KR20100065387A - 아제티디논 제조를 위한 케토리덕타제 폴리펩티드 - Google Patents

아제티디논 제조를 위한 케토리덕타제 폴리펩티드 Download PDF

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KR20100065387A
KR20100065387A KR1020107008910A KR20107008910A KR20100065387A KR 20100065387 A KR20100065387 A KR 20100065387A KR 1020107008910 A KR1020107008910 A KR 1020107008910A KR 20107008910 A KR20107008910 A KR 20107008910A KR 20100065387 A KR20100065387 A KR 20100065387A
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residues
residue
amino acid
polypeptide
nonpolar
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오노라토 캄파피아노
에밀리 문도르프
버스 보럽
라마 볼라드리
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코덱시스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020107008910A 2007-10-01 2008-10-01 아제티디논 제조를 위한 케토리덕타제 폴리펩티드 Withdrawn KR20100065387A (ko)

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US97655507P 2007-10-01 2007-10-01
US60/976,555 2007-10-01

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KR20100065387A true KR20100065387A (ko) 2010-06-16

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US (14) US7883879B2 (enExample)
EP (1) EP2205727B1 (enExample)
JP (1) JP5646328B2 (enExample)
KR (1) KR20100065387A (enExample)
CN (1) CN101883846A (enExample)
ES (1) ES2547528T3 (enExample)
HU (1) HUE027683T2 (enExample)
IL (2) IL204379A (enExample)
SI (1) SI2205727T1 (enExample)
WO (1) WO2009046153A1 (enExample)

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CN111378704A (zh) * 2020-03-23 2020-07-07 焦作健康元生物制品有限公司 一种酮还原酶生产4-aa中间体的方法
CN111363730A (zh) * 2020-03-23 2020-07-03 焦作健康元生物制品有限公司 一种用于生产4-aa的酮还原酶制备方法
CN114634957B (zh) * 2020-12-15 2024-08-16 苏州引航生物科技有限公司 一种生物催化合成4aa中间体的方法
CN112941043B (zh) * 2021-05-17 2021-09-10 中国科学院天津工业生物技术研究所 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用
CN115478057B (zh) * 2021-05-31 2025-04-04 尚科生物医药（上海）有限公司 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体
CN120981566A (zh) * 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽
CN119842647B (zh) * 2024-12-29 2025-07-22 苏州诺恩斯生物科技有限公司 一种用于合成度洛西汀中间体的脱氢酶突变体及其应用
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JP2010539952A (ja) 2010-12-24
US20110159567A1 (en) 2011-06-30
WO2009046153A1 (en) 2009-04-09
EP2205727A1 (en) 2010-07-14
US20170313992A1 (en) 2017-11-02
US20170121689A1 (en) 2017-05-04
US20240141304A1 (en) 2024-05-02
EP2205727B1 (en) 2015-06-24
ES2547528T3 (es) 2015-10-07
US20150197731A1 (en) 2015-07-16
US20150337271A1 (en) 2015-11-26
US12049649B2 (en) 2024-07-30
US12421503B2 (en) 2025-09-23
HUE027683T2 (en) 2016-10-28
US9133442B2 (en) 2015-09-15
IL232707A (en) 2015-11-30
US20140057330A1 (en) 2014-02-27
CN101883846A (zh) 2010-11-10
US11078466B2 (en) 2021-08-03
US20170002333A1 (en) 2017-01-05
US10597641B2 (en) 2020-03-24
US8980606B2 (en) 2015-03-17
US20090162909A1 (en) 2009-06-25
US20210324347A1 (en) 2021-10-21
IL232707A0 (en) 2014-07-31
US9476034B2 (en) 2016-10-25
US20130034895A1 (en) 2013-02-07
US10329540B2 (en) 2019-06-25
US20160281067A1 (en) 2016-09-29
US8470572B2 (en) 2013-06-25
US9580694B2 (en) 2017-02-28
US9382519B2 (en) 2016-07-05
US8257952B2 (en) 2012-09-04
WO2009046153A4 (en) 2009-06-25
IL204379A (en) 2014-06-30
US9719071B2 (en) 2017-08-01
JP5646328B2 (ja) 2014-12-24
US7883879B2 (en) 2011-02-08
SI2205727T1 (sl) 2015-09-30
US20190256825A1 (en) 2019-08-22
US20200172880A1 (en) 2020-06-04

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