JP2010539950A5 - - Google Patents
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- JP2010539950A5 JP2010539950A5 JP2010527254A JP2010527254A JP2010539950A5 JP 2010539950 A5 JP2010539950 A5 JP 2010539950A5 JP 2010527254 A JP2010527254 A JP 2010527254A JP 2010527254 A JP2010527254 A JP 2010527254A JP 2010539950 A5 JP2010539950 A5 JP 2010539950A5
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- Japan
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- item
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97678207P | 2007-10-01 | 2007-10-01 | |
| US60/976,782 | 2007-10-01 | ||
| PCT/US2008/078497 WO2009046141A2 (en) | 2007-10-01 | 2008-10-01 | Antisense modulation of fibroblast growth factor receptor 4 expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539950A JP2010539950A (ja) | 2010-12-24 |
| JP2010539950A5 true JP2010539950A5 (enExample) | 2011-11-24 |
| JP5792955B2 JP5792955B2 (ja) | 2015-10-14 |
Family
ID=40526946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527254A Expired - Fee Related JP5792955B2 (ja) | 2007-10-01 | 2008-10-01 | 線維芽細胞増殖因子受容体４発現のアンチセンスモジュレーション |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8486904B2 (enExample) |
| EP (1) | EP2215102B1 (enExample) |
| JP (1) | JP5792955B2 (enExample) |
| KR (1) | KR101660989B1 (enExample) |
| CN (1) | CN101883777B (enExample) |
| AU (1) | AU2008308691B2 (enExample) |
| BR (1) | BRPI0817527A2 (enExample) |
| CA (1) | CA2701128A1 (enExample) |
| IL (1) | IL204796A (enExample) |
| MX (1) | MX2010003606A (enExample) |
| NZ (1) | NZ584827A (enExample) |
| RU (1) | RU2501803C2 (enExample) |
| WO (1) | WO2009046141A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010003606A (es) | 2007-10-01 | 2010-07-02 | Isis Pharmaceuticals Inc | Modulacion antisentido de la expresion del receptor del factor de crecimiento fibroblastico 4. |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| NZ595891A (en) * | 2009-04-15 | 2013-06-28 | Isis Pharmaceuticals Inc | Modulation of inflammatory responses by factor xi |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| CA2832972C (en) * | 2011-04-13 | 2019-04-30 | Isis Pharmaceuticals, Inc. | Antisense modulation of ptp1b expression |
| CA2839437A1 (en) * | 2011-06-16 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102337247B (zh) * | 2011-09-13 | 2013-07-10 | 西安交通大学 | 一种fgfr4高表达的重组hek293细胞及其应用 |
| US9611267B2 (en) | 2012-06-13 | 2017-04-04 | Incyte Holdings Corporation | Substituted tricyclic compounds as FGFR inhibitors |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9175291B2 (en) * | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| JP6452614B2 (ja) | 2012-11-15 | 2019-01-16 | ロシュ イノベーション センター コペンハーゲン エーエス | オリゴヌクレオチドコンジュゲート |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| DK2951305T3 (en) | 2013-01-30 | 2018-10-29 | Hoffmann La Roche | LNA oligonucleotide KULHYDRATKONJUGATER |
| TWI649318B (zh) | 2013-04-19 | 2019-02-01 | 英塞特控股公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| PE20152002A1 (es) * | 2013-05-01 | 2016-01-21 | Isis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de ttr y vhb |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| EP3119888B1 (en) | 2014-03-19 | 2021-07-28 | Ionis Pharmaceuticals, Inc. | Compositions for modulating ataxin 2 expression |
| US10006027B2 (en) | 2014-03-19 | 2018-06-26 | Ionis Pharmaceuticals, Inc. | Methods for modulating Ataxin 2 expression |
| ES2812099T3 (es) | 2014-05-01 | 2021-03-16 | Ionis Pharmaceuticals Inc | Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MY192997A (en) * | 2015-07-10 | 2022-09-20 | Ionis Pharmaceuticals Inc | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| WO2017117496A1 (en) | 2015-12-31 | 2017-07-06 | Ionis Pharmaceuticals, Inc. | Methods for reducing ataxin-2 expression |
| KR20190065341A (ko) | 2016-10-06 | 2019-06-11 | 아이오니스 파마수티컬즈, 인코포레이티드 | 올리고머 화합물들의 접합 방법 |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| ES2991427T3 (es) | 2018-05-04 | 2024-12-03 | Incyte Corp | Formas sólidas de un inhibidor de FGFR y procedimientos para preparar las mismas |
| TW201946630A (zh) | 2018-05-04 | 2019-12-16 | 美商英塞特公司 | Fgfr抑制劑之鹽 |
| CA3106986A1 (en) | 2018-07-25 | 2020-01-30 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing atxn2 expression |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| GEAP202415945A (en) | 2019-10-14 | 2024-04-25 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN112759593A (zh) | 2019-11-01 | 2021-05-07 | 北京伯汇生物技术有限公司 | 桥环并醛基吡啶衍生物及其应用 |
| AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| AR126101A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0420081A1 (en) | 1989-09-26 | 1991-04-03 | Takeda Chemical Industries, Ltd. | Monoclonal antibody against an acidic FGF protein, its production and use |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US20040006005A1 (en) * | 2002-07-02 | 2004-01-08 | Sanjay Bhanot | Use of integrin-linked kinase inhibitors for treating insulin resistance, hyperglycemia and diabetes |
| EP0677055A1 (en) * | 1992-12-31 | 1995-10-18 | Texas Biotechnology Corporation | Antisense molecules directed against a fibroflast growth factor receptor gene family |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US20050053976A1 (en) | 1996-06-06 | 2005-03-10 | Baker Brenda F. | Chimeric oligomeric compounds and their use in gene modulation |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE69900847T2 (de) | 1998-04-17 | 2002-09-12 | Tufts College | Map kinase-inhibitoren zur behandlung von durch tnf-alpha induzierte lipolyse- verursachte krankheiten |
| US6821724B1 (en) * | 1998-09-17 | 2004-11-23 | Affymetrix, Inc. | Methods of genetic analysis using nucleic acid arrays |
| US6153432A (en) | 1999-01-29 | 2000-11-28 | Zen-Bio, Inc | Methods for the differentiation of human preadipocytes into adipocytes |
| US6136603A (en) * | 1999-03-26 | 2000-10-24 | Isis Pharmaceuticals Inc. | Antisense modulation of interleukin-5 signal transduction |
| ES2258459T3 (es) | 1999-05-21 | 2006-09-01 | Bristol-Myers Squibb Company | Pirrolotriazinas inhibidoras de quinasas. |
| ES2264929T3 (es) | 1999-09-08 | 2007-02-01 | Genentech, Inc. | Acidos nucleicos y polipeptidos del factor 19 de crecimiento fibroblastico (fgf-19) y procedimientos de utilizacion para el tratamiento de la obesidad. |
| WO2001049849A1 (en) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
| US6159734A (en) * | 2000-01-18 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of peroxisome proliferator-activated receptor gamma expression |
| US6261840B1 (en) * | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| EP1268793A2 (en) | 2000-03-22 | 2003-01-02 | Amgen, Inc. | Fibroblast growth factor receptor-like molecules and uses thereof |
| AU5056501A (en) | 2000-03-31 | 2001-10-08 | Nobuyuki Itoh | Fibroblast growth factor-like molecules and uses thereof |
| AU6459801A (en) | 2000-05-12 | 2001-11-26 | Mark T Keating | Compositions and methods for cell dedifferentiation and tissue regeneration |
| EP1202065A1 (en) | 2000-10-25 | 2002-05-02 | Aventis Pharma S.A. | Net, a transcription factor of the TCF family, as regulator of angiogenic expression. |
| CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| DE10152147A1 (de) | 2001-10-25 | 2003-05-15 | Chemogenix Gmbh | Verfahren zum Aufbringen von Nukleosiden und/oder Nukleotiden auf funktionalisierten Oberflächen sowie Verfahren zur Bestimmung von Kopplungsausbeuten bei der Synthese von Nukleotiden |
| MXPA04003954A (es) | 2001-10-26 | 2004-11-29 | Aventis Pharma Inc | Bencimidazoles. |
| US7655397B2 (en) * | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
| NZ537155A (en) | 2002-05-23 | 2006-09-29 | Cytopia Pty Ltd | Protein kinase inhibitors |
| TW200401638A (en) | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
| EP2267117A3 (en) | 2002-06-27 | 2011-07-13 | Verva Pharmaceuticals Pty Ltd | Differentiation modulating agents and uses therefor |
| AU2003232412A1 (en) | 2002-07-08 | 2004-01-23 | Koninklijke Philips Electronics N.V. | Reflective stereoscopic display |
| AU2003286757B2 (en) | 2002-11-01 | 2009-06-04 | Merck Sharp & Dohme Corp. | Carbonylamino-benzimidazole derivatives as androgen receptor modulators |
| US8090542B2 (en) * | 2002-11-14 | 2012-01-03 | Dharmacon Inc. | Functional and hyperfunctional siRNA |
| US7803781B2 (en) * | 2003-02-28 | 2010-09-28 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| US20050048494A1 (en) * | 2003-08-28 | 2005-03-03 | Yixin Wang | Colorectal cancer prognostics |
| SI1680140T1 (sl) * | 2003-10-16 | 2011-08-31 | Imclone Llc | Inhibitorji receptorja-1 za fibroblastni rastni faktor in metode za zdravljenje z le-temi |
| EP1697420A2 (en) * | 2003-12-19 | 2006-09-06 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| CA2555531A1 (en) * | 2004-02-05 | 2005-08-25 | Intradigm Corporation | Methods and compositions for combination rnai therapeutics |
| US20090247604A1 (en) * | 2004-02-05 | 2009-10-01 | Intradigm Corporation | RNAi Therapeutics for Treatment of Eye Neovascularization Diseases |
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| CA2582464A1 (en) * | 2004-10-13 | 2006-04-27 | Sanjay Bhanot | Antisense modulation of ptp1b expression |
| US20090299640A1 (en) * | 2005-11-23 | 2009-12-03 | University Of Utah Research Foundation | Methods and Compositions Involving Intrinsic Genes |
| EP1918376A1 (en) | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
| WO2008109369A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tnf gene expression and uses thereof |
| US20100105134A1 (en) * | 2007-03-02 | 2010-04-29 | Mdrna, Inc. | Nucleic acid compounds for inhibiting gene expression and uses thereof |
| MX2010003606A (es) | 2007-10-01 | 2010-07-02 | Isis Pharmaceuticals Inc | Modulacion antisentido de la expresion del receptor del factor de crecimiento fibroblastico 4. |
-
2008
- 2008-10-01 MX MX2010003606A patent/MX2010003606A/es active IP Right Grant
- 2008-10-01 JP JP2010527254A patent/JP5792955B2/ja not_active Expired - Fee Related
- 2008-10-01 BR BRPI0817527A patent/BRPI0817527A2/pt not_active IP Right Cessation
- 2008-10-01 RU RU2010116994/10A patent/RU2501803C2/ru not_active IP Right Cessation
- 2008-10-01 CN CN200880118757.3A patent/CN101883777B/zh not_active Expired - Fee Related
- 2008-10-01 US US12/681,360 patent/US8486904B2/en not_active Expired - Fee Related
- 2008-10-01 CA CA2701128A patent/CA2701128A1/en not_active Abandoned
- 2008-10-01 KR KR1020107009236A patent/KR101660989B1/ko not_active Expired - Fee Related
- 2008-10-01 AU AU2008308691A patent/AU2008308691B2/en not_active Ceased
- 2008-10-01 NZ NZ584827A patent/NZ584827A/xx not_active IP Right Cessation
- 2008-10-01 EP EP08835484.0A patent/EP2215102B1/en not_active Not-in-force
- 2008-10-01 WO PCT/US2008/078497 patent/WO2009046141A2/en not_active Ceased
-
2010
- 2010-03-28 IL IL204796A patent/IL204796A/en not_active IP Right Cessation
-
2013
- 2013-06-12 US US13/915,855 patent/US8895529B2/en not_active Expired - Fee Related