JP2010534646A5 - - Google Patents
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- JP2010534646A5 JP2010534646A5 JP2010517535A JP2010517535A JP2010534646A5 JP 2010534646 A5 JP2010534646 A5 JP 2010534646A5 JP 2010517535 A JP2010517535 A JP 2010517535A JP 2010517535 A JP2010517535 A JP 2010517535A JP 2010534646 A5 JP2010534646 A5 JP 2010534646A5
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- JP
- Japan
- Prior art keywords
- aza
- bicyclo
- hex
- methyl
- ylmethyl
- Prior art date
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- -1 4-methyl-piperazinyl Chemical group 0.000 claims 96
- 125000001424 substituent group Chemical group 0.000 claims 35
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 10
- VSQMBZXCDDTZAF-UHFFFAOYSA-N 6-methylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid Chemical compound S1C=CN2C(C(O)=O)=C(C)N=C21 VSQMBZXCDDTZAF-UHFFFAOYSA-N 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000005605 benzo group Chemical group 0.000 claims 5
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 5
- CHDSHBWEGSCEDX-UHFFFAOYSA-N 2,3-dihydro-1-benzofuran-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1CCO2 CHDSHBWEGSCEDX-UHFFFAOYSA-N 0.000 claims 4
- VFMGOJUUTAPPDA-UHFFFAOYSA-N 2-ethyl-5-methylpyrazole-3-carboxylic acid Chemical compound CCN1N=C(C)C=C1C(O)=O VFMGOJUUTAPPDA-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- QRWZFUBHOQWUGH-UHFFFAOYSA-N 2,5-dimethylpyrazole-3-carboxylic acid Chemical compound CC=1C=C(C(O)=O)N(C)N=1 QRWZFUBHOQWUGH-UHFFFAOYSA-N 0.000 claims 3
- QRDZFPUVLYEQTA-UHFFFAOYSA-N quinoline-8-carboxylic acid Chemical compound C1=CN=C2C(C(=O)O)=CC=CC2=C1 QRDZFPUVLYEQTA-UHFFFAOYSA-N 0.000 claims 3
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000597 dioxinyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000035622 drinking Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- SWVBPJMJJQONPB-UHFFFAOYSA-N pyrrolo[2,1-b][1,3]thiazole-7-carboxylic acid Chemical compound C1=CSC2=C(C(=O)O)C=CN21 SWVBPJMJJQONPB-UHFFFAOYSA-N 0.000 claims 2
- HJZYBDPHAHGHAZ-UHFFFAOYSA-N thiadiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSN=N1 HJZYBDPHAHGHAZ-UHFFFAOYSA-N 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- XYRXQPDMBJNYIU-UHFFFAOYSA-N 1,2-dimethylindole-3-carboxylic acid Chemical compound C1=CC=C2N(C)C(C)=C(C(O)=O)C2=C1 XYRXQPDMBJNYIU-UHFFFAOYSA-N 0.000 claims 1
- ORSZGLLQNYSMNO-UHFFFAOYSA-N 1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC=N2 ORSZGLLQNYSMNO-UHFFFAOYSA-N 0.000 claims 1
- KRCCCWVXRVDONW-UHFFFAOYSA-N 1,3-benzoxazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=CO2 KRCCCWVXRVDONW-UHFFFAOYSA-N 0.000 claims 1
- YALJPBXSARRWTA-UHFFFAOYSA-N 1,3-dimethylpyrazole-4-carboxylic acid Chemical compound CC1=NN(C)C=C1C(O)=O YALJPBXSARRWTA-UHFFFAOYSA-N 0.000 claims 1
- NRCLMJRHAKVTGI-KIVTUJJHSA-N 1-methyl-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]indole-3-carboxamide Chemical compound CC1=CC=CC(C2=C(C=CS2)C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)C=2)=C1 NRCLMJRHAKVTGI-KIVTUJJHSA-N 0.000 claims 1
- VAMUWDDVXBZXQV-KIVTUJJHSA-N 1-methyl-n-[[(1s,2s,5r)-3-[2-(4-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]indole-3-carboxamide Chemical compound C1=CC(C)=CC=C1C1=C(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)C=2)C=CS1 VAMUWDDVXBZXQV-KIVTUJJHSA-N 0.000 claims 1
- HFZZUCBVTBVLKQ-RCZSKKKRSA-N 1-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]indazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)N=2)=C1C1=CC=CC(C)=C1 HFZZUCBVTBVLKQ-RCZSKKKRSA-N 0.000 claims 1
- VFADSUPOYZNRIW-ZCVJKFOLSA-N 1-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]indole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)C=2)=C1C1=CC=CC(C)=C1 VFADSUPOYZNRIW-ZCVJKFOLSA-N 0.000 claims 1
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical compound C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 claims 1
- OJZMOFBVPNUPNY-ACIOBRDBSA-N 2,2-dimethyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3h-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OC(C)(C)CC=3C=CC=2)=C1C1=CC=CC(C)=C1 OJZMOFBVPNUPNY-ACIOBRDBSA-N 0.000 claims 1
- UHXBMSNEECJPSX-UHFFFAOYSA-N 2,3-dihydro-1-benzofuran-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1OCC2 UHXBMSNEECJPSX-UHFFFAOYSA-N 0.000 claims 1
- DCCRIIFBJZOPAV-UHFFFAOYSA-N 2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxylic acid Chemical compound O1CCOC2=C(C(=O)O)SC=C21 DCCRIIFBJZOPAV-UHFFFAOYSA-N 0.000 claims 1
- DKKBLJKJQFTWCY-SESVDKBCSA-N 2,3-dimethoxy-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound COC1=CC=CC(C(=O)NC[C@H]2N(C[C@@H]3C[C@@H]32)C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)=C1OC DKKBLJKJQFTWCY-SESVDKBCSA-N 0.000 claims 1
- WLAKHKRAILHTFE-ACIOBRDBSA-N 2,5-dimethyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC(C)=CC=C1C WLAKHKRAILHTFE-ACIOBRDBSA-N 0.000 claims 1
- CZKIDVYMBRVQBU-UHFFFAOYSA-N 2-chloro-1,3-benzothiazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=C(Cl)S2 CZKIDVYMBRVQBU-UHFFFAOYSA-N 0.000 claims 1
- ISHHSTAPRSERNY-NBHGPNQESA-N 2-chloro-4-fluoro-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=C(F)C=C1Cl ISHHSTAPRSERNY-NBHGPNQESA-N 0.000 claims 1
- JUTSOMMJEQZBHU-RCZSKKKRSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC=C2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 JUTSOMMJEQZBHU-RCZSKKKRSA-N 0.000 claims 1
- AZZLGTAMUJJCDM-RCZSKKKRSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[2-(4-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC=C2)C=2C=CC(C)=CC=2)C[C@@H]2C[C@@H]21 AZZLGTAMUJJCDM-RCZSKKKRSA-N 0.000 claims 1
- UYCBBSWKXKCKOJ-HFSMHLIXSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(2-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C(=CC=CC=2)C)C[C@@H]2C[C@@H]21 UYCBBSWKXKCKOJ-HFSMHLIXSA-N 0.000 claims 1
- LSGKFHYVDHKTIM-IRFCIJBXSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 LSGKFHYVDHKTIM-IRFCIJBXSA-N 0.000 claims 1
- MHUOAKDHOQWMBD-IRFCIJBXSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(4-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=CC(C)=CC=2)C[C@@H]2C[C@@H]21 MHUOAKDHOQWMBD-IRFCIJBXSA-N 0.000 claims 1
- KOFKVWGOKWCPLV-CMKODMSKSA-N 2-ethyl-5-methyl-n-[[(1s,2s,5r)-3-[5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC=N2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 KOFKVWGOKWCPLV-CMKODMSKSA-N 0.000 claims 1
- GOBMDQRSJKYRPY-XKGZKEIXSA-N 2-ethyl-n-[[(1s,2s,5r)-3-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=CC(F)=CC=2)C[C@@H]2C[C@@H]21 GOBMDQRSJKYRPY-XKGZKEIXSA-N 0.000 claims 1
- DFFRYSURYKQACR-SESVDKBCSA-N 2-methoxy-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound COC1=CC=CC=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 DFFRYSURYKQACR-SESVDKBCSA-N 0.000 claims 1
- KDPOFQJHFWJFCB-UHFFFAOYSA-N 2-methyl-1,3-benzoxazole-7-carboxylic acid Chemical compound C1=CC(C(O)=O)=C2OC(C)=NC2=C1 KDPOFQJHFWJFCB-UHFFFAOYSA-N 0.000 claims 1
- OYGIFSYPMQJDON-YUXAGFNASA-N 2-methyl-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzoxazole-4-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=C3N=C(OC3=CC=C2)C)N1C(=O)C=1C=CSC=1C1=CC=CC(C)=C1 OYGIFSYPMQJDON-YUXAGFNASA-N 0.000 claims 1
- RPOPKIAJTHXTPB-AVCGJXAMSA-N 2-methyl-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzoxazole-7-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2C=CC=C3N=C(OC3=2)C)N1C(=O)C=1C=CSC=1C1=CC=CC(C)=C1 RPOPKIAJTHXTPB-AVCGJXAMSA-N 0.000 claims 1
- HKLSMGHQQFAPMZ-YUXAGFNASA-N 2-methyl-n-[[(1s,2s,5r)-3-[2-(4-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzoxazole-4-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=C3N=C(OC3=CC=C2)C)N1C(=O)C=1C=CSC=1C1=CC=C(C)C=C1 HKLSMGHQQFAPMZ-YUXAGFNASA-N 0.000 claims 1
- UPWMRSHUOUQKQG-GBESFXJTSA-N 2-methyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2N3C=C(SC3=NC=2)C)N1C(=O)C=1N=C(C)SC=1C1=CC=CC(C)=C1 UPWMRSHUOUQKQG-GBESFXJTSA-N 0.000 claims 1
- CMHLOPJCPPUIFY-BBTUJRGHSA-N 3,4-dichloro-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 CMHLOPJCPPUIFY-BBTUJRGHSA-N 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- YASYZISYAPAIBW-AJSBUHFISA-N 3,5-dimethoxy-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound COC1=CC(OC)=CC(C(=O)NC[C@H]2N(C[C@@H]3C[C@@H]32)C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)=C1 YASYZISYAPAIBW-AJSBUHFISA-N 0.000 claims 1
- MGLXZOZEHUJQFF-GBESFXJTSA-N 3,5-dimethyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,2-oxazole-4-carboxamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C=1C(C)=NOC=1C MGLXZOZEHUJQFF-GBESFXJTSA-N 0.000 claims 1
- IPOOPXOWQJGXPR-RJGXRXQPSA-N 3,5-dimethyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC(C)=CC(C)=C1 IPOOPXOWQJGXPR-RJGXRXQPSA-N 0.000 claims 1
- WWRNXUZMHPVMKS-SLFFLAALSA-N 3,6-dimethyl-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C(C)=CSC3=NC=2C)=C1C1=CC=CC(C)=C1 WWRNXUZMHPVMKS-SLFFLAALSA-N 0.000 claims 1
- VUSREIKLDQITMY-YUXAGFNASA-N 3-bromo-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound CC1=CC=CC(C2=C(C=CS2)C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=C(Br)C=CC=2)=C1 VUSREIKLDQITMY-YUXAGFNASA-N 0.000 claims 1
- YHADWGHBVHHELC-YUXAGFNASA-N 3-bromo-n-[[(1s,2s,5r)-3-[2-(4-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C1=CC(C)=CC=C1C1=C(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=C(Br)C=CC=2)C=CS1 YHADWGHBVHHELC-YUXAGFNASA-N 0.000 claims 1
- AMFPXEDRITUZLS-SESVDKBCSA-N 3-bromo-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(Br)=C1 AMFPXEDRITUZLS-SESVDKBCSA-N 0.000 claims 1
- GFVXASGGYZUDCU-YUXAGFNASA-N 3-chloro-n-[[(1s,2s,5r)-3-[2-(3-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound CC1=CC=CC(C2=C(C=CS2)C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=C(Cl)C=CC=2)=C1 GFVXASGGYZUDCU-YUXAGFNASA-N 0.000 claims 1
- GYVTWHNVWIDRMN-YUXAGFNASA-N 3-chloro-n-[[(1s,2s,5r)-3-[2-(4-methylphenyl)thiophene-3-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C1=CC(C)=CC=C1C1=C(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=C(Cl)C=CC=2)C=CS1 GYVTWHNVWIDRMN-YUXAGFNASA-N 0.000 claims 1
- JWBLGTXMCVPDBW-SESVDKBCSA-N 3-chloro-n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(Cl)=C1 JWBLGTXMCVPDBW-SESVDKBCSA-N 0.000 claims 1
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- XEWXYDBXJJLPQJ-NBHGPNQESA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,2-dimethylindole-3-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=C(N(C3=CC=CC=C32)C)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 XEWXYDBXJJLPQJ-NBHGPNQESA-N 0.000 claims 1
- IGARYXYJHVOUGO-UCLAIMLFSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-methylindazole-3-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=NN(C3=CC=CC=C32)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 IGARYXYJHVOUGO-UCLAIMLFSA-N 0.000 claims 1
- OGJPFPVCZRHAKY-UQASEVPWSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-methylindole-3-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=CN(C3=CC=CC=C32)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 OGJPFPVCZRHAKY-UQASEVPWSA-N 0.000 claims 1
- ITPCLUQPLHADSE-QANKJYHBSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(F)=C1 ITPCLUQPLHADSE-QANKJYHBSA-N 0.000 claims 1
- FLBFVRFVSJIFGC-FFZOFVMBSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,2-dimethyl-3h-1-benzofuran-7-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2C=CC=C3CC(OC3=2)(C)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 FLBFVRFVSJIFGC-FFZOFVMBSA-N 0.000 claims 1
- ARGNEUPSWWWVNM-JCGIZDLHSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 ARGNEUPSWWWVNM-JCGIZDLHSA-N 0.000 claims 1
- PKSBUKWLWYVDOI-ZOCIIQOWSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 PKSBUKWLWYVDOI-ZOCIIQOWSA-N 0.000 claims 1
- ONWSFTHJUUPPDV-AEGPPILISA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C2=C3OCCOC3=CS2)=C1C1=CC=CC(F)=C1 ONWSFTHJUUPPDV-AEGPPILISA-N 0.000 claims 1
- HKXUAXOLOVIKIR-JLJPHGGASA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)C[C@@H]2C[C@@H]21 HKXUAXOLOVIKIR-JLJPHGGASA-N 0.000 claims 1
- UISMHNSSJALHLO-QILLFSRXSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)C[C@@H]2C[C@@H]21 UISMHNSSJALHLO-QILLFSRXSA-N 0.000 claims 1
- ZFWHDYVJZGXIKO-RYGJVYDSSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,5-dimethoxybenzamide Chemical compound COC1=CC(OC)=CC(C(=O)NC[C@H]2N(C[C@@H]3C[C@@H]32)C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)=C1 ZFWHDYVJZGXIKO-RYGJVYDSSA-N 0.000 claims 1
- SDZBRIKLODDQDX-CWRNSKLLSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound CC1=NOC(C)=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)C[C@@H]2C[C@@H]21 SDZBRIKLODDQDX-CWRNSKLLSA-N 0.000 claims 1
- AKEGJGIPAGBAFZ-JCGIZDLHSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(F)C=CC=1)N)NC(=O)C1=CC=CC(C(F)(F)F)=C1 AKEGJGIPAGBAFZ-JCGIZDLHSA-N 0.000 claims 1
- BUEJDIDYVNAFKL-JCGIZDLHSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-chlorobenzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(F)C=CC=1)N)NC(=O)C1=CC=CC(Cl)=C1 BUEJDIDYVNAFKL-JCGIZDLHSA-N 0.000 claims 1
- DNGBMROTPDPOOA-CWRNSKLLSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C2=C(N3C=CN=C3S2)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 DNGBMROTPDPOOA-CWRNSKLLSA-N 0.000 claims 1
- TUYCYEMRXTVSQW-UQASEVPWSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2N(C3=CC=C(F)C=C3C=2)C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 TUYCYEMRXTVSQW-UQASEVPWSA-N 0.000 claims 1
- AFQIZYQFXIXFKK-SOVGHPHASA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-fluoro-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(F)=C1 AFQIZYQFXIXFKK-SOVGHPHASA-N 0.000 claims 1
- MZTKSDWOOJZEOC-CWRNSKLLSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2N3C=CSC3=NC=2C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 MZTKSDWOOJZEOC-CWRNSKLLSA-N 0.000 claims 1
- ABHIYRSCCDNLKL-BHYGNILZSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=CC(F)=C1 ABHIYRSCCDNLKL-BHYGNILZSA-N 0.000 claims 1
- ZIOWGURXHXKYFM-AEGPPILISA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2)=C1C1=CC=CC(F)=C1 ZIOWGURXHXKYFM-AEGPPILISA-N 0.000 claims 1
- YMDVSZXZUBSSHU-FFZOFVMBSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(F)=C1 YMDVSZXZUBSSHU-FFZOFVMBSA-N 0.000 claims 1
- VMKHACZTKXWPFI-FFZOFVMBSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(F)=C1 VMKHACZTKXWPFI-FFZOFVMBSA-N 0.000 claims 1
- DIXKVDJBTPYIFW-JENIJYKNSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 DIXKVDJBTPYIFW-JENIJYKNSA-N 0.000 claims 1
- CZLVJMWJLDTFAT-YESZJQIVSA-N n-[[(1s,2s,5r)-3-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2N3C=CSC3=NC=2C)N1C(=O)C=1N=C(N)SC=1C1=CC=CC(C)=C1 CZLVJMWJLDTFAT-YESZJQIVSA-N 0.000 claims 1
- QWJMITAKENFKSL-YESZJQIVSA-N n-[[(1s,2s,5r)-3-[2-bromo-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound C([C@@H]1C[C@@H]1[C@H]1CNC(=O)C=2N3C=CSC3=NC=2C)N1C(=O)C=1N=C(Br)SC=1C1=CC=CC(C)=C1 QWJMITAKENFKSL-YESZJQIVSA-N 0.000 claims 1
- JWGHXPRUGVUXHZ-JAXLGGSGSA-N n-[[(1s,2s,5r)-3-[2-cyclopropyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(=N2)C2CC2)C=2C=C(C)C=CC=2)C[C@@H]2C[C@@H]21 JWGHXPRUGVUXHZ-JAXLGGSGSA-N 0.000 claims 1
- REHXIWONKZCWAL-OKZBNKHCSA-N n-[[(1s,2s,5r)-3-[2-methoxy-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(OC)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC(C)=C1 REHXIWONKZCWAL-OKZBNKHCSA-N 0.000 claims 1
- MOVVYQYVZMJZSE-YSIASYRMSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,2-benzoxazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3ON=2)=C1C1=CC=CC(C)=C1 MOVVYQYVZMJZSE-YSIASYRMSA-N 0.000 claims 1
- HMVSQSHRVCQSDB-YSIASYRMSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzothiazole-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3N=CSC=3C=CC=2)=C1C1=CC=CC(C)=C1 HMVSQSHRVCQSDB-YSIASYRMSA-N 0.000 claims 1
- HZRLXUCFZRZQJH-HFSMHLIXSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzothiazole-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3SC=NC=3C=CC=2)=C1C1=CC=CC(C)=C1 HZRLXUCFZRZQJH-HFSMHLIXSA-N 0.000 claims 1
- IJNLVNRJGHYYQP-HFSMHLIXSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-benzoxazole-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OC=NC=3C=CC=2)=C1C1=CC=CC(C)=C1 IJNLVNRJGHYYQP-HFSMHLIXSA-N 0.000 claims 1
- UNBDYRIBKUHFRM-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC(C)=C1 UNBDYRIBKUHFRM-YUXAGFNASA-N 0.000 claims 1
- UBYKYVUWIXVDNZ-HFSMHLIXSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(C)=C1 UBYKYVUWIXVDNZ-HFSMHLIXSA-N 0.000 claims 1
- YXVYWORFALNWAM-GREBRCKQSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1h-indole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3NC=2)=C1C1=CC=CC(C)=C1 YXVYWORFALNWAM-GREBRCKQSA-N 0.000 claims 1
- XELKWVIFRJCOBV-SESVDKBCSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 XELKWVIFRJCOBV-SESVDKBCSA-N 0.000 claims 1
- SQWTYOSGFSRIKH-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 SQWTYOSGFSRIKH-YUXAGFNASA-N 0.000 claims 1
- ANENVGLHGMWBNR-ILWGZMRPSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCC=3C=CC=2)=C1C1=CC=CC(C)=C1 ANENVGLHGMWBNR-ILWGZMRPSA-N 0.000 claims 1
- QVMFXMNYLWITEP-OKZBNKHCSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C2=C3OCCOC3=CS2)=C1C1=CC=CC(C)=C1 QVMFXMNYLWITEP-OKZBNKHCSA-N 0.000 claims 1
- JXZKEEIUQILFTQ-UMXIMWEHSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-morpholin-4-ylbenzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC=C1N1CCOCC1 JXZKEEIUQILFTQ-UMXIMWEHSA-N 0.000 claims 1
- NZZCFRALJKIDSG-AJSBUHFISA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2h-chromene-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=CCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 NZZCFRALJKIDSG-AJSBUHFISA-N 0.000 claims 1
- ICSQFVAPIVXNTH-SESVDKBCSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,4-dihydro-2h-1,4-benzoxazine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3NCCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 ICSQFVAPIVXNTH-SESVDKBCSA-N 0.000 claims 1
- JCOHQHRDPVDSGF-ACIOBRDBSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,4-dihydro-2h-chromene-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCCC=3C=CC=2)=C1C1=CC=CC(C)=C1 JCOHQHRDPVDSGF-ACIOBRDBSA-N 0.000 claims 1
- PNNAWNSUSQLULE-SESVDKBCSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(C(F)(F)F)=C1 PNNAWNSUSQLULE-SESVDKBCSA-N 0.000 claims 1
- AXGAQLXJTSHVCG-HFSMHLIXSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-oxo-4h-1,4-benzoxazine-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCC(=O)NC=3C=CC=2)=C1C1=CC=CC(C)=C1 AXGAQLXJTSHVCG-HFSMHLIXSA-N 0.000 claims 1
- CBWHAUIOSUEOKJ-YESZJQIVSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C(F)(F)F)=C1C1=CC=CC(C)=C1 CBWHAUIOSUEOKJ-YESZJQIVSA-N 0.000 claims 1
- NZURLGJYKPAWQK-ACIOBRDBSA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(C)=C1 NZURLGJYKPAWQK-ACIOBRDBSA-N 0.000 claims 1
- GUFQZLCDGLJFSY-AWRGLXIESA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]quinoline-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N=C3C=CC=CC3=CC=2)=C1C1=CC=CC(C)=C1 GUFQZLCDGLJFSY-AWRGLXIESA-N 0.000 claims 1
- YSXLJBWXXZUYRP-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[2-methyl-5-(4-methylphenyl)-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=C(C)C=C1 YSXLJBWXXZUYRP-YUXAGFNASA-N 0.000 claims 1
- MIFFOTVULVZBIM-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[4-(3-fluorophenyl)-2-methyl-1,3-thiazole-5-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@@H]([C@H]2C[C@H]2C1)CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C=1SC(C)=NC=1C1=CC=CC(F)=C1 MIFFOTVULVZBIM-RYQLBKOJSA-N 0.000 claims 1
- TWYPJFIXHOUEMM-QILLFSRXSA-N n-[[(1s,2s,5r)-3-[5-(2,3-dichlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=CC(Cl)=C1Cl TWYPJFIXHOUEMM-QILLFSRXSA-N 0.000 claims 1
- OWEDFUNCLKHCKX-QILLFSRXSA-N n-[[(1s,2s,5r)-3-[5-(2-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC=C1F OWEDFUNCLKHCKX-QILLFSRXSA-N 0.000 claims 1
- ZCVLVYRHBILODY-AJSBUHFISA-N n-[[(1s,2s,5r)-3-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(C)C(C)=C1 ZCVLVYRHBILODY-AJSBUHFISA-N 0.000 claims 1
- BXAVMHIQXRKOOD-JAXLGGSGSA-N n-[[(1s,2s,5r)-3-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C(C)=CC=2)C[C@@H]2C[C@@H]21 BXAVMHIQXRKOOD-JAXLGGSGSA-N 0.000 claims 1
- IYCVQLLGXGBWMK-JAXLGGSGSA-N n-[[(1s,2s,5r)-3-[5-(3,5-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=C(C)C=2)C[C@@H]2C[C@@H]21 IYCVQLLGXGBWMK-JAXLGGSGSA-N 0.000 claims 1
- MLUWJWHJLSABOR-TWOQFEAHSA-N n-[[(1s,2s,5r)-3-[5-(3-bromo-4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Br)C(F)=CC=2)C[C@@H]2C[C@@H]21 MLUWJWHJLSABOR-TWOQFEAHSA-N 0.000 claims 1
- GRFADMYQLGCWPJ-AVCGJXAMSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,2-dimethylindole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)C=2C)=C1C1=CC=CC(Cl)=C1 GRFADMYQLGCWPJ-AVCGJXAMSA-N 0.000 claims 1
- GKSBFHFNLYWQIA-VDZJLULYSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1,3-dimethylpyrazole-4-carboxamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(Cl)C=CC=1)C)NC(=O)C1=CN(C)N=C1C GKSBFHFNLYWQIA-VDZJLULYSA-N 0.000 claims 1
- ZJFUKRRQEKFASS-NBHGPNQESA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-methylindazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)N=2)=C1C1=CC=CC(Cl)=C1 ZJFUKRRQEKFASS-NBHGPNQESA-N 0.000 claims 1
- LFWDABBCBPMGBT-KPDCDPCYSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-methylindole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3N(C)C=2)=C1C1=CC=CC(Cl)=C1 LFWDABBCBPMGBT-KPDCDPCYSA-N 0.000 claims 1
- OOJWZJLCQFQQTM-ZAAXVRCTSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(Cl)=C1 OOJWZJLCQFQQTM-ZAAXVRCTSA-N 0.000 claims 1
- FAWNNISAHINNRD-XWFZLUIHSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1h-indole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3NC=2)=C1C1=CC=CC(Cl)=C1 FAWNNISAHINNRD-XWFZLUIHSA-N 0.000 claims 1
- BJNDAZOMPKLZRW-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,2-dimethyl-3h-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OC(C)(C)CC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 BJNDAZOMPKLZRW-YUXAGFNASA-N 0.000 claims 1
- AYAVQNMWGYEQPB-FFZOFVMBSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 AYAVQNMWGYEQPB-FFZOFVMBSA-N 0.000 claims 1
- FTFHOZMHYBMSBN-ORYQWCPZSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 FTFHOZMHYBMSBN-ORYQWCPZSA-N 0.000 claims 1
- KMJLYJRGPIMURG-DZFGPLHGSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCCC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 KMJLYJRGPIMURG-DZFGPLHGSA-N 0.000 claims 1
- OFOKMKYQBFUWGN-BHYGNILZSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C2=C3OCCOC3=CS2)=C1C1=CC=CC(Cl)=C1 OFOKMKYQBFUWGN-BHYGNILZSA-N 0.000 claims 1
- FXSDJQSESMPUIT-VDZJLULYSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)C[C@@H]2C[C@@H]21 FXSDJQSESMPUIT-VDZJLULYSA-N 0.000 claims 1
- KYZZIWKAAXXHSB-XKGZKEIXSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)C[C@@H]2C[C@@H]21 KYZZIWKAAXXHSB-XKGZKEIXSA-N 0.000 claims 1
- QTMIVEODGZAEIV-BULFRSBZSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,5-dimethoxybenzamide Chemical compound COC1=CC(OC)=CC(C(=O)NC[C@H]2N(C[C@@H]3C[C@@H]32)C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)=C1 QTMIVEODGZAEIV-BULFRSBZSA-N 0.000 claims 1
- KADVDBPUSVOPTA-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(Cl)C=CC=1)C)NC(=O)C=1C(C)=NOC=1C KADVDBPUSVOPTA-RYQLBKOJSA-N 0.000 claims 1
- ZHBPFSSBYHWNBG-FFZOFVMBSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C([C@@H]1[C@H]2C[C@H]2CN1C(=O)C=1N=C(SC=1C=1C=C(Cl)C=CC=1)C)NC(=O)C1=CC=CC(C(F)(F)F)=C1 ZHBPFSSBYHWNBG-FFZOFVMBSA-N 0.000 claims 1
- HEIQULQRIOQKMV-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C2=C(N3C=CN=C3S2)C)=C1C1=CC=CC(Cl)=C1 HEIQULQRIOQKMV-RYQLBKOJSA-N 0.000 claims 1
- ZLDHZDIDBXKCLE-KPDCDPCYSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N(C3=CC=C(F)C=C3C=2)C)=C1C1=CC=CC(Cl)=C1 ZLDHZDIDBXKCLE-KPDCDPCYSA-N 0.000 claims 1
- YQGFMRZDXGIBOQ-PAXLWEDBSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-fluoro-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(Cl)=C1 YQGFMRZDXGIBOQ-PAXLWEDBSA-N 0.000 claims 1
- SLBPWJDMBYOVCC-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC(Cl)=C1 SLBPWJDMBYOVCC-RYQLBKOJSA-N 0.000 claims 1
- DFEMPSFKSGHEOM-YTQUADARSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=CC(Cl)=C1 DFEMPSFKSGHEOM-YTQUADARSA-N 0.000 claims 1
- YZJYTBRAGFFVOS-BHYGNILZSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2)=C1C1=CC=CC(Cl)=C1 YZJYTBRAGFFVOS-BHYGNILZSA-N 0.000 claims 1
- XEVPSHXPROTPOW-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(Cl)=C1 XEVPSHXPROTPOW-YUXAGFNASA-N 0.000 claims 1
- WSNITFYNGWERRA-DJPFJPOOSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C2=C3C=CC=CN3N=C2)=C1C1=CC=CC(Cl)=C1 WSNITFYNGWERRA-DJPFJPOOSA-N 0.000 claims 1
- AGLZKLZCKAKJSA-GREBRCKQSA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]quinoline-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N=C3C=CC=CC3=CC=2)=C1C1=CC=CC(Cl)=C1 AGLZKLZCKAKJSA-GREBRCKQSA-N 0.000 claims 1
- KRTLOHHQQIEOCF-YUXAGFNASA-N n-[[(1s,2s,5r)-3-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(Cl)=C1 KRTLOHHQQIEOCF-YUXAGFNASA-N 0.000 claims 1
- NCPOGPUCNZQPDH-ORYQWCPZSA-N n-[[(1s,2s,5r)-3-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC(F)=C1 NCPOGPUCNZQPDH-ORYQWCPZSA-N 0.000 claims 1
- CYSRPMFYEOQUMK-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC(F)=C1 CYSRPMFYEOQUMK-RYQLBKOJSA-N 0.000 claims 1
- RFOFOLNWAXSBSU-AJSBUHFISA-N n-[[(1s,2s,5r)-3-[5-(4-ethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound C1=CC(CC)=CC=C1C1=C(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=COC=3C=CC=2)N=C(C)S1 RFOFOLNWAXSBSU-AJSBUHFISA-N 0.000 claims 1
- FPHMXTTVWDGNEM-SLFFLAALSA-N n-[[(1s,2s,5r)-3-[5-(4-ethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound C1=CC(CC)=CC=C1C1=C(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)N=C(C)S1 FPHMXTTVWDGNEM-SLFFLAALSA-N 0.000 claims 1
- HKIWPDQDSZVWMW-ORYQWCPZSA-N n-[[(1s,2s,5r)-3-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=C(F)C=C1 HKIWPDQDSZVWMW-ORYQWCPZSA-N 0.000 claims 1
- CVCXAGRYPSSFHZ-RYQLBKOJSA-N n-[[(1s,2s,5r)-3-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-3-azabicyclo[3.1.0]hexan-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H]([C@H]3C[C@H]3C2)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=C(F)C=C1 CVCXAGRYPSSFHZ-RYQLBKOJSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 229940001470 psychoactive drug Drugs 0.000 claims 1
- 239000004089 psychotropic agent Substances 0.000 claims 1
- HRSDPDBQVZHCRC-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine-3-carboxylic acid Chemical compound C1=CC=CC2=C(C(=O)O)C=NN21 HRSDPDBQVZHCRC-UHFFFAOYSA-N 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
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| IB2008051167 | 2008-03-28 | ||
| PCT/IB2008/052985 WO2009016560A2 (en) | 2007-07-27 | 2008-07-25 | Trans-3-aza-bicyclo[3.1.0]hexane derivatives |
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| TW (1) | TW200904799A (enExample) |
| WO (1) | WO2009016560A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CL2007002809A1 (es) * | 2006-09-29 | 2008-04-18 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas |
| US8030495B2 (en) | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
| EP2275421A1 (en) | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
| CA2778949C (en) | 2009-10-30 | 2018-02-27 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors |
| WO2011082268A2 (en) | 2009-12-30 | 2011-07-07 | Arqule Inc. | Substituted naphthalenyl-pyrimidine compounds |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| WO2012110986A1 (en) | 2011-02-18 | 2012-08-23 | Actelion Pharmaceuticals Ltd | Novel pyrazole and imidazole derivatives useful as orexin antagonists |
| BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
| KR20140048257A (ko) | 2011-07-15 | 2014-04-23 | 바스프 에스이 | 동물 해충을 퇴치하기 위해 치환된 3-피리딜 티아졸 화합물 및 유도체 i을 사용하는 살충 방법 |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| WO2013119639A1 (en) | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| ITMI20120322A1 (it) | 2012-03-01 | 2013-09-02 | Rottapharm Spa | Composti di 4,4-difluoro piperidina |
| TWI570120B (zh) | 2012-06-04 | 2017-02-11 | 艾克泰聯製藥有限公司 | 苯并咪唑脯胺酸衍生物 |
| RU2657540C2 (ru) | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
| EP2869822B1 (en) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Inhibitors of phosphodiesterase 10 enzyme |
| CA2879460C (en) * | 2012-07-18 | 2021-10-19 | Garrett MORASKI | 5,5-heteroaromatic anti-infective compounds |
| AU2013328301A1 (en) | 2012-10-10 | 2015-05-28 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives |
| CN105051040A (zh) | 2013-03-12 | 2015-11-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物 |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| JP6496733B2 (ja) | 2013-12-03 | 2019-04-03 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | （ｓ）−（２−（６−クロロ−７−メチル−１ｈ−ベンゾ［ｄ］イミダゾール−２−イル）−２−メチルピロリジン−１−イル）（５−メトキシ−２−（２ｈ−１，２，３−トリアゾール−２−イル）フェニル）メタノンの結晶形及びオレキシン受容体アンタゴニストとしてのその使用 |
| KR102330133B1 (ko) | 2013-12-04 | 2021-11-23 | 이도르시아 파마슈티컬스 리미티드 | 벤즈이미다졸-프롤린 유도체의 용도 |
| TW201613902A (en) | 2014-08-13 | 2016-04-16 | Eolas Therapeutics Inc | Difluoropyrrolidines as orexin receptor modulators |
| LT3414241T (lt) | 2016-02-12 | 2022-08-25 | Astrazeneca Ab | Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai |
| WO2020007964A1 (en) | 2018-07-05 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives |
| WO2020099511A1 (en) | 2018-11-14 | 2020-05-22 | Idorsia Pharmaceuticals Ltd | Benzimidazole-2-methyl-morpholine derivatives |
| EP4196118A1 (en) | 2020-08-13 | 2023-06-21 | Boehringer Ingelheim International GmbH | Treatment of cognitive impairement associated with schizophrenia |
| CN117567449A (zh) | 2020-10-13 | 2024-02-20 | 勃林格殷格翰国际有限公司 | 再加工方法 |
| EP4289834B1 (en) * | 2021-02-02 | 2025-11-26 | Medshine Discovery Inc. | Tetrahydropyrrolocyclic compound and application thereof |
| TW202400149A (zh) | 2022-05-13 | 2024-01-01 | 瑞士商愛杜西亞製藥有限公司 | 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物 |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
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| GB0130335D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| WO2004026866A1 (en) * | 2002-09-18 | 2004-04-01 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
| CL2007002809A1 (es) * | 2006-09-29 | 2008-04-18 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas |
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- 2008-07-25 JP JP2010517535A patent/JP2010534646A/ja active Pending
- 2008-07-25 CN CN200880100366A patent/CN101790515A/zh active Pending
- 2008-07-25 DE DE602008004265T patent/DE602008004265D1/de active Active
- 2008-07-25 AT AT08789439T patent/ATE493386T1/de not_active IP Right Cessation
- 2008-07-25 CA CA2693817A patent/CA2693817A1/en not_active Abandoned
- 2008-07-25 TW TW097128494A patent/TW200904799A/zh unknown
- 2008-07-25 WO PCT/IB2008/052985 patent/WO2009016560A2/en not_active Ceased
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