JP2010538610A5 - - Google Patents
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- JP2010538610A5 JP2010538610A5 JP2010524221A JP2010524221A JP2010538610A5 JP 2010538610 A5 JP2010538610 A5 JP 2010538610A5 JP 2010524221 A JP2010524221 A JP 2010524221A JP 2010524221 A JP2010524221 A JP 2010524221A JP 2010538610 A5 JP2010538610 A5 JP 2010538610A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- ovarian cancer
- subject
- cell
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091070501 miRNA Proteins 0.000 claims 54
- 206010033128 Ovarian cancer Diseases 0.000 claims 32
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 32
- 210000004027 cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 23
- 230000014509 gene expression Effects 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 12
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 10
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 10
- 108091074450 miR-200c stem-loop Proteins 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 108091058688 miR-141 stem-loop Proteins 0.000 claims 9
- 108091028684 Mir-145 Proteins 0.000 claims 7
- 108091084619 miR-125b-1 stem-loop Proteins 0.000 claims 7
- 108091060382 miR-140 stem-loop Proteins 0.000 claims 7
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 108091062154 Mir-205 Proteins 0.000 claims 3
- 108091055059 miR-30c stem-loop Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091028141 MiR-203 Proteins 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 2
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 2
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 2
- 201000004228 ovarian endometrial cancer Diseases 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical group O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- 230000006429 DNA hypomethylation Effects 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000012649 demethylating agent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108091023796 miR-182 stem-loop Proteins 0.000 claims 1
- -1 miR-30-5p Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 208000030806 ovarian endometrioid adenocarcinoma Diseases 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96766307P | 2007-09-06 | 2007-09-06 | |
| US60/967,663 | 2007-09-06 | ||
| PCT/US2008/075565 WO2009033140A1 (en) | 2007-09-06 | 2008-09-08 | Microrna signatures in human ovarian cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013223103A Division JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538610A JP2010538610A (ja) | 2010-12-16 |
| JP2010538610A5 true JP2010538610A5 (https=) | 2011-10-27 |
| JP5401460B2 JP5401460B2 (ja) | 2014-01-29 |
Family
ID=40429408
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524221A Expired - Fee Related JP5401460B2 (ja) | 2007-09-06 | 2008-09-08 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2013223103A Pending JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2015076636A Ceased JP2015130879A (ja) | 2007-09-06 | 2015-04-03 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013223103A Pending JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2015076636A Ceased JP2015130879A (ja) | 2007-09-06 | 2015-04-03 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100249213A1 (https=) |
| EP (4) | EP2775001B1 (https=) |
| JP (3) | JP5401460B2 (https=) |
| CN (1) | CN101939446B (https=) |
| AU (1) | AU2008296022B2 (https=) |
| CA (1) | CA2698771A1 (https=) |
| WO (1) | WO2009033140A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法 |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| US9096906B2 (en) | 2007-03-27 | 2015-08-04 | Rosetta Genomics Ltd. | Gene expression signature for classification of tissue of origin of tumor samples |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| CA2766210A1 (en) * | 2009-06-25 | 2010-12-29 | Yale University | Single nucleotide polymorphisms in brca1 and cancer risk |
| US8828656B2 (en) | 2009-08-31 | 2014-09-09 | University Of Bremen | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of tumor involving chromosomal rearrangements |
| AU2010294197C9 (en) * | 2009-09-10 | 2018-09-13 | Velin-Pharma A/S | Method for the preparation of micro-RNA and its therapeutic application |
| WO2011057304A2 (en) * | 2009-11-09 | 2011-05-12 | Yale University | Microrna signatures differentiating uterine and ovarian papillary serous tumors |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| EP2354246A1 (en) * | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| EP2643479B1 (en) * | 2010-11-22 | 2017-09-13 | Rosetta Genomics Ltd | Methods and materials for classification of tissue of origin of tumor samples |
| WO2012093384A1 (en) * | 2011-01-03 | 2012-07-12 | Rosetta Genomics Ltd. | Compositions and methods for treatment of ovarian cancer |
| JP5836397B2 (ja) * | 2011-01-13 | 2015-12-24 | インダストリアル テクノロジー リサーチ インスティテュートＩｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 結腸直腸がんの再発予測のためのバイオマーカー |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| CN102178959B (zh) * | 2011-03-15 | 2013-10-23 | 清华大学深圳研究生院 | 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用 |
| WO2012145743A1 (en) * | 2011-04-22 | 2012-10-26 | University Of Houston | Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy |
| EP2766500A4 (en) * | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2013148151A1 (en) * | 2012-03-29 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer |
| US20140274780A1 (en) * | 2013-03-15 | 2014-09-18 | PSertain Technologies | Methods of improving survival in cancer |
| CN103343160B (zh) * | 2013-05-03 | 2014-12-10 | 中国人民解放军南京军区南京总医院 | microRNA-30家族的新用途 |
| CN103243163A (zh) * | 2013-05-09 | 2013-08-14 | 江苏省中医院 | miR-27a的新用途 |
| KR101508580B1 (ko) | 2013-05-14 | 2015-04-07 | 연세대학교 산학협력단 | 재발성 난소암의 예측 또는 진단 방법 |
| WO2014193309A1 (en) * | 2013-05-30 | 2014-12-04 | Agency For Science, Technology And Research | Method For Determining Cancer Prognosis |
| WO2014210341A2 (en) * | 2013-06-27 | 2014-12-31 | Institute For Systems Biology | Products and methods relating to micro rnas and cancer |
| CN103952465A (zh) * | 2013-12-10 | 2014-07-30 | 长沙赢润生物技术有限公司 | 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法 |
| CN104975019B (zh) * | 2014-04-01 | 2019-07-12 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用 |
| WO2016144265A1 (en) * | 2015-03-09 | 2016-09-15 | Agency For Science, Technology And Research | Method of determining the risk of developing breast cancer by detecting the expression levels of micrornas (mirnas) |
| CN105177173A (zh) * | 2015-11-02 | 2015-12-23 | 崔长友 | 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒 |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
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| CN108992457A (zh) * | 2018-01-15 | 2018-12-14 | 广东省实验动物监测所 | miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用 |
| CN108103199B (zh) * | 2018-02-13 | 2021-08-10 | 朱伟 | 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用 |
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| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN114854756B (zh) * | 2022-05-31 | 2023-08-29 | 华南农业大学 | miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用 |
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2008
- 2008-09-08 EP EP14164377.5A patent/EP2775001B1/en not_active Not-in-force
- 2008-09-08 EP EP16184406.3A patent/EP3138926A3/en not_active Withdrawn
- 2008-09-08 WO PCT/US2008/075565 patent/WO2009033140A1/en not_active Ceased
- 2008-09-08 CA CA2698771A patent/CA2698771A1/en not_active Abandoned
- 2008-09-08 US US12/676,670 patent/US20100249213A1/en not_active Abandoned
- 2008-09-08 JP JP2010524221A patent/JP5401460B2/ja not_active Expired - Fee Related
- 2008-09-08 EP EP08799295.4A patent/EP2183393B1/en not_active Not-in-force
- 2008-09-08 AU AU2008296022A patent/AU2008296022B2/en not_active Ceased
- 2008-09-08 EP EP16156869.6A patent/EP3048177A1/en not_active Withdrawn
- 2008-09-08 CN CN200880112585.9A patent/CN101939446B/zh not_active Expired - Fee Related
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