JP2010539952A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010539952A5 JP2010539952A5 JP2010527257A JP2010527257A JP2010539952A5 JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5 JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5
- Authority
- JP
- Japan
- Prior art keywords
- residue corresponding
- formula
- substrate
- seq
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O Chemical compound C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O 0.000 description 8
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O Chemical compound C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 3
- JUZNIMUFDBIJCM-GATUNPTCSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O JUZNIMUFDBIJCM-GATUNPTCSA-N 0.000 description 2
- XFPGUZAJZDKQEC-VFCYFNJJSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O XFPGUZAJZDKQEC-VFCYFNJJSA-N 0.000 description 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O Chemical compound C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 2
- HOYUMWJOTCLELZ-OLNVJHKFSA-N C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O Chemical compound C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O HOYUMWJOTCLELZ-OLNVJHKFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97655507P | 2007-10-01 | 2007-10-01 | |
| US60/976,555 | 2007-10-01 | ||
| PCT/US2008/078513 WO2009046153A1 (en) | 2007-10-01 | 2008-10-01 | Ketoreductase polypeptides for the production of azetidinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539952A JP2010539952A (ja) | 2010-12-24 |
| JP2010539952A5 true JP2010539952A5 (enExample) | 2011-11-10 |
| JP5646328B2 JP5646328B2 (ja) | 2014-12-24 |
Family
ID=40262027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527257A Expired - Fee Related JP5646328B2 (ja) | 2007-10-01 | 2008-10-01 | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US7883879B2 (enExample) |
| EP (1) | EP2205727B1 (enExample) |
| JP (1) | JP5646328B2 (enExample) |
| KR (1) | KR20100065387A (enExample) |
| CN (1) | CN101883846A (enExample) |
| ES (1) | ES2547528T3 (enExample) |
| HU (1) | HUE027683T2 (enExample) |
| IL (2) | IL204379A (enExample) |
| SI (1) | SI2205727T1 (enExample) |
| WO (1) | WO2009046153A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101287764B (zh) | 2005-10-12 | 2013-11-13 | 莫佛塞斯公司 | 特异性针对人CD38的完全人HuCAL GOLD-衍生治疗抗体的生成和鉴定 |
| CN101627116B (zh) | 2007-02-08 | 2013-07-10 | 科德克希思公司 | 酮还原酶及其用途 |
| JP2010536385A (ja) * | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| CN101889081B (zh) * | 2007-09-28 | 2014-06-18 | 科德克希思公司 | 酮还原酶多肽及其用途 |
| HUE027683T2 (en) | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| WO2010027710A2 (en) | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| WO2011071982A2 (en) | 2009-12-08 | 2011-06-16 | Codexis, Inc. | Synthesis of prazole compounds |
| US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| DK2649187T3 (da) | 2010-12-08 | 2018-01-29 | Codexis Inc | Biokatalysatorer og fremgangsmåder til syntesen af armodafinil |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| CN106479990B (zh) | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| WO2013170050A1 (en) | 2012-05-11 | 2013-11-14 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN103045504B (zh) * | 2012-12-05 | 2014-06-04 | 浙江工业大学 | 微生物催化制备(2s, 3r)-2-苯甲酰氨甲基-3-羟基丁酸酯及菌株 |
| US10150959B2 (en) | 2013-03-15 | 2018-12-11 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| CN103373934A (zh) * | 2013-06-14 | 2013-10-30 | 苏州汇和药业有限公司 | 碳青霉烯和青霉烯类药物的手性中间体的催化合成方法 |
| JP6521967B2 (ja) | 2013-08-06 | 2019-05-29 | イマーゴ バイオサイエンシーズ インコーポレイテッド | 疾患の治療のためのｋｄｍ１ａ阻害剤 |
| CN104342412B (zh) * | 2013-08-09 | 2018-12-21 | 南京朗恩生物科技有限公司 | 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体 |
| DK3049973T3 (en) | 2013-09-27 | 2018-10-22 | Codexis Inc | AUTOMATED SCREENING OF ENZYM VARIENTS |
| CN106232619B (zh) | 2013-11-13 | 2022-09-09 | 科德克希思公司 | 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| CN121203988A (zh) | 2014-04-22 | 2025-12-26 | C-乐克塔股份有限公司 | 酮还原酶 |
| CN107002050A (zh) | 2014-11-25 | 2017-08-01 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| CN104531627B (zh) * | 2014-12-23 | 2017-07-21 | 浙江大学 | 羰基还原酶、工程菌及其应用 |
| DK3256577T3 (da) | 2015-02-10 | 2020-09-14 | Codexis Inc | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
| JP6727216B2 (ja) | 2015-02-12 | 2020-07-22 | イマーゴ バイオサイエンシーズ インコーポレイテッド | 疾患の治療のためのｋｄｍ１ａ阻害剤 |
| CN104846025B (zh) * | 2015-03-31 | 2018-06-01 | 浙江大学 | 一种制备(2s，3r)-2-苯甲酰氨甲基-3-羟基丁酸甲酯的方法 |
| WO2017001907A1 (en) | 2015-06-29 | 2017-01-05 | Teva Pharmaceuticals International Gmbh | Biocatalytic processes for the preparation of vilanterol |
| CN106811491B (zh) * | 2015-12-01 | 2022-07-19 | 焦作健康元生物制品有限公司 | 光学活性的β-羟基酯类化合物的制备方法及其中间体 |
| CN107354179B (zh) * | 2016-05-09 | 2021-02-19 | 上海医药工业研究院 | 一种制备含有羟基的手性化合物的方法 |
| CN111194306B (zh) | 2016-08-16 | 2023-05-16 | 伊美格生物科学公司 | 用于制备kdm1a抑制剂的方法和过程 |
| CN110268067A (zh) * | 2016-08-16 | 2019-09-20 | 伊美格生物科学公司 | 用于产生立体异构纯的氨基环丙烷的组合物和方法 |
| JP7045725B2 (ja) * | 2017-04-27 | 2022-04-01 | コデクシス， インコーポレイテッド | ケトレダクターゼポリペプチドおよびポリヌクレオチド |
| EP3652328A1 (en) | 2017-07-14 | 2020-05-20 | c-LEcta GmbH | Ketoreductases |
| JP7450559B2 (ja) | 2018-05-11 | 2024-03-15 | イマーゴ バイオサイエンシーズ インコーポレイテッド | 疾患の処置のためのｋｄｍ１ａ阻害剤 |
| CN109295019B (zh) * | 2018-10-29 | 2021-01-12 | 浙江大学 | 一种醇脱氢酶突变体及其应用 |
| TWI924633B (zh) | 2019-03-15 | 2026-05-11 | 德商莫菲西斯公司 | 用於治療自體抗體介導的自體免疫疾病的抗-cd38 抗體及其醫藥組成物 |
| CN111363730A (zh) * | 2020-03-23 | 2020-07-03 | 焦作健康元生物制品有限公司 | 一种用于生产4-aa的酮还原酶制备方法 |
| CN111378704A (zh) * | 2020-03-23 | 2020-07-07 | 焦作健康元生物制品有限公司 | 一种酮还原酶生产4-aa中间体的方法 |
| WO2022036662A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江华睿生物技术有限公司 | 酶法合成3-羟基丁酸酯的方法 |
| CN114634957B (zh) * | 2020-12-15 | 2024-08-16 | 苏州引航生物科技有限公司 | 一种生物催化合成4aa中间体的方法 |
| CN112941043B (zh) * | 2021-05-17 | 2021-09-10 | 中国科学院天津工业生物技术研究所 | 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用 |
| CN115478057B (zh) * | 2021-05-31 | 2025-04-04 | 尚科生物医药（上海）有限公司 | 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体 |
| IL322082A (en) * | 2023-01-12 | 2025-09-01 | Novartis Ag | Engineered ketoreductase polypeptides |
| CN119842647B (zh) * | 2024-12-29 | 2025-07-22 | 苏州诺恩斯生物科技有限公司 | 一种用于合成度洛西汀中间体的脱氢酶突变体及其应用 |
| CN119570755B (zh) * | 2025-01-07 | 2026-03-17 | 上海泓博尚奕药物技术有限公司 | 一种酮还原酶突变体及其在合成(r)-1-(2,6-二氯苯基)乙醇中的应用 |
| WO2026154090A1 (en) | 2025-01-17 | 2026-07-23 | Boehringer Ingelheim International Gmbh | Modified bacterial ketoreductase |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4619924A (en) | 1984-05-18 | 1986-10-28 | Pfizer Inc. | 2-alkylthiopenem derivatives |
| ES2045180T3 (es) | 1987-05-04 | 1994-01-16 | Ciba Geigy Ag | Nuevo procedimiento para la obtencion de 4-aciloxi-3-hidroxietil-azetidinonas. |
| JPH0623150B2 (ja) | 1988-11-15 | 1994-03-30 | 高砂香料工業株式会社 | 光学活性３−ヒドロキシブタン酸類の製造方法 |
| DE4014573C1 (enExample) | 1990-05-07 | 1991-10-10 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| US5225339A (en) | 1992-02-26 | 1993-07-06 | The Scripps Research Institute | Lactobacillus kefir alcohol dehydrogenase |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5491077A (en) | 1994-07-20 | 1996-02-13 | Merck & Co., Inc. | Microbial method |
| US5427933A (en) | 1994-07-20 | 1995-06-27 | Merck & Co., Inc. | Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| JP2948504B2 (ja) | 1995-05-11 | 1999-09-13 | 高砂香料工業株式会社 | 光学活性アゼチジン−２−オン誘導体の製造方法 |
| DE19610984A1 (de) | 1996-03-21 | 1997-09-25 | Boehringer Mannheim Gmbh | Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen |
| US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| DE19812004A1 (de) | 1998-03-19 | 1999-09-30 | Forschungszentrum Juelich Gmbh | Dehydrogenasen mit verbesserter NAD-Abhängigkeit, deren Herstellung und Verwendung |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| AU1551701A (en) | 1999-12-03 | 2001-06-12 | Kaneka Corporation | Novel carbonyl reductase, gene thereof and method of using the same |
| DE10037101A1 (de) | 2000-07-27 | 2002-02-07 | Degussa | Rekombinant hergestellte Enzyme mit verbesserter NAD(H)-Akzeptanz |
| US7202070B2 (en) | 2000-10-31 | 2007-04-10 | Biocatalytics, Inc. | Method for reductive amination of a ketone using a mutated enzyme |
| HUP0400261A3 (en) | 2001-03-22 | 2005-11-28 | Bristol Myers Squibb Co | Stereoselective reduction of substituted acetophenone |
| DE10119274A1 (de) | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| JP4213524B2 (ja) | 2003-04-17 | 2009-01-21 | ダイセル化学工業株式会社 | 新規なカルボニル還元酵素、その酵素をコードするｄｎａを含むポリヌクレオチド、その製造方法、およびこれを利用した光学活性アルコールの製造方法 |
| US7629157B2 (en) | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
| WO2005018579A2 (en) | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| DE10345772A1 (de) | 2003-10-01 | 2005-04-21 | Basf Ag | Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol |
| US20080050787A1 (en) | 2003-12-02 | 2008-02-28 | Hazuki Nagai | Method for Manufacturing Optically Active Tetrahydrothiophene Derivative and Method for Crystallization of Optically Active Tetrahydrothiophene-3-Ol |
| WO2006130657A2 (en) | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
| JP5090910B2 (ja) | 2005-07-20 | 2012-12-05 | 株式会社カネカ | 光学活性２−（ｎ−置換アミノメチル）−３−ヒドロキシ酪酸エステル類の製造方法 |
| AT502395B1 (de) | 2005-07-27 | 2007-03-15 | Iep Gmbh | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| WO2008042876A2 (en) | 2006-10-02 | 2008-04-10 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| CN101627116B (zh) | 2007-02-08 | 2013-07-10 | 科德克希思公司 | 酮还原酶及其用途 |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| CN101889081B (zh) | 2007-09-28 | 2014-06-18 | 科德克希思公司 | 酮还原酶多肽及其用途 |
| HUE027683T2 (en) | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| WO2010027710A2 (en) * | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025238A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) * | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| WO2011022548A2 (en) * | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| HUE038800T2 (hu) * | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| DK3256577T3 (da) * | 2015-02-10 | 2020-09-14 | Codexis Inc | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
-
2008
- 2008-10-01 HU HUE08836133A patent/HUE027683T2/en unknown
- 2008-10-01 KR KR1020107008910A patent/KR20100065387A/ko not_active Withdrawn
- 2008-10-01 SI SI200831472T patent/SI2205727T1/sl unknown
- 2008-10-01 ES ES08836133.2T patent/ES2547528T3/es active Active
- 2008-10-01 CN CN2008801185718A patent/CN101883846A/zh active Pending
- 2008-10-01 JP JP2010527257A patent/JP5646328B2/ja not_active Expired - Fee Related
- 2008-10-01 US US12/243,968 patent/US7883879B2/en active Active
- 2008-10-01 WO PCT/US2008/078513 patent/WO2009046153A1/en not_active Ceased
- 2008-10-01 EP EP08836133.2A patent/EP2205727B1/en active Active
-
2010
- 2010-03-09 IL IL204379A patent/IL204379A/en active IP Right Grant
- 2010-12-23 US US12/977,825 patent/US8257952B2/en active Active
-
2012
- 2012-08-08 US US13/569,900 patent/US8470572B2/en active Active
-
2013
- 2013-06-24 US US13/925,096 patent/US8980606B2/en active Active
-
2014
- 2014-05-20 IL IL232707A patent/IL232707A/en active IP Right Grant
-
2015
- 2015-03-16 US US14/658,407 patent/US9133442B2/en active Active
- 2015-08-10 US US14/822,624 patent/US9382519B2/en active Active
-
2016
- 2016-06-07 US US15/175,317 patent/US9476034B2/en active Active
- 2016-09-22 US US15/272,664 patent/US9580694B2/en active Active
-
2017
- 2017-01-18 US US15/408,673 patent/US9719071B2/en active Active
- 2017-06-23 US US15/631,359 patent/US10329540B2/en active Active
-
2019
- 2019-05-07 US US16/404,988 patent/US10597641B2/en active Active
-
2020
- 2020-02-13 US US16/790,474 patent/US11078466B2/en active Active
-
2021
- 2021-06-24 US US17/357,673 patent/US12049649B2/en active Active
-
2023
- 2023-09-22 US US18/472,540 patent/US12421503B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015091269A5 (enExample) | ||
| JP2010539948A5 (enExample) | ||
| JP2010538657A5 (enExample) | ||
| Wang et al. | Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones via carbonylation of γ-C (sp3)–H bonds of aliphatic amine substrates | |
| JP2012507568A5 (enExample) | ||
| RU2010107283A (ru) | Способ получения пептида | |
| JP2013520519A5 (enExample) | ||
| RU2015106856A (ru) | Способ получения производных пиразолкарбоновой кислоты | |
| JP2009527517A5 (enExample) | ||
| CN1756734A (zh) | 谷氨酸衍生物和焦谷氨酸衍生物的制造方法和新型的制造用中间体 | |
| JP2019505521A5 (enExample) | ||
| JP2018522012A5 (enExample) | ||
| RU2014148530A (ru) | Производные дипептида лизин-глутаминовая кислота | |
| WO2012162507A1 (en) | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | |
| RU2015138545A (ru) | Способ и промежуточные соединения для получения прегабалина | |
| JP5623711B2 (ja) | アミノ酸を構成イオンとするハロゲンフリーなイオン液体の製造方法 | |
| ES2607490T3 (es) | Péptidos antienvejecimiento activadores del proteasoma y composiciones que los contienen | |
| TW200407285A (en) | Method for producing aminoalkylsulfonic acid and exchanging its salt | |
| Hopkinson et al. | Peptide radical cations | |
| US20130012737A1 (en) | Process for producing sulfur-containing amino acid or salt thereof | |
| JP2020529435A5 (enExample) | ||
| PE20061006A1 (es) | Proceso para preparacion de aminoacidos utiles en la preparacion de moduladores del receptor del peptido | |
| JP2011519884A5 (enExample) | ||
| JP4780437B2 (ja) | ２−オキソイミダゾリジン誘導体の製造方法 | |
| CN1140494C (zh) | 制备碳酸二芳基酯的方法 |