HUE027683T2 - Ketoreductase polypeptides for the production of azetidinone - Google Patents

Ketoreductase polypeptides for the production of azetidinone Download PDF

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Publication number
HUE027683T2
HUE027683T2 HUE08836133A HUE08836133A HUE027683T2 HU E027683 T2 HUE027683 T2 HU E027683T2 HU E08836133 A HUE08836133 A HU E08836133A HU E08836133 A HUE08836133 A HU E08836133A HU E027683 T2 HUE027683 T2 HU E027683T2
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Hungary
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HUE08836133A
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English (en)
Hungarian (hu)
Inventor
Onorato Campapiano
Emily Mundorff
Birthe Borup
Rama Voladri
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Codexis Inc
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Publication of HUE027683T2 publication Critical patent/HUE027683T2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE08836133A 2007-10-01 2008-10-01 Ketoreductase polypeptides for the production of azetidinone HUE027683T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97655507P 2007-10-01 2007-10-01

Publications (1)

Publication Number Publication Date
HUE027683T2 true HUE027683T2 (en) 2016-10-28

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ID=40262027

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE08836133A HUE027683T2 (en) 2007-10-01 2008-10-01 Ketoreductase polypeptides for the production of azetidinone

Country Status (10)

Country Link
US (14) US7883879B2 (enExample)
EP (1) EP2205727B1 (enExample)
JP (1) JP5646328B2 (enExample)
KR (1) KR20100065387A (enExample)
CN (1) CN101883846A (enExample)
ES (1) ES2547528T3 (enExample)
HU (1) HUE027683T2 (enExample)
IL (2) IL204379A (enExample)
SI (1) SI2205727T1 (enExample)
WO (1) WO2009046153A1 (enExample)

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CN101889081B (zh) * 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
WO2010027710A2 (en) 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
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WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329014T1 (sl) 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
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US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
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DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN106479990B (zh) 2011-11-18 2020-09-18 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
WO2013170050A1 (en) 2012-05-11 2013-11-14 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN103045504B (zh) * 2012-12-05 2014-06-04 浙江工业大学 微生物催化制备(2s, 3r)-2-苯甲酰氨甲基-3-羟基丁酸酯及菌株
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CN103373934A (zh) * 2013-06-14 2013-10-30 苏州汇和药业有限公司 碳青霉烯和青霉烯类药物的手性中间体的催化合成方法
JP6521967B2 (ja) 2013-08-06 2019-05-29 イマーゴ バイオサイエンシーズ インコーポレイテッド 疾患の治療のためのｋｄｍ１ａ阻害剤
CN104342412B (zh) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体
DK3049973T3 (en) 2013-09-27 2018-10-22 Codexis Inc AUTOMATED SCREENING OF ENZYM VARIENTS
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
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CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
CN104531627B (zh) * 2014-12-23 2017-07-21 浙江大学 羰基还原酶、工程菌及其应用
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
JP6727216B2 (ja) 2015-02-12 2020-07-22 イマーゴ バイオサイエンシーズ インコーポレイテッド 疾患の治療のためのｋｄｍ１ａ阻害剤
CN104846025B (zh) * 2015-03-31 2018-06-01 浙江大学 一种制备(2s，3r)-2-苯甲酰氨甲基-3-羟基丁酸甲酯的方法
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CN106811491B (zh) * 2015-12-01 2022-07-19 焦作健康元生物制品有限公司 光学活性的β-羟基酯类化合物的制备方法及其中间体
CN107354179B (zh) * 2016-05-09 2021-02-19 上海医药工业研究院 一种制备含有羟基的手性化合物的方法
CN111194306B (zh) 2016-08-16 2023-05-16 伊美格生物科学公司 用于制备kdm1a抑制剂的方法和过程
CN110268067A (zh) * 2016-08-16 2019-09-20 伊美格生物科学公司 用于产生立体异构纯的氨基环丙烷的组合物和方法
JP7045725B2 (ja) * 2017-04-27 2022-04-01 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびポリヌクレオチド
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CN109295019B (zh) * 2018-10-29 2021-01-12 浙江大学 一种醇脱氢酶突变体及其应用
TWI924633B (zh) 2019-03-15 2026-05-11 德商莫菲西斯公司 用於治療自體抗體介導的自體免疫疾病的抗-cd38 抗體及其醫藥組成物
CN111363730A (zh) * 2020-03-23 2020-07-03 焦作健康元生物制品有限公司 一种用于生产4-aa的酮还原酶制备方法
CN111378704A (zh) * 2020-03-23 2020-07-07 焦作健康元生物制品有限公司 一种酮还原酶生产4-aa中间体的方法
WO2022036662A1 (zh) * 2020-08-21 2022-02-24 浙江华睿生物技术有限公司 酶法合成3-羟基丁酸酯的方法
CN114634957B (zh) * 2020-12-15 2024-08-16 苏州引航生物科技有限公司 一种生物催化合成4aa中间体的方法
CN112941043B (zh) * 2021-05-17 2021-09-10 中国科学院天津工业生物技术研究所 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用
CN115478057B (zh) * 2021-05-31 2025-04-04 尚科生物医药（上海）有限公司 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体
IL322082A (en) * 2023-01-12 2025-09-01 Novartis Ag Engineered ketoreductase polypeptides
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JP5646328B2 (ja) 2014-12-24
EP2205727A1 (en) 2010-07-14
US9382519B2 (en) 2016-07-05
US9476034B2 (en) 2016-10-25
US12049649B2 (en) 2024-07-30
US20110159567A1 (en) 2011-06-30
US20170313992A1 (en) 2017-11-02
US20140057330A1 (en) 2014-02-27
US20170121689A1 (en) 2017-05-04
WO2009046153A1 (en) 2009-04-09
US7883879B2 (en) 2011-02-08
US9133442B2 (en) 2015-09-15
US8257952B2 (en) 2012-09-04
US8470572B2 (en) 2013-06-25
US20190256825A1 (en) 2019-08-22
KR20100065387A (ko) 2010-06-16
IL232707A0 (en) 2014-07-31
US10329540B2 (en) 2019-06-25
EP2205727B1 (en) 2015-06-24
JP2010539952A (ja) 2010-12-24
US10597641B2 (en) 2020-03-24
US20210324347A1 (en) 2021-10-21
IL232707A (en) 2015-11-30
US20160281067A1 (en) 2016-09-29
WO2009046153A4 (en) 2009-06-25
US20150197731A1 (en) 2015-07-16
US9719071B2 (en) 2017-08-01
US20170002333A1 (en) 2017-01-05
US20130034895A1 (en) 2013-02-07
ES2547528T3 (es) 2015-10-07
US20240141304A1 (en) 2024-05-02
US9580694B2 (en) 2017-02-28
US8980606B2 (en) 2015-03-17
IL204379A (en) 2014-06-30
US20150337271A1 (en) 2015-11-26
SI2205727T1 (sl) 2015-09-30
US20200172880A1 (en) 2020-06-04
CN101883846A (zh) 2010-11-10
US12421503B2 (en) 2025-09-23
US20090162909A1 (en) 2009-06-25
US11078466B2 (en) 2021-08-03

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