JP2010539097A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010539097A5 JP2010539097A5 JP2010524249A JP2010524249A JP2010539097A5 JP 2010539097 A5 JP2010539097 A5 JP 2010539097A5 JP 2010524249 A JP2010524249 A JP 2010524249A JP 2010524249 A JP2010524249 A JP 2010524249A JP 2010539097 A5 JP2010539097 A5 JP 2010539097A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- item
- furan
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 115
- 201000011510 cancer Diseases 0.000 claims description 96
- 239000008194 pharmaceutical composition Substances 0.000 claims description 71
- 150000001875 compounds Chemical class 0.000 claims description 52
- 208000014018 liver neoplasm Diseases 0.000 claims description 49
- 201000007270 liver cancer Diseases 0.000 claims description 46
- DPHUWDIXHNQOSY-UHFFFAOYSA-N napabucasin Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(=O)C)=C2 DPHUWDIXHNQOSY-UHFFFAOYSA-N 0.000 claims description 38
- 206010009944 Colon cancer Diseases 0.000 claims description 31
- 210000004027 cell Anatomy 0.000 claims description 31
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 28
- 201000010536 head and neck cancer Diseases 0.000 claims description 28
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 28
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 27
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 27
- 201000002528 pancreatic cancer Diseases 0.000 claims description 27
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 27
- 210000000130 stem cell Anatomy 0.000 claims description 25
- 206010006187 Breast cancer Diseases 0.000 claims description 22
- 208000026310 Breast neoplasm Diseases 0.000 claims description 22
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 22
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 22
- 201000010881 cervical cancer Diseases 0.000 claims description 22
- 206010017758 gastric cancer Diseases 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 22
- 201000011549 stomach cancer Diseases 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 21
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 20
- 206010060862 Prostate cancer Diseases 0.000 claims description 20
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 20
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 18
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 18
- 208000032839 leukemia Diseases 0.000 claims description 18
- 201000005202 lung cancer Diseases 0.000 claims description 18
- 208000020816 lung neoplasm Diseases 0.000 claims description 18
- 208000034578 Multiple myelomas Diseases 0.000 claims description 17
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 17
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- SKUFZJDSGCDXDR-UHFFFAOYSA-N 1-(4,9-dioxo-3a,9a-dihydrobenzo[f][1]benzofuran-2-yl)ethenyl dimethyl phosphate Chemical compound C1=CC=C2C(=O)C3C=C(C(=C)OP(=O)(OC)OC)OC3C(=O)C2=C1 SKUFZJDSGCDXDR-UHFFFAOYSA-N 0.000 claims description 14
- RPCXZIRGAHYOKZ-UHFFFAOYSA-N 2-acetyl-7-fluorobenzo[f][1]benzofuran-4,9-dione Chemical compound O=C1C2=CC(F)=CC=C2C(=O)C2=C1OC(C(=O)C)=C2 RPCXZIRGAHYOKZ-UHFFFAOYSA-N 0.000 claims description 14
- RVIUPSHRLLQFOH-UHFFFAOYSA-N 2-acetyl-7-chlorobenzo[f][1]benzofuran-4,9-dione Chemical compound O=C1C2=CC(Cl)=CC=C2C(=O)C2=C1OC(C(=O)C)=C2 RVIUPSHRLLQFOH-UHFFFAOYSA-N 0.000 claims description 13
- -1 4,9-dioxo-3a, 4,9,9a-tetrahydro-naphtho [2,3-b] furan phosphate Chemical compound 0.000 claims description 13
- 206010033128 Ovarian cancer Diseases 0.000 claims description 13
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 13
- 206010039491 Sarcoma Diseases 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 13
- 201000001441 melanoma Diseases 0.000 claims description 12
- 229920002554 vinyl polymer Polymers 0.000 claims description 12
- 206010025323 Lymphomas Diseases 0.000 claims description 11
- 201000009030 Carcinoma Diseases 0.000 claims description 10
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 10
- 206010038389 Renal cancer Diseases 0.000 claims description 10
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 10
- 201000010982 kidney cancer Diseases 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- XFJYHILCBBEPTC-UHFFFAOYSA-N 1-(4,9-dioxo-3a,9a-dihydrobenzo[f][1]benzofuran-2-yl)ethenyl dihydrogen phosphate Chemical compound C1=CC=C2C(=O)C3C=C(C(=C)OP(O)(=O)O)OC3C(=O)C2=C1 XFJYHILCBBEPTC-UHFFFAOYSA-N 0.000 claims description 9
- 201000010989 colorectal carcinoma Diseases 0.000 claims description 9
- 206010055113 Breast cancer metastatic Diseases 0.000 claims description 8
- 239000003085 diluting agent Substances 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 8
- 206010005003 Bladder cancer Diseases 0.000 claims description 7
- 206010014733 Endometrial cancer Diseases 0.000 claims description 7
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 7
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 7
- 206010061934 Salivary gland cancer Diseases 0.000 claims description 7
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 7
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 206010038038 rectal cancer Diseases 0.000 claims description 7
- 201000001275 rectum cancer Diseases 0.000 claims description 7
- 201000002510 thyroid cancer Diseases 0.000 claims description 7
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 229940046009 vitamin E Drugs 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- 206010004593 Bile duct cancer Diseases 0.000 claims description 6
- 206010005949 Bone cancer Diseases 0.000 claims description 6
- 208000018084 Bone neoplasm Diseases 0.000 claims description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 6
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 6
- 208000032612 Glial tumor Diseases 0.000 claims description 6
- 206010018338 Glioma Diseases 0.000 claims description 6
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 6
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 6
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 6
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims description 6
- 201000000582 Retinoblastoma Diseases 0.000 claims description 6
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 6
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 6
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 6
- 201000004101 esophageal cancer Diseases 0.000 claims description 6
- 208000024519 eye neoplasm Diseases 0.000 claims description 6
- 201000010175 gallbladder cancer Diseases 0.000 claims description 6
- 201000008106 ocular cancer Diseases 0.000 claims description 6
- 201000002511 pituitary cancer Diseases 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 208000000172 Medulloblastoma Diseases 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 206010029260 Neuroblastoma Diseases 0.000 claims description 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 230000002440 hepatic effect Effects 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 210000002510 keratinocyte Anatomy 0.000 claims description 3
- 239000000693 micelle Substances 0.000 claims description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 206010047741 Vulval cancer Diseases 0.000 claims description 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 235000012000 cholesterol Nutrition 0.000 claims description 2
- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 claims description 2
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 239000007908 nanoemulsion Substances 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 239000006070 nanosuspension Substances 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002353 niosome Substances 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 201000002628 peritoneum cancer Diseases 0.000 claims description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 239000008348 synthetic phosphatidyl choline Substances 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 201000005102 vulva cancer Diseases 0.000 claims description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 208000000649 small cell carcinoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 129
- 101150099493 STAT3 gene Proteins 0.000 description 75
- 230000037361 pathway Effects 0.000 description 45
- 230000000694 effects Effects 0.000 description 39
- BVRDQVRQVGRNHG-UHFFFAOYSA-N 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one Chemical compound N1=C2C3=CC=CC=C3C=CN2C(=O)C=C1N1CCOCC1 BVRDQVRQVGRNHG-UHFFFAOYSA-N 0.000 description 28
- SAXKEWRSGLPYPB-UHFFFAOYSA-N 2-(1-hydroxyethyl)benzo[f][1]benzofuran-4,9-dione Chemical group O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(O)C)=C2 SAXKEWRSGLPYPB-UHFFFAOYSA-N 0.000 description 26
- 230000002159 abnormal effect Effects 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
- 208000035475 disorder Diseases 0.000 description 16
- QORFLTDEUGKOSZ-UHFFFAOYSA-N 2-ethylbenzo[f][1]benzofuran-4,9-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1OC(CC)=C2 QORFLTDEUGKOSZ-UHFFFAOYSA-N 0.000 description 15
- 239000003112 inhibitor Substances 0.000 description 13
- 230000002401 inhibitory effect Effects 0.000 description 11
- 102000004495 STAT3 Transcription Factor Human genes 0.000 description 10
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 10
- 229940000406 drug candidate Drugs 0.000 description 10
- 229910019142 PO4 Inorganic materials 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000002512 chemotherapy Methods 0.000 description 8
- 239000010452 phosphate Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 238000001727 in vivo Methods 0.000 description 7
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 230000001394 metastastic effect Effects 0.000 description 6
- 206010061289 metastatic neoplasm Diseases 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 230000004568 DNA-binding Effects 0.000 description 5
- 206010027476 Metastases Diseases 0.000 description 5
- 230000001594 aberrant effect Effects 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 5
- 230000009401 metastasis Effects 0.000 description 5
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
- 208000023275 Autoimmune disease Diseases 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 201000008211 brain sarcoma Diseases 0.000 description 4
- 239000000919 ceramic Substances 0.000 description 4
- 208000027866 inflammatory disease Diseases 0.000 description 4
- 230000026731 phosphorylation Effects 0.000 description 4
- 238000006366 phosphorylation reaction Methods 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- 229920001567 vinyl ester resin Polymers 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 3
- 102000004889 Interleukin-6 Human genes 0.000 description 3
- 108090001005 Interleukin-6 Proteins 0.000 description 3
- 206010063837 Reperfusion injury Diseases 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 230000001363 autoimmune Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000011221 initial treatment Methods 0.000 description 3
- 238000001038 ionspray mass spectrometry Methods 0.000 description 3
- 208000012947 ischemia reperfusion injury Diseases 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 208000016192 Demyelinating disease Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- 108091030071 RNAI Proteins 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000006471 dimerization reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000005937 nuclear translocation Effects 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 239000000816 peptidomimetic Substances 0.000 description 2
- 230000009822 protein phosphorylation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000001646 side-population cell Anatomy 0.000 description 2
- 150000003384 small molecules Chemical group 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000011272 standard treatment Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000005758 transcription activity Effects 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000006311 Cyclin D1 Human genes 0.000 description 1
- 108010058546 Cyclin D1 Proteins 0.000 description 1
- 101100372758 Danio rerio vegfaa gene Proteins 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 101150029707 ERBB2 gene Proteins 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010027457 Metastases to liver Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
- 206010028570 Myelopathy Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102000000763 Survivin Human genes 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
- 101150030763 Vegfa gene Proteins 0.000 description 1
- NGFFLHMFSINFGB-UHFFFAOYSA-N [chloro(methoxy)phosphoryl]oxymethane Chemical compound COP(Cl)(=O)OC NGFFLHMFSINFGB-UHFFFAOYSA-N 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002001 anti-metastasis Effects 0.000 description 1
- 238000011717 athymic nude mouse Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 201000000053 blastoma Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- IYYIVELXUANFED-UHFFFAOYSA-N bromo(trimethyl)silane Chemical compound C[Si](C)(C)Br IYYIVELXUANFED-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000013557 cerebral hemisphere cancer Diseases 0.000 description 1
- 201000008860 cerebrum cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000008184 embryoma Diseases 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 231100001221 nontumorigenic Toxicity 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 102000037983 regulatory factors Human genes 0.000 description 1
- 108091008025 regulatory factors Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000003804 salivary gland carcinoma Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
- 238000011255 standard chemotherapy Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 208000035458 subtype of a disease Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 208000012991 uterine carcinoma Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97114407P | 2007-09-10 | 2007-09-10 | |
| US60/971,144 | 2007-09-10 | ||
| US1337207P | 2007-12-13 | 2007-12-13 | |
| US61/013,372 | 2007-12-13 | ||
| PCT/US2008/075903 WO2009036099A1 (en) | 2007-09-10 | 2008-09-10 | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014177908A Division JP5925849B2 (ja) | 2007-09-10 | 2014-09-02 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539097A JP2010539097A (ja) | 2010-12-16 |
| JP2010539097A5 true JP2010539097A5 (OSRAM) | 2014-01-23 |
| JP5701603B2 JP5701603B2 (ja) | 2015-04-15 |
Family
ID=40452461
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524249A Expired - Fee Related JP5701603B2 (ja) | 2007-09-10 | 2008-09-10 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2010524251A Expired - Fee Related JP5872160B2 (ja) | 2007-09-10 | 2008-09-10 | 癌治療のための新規の組成物および方法 |
| JP2010524243A Expired - Fee Related JP5688840B2 (ja) | 2007-09-10 | 2008-09-10 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2014177908A Expired - Fee Related JP5925849B2 (ja) | 2007-09-10 | 2014-09-02 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2014177915A Expired - Fee Related JP5938072B2 (ja) | 2007-09-10 | 2014-09-02 | 癌治療のための新規の組成物および方法 |
| JP2014232397A Withdrawn JP2015034179A (ja) | 2007-09-10 | 2014-11-17 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2014232396A Expired - Fee Related JP6106149B2 (ja) | 2007-09-10 | 2014-11-17 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2015230291A Expired - Fee Related JP6358659B2 (ja) | 2007-09-10 | 2015-11-26 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2016004076A Expired - Fee Related JP6347795B2 (ja) | 2007-09-10 | 2016-01-13 | 癌治療のための新規の組成物および方法 |
| JP2016016973A Expired - Fee Related JP6346628B2 (ja) | 2007-09-10 | 2016-02-01 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2016097607A Withdrawn JP2016147906A (ja) | 2007-09-10 | 2016-05-16 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2017242778A Withdrawn JP2018076349A (ja) | 2007-09-10 | 2017-12-19 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2018102234A Withdrawn JP2018131464A (ja) | 2007-09-10 | 2018-05-29 | 癌治療のための新規の組成物および方法 |
| JP2019029436A Pending JP2019073560A (ja) | 2007-09-10 | 2019-02-21 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2020085065A Pending JP2020117547A (ja) | 2007-09-10 | 2020-05-14 | 癌治療のための新規の組成物および方法 |
| JP2020091326A Pending JP2020143135A (ja) | 2007-09-10 | 2020-05-26 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
Family Applications After (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524251A Expired - Fee Related JP5872160B2 (ja) | 2007-09-10 | 2008-09-10 | 癌治療のための新規の組成物および方法 |
| JP2010524243A Expired - Fee Related JP5688840B2 (ja) | 2007-09-10 | 2008-09-10 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2014177908A Expired - Fee Related JP5925849B2 (ja) | 2007-09-10 | 2014-09-02 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2014177915A Expired - Fee Related JP5938072B2 (ja) | 2007-09-10 | 2014-09-02 | 癌治療のための新規の組成物および方法 |
| JP2014232397A Withdrawn JP2015034179A (ja) | 2007-09-10 | 2014-11-17 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2014232396A Expired - Fee Related JP6106149B2 (ja) | 2007-09-10 | 2014-11-17 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2015230291A Expired - Fee Related JP6358659B2 (ja) | 2007-09-10 | 2015-11-26 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2016004076A Expired - Fee Related JP6347795B2 (ja) | 2007-09-10 | 2016-01-13 | 癌治療のための新規の組成物および方法 |
| JP2016016973A Expired - Fee Related JP6346628B2 (ja) | 2007-09-10 | 2016-02-01 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2016097607A Withdrawn JP2016147906A (ja) | 2007-09-10 | 2016-05-16 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2017242778A Withdrawn JP2018076349A (ja) | 2007-09-10 | 2017-12-19 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
| JP2018102234A Withdrawn JP2018131464A (ja) | 2007-09-10 | 2018-05-29 | 癌治療のための新規の組成物および方法 |
| JP2019029436A Pending JP2019073560A (ja) | 2007-09-10 | 2019-02-21 | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
| JP2020085065A Pending JP2020117547A (ja) | 2007-09-10 | 2020-05-14 | 癌治療のための新規の組成物および方法 |
| JP2020091326A Pending JP2020143135A (ja) | 2007-09-10 | 2020-05-26 | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ |
Country Status (14)
| Country | Link |
|---|---|
| US (12) | US8877803B2 (OSRAM) |
| EP (6) | EP3050566B1 (OSRAM) |
| JP (16) | JP5701603B2 (OSRAM) |
| CN (6) | CN101854930B (OSRAM) |
| CA (4) | CA2736563C (OSRAM) |
| CY (3) | CY1117604T1 (OSRAM) |
| DK (4) | DK2190429T3 (OSRAM) |
| ES (3) | ES2569215T3 (OSRAM) |
| HR (3) | HRP20160625T1 (OSRAM) |
| HU (3) | HUE027443T2 (OSRAM) |
| PL (4) | PL3067054T3 (OSRAM) |
| PT (2) | PT2200431T (OSRAM) |
| SI (3) | SI2194987T1 (OSRAM) |
| WO (3) | WO2009036101A1 (OSRAM) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
| TW200803892A (en) | 2005-11-04 | 2008-01-16 | Wyeth Corp | Antineoplastic combinations with MTOR inhibitor, herceptin, and/or HKI-272 |
| EP3050566B1 (en) | 2007-09-10 | 2018-11-28 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| US20130331294A1 (en) | 2007-11-09 | 2013-12-12 | Fox Chase Cancer Center | Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders |
| WO2009062199A1 (en) * | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| DK2310011T3 (da) | 2008-06-17 | 2013-10-14 | Wyeth Llc | Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin |
| AU2009268841B2 (en) | 2008-07-08 | 2014-02-06 | Board Of Regents, The University Of Texas System | Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (STATS) |
| KR101434009B1 (ko) | 2008-08-04 | 2014-08-25 | 와이어쓰 엘엘씨 | 4-아닐리노-3-사이아노퀴놀린과 카페시타빈의 항신생물성 조합물 |
| CA2745265A1 (en) * | 2008-12-01 | 2010-06-10 | James Turkson | Drug composition cytotoxic for pancreatic cancer cells |
| US9211291B2 (en) | 2009-04-06 | 2015-12-15 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| CN101897979B (zh) * | 2009-05-27 | 2012-08-22 | 上海市计划生育科学研究所 | 治疗前列腺疾病的靶向药物 |
| US20130129675A1 (en) * | 2009-12-04 | 2013-05-23 | Board Of Regents, The University Of Texas System | Interferon therapies in combination with blockade of stat3 activation |
| EA022458B1 (ru) * | 2009-12-28 | 2016-01-29 | Дженерал Инкорпорейтед Ассошиэйшн Фарма Вэлли Проджект Саппортинг Организейшн | 1,3,4-оксадиазол-2-карбоксамидное соединение |
| US20110275577A1 (en) * | 2010-01-08 | 2011-11-10 | Moleculin, Llc | Methods of treating dermatologic, gynecologic, and genital disorders with caffeic acid analogs |
| EP2542155B1 (en) | 2010-03-01 | 2015-11-04 | TAU Therapeutics LLC | Method for imaging a disease |
| CA2993363A1 (en) * | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Naphthofuran compounds and compositions for targeting cancer stem cells |
| ES2987670T3 (es) * | 2010-03-19 | 2024-11-15 | 1Globe Biomedical Co Ltd | Métodos novedosos para actuar sobre células madre cancerosas |
| AU2015218436B9 (en) * | 2010-03-19 | 2017-03-09 | Boston Biomedical, Inc. | Novel Methods For Targeting Cancer Stem Cells |
| RU2571661C2 (ru) * | 2010-03-19 | 2015-12-20 | Бостон Байомедикал, Инк. | Новые соединения и композиции для нацеливания на злокачественные стволовые клетки |
| WO2011130677A1 (en) * | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibitors of cancer stem cells |
| US20110301194A1 (en) * | 2010-06-02 | 2011-12-08 | Arqule, Inc. | Method for Determining Treatment Efficacy |
| US8871802B2 (en) | 2010-08-24 | 2014-10-28 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | Naphthoquinones for disease therapies |
| WO2012036214A1 (ja) * | 2010-09-16 | 2012-03-22 | 国立大学法人大阪大学 | 自己免疫疾患、炎症性疾患、アレルギー性疾患、臓器移植に伴う症状の治療薬および予防薬 |
| WO2012071321A1 (en) * | 2010-11-22 | 2012-05-31 | Glaxosmithkline Llc | Method of treating cancer |
| US20130230581A1 (en) * | 2010-11-30 | 2013-09-05 | Qingping Feng | Egfr antagonist for the treatment of heart disease |
| WO2012078982A2 (en) * | 2010-12-09 | 2012-06-14 | The Ohio State University | Xzh-5 inhibits constitutive and interleukin-6-induced stat3 phosphorylation in human hepatocellular carcinoma cells |
| US9150530B2 (en) | 2011-03-04 | 2015-10-06 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies |
| KR20120130658A (ko) * | 2011-05-23 | 2012-12-03 | 주식회사 파멥신 | 펩타이드가 융합된 이중표적항체 및 그 용도 |
| JP2014522410A (ja) * | 2011-06-06 | 2014-09-04 | アケビア セラピューティクス インコーポレイテッド | がん治療のための方法として低酸素誘導因子−2αを安定化するための、化合物および組成物 |
| US20130064814A1 (en) * | 2011-09-12 | 2013-03-14 | Lloyd S. Gray | Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells |
| JP6286358B2 (ja) * | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
| WO2013120229A1 (en) * | 2012-02-17 | 2013-08-22 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | METHOD FOR PREPARING AQUEOUS MANO PARTICLE SUSPENSIONS OF DERIVATIVES OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURAN ALIPHATIC ACID ESTERS |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2013166618A1 (en) * | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
| SG10201805807PA (en) | 2012-06-26 | 2018-08-30 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| CN103705926A (zh) * | 2012-10-08 | 2014-04-09 | 贾力 | 预防原发性肿瘤在手术切除后再转移的药用组合物 |
| DE102013003107A1 (de) | 2013-02-25 | 2014-09-11 | Thomas Rühl | Naphthofurandione mit einer 1-Bromalkylgruppe oder einer 1-Hydroxyalkylgruppe in 2-Position und einer Alkylgruppe in 3-Position zum Furanring-Sauerstoff und Verfahren zu deren Herstellung |
| EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| CN106211758B (zh) | 2013-04-09 | 2021-03-23 | 北京强新生物科技有限公司 | 2-乙酰基萘并[2,3-b]呋喃-4,9-二酮用于治疗癌症的用途 |
| US10745489B2 (en) | 2013-04-29 | 2020-08-18 | Ogd2 Pharma | Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells cancer |
| AU2014261788B2 (en) * | 2013-04-29 | 2019-07-11 | Nantes Université | Targeting O-acetylated GD2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells Cancer |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
| SG11201605070UA (en) | 2014-01-27 | 2016-07-28 | Boston Biomedical Inc | Novel methods for treating cancer |
| CN106163284A (zh) | 2014-02-07 | 2016-11-23 | 北京强新生物科技有限公司 | 3‑取代的羰基萘并[2,3‑b]呋喃衍生物或其药学上可接受的盐 |
| US11406707B2 (en) | 2014-02-10 | 2022-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | STAT3 phosphorylation during graft-versus-host disease |
| SG11201607705XA (en) | 2014-03-19 | 2016-10-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| ES2779149T3 (es) * | 2014-03-26 | 2020-08-13 | Tocagen Inc | Vector retroviral que tiene actividad inmunoestimuladora |
| WO2015164870A1 (en) | 2014-04-25 | 2015-10-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Gamma-aa-peptide stat3/dna inhibitors and methods of use |
| WO2015171985A1 (en) * | 2014-05-09 | 2015-11-12 | The Brigham And Women's Hospital, Inc. | Treatment of igg-immune complex-mediated organ damage |
| JP6549115B2 (ja) | 2014-06-09 | 2019-07-24 | 京都薬品工業株式会社 | 新規抗癌剤 |
| US10869926B2 (en) * | 2014-07-15 | 2020-12-22 | The Johns Hopkins University | Suppression of myeloid derived suppressor cells and immune checkpoint blockade |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
| CN113501826B (zh) | 2015-01-08 | 2025-04-04 | 美国政府健康及人类服务部 | 作为tdp2的抑制剂的呋喃并喹啉二酮 |
| TWI710555B (zh) | 2015-03-27 | 2020-11-21 | 美商美國波士頓生物技術公司 | 新穎水溶性前藥 |
| CN104725480A (zh) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | 一种信号传导及转录激活因子抑制多肽及其应用 |
| CN104693279A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 关于信号传导及转录激活因子抑制多肽及其应用 |
| CN104693280A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 信号传导及转录激活因子抑制多肽及其应用 |
| AU2016249158A1 (en) * | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
| AU2016249157A1 (en) * | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
| EA201792287A1 (ru) * | 2015-04-17 | 2018-03-30 | Бостон Биомедикал, Инк. | Способы лечения рака |
| BR112017022958A2 (pt) * | 2015-04-27 | 2018-07-17 | Boston Biomedical Inc | métodos para tratamento de câncer com inibidor da via da stat3 e inibidor de quinase |
| EP3197456B2 (en) * | 2015-05-14 | 2023-10-11 | NuCana plc | Cancer treatments |
| WO2016185333A1 (en) * | 2015-05-15 | 2016-11-24 | Novartis Ag | Methods for treating egfr mutant cancers |
| CN107847481A (zh) * | 2015-06-03 | 2018-03-27 | 波士顿生物医药有限公司 | 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 |
| JP6810036B2 (ja) * | 2015-07-17 | 2021-01-06 | 大日本住友製薬株式会社 | 2−アセチル−4H,9H−ナフト[2,3−b]フラン−4,9−ジオンの製造方法 |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| WO2017023866A1 (en) * | 2015-07-31 | 2017-02-09 | Boston Biomedical, Inc. | Method of targeting stat3 and other non-druggable proteins |
| CN114230571B (zh) | 2015-09-14 | 2025-07-08 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| JP7038653B2 (ja) | 2015-10-05 | 2022-03-18 | ニューカナ パブリック リミテッド カンパニー | 併用療法 |
| CA3010786A1 (en) * | 2016-01-07 | 2017-07-13 | Virginia Commonwealth University | A method of modulating survival and stemness of cancer stem cells by mda-9/syntenin (sdcbp) |
| CN109069469A (zh) * | 2016-01-20 | 2018-12-21 | 北京强新生物科技有限公司 | 治疗癌症的方法 |
| US11434229B2 (en) * | 2016-03-01 | 2022-09-06 | Academia Sinica | 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases |
| US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
| US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017164379A1 (ja) * | 2016-03-25 | 2017-09-28 | 大日本住友製薬株式会社 | 2-アルキルカルボニルナフト[2,3-b]フラン-4,9-ジオンの関連物質の製造方法、及びその関連物質 |
| JP2017171640A (ja) * | 2016-03-25 | 2017-09-28 | 学校法人兵庫医科大学 | 癌の治療システム |
| CN105906595A (zh) * | 2016-04-23 | 2016-08-31 | 陈斌 | 丙酸倍氯米松的药物组合物及其在生物医药中的应用 |
| CN105837541A (zh) * | 2016-04-23 | 2016-08-10 | 何淑琼 | 磷酸苯丙哌林的药物组合物及其在生物医药中的应用 |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル, インコーポレイテッド | がんを処置するための方法 |
| CN106380456B (zh) * | 2016-08-29 | 2019-03-26 | 中南大学 | 一种合成苯并呋喃萘醌衍生物的方法 |
| WO2018096401A1 (en) | 2016-11-22 | 2018-05-31 | Hitoshi Ban | New naphtho[2,3-b]furan derivatives |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| WO2018102427A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| CN110062633A (zh) * | 2016-11-30 | 2019-07-26 | 迪美公司 | 酪氨酸衍生物以及包含所述酪氨酸衍生物的组合物 |
| CN113769097A (zh) * | 2017-01-22 | 2021-12-10 | 江苏恒瑞医药股份有限公司 | Egfr/her2抑制剂联合嘧啶类抗代谢药物的用途 |
| US11963966B2 (en) | 2017-03-31 | 2024-04-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| IL271116B2 (en) * | 2017-06-04 | 2025-12-01 | Rappaport Family Institute For Res In The Medical Sciences | Method of predicting personalized response to cancer therapy and kit therefor |
| WO2019018207A1 (en) * | 2017-07-20 | 2019-01-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | TARGETED OSMOTIC LYSE OF MALIGNANT CANCER CELLS USING PULSED MAGNETIC FIELD GRADIENTS |
| JPWO2019059344A1 (ja) | 2017-09-22 | 2020-11-26 | 大日本住友製薬株式会社 | 化学活性化型水溶性プロドラッグ |
| JP7236163B2 (ja) * | 2017-11-16 | 2023-03-09 | ティルノーヴォ リミテッド | がん治療のためのirs/stat3デュアルモジュレーターと抗pd-1/pd-l1抗体との組み合わせ |
| EP3501511A1 (en) * | 2017-12-22 | 2019-06-26 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III | Means for preventing and treating brain metastasis |
| CN111542598B (zh) * | 2017-12-28 | 2024-07-30 | 株式会社钟化 | 多能干细胞聚集抑制剂 |
| CN107973788B (zh) * | 2018-01-09 | 2021-07-09 | 沈阳药科大学 | Bbi608衍生物及其制备与用途 |
| SG11202007979UA (en) * | 2018-03-20 | 2020-09-29 | Sumitomo Dainippon Pharma Co Ltd | Dihydrochromene derivative |
| MX2020011065A (es) * | 2018-04-19 | 2021-01-20 | Tvardi Therapeutics Inc | Inhibidores stat3. |
| WO2019232214A1 (en) | 2018-05-31 | 2019-12-05 | Boston Biomedical, Inc. | Methods of using napabucasin |
| CN112703001A (zh) * | 2018-09-18 | 2021-04-23 | 株式会社益力多本社 | 使用喹啉羧酰胺衍生物的癌症联用疗法 |
| CA3115869A1 (en) * | 2018-10-12 | 2020-04-16 | 1Globe Biomedical Co., Ltd. | New combination solution for treating chemotherapy refractory cancer |
| CN109331004A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂甲磺酸盐A晶型联合用药物组合物 |
| CN109288847A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat抑制剂甲磺酸盐晶型p联合用药物组合物 |
| CN109966297A (zh) * | 2018-10-31 | 2019-07-05 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat抑制剂马来酸盐晶型i联合用药物组合物 |
| CN109288846A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat3抑制剂晶型a联合用药物组合物 |
| CN109288845A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种咔唑类stat抑制剂马来酸盐晶型ii联合用药物组合物及其制备方法 |
| CN109200044A (zh) * | 2018-10-31 | 2019-01-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂酒石酸盐联合用药物组合物 |
| CN109200052A (zh) * | 2018-10-31 | 2019-01-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和芴酮类stat3抑制剂联合用药物组合物 |
| CN109846888A (zh) * | 2018-10-31 | 2019-06-07 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和吲哚类stat3抑制剂联合用药物组合物 |
| CN109172563A (zh) * | 2018-10-31 | 2019-01-11 | 南京先进生物材料与过程装备研究院有限公司 | 一种噻吨酮类紫杉醇和stat3抑制剂联合用药物组合物 |
| CN109223758A (zh) * | 2018-10-31 | 2019-01-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和芴类stat3抑制剂联合用药物组合物 |
| CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
| EP3954374A4 (en) * | 2019-04-09 | 2023-05-03 | Generos Biopharma Ltd. | PHARMACEUTICAL COMBINATION OF PIMOZIDE AND METHOTREXATE AND ITS USE |
| US11564913B2 (en) | 2019-05-03 | 2023-01-31 | Children's Hospital Medical Center | Compositions and methods for treating cancer |
| CN110218198B (zh) * | 2019-05-22 | 2022-06-28 | 广州中医药大学(广州中医药研究院) | 一种萘醌并三氮唑核心骨架衍生物化合物及其制备方法和应用 |
| US20220315551A1 (en) * | 2019-06-14 | 2022-10-06 | Sumitomo Dainippon Pharma Co., Ltd. | 2-ALKYLCARBONYL[2,3-b]FURAN-4,9-DIONE PRODUCTION METHOD AND PRODUCTION INTERMEDIATE THEREFOR |
| JP7287929B2 (ja) * | 2019-09-25 | 2023-06-06 | 住友ファーマ株式会社 | ジヒドロクロメン誘導体を含有する医薬 |
| JP2023500906A (ja) * | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| CA3158371A1 (en) * | 2019-11-20 | 2021-05-27 | Dianqing Wu | Compounds, compositions, and methods for treating ischemia-reperfusion injury and/or lung injury |
| CA3164248A1 (en) * | 2019-12-05 | 2021-06-10 | Board Of Regents, The University Of Texas System | Exosomes-based therapy for liver fibrosis and other diseases associated with fibrosis |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| CN115135326B (zh) * | 2020-03-16 | 2024-09-13 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
| EP4149667A4 (en) * | 2020-05-11 | 2024-06-19 | Purdue Research Foundation | LOMUSTINE SCALE SYNTHESIS UNDER CONTINUOUS FLOW CONDITIONS |
| CN114286684B (zh) * | 2020-07-27 | 2024-01-05 | 华中科技大学 | 与stat3相关的疾病的预防和/或治疗 |
| WO2022216930A1 (en) * | 2021-04-08 | 2022-10-13 | Virginia Commonwealth University | Novel mda-9 antagonist with anti-metastatic potential |
| CN114591306B (zh) * | 2022-03-03 | 2024-03-01 | 陕西中医药大学 | 一种1,2,4-三唑环的1,4萘醌类stat3抑制剂及其应用 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2472133A (en) * | 1947-03-20 | 1949-06-07 | Du Pont | Thiophanthraquinone derivatives |
| SU1049490A1 (ru) | 1982-05-18 | 1983-10-23 | Ордена Трудового Красного Знамени Институт Химии Ан Мсср | (3 @ ,9 @ ,9 @ )-6,6,9 @ -Триметилтранспергидронафто(2,1- @ )фуран,в качестве душистого компонента парфюмерной композиции |
| JPS616149A (ja) | 1984-06-20 | 1986-01-11 | Mitsubishi Electric Corp | 無機絶縁体の製法 |
| JPS63196576A (ja) * | 1987-02-10 | 1988-08-15 | Tetsuo Ikegawa | フラルナフトキノン誘導体と制癌剤及びその製造方法 |
| EP0309926A3 (de) | 1987-09-29 | 1990-12-05 | Siemens Aktiengesellschaft | Verfahren zur Herstellung vollparametrisierbarer Schaltungen in integrierter Schaltkreistechnik |
| JPH01121284A (ja) | 1987-11-06 | 1989-05-12 | Eisai Co Ltd | トコフェロール n,n−ジアルキルアミノアルキルカルボン酸エステルの胆汁酸塩 |
| EP0402192A1 (fr) | 1989-05-31 | 1990-12-12 | BODET, Jean Augustin | Article en carton ou matière analogue et procédé de fabrication |
| JPH04139177A (ja) | 1989-12-28 | 1992-05-13 | Dainippon Ink & Chem Inc | フラルベンゾキノン誘導体及びその製造方法並びに制癌剤 |
| DE69131874T2 (de) * | 1990-07-10 | 2000-06-15 | Canon K.K., Tokio/Tokyo | Elektrophotographisches empfindliches Element |
| JP2942015B2 (ja) * | 1990-07-10 | 1999-08-30 | キヤノン株式会社 | 電子写真感光体およびそれを用いた電子写真装置 |
| TW252136B (OSRAM) * | 1992-10-08 | 1995-07-21 | Ciba Geigy | |
| JP3598168B2 (ja) | 1996-03-18 | 2004-12-08 | 独立行政法人 科学技術振興機構 | 抗ウイルス剤 |
| JPH1121284A (ja) | 1997-06-30 | 1999-01-26 | Kotobuki:Kk | フラノナフトキノン誘導体及びこれを含有する医薬 |
| JPH1165141A (ja) * | 1997-08-11 | 1999-03-05 | Canon Inc | 電子写真感光体、該電子写真感光体を有するプロセスカ−トリッジ及び電子写真装置 |
| US6174913B1 (en) * | 1998-06-05 | 2001-01-16 | The University Of North Carolina At Chapel Hill | Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents |
| JP2003525862A (ja) | 1999-01-27 | 2003-09-02 | ザ ユニヴァーシティー オブ サウス フロリダ | ヒト癌の治療のためのstat3シグナル伝達の阻害 |
| ATE442839T1 (de) | 1999-04-01 | 2009-10-15 | Hana Biosciences Inc | Zusammensetzungen und methoden zur behandlung lymphoma |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| DK1206436T3 (da) | 1999-08-02 | 2005-02-14 | Hoffmann La Roche | Retinoider til behandling af emfysem |
| JP2001097860A (ja) | 1999-09-29 | 2001-04-10 | Japan Science & Technology Corp | 抗薬剤耐性菌剤と抗クラミジア剤 |
| UA75055C2 (uk) | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| KR20010100194A (ko) | 2000-03-13 | 2001-11-14 | 박호군 | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 |
| AU2002307217A1 (en) * | 2001-03-28 | 2002-10-15 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
| GB0117696D0 (en) | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
| US20040092428A1 (en) * | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
| EP1469733A4 (en) | 2001-11-29 | 2008-07-23 | Therakos Inc | METHOD FOR PRE-TREATING A PATIENT WITH EXTRACORPORAL PHOTOPHERESIS AND / OR APOPTOTIC CELLS |
| CA2478338A1 (en) * | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| US7462596B2 (en) | 2002-03-15 | 2008-12-09 | Natimmune A/S | Pharmaceutical compositions comprising mannose binding lectin |
| WO2004024145A1 (en) | 2002-09-10 | 2004-03-25 | Dabur Research Foundation | Anti-cancer activity of carvedilol and its isomers |
| US20060142271A1 (en) | 2002-09-17 | 2006-06-29 | Klaus Muller | Novel lapacho compounds and methods of use thereof |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| TWI323662B (en) | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| IS6633A (is) | 2002-11-22 | 2004-05-23 | Omega Farma Ehf. | Samsetningar af fínasteríð töflum |
| AU2004256425A1 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| JP2007502777A (ja) | 2003-08-13 | 2007-02-15 | ユニバーシティー オブ サウス フロリダ | 腫瘍の処置のための白金錯体 |
| US20050049207A1 (en) | 2003-09-03 | 2005-03-03 | Kaufmann Doug A. | Method of treating and preventing cancer |
| WO2005033048A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Wnt pathway antagonists |
| CN1913915B (zh) | 2003-12-02 | 2010-12-01 | 克里夫兰临床基金会 | 使用鞭毛蛋白防止辐射的方法 |
| CN1894215B (zh) | 2003-12-11 | 2012-03-21 | 得克萨斯州大学系统董事会 | 治疗细胞增殖疾病的化合物 |
| DE10359828A1 (de) * | 2003-12-12 | 2005-07-28 | Zoser B. Dr.Rer.Nat. Salama | CHP-Gemcitabin- Kombinationsmittel und ihre Verwendung als Antitumorwirkstoffe, insbesondere Antimetastasierungswirkstoffe |
| US20060030536A1 (en) * | 2004-04-09 | 2006-02-09 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
| JP2004224802A (ja) | 2004-04-21 | 2004-08-12 | Japan Science & Technology Agency | 抗菌剤 |
| US7560462B2 (en) * | 2004-07-02 | 2009-07-14 | Icos Corporation | Compounds useful for inhibiting CHK1 |
| DE602005017283D1 (de) * | 2004-08-18 | 2009-12-03 | Astrazeneca Ab | Ausgewählte kondensierte heterocyclen und deren anwendung |
| ES2424255T3 (es) * | 2004-11-08 | 2013-09-30 | Baxter International Inc. | Composiciones particuladas de inhibidores de tubulina |
| MX2007006204A (es) * | 2004-11-24 | 2007-06-20 | Novartis Ag | Combinaciones que comprenden inhibidores de jak y cuando menos uno de entre inhibidores de bcr-abl, flt-3, fak o raf cinasa. |
| US7807662B2 (en) | 2004-12-23 | 2010-10-05 | University Of South Florida | Platinum IV complex inhibitor |
| CA2599393A1 (en) * | 2005-02-25 | 2006-08-31 | The Regents Of The University Of Michigan | Small molecule inhibitors of stat3 and the uses thereof |
| JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| JP2006290871A (ja) | 2005-03-16 | 2006-10-26 | Taheebo Japan Kk | 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法 |
| US20060252073A1 (en) | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| WO2006126505A1 (ja) | 2005-05-26 | 2006-11-30 | The University Of Tokyo | Stat機能阻害剤およびその応用 |
| US8133692B2 (en) * | 2005-07-20 | 2012-03-13 | University Of South Florida | Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments |
| NZ567266A (en) | 2005-10-13 | 2010-09-30 | Orchid Res Lab Ltd | Carbazole derivatives as pSTAT3/IL-6 inhibitors (carvedilol) |
| UA96139C2 (uk) * | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| JP2007145680A (ja) | 2005-11-30 | 2007-06-14 | Idemitsu Kosan Co Ltd | 水素発生材料および水素発生方法 |
| CA2628728A1 (en) * | 2005-12-24 | 2007-07-05 | Biotica Technology Ltd. | 21-deoxymacbecin analogues useful as antitumor agents |
| AU2007208494A1 (en) * | 2006-01-12 | 2007-08-02 | Merck Sharp & Dohme Corp. | Fluorinated arylamide derivatives |
| WO2007092620A2 (en) * | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| WO2007100640A2 (en) * | 2006-02-21 | 2007-09-07 | The Regents Of The University Of Michigan | Growth hormone receptor antagonist cancer treatment |
| EP1989187A4 (en) * | 2006-02-24 | 2009-07-08 | Merck Frosst Canada Ltd | 2- (PHENYL OR HETEROCYCLYL) -1H-PHENANTHRO (9,10-D) IMIDAZOLE |
| RU2456265C2 (ru) * | 2006-03-31 | 2012-07-20 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Биологически доступная для перорального применения кофейная кислота, относящаяся к противоопухолевым лекарственным средствам |
| US20070238770A1 (en) | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
| WO2008094321A2 (en) | 2006-10-04 | 2008-08-07 | Universtiy Of South Florida | Akt sensitization of cancer cells |
| WO2008077062A2 (en) * | 2006-12-19 | 2008-06-26 | Board Of Regents, The University Of Texas System | Suppression of stat3 reactivation after src kinase inhibition to treat cancer |
| JP4077863B1 (ja) | 2007-05-31 | 2008-04-23 | タヒボジャパン株式会社 | 抗癌活性を有する光学活性2−(1−ヒドロキシエチル)−5−ヒドロキシナフト[2,3−b]フラン−4,9−ジオンの製法 |
| EP3050566B1 (en) | 2007-09-10 | 2018-11-28 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| WO2009060282A2 (en) | 2007-11-06 | 2009-05-14 | Orchid Research Laboratories Limited | Stilbene derivatives as pstat3/il-6 inhibitors |
| RU2571661C2 (ru) | 2010-03-19 | 2015-12-20 | Бостон Байомедикал, Инк. | Новые соединения и композиции для нацеливания на злокачественные стволовые клетки |
| AU2015218436B9 (en) | 2010-03-19 | 2017-03-09 | Boston Biomedical, Inc. | Novel Methods For Targeting Cancer Stem Cells |
| ES2987670T3 (es) | 2010-03-19 | 2024-11-15 | 1Globe Biomedical Co Ltd | Métodos novedosos para actuar sobre células madre cancerosas |
| CA2993363A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Naphthofuran compounds and compositions for targeting cancer stem cells |
| US9150530B2 (en) | 2011-03-04 | 2015-10-06 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies |
| US8977803B2 (en) | 2011-11-21 | 2015-03-10 | Western Digital Technologies, Inc. | Disk drive data caching using a multi-tiered memory |
| WO2013166618A1 (en) | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
| CN106211758B (zh) | 2013-04-09 | 2021-03-23 | 北京强新生物科技有限公司 | 2-乙酰基萘并[2,3-b]呋喃-4,9-二酮用于治疗癌症的用途 |
| AU2016249157A1 (en) | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
| EA201792287A1 (ru) | 2015-04-17 | 2018-03-30 | Бостон Биомедикал, Инк. | Способы лечения рака |
| AU2016249158A1 (en) | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
| BR112017022958A2 (pt) | 2015-04-27 | 2018-07-17 | Boston Biomedical Inc | métodos para tratamento de câncer com inibidor da via da stat3 e inibidor de quinase |
| CN107847481A (zh) | 2015-06-03 | 2018-03-27 | 波士顿生物医药有限公司 | 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 |
| CN109069469A (zh) | 2016-01-20 | 2018-12-21 | 北京强新生物科技有限公司 | 治疗癌症的方法 |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
-
2008
- 2008-09-10 EP EP16156335.8A patent/EP3050566B1/en active Active
- 2008-09-10 US US12/677,511 patent/US8877803B2/en not_active Expired - Fee Related
- 2008-09-10 CA CA2736563A patent/CA2736563C/en not_active Expired - Fee Related
- 2008-09-10 DK DK08830619.6T patent/DK2190429T3/en active
- 2008-09-10 SI SI200831626A patent/SI2194987T1/sl unknown
- 2008-09-10 PT PT88306337T patent/PT2200431T/pt unknown
- 2008-09-10 CA CA2911990A patent/CA2911990C/en not_active Expired - Fee Related
- 2008-09-10 CN CN200880115250.2A patent/CN101854930B/zh active Active
- 2008-09-10 JP JP2010524249A patent/JP5701603B2/ja not_active Expired - Fee Related
- 2008-09-10 SI SI200831655A patent/SI2200431T1/sl unknown
- 2008-09-10 CN CN201310052882.1A patent/CN103288787B/zh active Active
- 2008-09-10 EP EP08830633.7A patent/EP2200431B1/en active Active
- 2008-09-10 CN CN201410583457.XA patent/CN104586832B/zh active Active
- 2008-09-10 EP EP16156290.5A patent/EP3058941B1/en active Active
- 2008-09-10 PT PT88304712T patent/PT2194987T/pt unknown
- 2008-09-10 DK DK08830471.2T patent/DK2194987T3/en active
- 2008-09-10 US US12/677,516 patent/US9732055B2/en not_active Expired - Fee Related
- 2008-09-10 HR HRP20160625TT patent/HRP20160625T1/hr unknown
- 2008-09-10 DK DK16156335.8T patent/DK3050566T3/en active
- 2008-09-10 ES ES08830619.6T patent/ES2569215T3/es active Active
- 2008-09-10 HU HUE08830619A patent/HUE027443T2/en unknown
- 2008-09-10 JP JP2010524251A patent/JP5872160B2/ja not_active Expired - Fee Related
- 2008-09-10 HU HUE08830471A patent/HUE027657T2/en unknown
- 2008-09-10 HR HRP20160949TT patent/HRP20160949T1/hr unknown
- 2008-09-10 SI SI200831606A patent/SI2190429T1/sl unknown
- 2008-09-10 PL PL16156278T patent/PL3067054T3/pl unknown
- 2008-09-10 HR HRP20160430TT patent/HRP20160430T1/hr unknown
- 2008-09-10 EP EP08830619.6A patent/EP2190429B1/en active Active
- 2008-09-10 CA CA2736532A patent/CA2736532C/en not_active Expired - Fee Related
- 2008-09-10 PL PL08830471T patent/PL2194987T3/pl unknown
- 2008-09-10 DK DK08830633.7T patent/DK2200431T3/en active
- 2008-09-10 PL PL08830619.6T patent/PL2190429T3/pl unknown
- 2008-09-10 CN CN200880115249.XA patent/CN101854802B/zh active Active
- 2008-09-10 CN CN201610134121.4A patent/CN105963289B/zh active Active
- 2008-09-10 PL PL08830633T patent/PL2200431T3/pl unknown
- 2008-09-10 WO PCT/US2008/075906 patent/WO2009036101A1/en not_active Ceased
- 2008-09-10 WO PCT/US2008/075848 patent/WO2009036059A2/en not_active Ceased
- 2008-09-10 HU HUE08830633A patent/HUE029111T2/en unknown
- 2008-09-10 CN CN2008801152470A patent/CN101854937B/zh active Active
- 2008-09-10 WO PCT/US2008/075903 patent/WO2009036099A1/en not_active Ceased
- 2008-09-10 EP EP08830471.2A patent/EP2194987B1/en active Active
- 2008-09-10 CA CA2736564A patent/CA2736564A1/en not_active Abandoned
- 2008-09-10 EP EP16156278.0A patent/EP3067054B1/en active Active
- 2008-09-10 JP JP2010524243A patent/JP5688840B2/ja not_active Expired - Fee Related
- 2008-09-10 ES ES08830471.2T patent/ES2583010T3/es active Active
- 2008-09-10 US US12/677,513 patent/US9745278B2/en not_active Expired - Fee Related
- 2008-09-10 ES ES08830633.7T patent/ES2584904T3/es active Active
-
2014
- 2014-09-02 JP JP2014177908A patent/JP5925849B2/ja not_active Expired - Fee Related
- 2014-09-02 JP JP2014177915A patent/JP5938072B2/ja not_active Expired - Fee Related
- 2014-09-29 US US14/499,299 patent/US9834532B2/en not_active Expired - Fee Related
- 2014-11-17 JP JP2014232397A patent/JP2015034179A/ja not_active Withdrawn
- 2014-11-17 JP JP2014232396A patent/JP6106149B2/ja not_active Expired - Fee Related
-
2015
- 2015-11-26 JP JP2015230291A patent/JP6358659B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-13 JP JP2016004076A patent/JP6347795B2/ja not_active Expired - Fee Related
- 2016-02-01 JP JP2016016973A patent/JP6346628B2/ja not_active Expired - Fee Related
- 2016-05-11 CY CY20161100393T patent/CY1117604T1/el unknown
- 2016-05-16 JP JP2016097607A patent/JP2016147906A/ja not_active Withdrawn
- 2016-07-19 CY CY20161100701T patent/CY1118476T1/el unknown
- 2016-07-26 CY CY20161100733T patent/CY1117833T1/el unknown
-
2017
- 2017-02-10 US US15/429,939 patent/US20170197932A1/en not_active Abandoned
- 2017-07-11 US US15/647,054 patent/US20180030021A1/en not_active Abandoned
- 2017-07-20 US US15/655,366 patent/US20180030022A1/en not_active Abandoned
- 2017-12-19 JP JP2017242778A patent/JP2018076349A/ja not_active Withdrawn
-
2018
- 2018-05-29 JP JP2018102234A patent/JP2018131464A/ja not_active Withdrawn
- 2018-10-16 US US16/161,413 patent/US10851075B2/en not_active Expired - Fee Related
- 2018-12-31 US US16/236,948 patent/US20200039948A1/en not_active Abandoned
-
2019
- 2019-01-14 US US16/246,829 patent/US10377731B2/en not_active Expired - Fee Related
- 2019-02-21 JP JP2019029436A patent/JP2019073560A/ja active Pending
-
2020
- 2020-05-14 JP JP2020085065A patent/JP2020117547A/ja active Pending
- 2020-05-15 US US16/875,479 patent/US20210024482A1/en not_active Abandoned
- 2020-05-26 JP JP2020091326A patent/JP2020143135A/ja active Pending
- 2020-10-09 US US17/066,885 patent/US20210115006A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010539097A5 (OSRAM) | ||
| JP5701603B2 (ja) | Stat3経路阻害剤および癌幹細胞経路阻害剤の新規のグループ | |
| KR20210151820A (ko) | 암을 치료하기 위한 조성물 및 방법 | |
| WO2014141129A2 (en) | Novel methods, compounds, and compositions for inhibition of ros | |
| JPWO2019074116A1 (ja) | Axl阻害剤を有効成分として含む固形がん治療剤 | |
| BR112015031278B1 (pt) | Compostos e nanopartículas de platina com base em lipídio, seus processos de preparação, composições farmacêuticas compreendendo os mesmos e seus usos no tratamento de câncer | |
| JP7749542B2 (ja) | 癌標的薬物ビヒクルとしてのリン脂質エーテルコンジュゲート | |
| CA2944255C (en) | New derivatives of cephalosporin for treating cancer | |
| CN107141287B (zh) | 2-亚胺-5-酮基-2,5-二氢-1-h-二吡啶并嘧啶类化合物 | |
| JP2008501690A (ja) | がんの治療方法 | |
| JP2014515026A (ja) | アカデシン誘導体、それを含有する製剤および組成物、その治療目的での使用、ならびにその合成法 | |
| WO2026006342A1 (en) | Direct-binding dual inhibitors of hypoxia-inducible factor 1 (hif-1) and hif-2 | |
| ES2713455T3 (es) | Un grupo novedoso de inhibidores de la ruta STAT3 e inhibidores de la ruta de células madre de cáncer | |
| HK1227310B (en) | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors | |
| HK1227310A1 (en) | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors | |
| EA044668B1 (ru) | Композиции и способы для лечения рака | |
| HK1229259B (zh) | 一类stat3通路抑制剂和癌干细胞通路抑制剂 | |
| HK1233924B (en) | Derivatives of cephalosporin for treating cancer | |
| HK1233924A1 (en) | Derivatives of cephalosporin for treating cancer |