CA2701128A1 - Antisense modulation of fibroblast growth factor receptor 4 expression - Google Patents
Antisense modulation of fibroblast growth factor receptor 4 expression Download PDFInfo
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- CA2701128A1 CA2701128A1 CA2701128A CA2701128A CA2701128A1 CA 2701128 A1 CA2701128 A1 CA 2701128A1 CA 2701128 A CA2701128 A CA 2701128A CA 2701128 A CA2701128 A CA 2701128A CA 2701128 A1 CA2701128 A1 CA 2701128A1
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| US9744183B2 (en) | 2009-07-06 | 2017-08-29 | Wave Life Sciences Ltd. | Nucleic acid prodrugs and methods of use thereof |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| AU2012242642A1 (en) * | 2011-04-13 | 2013-05-02 | Ionis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
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| RU2014105311A (ru) | 2011-07-19 | 2015-08-27 | Уэйв Лайф Сайенсес Пте. Лтд. | Способы синтеза функционализованных нуклеиновых кислот |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102337247B (zh) * | 2011-09-13 | 2013-07-10 | 西安交通大学 | 一种fgfr4高表达的重组hek293细胞及其应用 |
| EP3176170B1 (en) | 2012-06-13 | 2018-11-14 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| PT2872485T (pt) | 2012-07-13 | 2021-03-05 | Wave Life Sciences Ltd | Grupo auxiliar assimétrico |
| BR112015000723A2 (pt) | 2012-07-13 | 2017-06-27 | Shin Nippon Biomedical Laboratories Ltd | adjuvante de ácido nucléico quiral |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
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| SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
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| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
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| EP3119888B1 (en) * | 2014-03-19 | 2021-07-28 | Ionis Pharmaceuticals, Inc. | Compositions for modulating ataxin 2 expression |
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| US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
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| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EP4092119A3 (en) * | 2015-07-10 | 2023-03-22 | Ionis Pharmaceuticals, Inc. | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
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| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
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| JOP20220083A1 (ar) | 2019-10-14 | 2023-01-30 | Incyte Corp | حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr |
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| CN112759593A (zh) | 2019-11-01 | 2021-05-07 | 北京伯汇生物技术有限公司 | 桥环并醛基吡啶衍生物及其应用 |
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-
2008
- 2008-10-01 KR KR1020107009236A patent/KR101660989B1/ko not_active Expired - Fee Related
- 2008-10-01 CN CN200880118757.3A patent/CN101883777B/zh not_active Expired - Fee Related
- 2008-10-01 EP EP08835484.0A patent/EP2215102B1/en not_active Not-in-force
- 2008-10-01 WO PCT/US2008/078497 patent/WO2009046141A2/en not_active Ceased
- 2008-10-01 US US12/681,360 patent/US8486904B2/en not_active Expired - Fee Related
- 2008-10-01 CA CA2701128A patent/CA2701128A1/en not_active Abandoned
- 2008-10-01 BR BRPI0817527A patent/BRPI0817527A2/pt not_active IP Right Cessation
- 2008-10-01 MX MX2010003606A patent/MX2010003606A/es active IP Right Grant
- 2008-10-01 AU AU2008308691A patent/AU2008308691B2/en not_active Ceased
- 2008-10-01 RU RU2010116994/10A patent/RU2501803C2/ru not_active IP Right Cessation
- 2008-10-01 JP JP2010527254A patent/JP5792955B2/ja not_active Expired - Fee Related
- 2008-10-01 NZ NZ584827A patent/NZ584827A/xx not_active IP Right Cessation
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2010
- 2010-03-28 IL IL204796A patent/IL204796A/en not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101883777A (zh) | 2010-11-10 |
| US8486904B2 (en) | 2013-07-16 |
| NZ584827A (en) | 2012-10-26 |
| KR20100081994A (ko) | 2010-07-15 |
| AU2008308691B2 (en) | 2013-11-07 |
| WO2009046141A3 (en) | 2009-05-28 |
| US20100292140A1 (en) | 2010-11-18 |
| JP2010539950A (ja) | 2010-12-24 |
| EP2215102B1 (en) | 2016-02-17 |
| JP5792955B2 (ja) | 2015-10-14 |
| US8895529B2 (en) | 2014-11-25 |
| AU2008308691A1 (en) | 2009-04-09 |
| EP2215102A2 (en) | 2010-08-11 |
| RU2010116994A (ru) | 2013-01-20 |
| IL204796A (en) | 2014-04-30 |
| CN101883777B (zh) | 2015-03-25 |
| IL204796A0 (en) | 2010-11-30 |
| EP2215102A4 (en) | 2012-04-11 |
| KR101660989B1 (ko) | 2016-09-28 |
| MX2010003606A (es) | 2010-07-02 |
| RU2501803C2 (ru) | 2013-12-20 |
| WO2009046141A2 (en) | 2009-04-09 |
| BRPI0817527A2 (pt) | 2017-05-02 |
| HK1146726A1 (zh) | 2011-07-08 |
| US20140080892A1 (en) | 2014-03-20 |
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