhibitors for the treatment of disease |
| CN104342412B (zh) * | 2013-08-09 | 2018-12-21 | 南京朗恩生物科技有限公司 | 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体 |
| CN105765592B (zh) | 2013-09-27 | 2019-12-17 | 科德克希思公司 | 用于酶变体的自动筛选的方法、装置和系统 |
| HUE053379T2 (hu) | 2013-11-13 | 2021-06-28 | Codexis Inc | Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására |
| EP3134519B1 (en) | 2014-04-22 | 2018-06-06 | c-LEcta GmbH | Ketoreductases |
| CA2968275C (en) | 2014-11-25 | 2023-09-12 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN104531627B (zh) * | 2014-12-23 | 2017-07-21 | 浙江大学 | 羰基还原酶、工程菌及其应用 |
| US10696953B2 (en) | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| MX387224B (es) | 2015-02-12 | 2025-03-18 | Imago Biosciences Inc | Inhibidores de kdm1a para el tratamiento de enfermedades. |
| CN104846025B (zh) * | 2015-03-31 | 2018-06-01 | 浙江大学 | 一种制备(2s，3r)-2-苯甲酰氨甲基-3-羟基丁酸甲酯的方法 |
| WO2017001907A1 (en) | 2015-06-29 | 2017-01-05 | Teva Pharmaceuticals International Gmbh | Biocatalytic processes for the preparation of vilanterol |
| CN106811491B (zh) * | 2015-12-01 | 2022-07-19 | 焦作健康元生物制品有限公司 | 光学活性的β-羟基酯类化合物的制备方法及其中间体 |
| CN107354179B (zh) * | 2016-05-09 | 2021-02-19 | 上海医药工业研究院 | 一种制备含有羟基的手性化合物的方法 |
| WO2018035249A1 (en) * | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Compositions and methods for producing stereoisomerically pure aminocyclopropanes |
| WO2018035259A1 (en) | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Methods and processes for the preparation of kdm1a inhibitors |
| CA3061133A1 (en) | 2017-04-27 | 2018-11-01 | Codexis, Inc. | Ketoreductase polypeptides and polynucleotides |
| WO2019012095A1 (en) | 2017-07-14 | 2019-01-17 | C-Lecta Gmbh | TCO-reductase |
| IL279260B2 (en) | 2018-05-11 | 2024-10-01 | Imago Biosciences Inc | Kdm1a inhibitors for the treatment of disease |
| CN109295019B (zh) * | 2018-10-29 | 2021-01-12 | 浙江大学 | 一种醇脱氢酶突变体及其应用 |
| WO2020187718A1 (en) | 2019-03-15 | 2020-09-24 | Morphosys Ag | Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
| CN111378704A (zh) * | 2020-03-23 | 2020-07-07 | 焦作健康元生物制品有限公司 | 一种酮还原酶生产4-aa中间体的方法 |
| CN111363730A (zh) * | 2020-03-23 | 2020-07-03 | 焦作健康元生物制品有限公司 | 一种用于生产4-aa的酮还原酶制备方法 |
| CN114634957B (zh) * | 2020-12-15 | 2024-08-16 | 苏州引航生物科技有限公司 | 一种生物催化合成4aa中间体的方法 |
| CN112941043B (zh) * | 2021-05-17 | 2021-09-10 | 中国科学院天津工业生物技术研究所 | 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用 |
| CN115478057B (zh) * | 2021-05-31 | 2025-04-04 | 尚科生物医药（上海）有限公司 | 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体 |
| CN120981566A (zh) * | 2023-01-12 | 2025-11-18 | 诺华股份有限公司 | 工程化酮还原酶多肽 |
| CN119842647B (zh) * | 2024-12-29 | 2025-07-22 | 苏州诺恩斯生物科技有限公司 | 一种用于合成度洛西汀中间体的脱氢酶突变体及其应用 |
| CN119570755A (zh) * | 2025-01-07 | 2025-03-07 | 上海泓博尚奕药物技术有限公司 | 一种酮还原酶突变体及其在合成(r)-1-(2,6-二氯苯基)乙醇中的应用 |
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2008
- 2008-10-01 SI SI200831472T patent/SI2205727T1/sl unknown
- 2008-10-01 WO PCT/US2008/078513 patent/WO2009046153A1/en not_active Ceased
- 2008-10-01 JP JP2010527257A patent/JP5646328B2/ja active Active
- 2008-10-01 KR KR1020107008910A patent/KR20100065387A/ko not_active Withdrawn
- 2008-10-01 HU HUE08836133A patent/HUE027683T2/en unknown
- 2008-10-01 EP EP08836133.2A patent/EP2205727B1/en active Active
- 2008-10-01 US US12/243,968 patent/US7883879B2/en active Active
- 2008-10-01 ES ES08836133.2T patent/ES2547528T3/es active Active
- 2008-10-01 CN CN2008801185718A patent/CN101883846A/zh active Pending
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2010
- 2010-03-09 IL IL204379A patent/IL204379A/en active IP Right Grant
- 2010-12-23 US US12/977,825 patent/US8257952B2/en active Active
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2012
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