SI2205727T1 - Polipeptidi ketoreduktaze za izdelavo azetidinona - Google Patents

Polipeptidi ketoreduktaze za izdelavo azetidinona

Info

Publication number
SI2205727T1
SI2205727T1 SI200831472T SI200831472T SI2205727T1 SI 2205727 T1 SI2205727 T1 SI 2205727T1 SI 200831472 T SI200831472 T SI 200831472T SI 200831472 T SI200831472 T SI 200831472T SI 2205727 T1 SI2205727 T1 SI 2205727T1
Authority
SI
Slovenia
Prior art keywords
azetidinone
production
ketoreductase polypeptides
ketoreductase
polypeptides
Prior art date
Application number
SI200831472T
Other languages
English (en)
Slovenian (sl)
Inventor
Onorato Campapiano
Emily Mundorff
Birthe Borup
Rama Voladri
Original Assignee
Codexis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis, Inc. filed Critical Codexis, Inc.
Publication of SI2205727T1 publication Critical patent/SI2205727T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200831472T 2007-10-01 2008-10-01 Polipeptidi ketoreduktaze za izdelavo azetidinona SI2205727T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97655507P 2007-10-01 2007-10-01
EP08836133.2A EP2205727B1 (en) 2007-10-01 2008-10-01 Ketoreductase polypeptides for the production of azetidinone
PCT/US2008/078513 WO2009046153A1 (en) 2007-10-01 2008-10-01 Ketoreductase polypeptides for the production of azetidinone

Publications (1)

Publication Number Publication Date
SI2205727T1 true SI2205727T1 (sl) 2015-09-30

Family

ID=40262027

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200831472T SI2205727T1 (sl) 2007-10-01 2008-10-01 Polipeptidi ketoreduktaze za izdelavo azetidinona

Country Status (10)

Country Link
US (14) US7883879B2 (enExample)
EP (1) EP2205727B1 (enExample)
JP (1) JP5646328B2 (enExample)
KR (1) KR20100065387A (enExample)
CN (1) CN101883846A (enExample)
ES (1) ES2547528T3 (enExample)
HU (1) HUE027683T2 (enExample)
IL (2) IL204379A (enExample)
SI (1) SI2205727T1 (enExample)
WO (1) WO2009046153A1 (enExample)

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CN109295019B (zh) * 2018-10-29 2021-01-12 浙江大学 一种醇脱氢酶突变体及其应用
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CN111363730A (zh) * 2020-03-23 2020-07-03 焦作健康元生物制品有限公司 一种用于生产4-aa的酮还原酶制备方法
CN111378704A (zh) * 2020-03-23 2020-07-07 焦作健康元生物制品有限公司 一种酮还原酶生产4-aa中间体的方法
WO2022036662A1 (zh) * 2020-08-21 2022-02-24 浙江华睿生物技术有限公司 酶法合成3-羟基丁酸酯的方法
CN114634957B (zh) * 2020-12-15 2024-08-16 苏州引航生物科技有限公司 一种生物催化合成4aa中间体的方法
CN112941043B (zh) * 2021-05-17 2021-09-10 中国科学院天津工业生物技术研究所 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用
CN115478057B (zh) * 2021-05-31 2025-04-04 尚科生物医药（上海）有限公司 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体
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Publication number Publication date
JP5646328B2 (ja) 2014-12-24
EP2205727A1 (en) 2010-07-14
US9382519B2 (en) 2016-07-05
US9476034B2 (en) 2016-10-25
US12049649B2 (en) 2024-07-30
US20110159567A1 (en) 2011-06-30
US20170313992A1 (en) 2017-11-02
US20140057330A1 (en) 2014-02-27
US20170121689A1 (en) 2017-05-04
WO2009046153A1 (en) 2009-04-09
US7883879B2 (en) 2011-02-08
US9133442B2 (en) 2015-09-15
US8257952B2 (en) 2012-09-04
US8470572B2 (en) 2013-06-25
US20190256825A1 (en) 2019-08-22
KR20100065387A (ko) 2010-06-16
IL232707A0 (en) 2014-07-31
US10329540B2 (en) 2019-06-25
EP2205727B1 (en) 2015-06-24
JP2010539952A (ja) 2010-12-24
US10597641B2 (en) 2020-03-24
US20210324347A1 (en) 2021-10-21
IL232707A (en) 2015-11-30
US20160281067A1 (en) 2016-09-29
WO2009046153A4 (en) 2009-06-25
US20150197731A1 (en) 2015-07-16
US9719071B2 (en) 2017-08-01
US20170002333A1 (en) 2017-01-05
US20130034895A1 (en) 2013-02-07
ES2547528T3 (es) 2015-10-07
HUE027683T2 (en) 2016-10-28
US20240141304A1 (en) 2024-05-02
US9580694B2 (en) 2017-02-28
US8980606B2 (en) 2015-03-17
IL204379A (en) 2014-06-30
US20150337271A1 (en) 2015-11-26
US20200172880A1 (en) 2020-06-04
CN101883846A (zh) 2010-11-10
US12421503B2 (en) 2025-09-23
US20090162909A1 (en) 2009-06-25
US11078466B2 (en) 2021-08-03

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